Direct-Acting Oral Anticoagulants in the Management of Cerebral Venous Sinus Thrombosis—Where Do We Stand? by Nikhil Vojjala, Supriya Peshin, Lakshmi Prasanna Vaishnavi Kattamuri, Rabia Iqbal, Adit Dharia, Jayalekshmi Jayakumar, Rafi Iftekhar, Shagun Singh, Mamtha Balla, Claudia S. Villa Celi, Ramya Ramachandran, Rishab Prabhu, Sumeet K. Yadav, Geetha Krishnamoorthy, Vijendra Singh, Karan Seegobin

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Nomogram model and risk score predicting overall survival and guiding clinical decision in patients with Hodgkin’s lymphoma: an observational study using SEER population-based data... by Yue Yang, Shang Li, Xiao Zhu, Yi Kong, Mingtao Zhang, Xiangping Liang, Zherui Zhang, Shuzhen Tan, Yingqi Li, Yueyuan Zhong, Yingqi Shao, Jiayi Xu, Zesong Li

“…We discovered that Derived American Joint Committee on Cancer (AJCC) Stage Group, lymphoma subtype, radiotherapy and chemotherapy were four independent risk factors affecting the prognosis of HL patients. …”
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Bioassay-guided isolation and identification of antimutagenic compounds from Morina coulteriana and evaluation of its therapeutic potential by Jasbir Kour, Bashir Ahmad Lone, Amit Kumar, Bashir A. Ganai, Govind Yadav, Prasoon Gupta, Md.Niamat Ali, Seema Akbar

“…Background: In the expanding field of cancer research, antimutagenic studies hold a promising ground. …”
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GsMTx-4 venom toxin antagonizes biophysical modulation of metastatic traits in human osteosarcoma cells by Arianna Buglione, Giulia Alloisio, Chiara Ciaccio, David Becerril Rodriguez, Simone Dogali, Marco Luce, Stefano Marini, Antonio Cricenti, Magda Gioia

“…At the nanoscale, these forces can induce substantial molecular deformations, altering the structure and behavior of cancer cells. To address the challenges of osteosarcoma (OS), a highly aggressive cancer, we explored the mechanobiology of OS cells, in vitro. …”
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Human Serum Albumin and Human Serum Albumin Nanoparticles as Carriers of 10-(2′-Pyrimidyl)-3,6-diazaphenothiazine: In Vitro Spectroscopic Studies by Aleksandra Owczarzy, Karolina Kulig, Beata Morak-Młodawska, Małgorzata Jeleń, Tammam Muhammetoglu, Wojciech Rogóż, Małgorzata Maciążek-Jurczyk

“…Due to nontoxicity and biocompatibility, this protein can be used as a nanocarrier. 10-(2′-Pyrimidyl)-3,6-diazaphenothiazine (10-Pyr-3,6-DAPT) is a phenothiazine showing high anticancer potential in vitro against glioma, melanoma and breast cancer cells. Additionally, this compound is characterized by selectivity of action towards MCF-7 breast cancer and has low cytotoxicity towards normal cells. …”
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Health benefits of pedestrian and cyclist commuting: evidence from the Scottish Longitudinal Study by Paul Kelly, David Walsh, Bruce Whyte, Zhiqiang Feng, Chris Dibben, Graham Baker, Ruth Dundas, Evangelia Demou, Catherine Friel

“…Cox proportional hazard models were used to compare cyclist and pedestrian commuters with non-active commuters for a range of health outcomes, controlling for pre-existing health conditions, and demographic and socioeconomic characteristics.Results Compared with non-active commuting, cyclist commuting was associated with lower all-cause mortality risk (HR 0.53, 95% CI 0.38 to 0.73), lower risk of any hospitalisation (HR 0.90, 95% CI 0.84 to 0.97), lower risk of cardiovascular disease (CVD) hospitalisation (HR 0.76, 95% CI 0.64 to 0.91) and of having a CVD prescription (HR 0.70, 95% CI 0.63 to 0.78), lower risk of cancer mortality (HR 0.49, 95% CI 0.30 to 0.82) and cancer hospitalisation (HR 0.76, 95% CI 0.59 to 0.98), and lower risk of having a prescription for mental health problems (HR 0.80, 95% CI 0.73 to 0.89). …”
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Genetically and chemically intraspecific variations of Ficus hirta provide novel insights into its protection and utilization by Jianling Chen, Qianqian Liu, Huihong Wang, Zhi Chao, Enwei Tian

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High interstitial fluid pressure enhances USP1-dependent KIF11 protein stability to promote hepatocellular carcinoma progression by Zhengyi Wu, Chao Li, Shouhua Zhang, Liang Sun, Junwen Hu, Bingbing Qiu, Shuiqiu Liu, Yiran Hong, Tianxiang Chen, Kai Wang, Xiangbao Yin, Jinlong Yan

“…Abstract Background HCC is characterized by a high interstitial fluid pressure (HIFP) environment, which appears to support cancer cell survival. However, the mechanisms behind this phenomenon are not fully understood. …”
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Reactivity in cell culture medium and in vitro anticancer activity of 3,5-di-tert-butylcatechol: link to metal-catechol interactions by Aviva Levina, Debbie C. Crans, Peter A. Lay

“…The resultant adduct is likely to be responsible for the high toxicity of dtbH2 and dtbQ in GSH-rich cancer cells via oxygen-dependent radical chain reactions. …”
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Synthesis, X-Ray Crystal Structures, Biological Evaluation, and Molecular Docking Studies of a Series of Barbiturate Derivatives by Assem Barakat, Hazem A. Ghabbour, Abdullah Mohammed Al-Majid, Qurat-ul-ain, Rehan Imad, Kulsoom Javaid, Nimra Naveed Shaikh, Sammer Yousuf, M. Iqbal Choudhary, Abdul Wadood

