Pyrrolizine-5-carboxamides: Exploring the impact of various substituents on anti-inflammatory and anticancer activities by Gouda Ahmed M., Abdelazeem Ahmed H., Abdalla Ashraf N., Ahmed Muhammad

“…Taken together, this study highlighted the significant impact of the substituents on the anti-inflammatory and anticancer activity of pyrrolizine-5-carboxamides, which could help in further optimization to discover good leads for the treatment of cancer and inflammation.…”
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Theranostic nanoemulsions suppress macrophage-mediated acute inflammation in rats by Riddhi Vichare, Yalcin Kulahci, Rebecca McCallin, Fatih Zor, Fatma Nurefsan Selek, Lu Liu, Caitlin Crelli, Anneliese Troidle, Michele Herneisey, James M. Nichols, Andrew J. Shepherd, Vijay S. Gorantla, Jelena M. Janjic

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Cytotoxic Activity of Bisphosphonic Derivatives Obtained by the Michaelis–Arbuzov or the Pudovik Reaction by Zsuzsanna Szalai, Janka Bednárik, Boldizsár Szigfrid Tóth, Angéla Takács, Szilárd Tekula, László Kőhidai, Konstantin Karaghiosoff, László Drahos, György Keglevich

“…Compounds lacking hydroxy groups showed anti-myeloma activity or limited effect on pancreatic cancer (PANC-1) cells unless substituted with para-trifluoromethyl group. …”
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Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity by Jelena Radović, Aleksandra Leković, Ana Tačić, Margarita Dodevska, Tatjana Stanojković, Tijana Marinković, Čedomir Jelić, Tatjana Kundakovic-Vasović

“…Cyclohexane and dichloromethane extracts expressed significant cytotoxic activity against selected cell lines, human epithelial cervical cancer cells (HeLa), adenocarcinomic human alveolar basal epithelial cells (A549), colorectal cancer cells (LS174) and normal MRC-5 human embryonic lung fibroblast cells (IC50 of 78.3–155.6 μg/mL). …”
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Identification of alterations in the nucleotide sequence of the chromatin remodeling gene PBRM1 in clear cell renal cell carcinoma patients by E. A. Klimentova, I. R. Gilyazova, A. A. Izmailov, I. M. Sultanov, M. A. Bermisheva, V. N. Pavlov, E. K. Khusnutdinova

“…Kidney cancer is a heterogeneous group of malignant tumors, the vast majority of which are renal cell carcinomas (RCC) of various morphological types, of which the most common is the clear cell renal cell carcinoma (ccRCC). …”
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HLA-DMB correlates with antitumor immunity and an improved prognosis in endometrial carcinoma tumors by Xiaoyu Xi, Xiaona Zhang, Jianxin Tang, Xiumei Fan, Jiexian Du

“…HLA-DMB, the beta chain of the non-classical MHC class II protein HLA-DM, has been implicated in the progression of various cancers. However, its role in the development of endometrial carcinoma remains unclear. …”
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Postoperative Ratio of C-Reactive Protein to Albumin as a Predictive Marker in Patients with Crohn’s Disease Undergoing Bowel Resection by Hangfen Zhao, Huaying Liu, Weilin Qi, Wei Liu, Lingna Ye, Qian Cao, Xiaolong Ge, Wei Zhou, Xianfa Wang

“…The ratio of C-reactive protein (CRP) to albumin (CAR) has a significant correlation with postoperative complications and acts as a predictor in patients with pancreatic cancer and colorectal cancer. However, whether the CAR can be used to predict complications in Crohn’s disease (CD) patients after surgery has not yet been reported. …”
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Personalized Therapy in a Patient With EGFR-Mutated NSCLC Developing Sequential CCDC6-RET Fusion and BRAF V600E Mutation as Bypass Resistance Mechanisms by Arianna Marinello, MD, Claudia Parisi, MD, Damien Vasseur, PhD, David Combarel, PharmD, Juliette Bihoreau, NP, Pernelle Lavaud, MD, Rémy Ezzedine, MD, Lodovica Zullo, MD, Luc Friboulet, PhD, Gerard Zalcman, MD, PhD, Antoine Italiano, MD, PhD, Benjamin Besse, MD, PhD, Mihaela Aldea, MD, PhD

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Diagnostics and treatment of cardiac achalasia and cardiospasm: guidelines of the Russian gastroenterological association by V. T. Ivashkin, A. S. Trukhmanov, E. A. Godzhello, I. V. Mayev, Yu. V. Evsyutina, T. L. Lapina, O. A. Storonova

“…Differential diagnosis is carried out with cardioesophageal cancer, peptic stricture, esophageal webs and rings, neurogenic anorexia and coronary heart disease in the cases with chest pain. …”
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L-shaped association of body mass index with prognosis in individuals with sepsis: a multicenter cohort study by Kunping Cui, Xiangnan Teng, Wei liu, Xiaoxiao Zhao, Shanling Xu, Lang Bai

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Volatile Organic Compounds as Biomarkers of Gastrointestinal Diseases and Nutritional Status by Mariangela Rondanelli, Federica Perdoni, Vittoria Infantino, Milena Anna Faliva, Gabriella Peroni, Giancarlo Iannello, Mara Nichetti, Tariq A. Alalwan, Simone Perna, Clementina Cocuzza

