Plaguicidas y salud de la población by Miguel Ángel Karam, Guadalupe Ramírez, L. Patricia Bustamante Montes, Juan Manuel Galván

“…Los efectos a la salud de tipo agudo eran anteriormente los más considerados; sin embargo, en las dos últimas décadas han tomado importancia los efectos crónicos, tales como daños en el sistema nervioso central, teratogénesis, mutaciones, cáncer, entre otros. En este artículo se resumen los principales efectos a la salud reportados en la literatura mundial por la exposición a plaguicidas, particularmente los de tipo crónico en la población ocupacionalmente expuesta, concluyendo con las propuestas de investigación hechas en el área.…”
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Pep2TCR: Accurate prediction of CD4 T cell receptor binding specificity through transfer learning and ensemble approach by Kaixuan Diao, Tao Wu, Xiangyu Zhao, Nan Wang, Die Qiu, Wei‐Liang Wang, Xinxiang Li, Xue‐Song Liu

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Commensalism of Fusobacterium nucleatum - The dilemma by Sangeeta Nayak, Nishmitha D. Shetty, Deepa G. Kamath

“…It could cause numerous conditions such as halitosis, dental pulp infection, oral cancer, and systemic diseases. The present review discusses the virulence mechanisms involved in the diseases, with emphasis on its colonization, systemic dissemination, and induction of host inflammatory and tumorigenic responses. …”
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Melatonin as a powerful antioxidant by Chrustek Agnieszka, Olszewska-Słonina Dorota

“…There is a relationship between failure in melatonin production in the pineal gland, an insufficient supply of this hormone to the body, and the occurrence of free radical etiology diseases such as neurodegenerative diseases, cardiovascular diseases, diabetes, cancer and others. Despite the development of molecular biology, numerous in vitro and in vivo studies, the exact mechanism of melatonin antioxidant activity is still unknown. …”
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Concurrent Presentation of Hodgkin Lymphoma and Multiple Myeloma by Rekha Chandran, Miklos Simon, Stephen E. Spurgeon

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Clinicopathological and Prognostic Significance of CD47 Expression in Lung Neuroendocrine Tumors by Mario Orozco-Morales, Alejandro Avilés-Salas, Norma Hernández-Pedro, Rodrigo Catalán, Graciela Cruz-Rico, Ana Laura Colín-González, Elsa Dosal-Mancilla, Pedro Barrios-Bernal, Oscar Arrieta

“…Lung neuroendocrine tumors account for approximately 15% of all lung cancer cases. LNET are subdivided into typical carcinoid (TC), atypical carcinoid (AC), large cell neuroendocrine carcinoma (LCNEC), and small-cell lung cancer (SCLC). …”
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PARylation of HMGA1 desensitizes esophageal squamous cell carcinoma to olaparib by Xin‐Yuan Lei, Kai‐Yue He, Qiu‐Tong Li, Lei Zhang, Dan‐Hui Wu, Jing‐Yu Yang, Jin‐Rong Guo, Meng‐Jie Liu, Zi‐Long Zhao, Jun‐Qi Li, Huai Liu, Yuan Zhao, Yu‐Jia Li, Qian‐Hui Sun, Chen‐Guang Wu, Yun‐Fan Wang, Geng‐Sheng Cao, Gang Wang, Yong‐Ping Jian, Zhi‐Xiang Xu

“…In both subcutaneous tumour models and genetically engineered mouse models of in situ esophageal cancer, HMGA1 interference increased tumour sensitivity to olaparib. …”
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SETD2 loss-of-function uniquely sensitizes cells to epigenetic targeting of NSD1-directed H3K36 methylation by Ryan T. Wagner, Ryan A. Hlady, Xiaoyu Pan, Liguo Wang, Sungho Kim, Xia Zhao, Louis Y. El Khoury, Shafiq Shaikh, Jian Zhong, Jeong-Heon Lee, Jolanta Grembecka, Tomasz Cierpicki, Thai H. Ho, Keith D. Robertson

“…Conclusions These findings unify genome-wide screening approaches with the latest genetic and pharmacologic modeling methodologies to reveal an entirely novel epigenetic approach to individualize therapies against a challenging loss-of-function SETD2 mutation in cancer.…”
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Auricular Acupuncture for Perioperative Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Zhou Y, Bao Q, Yang C, Li S, Yin Z, Xiong J, Sun M, Yang J, Liu F, Liang F

“…Yan Zhou,1,* Qiongnan Bao,1,* Chen Yang,1,* Shuhao Li,1,* Zihan Yin,1 Jian Xiong,1 Mingsheng Sun,1 Jiao Yang,2 Fang Liu,3 Fanrong Liang1 1Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 2Rehabilitation Medicine Center, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 3Department of Integrated Chinese and Western Medicine, Sichuan Cancer Hospital, Chengdu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fanrong Liang, Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610075, People’s Republic of China, Email acuresearch@126.com Fang Liu, Department of Integrated Chinese and Western Medicine, Sichuan Cancer Hospital, Chengdu, Sichuan, 610041, People’s Republic of China, Email liufang@scszlyy.org.cnPurpose: We conducted a more comprehensive systematic review and meta-analysis to evaluate the effectiveness of auricular acupuncture (AA) in perioperative pain management.Methods: Randomized controlled trials (RCTs) findings were retrieved from the Embase, Cochrane Central Register of Controlled Trials, PubMed, Web of Science, Chinese Biomedical Literature Database, Wanfang, VIP, and China National Knowledge Infrastructure databases from their inception to March 2024 using the search terms “pain”, “auriculotherapy”, and “randomized controlled trial”. …”
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Enhanced Interleukin 6 Trans-Signaling Modulates Disease Process in Amyotrophic Lateral Sclerosis Mouse Models by Carol Milligan, Dale O. Cowley, William Stewart, Alyson M. Curry, Elizabeth Forbes, Brian Rector, Annette Hastie, Liang Liu, Gregory A. Hawkins