“…All barbiturates derivatives (4a–4x, 4z, and 5a–5m) were found to be noncytotoxic against human prostate (PC-3), Henrietta Lacks cervical (HeLa) and Michigan Cancer Foundation-7 breast (MCF-7) cancer cell lines, and 3T3 normal fibroblast cell line, except 4y which was cytotoxic against all the cell lines.…”
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PER3 suppresses tumor metastasis of oral squamous cell carcinoma by promoting HIF-1α degradation by Yaoxu Li, Bing Li, Kai Yang, Lihua Zhu, Hong Tang, Yinpei Huang, Jinhai Deng, Jun Duan

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Pathological and radiological assessment of benign breast lesions with BIRADS IVc/V subtypes. should we repeat the biopsy? by Wesam Rjoop, Anwar Rjoop, Alia Almohtaseb, Lama Bataineh, Zeina Nser Joubi, Maha Gharaibeh, Abdalrahman Al-Qwabah, Yousef Alasheh, Ismail Matalka

“…Abstract Background Timely diagnosis is a crucial factor in decreasing the death rate of patients with breast cancer. BI-RADS categories IVc and V indicate a strong suspicion of cancer. …”
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Renewed Avenues through Exercise Muscle Contractility and Inflammatory Status by Nelo Eidy Zanchi, Felipe Natali Almeida, Fábio Santos Lira, José César Rosa Neto, Humberto Nicastro, Claudia Ribeiro da Luz, Mário Alves de Siqueira Filho, Vitor Felitti, Mariz Vainzof, Marilia Seelaender, Jacques R. Poortmans, Antonio Herbert Lancha

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Cx43 Inhibition Attenuates Sepsis-Induced Intestinal Injury via Downregulating ROS Transfer and the Activation of the JNK1/Sirt1/FoxO3a Signaling Pathway by Zhaowei Zou, Bin Liu, Lisi Zeng, Xianzi Yang, Renli Huang, Cheng Wu, Huijuan Zhu, Yi Gao, Dongdong Yuan, Jinlong Yu

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Viral Transcript and Tumor Immune Microenvironment-Based Transcriptomic Profiling of HPV-Associated Head and Neck Squamous Cell Carcinoma Identifies Subtypes Associated with Progno... by Anastasiia Nikitina, Daria Kiriy, Andrey Tyshevich, Dmitry Tychinin, Zoya Antysheva, Anastasya Sobol, Vladimir Kushnarev, Nara Shin, Jessica H. Brown, James Lewis, Krystle A. Lang Kuhs, Robert Ferris, Lori Wirth, Nikita Kotlov, Daniel L. Faden

“…In order to understand specific factors associated with prognosis, we used the unsupervised clustering of an HPV-positive HNSCC cohort from The Cancer Genome Atlas (TCGA) (n = 53) based on HPV transcript expression, and identified four HPV-related subtypes (E2/E5, E6/E7, E1/E4 and L1/L2). …”
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Fatty Acid Composition and Anticancer Activity of Neutral and Polar Lipids of Pacific Oyster ( Crassostrea gigas ) Cultured in Khanh Hoa Coast in Vietnam by Minh Van Nguyen, Derrick Kakooza, Thi Hong Tuoi Do, Anh Phuong Thi Tran, Han The Nguyen, Ngoc Quang Tran

“…The polar lipid fraction exhibited stronger inhibitory effects on the growth of the three cancer cell lines (HepG2, MDA-MB-231, and RD) compared to the neutral lipid fraction. …”
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Lipids and C-reactive protein predict anhedonia and reward circuit functional connectivity responses to anti-cytokine and dopaminergic therapies in patients with depression by Aditya Singh, Mandakh Bekhbat, David R. Goldsmith, Ngoc-Anh Le, Evanthia C. Wommack, Zhihao Li, Ebrahim Haroon, Jennifer C. Felger

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The antidepressant drug sertraline is a novel inhibitor of yeast Pah1 and human lipin 1 phosphatidic acid phosphatases by Geordan J. Stukey, Matthew R. Breuer, Natalie Burchat, Ruta Jog, Kollin Schultz, Gil-Soo Han, Matthew S. Sachs, Harini Sampath, Ronen Marmorstein, George M. Carman

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Tumoral Prostate Shows Different Expression Pattern of Somatostatin Receptor 2 (SSTR2) and Phosphotyrosine Phosphatase SHP-1 (PTPN6) According to Tumor Progression by Ariel Ernesto Cariaga-Martinez, María Angelica Lorenzati, Mario Alejandro Riera, Marisa Angelica Cubilla, Andrés De La Rossa, Ernesto Martín Giorgio, María Mercedes Tiscornia, Esteban Mariano Gimenez, María Eugenia Rojas, Bárbara Julieta Chaneton, Dora Isabel Rodríguez, Pedro Darío Zapata

“…Many studies on SHP-1 revealed that the expression of this protein was diminished or abolished in several of the cancer cell lines and tissues examined. However, it is necessary to confront the cell lines data with real situation in cancer cases. …”
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The International Vitreoretinal B-Cell Lymphoma Registry: a protocol paper by David J Wilson, Valérie Touitou, Justine R Smith, Manabu Mochizuki, Hiroshi Takase, Steven Yeh, Alexandra L Farrall, H Nida Sen, Daniel V Vasconcelos-Santos, Joke H de Boer, Ninette H ten Dam-van Loon, Janet L Davis, Anthony J Hall, Mark H B Radford

“…Introduction Vitreoretinal lymphoma is a rare ocular cancer with high morbidity and mortality despite treatment. …”
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