DNA methylation of ACADS promotes immunogenic cell death in hepatocellular carcinoma by Ze Qian, Yifan Jiang, Yacong Wang, Yu Li, Lin Zhang, Xiaofeng Xu, Diyu Chen

“…Abstract Background Altered metabolism has become an important characteristic of cancer, and acyl-CoA dehydrogenase short-chain (ACADS), a regulator of lipid synthesis, is involved in carcinogenesis-associated metabolic pathways. …”
Get full text

Identification of GPD1L as a Potential Prognosis Biomarker and Associated with Immune Infiltrates in Lung Adenocarcinoma by Zhengyang Fan, Song Wu, Hongyang Sang, Qianping Li, Shaofei Cheng, Hongling Zhu

“…Lung adenocarcinoma (LUAD) is one of the most prevalent pathological kinds of lung cancer, which is a common form of cancer that has a high death rate. …”
Get full text

Exosomes as Mediators of Cell-to-Cell Communication in Thyroid Disease by Yi Wang, Feng Xu, Jia-Yu Zhong, Xiao Lin, Su-Kang Shan, Bei Guo, Ming-Hui Zheng, Ling-Qing Yuan

“…To date, several studies have demonstrated that exosomes play crucial roles in disease pathogenesis and development, such as breast and prostate cancer. However, studies investigating connections between exosomes and thyroid disease are limited. …”
Get full text

Tissue-specific roles of de novo DNA methyltransferases by Dániel Márton Tóth, Flóra Szeri, Mária Ashaber, Muhyiddeen Muazu, Lóránt Székvölgyi, Tamás Arányi

“…Overall, the expression patterns of DNMTs across tissues provide insights into potential therapeutic applications for treating neurologic diseases, cancer, and osteoporosis.…”
Get full text

Discovery of novel biphenyl compounds bearing hydroxamic acid moiety as the first PD-L1/class I HDACs dual inhibitors by Dandan Yuan, Yali Gao, Lin Xia, Han Liu, Xingye Wu, Xueyan Ding, Yudan Huang, Changchun Deng, Jin Li, Wenqi Dai, Jieqing Liu, Junjie Ma

“…Importantly, 14 could upregulate the expression of PD-L1 and CXCL10 in a PD-L1 low-expression cancer cell line (MCF-7), highlighting the potential to enhance efficacy by recruiting T-cell infiltration into TME and improving the response of PD-1/PD-L1 inhibitor associated with PD-L1 low-expression. …”
Get full text

Risk Factors for Contralateral Occult Papillary Thyroid Carcinoma in Patients with Clinical Unilateral Papillary Thyroid Carcinoma: A Case-Control Study by Liu Yihao, Li Shuo, Xi Pu, Wang Zipeng, Sun Hanlin, Chang Qungang, Wang Yongfei, Yin Detao

“…Introduction. Papillary thyroid cancer (PTC) is one of the most prevalent endocrine malignancies that has increased in recent decades around the world. …”
Get full text

Antiviral therapy can effectively suppress irAEs in HBV positive hepatocellular carcinoma treated with ICIs: validation based on multi machine learning by Shuxian Pan, Zibing Wang

“…The accuracy of the model is verified in the DCA curve.ResultsA total of 274 HBV-related liver cancer patients were enrolled in the study. Predictive models were constructed using three machine learning algorithms to analyze and statistically evaluate clinical characteristics, including immune cell data. …”
Get full text

Real-world use of tafasitamab preceding CD19-directed chimeric antigen receptor T-cell therapy for relapsed or refractory diffuse large B-cell lymphoma by Narendranath Epperla, Loretta J. Nastoupil, Bruce Feinberg, John Galvin, Prathamesh Pathak, Theresa Amoloja, Danielle Gentile, Kim Saverno

Get full text

MicroRNA-129-3p Suppresses Tumor Progression and Chemoradioresistance in Head and Neck Squamous Cell Carcinoma by Tae Mi Yoon, Sun-Ae Kim, Eun Kyung Jung, Young-Kook Kim, Kyung-Hwa Lee, Sang Chul Lim

“…(1) Background: MicroRNA-129 (miR-129) participates in tumor progression and chemoresistance in various cancer types. In this study, the role of miR-129-3p, the main mature form of miR-129, in tumor progression and chemoradiotherapy resistance in head and neck cancer was evaluated. (2) Methods: RT-PCR, western blotting, cell proliferation assays, cell apoptosis assays, and cell invasion and migration assays were used. (3) Results: In this study, the miR-129-3p overexpression suppressed the proliferation, invasion, and migration of SNU1041, SCC15, and SCC25 human HNSCC cell lines. …”
Get full text

Prognostic value of FCER1G expression and M2 macrophage infiltration in esophageal squamous cell carcinoma by Wei Peng, Yali Zhao, Ningning Yang, Yan Fang, Yintong Wu, Zhenzhong Feng, Qiang Wu, Xian Wang

