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9501
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9502
The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis
Published 2015-01-01“…In addition to the role of PARP-1 in DNA repair, multiple studies have also demonstrated its involvement in several inflammatory diseases, such as septic shock, asthma, atherosclerosis, and stroke, as well as in cancer. In these diseases, the pharmacological inhibition of PARP-1 has shown a beneficial effect, suggesting that PARP-1 regulates their inflammatory processes. …”
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9503
Women's Health Crisis in Pakistan
Published 2025-02-01“…Women also face a heightened risk of communicable and non-communicable diseases, including the highest breast cancer rate in Asia. Economic factors, such as low workforce participation and wage gaps, further exacerbate these challenges. …”
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9504
Breast Neuroendocrine Tumor. Case Report and Literature Review
Published 2017-04-01“…The prognosis for this type of cancer is not enough clear yet, although recent studies show that it is similar to that of conventional infiltrating ductal carcinomas. …”
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9505
PIDDosome Expression and the Role of Caspase-2 Activation for Chemotherapy-Induced Apoptosis in RCCs
Published 2010-01-01“…Background: The importance of caspase-2 activation for mediating apoptosis in cancer is not clear and seems to differ between different tumour types. …”
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9506
A Case Report on Ductal Carcinoma in situ Arising from Axillary Accessory Breast Tissue
Published 2025-01-01“…Malignancies arising in accessory breast tissue are rare, representing approximately 0.3%–0.6% of all breast cancer cases. When evaluating accessory breasts, it is essential to apply the same management strategies used for conventionally positioned breasts. …”
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9507
Antiproliferative evaluation of various aminoquinoline derivatives
Published 2019-12-01“…The results revealed a low activity of primaquine urea and bis-urea derivatives and high activity of all fumardiamides, with IC50 values in low micromolar range against all tested cancer cell lines.…”
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9508
Anatomical Considerations of Costal Abnormalities with its Clinical Significance
Published 2024-01-01“…These anomalies highlight the early organogenesis changes that may be associated with stillbirths, cancer, and other defects.…”
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9509
Whole-genome sequence of bioactive streptomycete derived from mangrove forest in Malaysia, Streptomyces sp. MUSC 14
Published 2021-04-01“… The contribution of streptomycetes to human health is undeniably important and significant, given that these filamentous microbes can produce interesting compounds that can be used to cure deadly infections and even cancer. Isolated from the east coast of Peninsular Malaysia, Streptomyces sp. …”
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9510
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9511
Supraglottic Neuroendocrine Carcinoma: A Case Report and Literature Review
Published 2024-01-01“…To date, nearly 700 cases of laryngeal neuroendocrine carcinoma (NEC) have been reported in the literature, with an estimated incidence as low as 0.23%. This type of cancer is more prevalent among men aged 50–83 who are heavy smokers. …”
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9512
Motion – All Patients with GERD Should Be Offered Once in a Lifetime Endoscopy: Arguments for the Motion
Published 2002-01-01“…For them, endoscopy is the only appropriate investigation for detecting Barrett’s esophagus and dysplasia or cancer. Because of the difficulty in distinguishing dysplasia from inflammatory and regenerative changes, endoscopy should be undertaken while the patient is on effective antisecretory therapy. …”
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9513
The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors
Published 2015-01-01“…Bone metastases are frequent and debilitating consequence for many tumors, such as breast, lung, prostate, and kidney cancer. Many studies report the importance of the immune system in the pathogenesis of bone metastasis. …”
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9514
Dual role of pyroptosis in liver diseases: mechanisms, implications, and therapeutic perspectives
Published 2025-01-01“…Furthermore, by sustaining an inflammatory state, impacts the survival and proliferation of cancer cells. This review comprehensively summarizes the dual role of pyroptosis in liver diseases and its therapeutic strategies, offering new theoretical foundations and practical guidance for preventing and treating of liver diseases.…”
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9515
Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases
Published 2017-01-01“…The different steps of immune cell, tissue cell, or cancer cell migration are tightly coordinated in time and place by growth factors, cytokines/chemokines, adhesion molecules, and receptors for these ligands. …”
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9517
Ileocecal Adenocarcinoma and Ureteral Transitional Cell Carcinoma with Multiple Sebaceous Tumors and Keratoacanthomas in a Case of Muir-Torre Syndrome
Published 2010-01-01“…We report a 56-year-old man with a diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC) and ureteral transitional cell carcinoma who subsequently developed two sebaceous gland neoplasms and several keratoacanthomas, leading to the diagnosis of MTS. …”
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9518
Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health
Published 2010-01-01“…While hormone therapy (HT) is an effective means to re-establish endogenous estrogen levels and reduce the risk of future fracture, its use can be accompanied by undesirable side effects such as stroke and breast cancer. In this paper, we revisit the issue of whether HT can be both safe and effective for the prevention of postmenopausal bone loss by examining standard and alternative doses and formulations of HT. …”
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9519
Castleman Disease of the Parotid Gland: A Report of a Case
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9520