Resetting the Hsc70-mediated lysosomal degradation of PD-L1 via a supramolecular meso peptide for the restoration of acquired anti-tumor T cell immunity by Yujia Zhao, Dan Liu, Wenguang Yang, Wangxiao He, Jin Yan, Leiqing Yao

“…Abstract The reduction of cellular PD-L1 abundance through lysosomal degradation is recognized as essential for effective and sustained targeting of PD-L1-dependent immune evasion in cancer. While Hsc70 can interact with PD-L1 to promote its lysosomal degradation, the overexpression of CMTM6 competitively inhibits this interaction, leading to the blockade of PD-L1 lysosomal degradation. …”
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Identification of key taste components in Baccaurea ramiflora Lour. fruit using non-targeted metabolomics by Jie Chen, Fengnian Wu, Huachen Wang, Chunce Guo, Wengen Zhang, Peisi Luo, Jing Zhou, Wenwen Hao, Guangyao Yang, Jianjian Huang

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Socioeconomic status correlates with clinical outcomes in patients with acral melanoma by Rong Huang, Jiayu Wang, Kelin Zheng, Mengke Zhao, Zhengyun Zou, Zhengyun Zou, Zhengyun Zou

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Dissecting macrophage heterogeneity and kaempferol in lung adenocarcinoma: a single-cell transcriptomic approach and network pharmacology by Laiyi Wan, Wentao Hao, Leilei Li, Lin Wang, Yanzheng Song

“…Abstract Background Lung adenocarcinoma (LUAD) is a leading form of non-small cell lung cancer characterized by a complex tumor microenvironment (TME) that influences disease progression and therapeutic response. …”
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Beyond the Definitions of the Phenotypic Complications of Sickle Cell Disease: An Update on Management by Samir K. Ballas, Muge R. Kesen, Morton F. Goldberg, Gerard A. Lutty, Carlton Dampier, Ifeyinwa Osunkwo, Winfred C. Wang, Carolyn Hoppe, Ward Hagar, Deepika S. Darbari, Punam Malik

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Phytochemical analysis and biological activities of solvent extracts and silver nanoparticles obtained from Woodwardia unigemmata (Makino) Nakai. by Syed Ahsan Shah, Alia Gul, Ghulam Mujtaba Shah, Maha Saeed Ibrahim Wizrah, Awais Khalid, Mamoona Munir, Zainab Maqbool, Arusa Aftab, Mazen R Alrahili, Ayesha Siddiqua, M Yasmin Begum

“…The ethanolic extracts (500 μg, 1000 μg, 2000 μg) of the W. unigemmata were found to have cytotoxicity against both gastric cancer (AGS and SGC7901) and normal cell lines (GES-1); a significant cellular proliferation arrest was observed. …”
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Activatable Sulfur Dioxide Nanosonosensitizer Enables Precisely Controllable Sono‐Gaseous Checkpoint Trimodal Therapy for Orthotopic Hepatocellular Carcinoma by Jing Liang, Guangwen Cheng, Luping Qiu, Liyun Xue, Huning Xu, Xiaohui Qiao, Na Guo, Huijing Xiang, Yu Chen, Hong Ding

“…Precisely controllable strategies combining sulfur dioxide (SO2) gas therapy with cancer immunotherapy can address these issues but remain lacking. …”
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Interaction of norsecurinine-type monomeric and dimeric alkaloids with α-tubulin: a molecular docking study by Gérard Vergoten, Christian Bailly

“…Aim: New microtubule-targeting agents are needed to improve cancer treatment. The recent characterization of the anticancer alkaloid securinine as a tubulin-binding agent prompted us to explore the interaction of related monomeric and dimeric analogues with tubulin. …”
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Radiation-induced impacts on mitochondrial DNA and the transgenerational genomic instability by Ryosuke Seino, Haruka Kubo, Kai Nishikubo, Hisanori Fukunaga

“…Methods: Human cervical cancer HeLa cells and telomerase-immortalized normal fibroblast BJ1-hTERT cells were exposed to X-rays at 0.5–8 Gy. …”
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Using Targeted Virotherapy to Treat a Resistant Ewing Sarcoma Model: From the Bedside to the Bench and Back by Hesham Abdelbary, Christopher W. Brown, Joel Werier, John Bell