“…The purpose of this review was to identify the best solution for rapid and noninvasive diagnosis and long-term monitoring of patients affected by inflammatory gastrointestinal diseases, colon and gastric cancer, obesity in correlation to diet, and breast milk to evaluate exposure to VOCs in women and infants. …”
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Physical parameters and biological factors affect the abscopal effect of combining radiotherapy with immunotherapy: an update on preclinical works by Wangcai Ren, Jialing Wen, Gang Guo, Gang Guo, Wenchao Gu, Shenke Zhang, Shenke Zhang, Chang Liu, Chang Liu, Kensuke Osada, Takashi Shimokawa, Qiaojuan Wang, Qiaojuan Wang, Yue Wang, Yue Wang, Xuanzhang Tu, Chen Li, Li Sui, Liqiu Ma, Liqiu Ma, Liqiu Ma

“…In the process of radiotherapy for cancer patients, there is an extremely low probability phenomenon that the distal tumor/metastasis away from the irradiation field undergoes regression after localized radiation therapy, which is called the abscopal effect. …”
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The Impact of Effective Vaccination on Clinical and Radiological Involvement in COVID-19 Patients by Coskun DOGAN, Deniz BILICI, Burcu ARPINAR YIGITBAS, Omer ZENGIN, Orhan ZOR, Oguzhan AKMAN, Ilyas KOCABAG, Gonul Seven YALCIN, Esra ERTAN YAZAR

“…Despite having chronic diseases and cancer, which is considered to have a significant effect on mortality in COVID-19 patients. …”
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Nanopore-based random genomic sampling for intraoperative molecular diagnosis by Francesco E. Emiliani, Abdol Aziz Ould Ismail, Edward G. Hughes, Gregory J. Tsongalis, George J. Zanazzi, Chun-Chieh Lin

“…Abstract Background Central nervous system tumors are among the most lethal types of cancer. A critical factor for tailored neurosurgical resection strategies depends on specific tumor types. …”
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A heteropolysaccharide from Rhodiola rosea L.: preparation, purification and anti-tumor activities in H22-bearing mice by Yaru Wu, Qing Wang, Huiping Liu, Lulu Niu, Mengyu Li, Qi Jia

“…Numerous polysaccharides isolated from plants have been used to augment traditional drugs in the treatment of cancer. In order to explore the influence to hepatocellular carcinoma, a novel cold water-soluble polysaccharide was separated from Rhodiola rosea L. root (RLP) and then its structure and anti-cancer activities were tested. …”
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Human Papillomavirus, Human Immunodeficiency Virus, and Oral Microbiota Interplay in Nigerian Youth (HOMINY): A Prospective Cohort Study Protocol by Jia Liu, Esosa Osagie, Paul Akhigbe, Nosakhare Idemudia, Ozoemene Obuekwe, Ruxton Adebiyi, Nicolas Schlecht, Yana Bromberg, Fidelis E Eki-Udoko, Nosayaba Osazuwa-Peters, Modupe Oluseun Coker

“…Introduction Persistent oral infections with high-risk human papillomavirus (HR-HPV) are a potential cause of most oropharyngeal cancers (OPCs). Oral HR-HPV infection and persistence are significantly higher in people living with HIV (PLWH). …”
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Intrinsic p53 activation restricts gammaherpesvirus driven germinal center B cell expansion during latency establishment by Shana M. Owens, Jeffrey M. Sifford, Gang Li, Steven J. Murdock, Eduardo Salinas, Darby Oldenburg, Debopam Ghosh, Jason S. Stumhofer, Intawat Nookaew, Mark Manzano, J. Craig Forrest

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FoxA1 knockdown promotes BMSC osteogenesis in part by activating the ERK1/2 signaling pathway and preventing ovariectomy-induced bone loss by Lijun Li, Renjin Lin, Yang Xu, Lingdi Li, Zhijun Pan, Jian Huang

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Ukrainian Patients’ Perspectives on Advanced Pharmaceutical Services Provided by Polish Pharmacists: A Cross-Border Support Initiative by Merks P, Religioni U, Borowska M, Hechman R, Konstanty M, Kaźmierczak J, Chełstowska B, Vaillancourt R, Drab A, Wdowiak K

“…Cardinal Stefan Wyszyński University, Warsaw, Poland; 2The Polish Pharmacy Practice Research Network (PPPRN), Warsaw, Poland; 3Trade Union of Pharmacy Workers (ZZPF), Warsaw, Poland; 4European Association of Employed Community Pharmacists (Epheu), Vienna, Austria; 5School of Public Health, Centre of Postgraduate Medical Education of Warsaw, Warsaw, Poland; 6Cancer Epidemiology and Primary Prevention Department, Maria Skłodowska-Curie National Cancer Institute, Warsaw, Poland; 7Farmaceuci.org, Katowice, Poland; 8Polish Pharmaceutical Chamber, Warsaw, Poland; 9Silesian Pharmacy Chamber, Katowice, Poland; 10Department of Biochemistry and Laboratory Diagnostics, Faculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszyński University, Warsaw, Poland; 11Department of Medical Informatics and Statistics with e-Health Lab, Medical University of Lublin, Lublin, Poland; 12Faculty of Medicine, Medical University of Lublin, Lublin, PolandCorrespondence: Mariola Borowska, Email mariola.borowska@nio.gov.plIntroduction: Pharmacists are essential healthcare professionals which play a pivotal role in public health protection by offering diverse pharmacy services. …”
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GK-1 Improves the Immune Response Induced by Bone Marrow Dendritic Cells Loaded with MAGE-AX in Mice with Melanoma by Gabriela Piñón-Zárate, Miguel Ángel Herrera-Enríquez, Beatriz Hernández-Téllez, Katia Jarquín-Yáñez, Andrés Eliú Castell-Rodríguez

“…The aim of dendritic cell (DC) vaccination in cancer is to induce tumor-specific effector T cells that may reduce and control tumor mass. …”
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