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Consensus on rapid screening for prodromal Alzheimer’s disease in China by Yao Lu, Ying Wang, Jianping Jia, Qihao Guo, Ya Miao, Lin Huang, Xiaochun Chen, Qinjie Li, Fengfeng Pan, Liang Cui, Tianlu Chen, Yatian Li, Jingnan Wu

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PTEN Sequence Analysis in Endometrial Hyperplasia and Endometrial Carcinoma in Slovak Women by H. Gbelcová, P. Bakeš, P. Priščáková, V. Šišovský, I. Hojsíková, Ľ. Straka, M. Konečný, J. Markus, C. W. D’Acunto, T. Ruml, D. Böhmer, Ľ. Danihel, V. Repiská

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Corrigendum to “Multicentre Harmonisation of a Six-Colour Flow Cytometry Panel for Naïve/Memory T Cell Immunomonitoring” by Iole Macchia, Valentina La Sorsa, Irene Ruspantini, Massimo Sanchez, Valentina Tirelli, Maria Carollo, Giorgio Fedele, Pasqualina Leone, Giovanna Schiavoni, Carla Buccione, Paola Rizza, Paola Nisticò, Belinda Palermo, Stefania Morrone, Helena Stabile, Aurelia Rughetti, Marianna Nuti, Ilaria Grazia Zizzari, Cinzia Fionda, Roberta Maggio, Cristina Capuano, Concetta Quintarelli, Matilde Sinibaldi, Chiara Agrati, Rita Casetti, Andrea Rozo Gonzalez, Floriana Iacobone, Angela Gismondi, Filippo Belardelli, Mauro Biffoni, Francesca Urbani

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CC-96673 (BMS-986358), an affinity-tuned anti-CD47 and CD20 bispecific antibody with fully functional fc, selectively targets and depletes non-Hodgkin’s lymphoma by Dan Zhu, Haralambos Hadjivassiliou, Catherine Jennings, David Mikolon, Massimo Ammirante, Sharmistha Acharya, Jon Lloyd, Mahan Abbasian, Rama Krishna Narla, Joseph R. Piccotti, Katie Stamp, Ho Cho, Kandasamy Hariharan

“…Collectively, these findings define CC-96673 as a promising CD47 × CD20 bispecific antibody that selectively destroys CD20+ cancer cells via enhanced phagocytosis and other effector functions.…”
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Students Participating as Ambassadors for Research in Kentucky (SPARK): A health equity undergraduate research training program by Ariel A. Arthur, Rebecca L. deLacerda Allen, Fidelis Y. Sesenu, Maxwell A. Groznik, Carrie B. Oser, Justin X. Moore, Jessica R. Thompson, Alexis N. James, Madeline N. Dunfee, Philip A. Kern, Nancy E. Schoenberg

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Progressive subchondral bone cyst formation following autologous chondrocyte implantation with all-suture anchors: a Case Report with histological evaluation by Takuma Kaibara, Eiji Kondo, Masatake Matsuoka, Koji Iwasaki, Tomohiro Onodera, Daisuke Momma, Zen-Ichi Tanei, Shinya Tanaka, Norimasa Iwasaki

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Tgfbr1 regulates lateral plate mesoderm and endoderm reorganization during the trunk to tail transition by Anastasiia Lozovska, Ana Casaca, Ana Novoa, Ying-Yi Kuo, Arnon D Jurberg, Gabriel G Martins, Anna-Katerina Hadjantonakis, Moises Mallo

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Efferocytosis and inflammation: a bibliometric and systematic analysis by Xin Cao, Xin Cao, Fen Li, Fen Li, Xi Xie, Xi Xie, Guanghui Ling, Guanghui Ling, Xiaoyu Tang, Xiaoyu Tang, Wenfang He, Jing Tian, Jing Tian, Yan Ge, Yan Ge

“…Future research will likely continue to explore these frontiers, with an emphasis on understanding efferocytosis in the context of chronic diseases and cancer, as well as developing novel therapeutic strategies.…”
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Gene mutation in diabetic patients with lung adenocarcinoma: a real-world retrospective cohort study by Lei Yang, Yang Hong, TingTing Zeng, HongMei Yue, DePeng Jiang

“…PurposeThe incidence of lung cancer is closely associated with diabetes; however, it remains unclear whether diabetes influences the genetic mutations present in lung cancer. …”
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Comparison of the Efficacy of Artificial Intelligence-Powered Software in Crown Design: An In Vitro Study by Ziqiong Wu, Chengqi Zhang, Xinjian Ye, Yuwei Dai, Jing Zhao, Wuyuan Zhao, Yuanna Zheng

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