“…Methods The expression of FCER1G and its prognostic value in ESCC was examined by The Cancer Genome Atlas and Gene Expression Omnibus databases. …”
Get full text

Visible light-responsive hydrogels for cellular dynamics and spatiotemporal viscoelastic regulation by Yan Lu, Cheng Chen, Hangyu Li, Peng Zhao, Yuanfeng Zhao, Bohan Li, Wei Zhou, Gaofeng Fan, Dongshi Guan, Yijun Zheng

“…Abstract Viscoelastic heterogeneity of matrices plays a pivotal role in cancer cell spreading, migration, and metastasis. …”
Get full text

Significance of Endoscopic Redness of Duodenum in Health Checkup by Atsushi Nakayama, Motohiko Kato, Yoshiki Sakaguchi, Yu Takahashi, Shinya Kodashima, Ai Fujimoto, Nobutake Yamamichi, Kazumasa Miki, Naohisa Yahagi

Get full text

Calculated Tumor Volume Is an Independent Predictor of Biochemical Recurrence in Patients Who Underwent Retropubic Radical Prostatectomy by Nobumichi Tanaka, Kiyohide Fujimoto, Akihide Hirayama, Yasushi Nakai, Yoshitomo Chihara, Satoshi Anai, Atsushi Tomioka, Keiji Shimada, Noboru Konishi, Yoshihiko Hirao

“…Among the significant preoperative and postoperative parameters, calculated cancer volume remained an independent predictive parameter in multivariate analysis (𝑃<0.01). …”
Get full text

Hubungan Depresi dan Sindrom Dispepsia pada Pasien Penderita Keganasan Yang Menjalani Kemoterapi di RSUP DR. M. Djamil Padang by Mona Rahmi Rulianti1, Dedy Almasdy, Arina Widya Murni

“…The final conclusion of this study is that there are sufficient and direct relationship (p &lt;0.01) between depression and dyspepsia syndrome that occurs in patients with malignancies who are undergoing chemotherapy.<br />Keywords: cancer, chemotherapy, depression, dyspepsia syndrome</p>…”
Get full text

Impact of NRAS Mutations on the Diagnosis of Follicular Neoplasm of the Thyroid by Ja-Seong Bae, Seung Kyu Choi, Sora Jeon, Yourha Kim, Sohee Lee, Youn Soo Lee, Chan Kwon Jung

“…Determining NRAS mutation status in FN helps to improve the accuracy of thyroid cancer diagnosis and to predict cancer risk in accompanying thyroid nodules.…”
Get full text

Uncarboxylated osteocalcin induced miR-143-3p targets SP7 and activates PI3K/Akt signaling in TNBC cells to promote invasion and migration by Qian Du, Jiaojiao Xu, Miao Zhang, Jianhong Yang

“…Triple-negative breast cancer (TNBC) is an exceptionally aggressive malignancy with poor prognosis. …”
Get full text

Differential expression of CD175 and CA19-9 in pancreatic adenocarcinoma by Jane J. Cheng, Yasuyuki Matsumoto, Gabrielle E. Dombek, Kathryn A. Stackhouse, Ana Sofia Ore, Jonathan N. Glickman, Jamie Heimburg-Molinaro, Richard D. Cummings

“…In addition, two other TACAs are CA19-9 (sialyl-Lewis a), which is used as a prognostic serum marker for pancreatic cancer, and its isomer sialyl-Lewis x (SLex, CD15s), which is overexpressed in many cancer types and associated with metastasis. …”
Get full text

Genetic analyses identify circulating genes related to brain structures associated with Parkinson’s disease by Zhe Han, Yanping Zhu, Zhenhong Xia, Qing Deng, Hongjie He, Quanting Yin, Hui Zhang, Mudan Yuan, Chunhua Yang, Geng Tian, Jia Mi, Fuyi Xu

Get full text

Effects of dietary fiber on human health by Yang He, Bixiang Wang, Liankui Wen, Fengzhong Wang, Hansong Yu, Dongxia Chen, Xin Su, Chi Zhang

“…The physicochemical properties of WHC and WSC can reduce the risk of cancer. The WHC, WSC and viscosity are beneficial to intestinal health.…”
Get full text

Spectral Imaging of Multi-Color Chromogenic Dyes in Pathological Specimens by Merryn V. E. Macville, Jeroen A. W. M. Van der Laak, Ernst J. M. Speel, Nir Katzir, Yuval Garini, Dirk Soenksen, George McNamara, Peter C. M. de Wilde, Antonius G. J. M. Hanselaar, Anton H.N. Hopman, Thomas Ried

“…A pixel‐by‐pixel spectrum‐based color classification is presented of single‐, double‐, and triple‐color in situ hybridization for centromeric probes in T24 bladder cancer cells, and immunocytochemical staining of nuclear antigens Ki‐67 and TP53 in paraffin‐embedded cervical brush material (AgarCyto). …”
Get full text