“…Adding OV to the armamentarium of sarcoma treatment can enhance the future therapeutic approach towards these cancer patients.…”
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The endonuclease activity of MCPIP1 controls the neoplastic transformation of epithelial cells via the c-Met/CD44 axis by Paulina Marona, Rafał Myrczek, Iga Piasecka, Judyta Gorka, Oliwia Kwapisz, Ewelina Pospiech, Janusz Rys, Jolanta Jura, Katarzyna Miekus

“…Proteomic analysis of mouse plasma revealed increased secretion of cancer-related proteins (CXCL13, CXCL16, and MMP2) in the MCPIP1-mutant group. …”
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Predictors and Significance of Readmission after Esophagogastric Surgery: A Nationwide Analysis by Richard PT Evans, MBBS, FRCS, Sivesh K Kamarajah, MBChB, MRCS, Felicity Evison, MSc, Xiaoxu Zou, PhD, Ben Coupland, MSci, Ewen A Griffiths, MD, FRCS

“…The aim of this study is to identify risk factors for readmission after elective esophagogastric cancer surgery and characterize the impact of readmission on long-term survival. …”
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Best Evidence for Each Surgical Step in Minimally Invasive Right Hemicolectomy: A Systematic Review by Alexander A.J. Grüter, MD, Julie M.L. Sijmons, MD, Usha K. Coblijn, MD, PhD, Boudewijn R. Toorenvliet, MD, PhD, Pieter J. Tanis, MD, PhD, Jurriaan B. Tuynman, MD, PhD

“…The aim of this study was to systematically review the literature for each surgical step of the minimally invasive right hemicolectomy (MIRH) for non-locally advanced colon cancer, to define the most optimal procedure with the highest level of evidence. …”
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HnRNPR-mediated UPF3B mRNA splicing drives hepatocellular carcinoma metastasis by Hong Wang, Dong Qian, Jiabei Wang, Yao Liu, Wenguang Luo, Hongyan Zhang, Jingjing Cheng, Heng Li, Yang Wu, Wuhan Li, Jing Wang, Xia Yang, Tianzhi Zhang, Dong Han, Qinyao Wang, Chris Zhiyi Zhang, Lianxin Liu

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Adherent junctions: Physiology, role in hydrocephalus and potential therapeutic targets by Zhiye Chen, Jian He, Yating Guo, Yue Hao, Wentao Lv, Zexin Chen, Junqiang Wang, Yijian Yang, Kaiyue Wang, Zhikun Liu, Qian Ouyang, Zhangjie Su, Pingsheng Hu, Gelei Xiao

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Mixture of Lindley and Lognormal Distributions: Properties, Estimation, and Application by A. S. Al-Moisheer

“…Also, the flexibility of the proposed mixture distribution is demonstrated by showing its superiority to fit a well-known real data set of 128 bladder cancer patients compared to several mixture and nonmixture distributions. …”
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Erythematous ulcero-proliferative exophytic lesion in an oral squamous cell carcinoma patient- An unusual case of Trichosporonosis by Umamaheswari Kesavachandran, C Arun Kumar

“…Our case highlights the occurrence of unusual yeast pathogens in patients with cancer with typical clinical presentations and warrants suspicion of fungal etiology to prevent misdiagnosis of trichosporonosis.…”
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TRP Channels in Human Prostate by Carl Van Haute, Dirk De Ridder, Bernd Nilius

“…Controversial data regarding the expression pattern and the potential impact of TRP channels in prostate function, and their involvement in prostate cancer and other prostate diseases, will be discussed.…”
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Design of studies on neoadjuvant therapy for intrahepatic cholangiocarcinoma by Yuan Cheng, Xiangcheng Li

“…In recent years, progress has been made in immunotherapy and targeted therapy for the treatment of advanced biliary tract cancer (BTC), leading to clinical exploration of the provision of these therapies in the perioperative period. …”
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Melanoma: From Melanocyte to Genetic Alterations and Clinical Options by Corine Bertolotto

“…Metastatic melanoma remained for decades without any effective treatment and was thus considered as a paradigm of cancer resistance. Recent progress with understanding of the molecular mechanisms underlying melanoma initiation and progression revealed that melanomas are genetically and phenotypically heterogeneous tumors. …”
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