Acyl-CoA Thioesterase 1 Contributes to Transition of Steatosis to Metabolic-Associated Steatohepatitis by Elisa Pasini, Cristina Baciu, Marc Angeli, Bianca Arendt, Diogo Pellegrina, Jüri Reimand, Keyur Patel, George Tomlinson, Mohammad T. Mazhab-Jafari, Lakshmi P. Kotra, Sandra Fischer, Johane P. Allard, Atul Humar, Mamatha Bhat

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Radical Cystectomy and Lymphadenectomy to Two Patients with Pelvic Kidney: Surgical Pitfalls and Considerations by I. Adamakis, C. Pournaras, I. Katafigiotis, G. Kousournas, E. Fragkiadis, I. Leotsakos, C. Alamanis, D. Mitropoulos, C. Constantinides

“…Our goal is to describe our experience in the difficulties encountered during radical cystectomy for muscle invasive bladder cancer in patients with contemporary pelvic kidney. …”
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Drug Target Investigation of <i>N</i>-<i>p</i>-Coumaroyl-<i>N</i>’-Caffeoylputrescine, a Naturally-Occurring Alkaloid Derived from <i>Saxifraga tangutica</i> by Chuang Liu, Jun Dang, Minchen Wu

“…An in vitro study on liver (HepG2) cells and breast (MCF-7) cancer cells revealed that PCC modulates HSP90AA1, subsequently affecting Mut-p53 expression, triggering a cascade effect that reduced adriamycin-induced drug resistance in cells. …”
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Overall quit in triple users of conventional cigarette, e-cigarette and heated tobacco product among healthy adults: a Korea Medical Institute health check-up study by Sun Ha Jee, Heejin Kimm, Keum Ji Jung, Hye Won Yun

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Biological Evaluation of Platinum(II) Sulfonamido Complexes: Synthesis, Characterization, Cytotoxicity, and Biological Imaging by Charini Maladeniya, Taniya Darshani, Sameera R. Samarakoon, Frank R. Fronczek, W. M. C. Sameera, Inoka C. Perera, Theshini Perera

“…All four compounds are promising novel candidates that can be further investigated on their usage as potential anticancer agents and cancer cell imaging agents.…”
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Synthesis, Characterization, and Biological Evaluation of Gabapentinoid Hybrids with Isoindole-1,3(2H)-Dione Moiety as Potential Antioxidant, Antimicrobial, and Anticancer Agents by Mirna Jabbour, Mohammad Ammar Al-Khayat, Mahmoud Al-Ktaifani

“…Furthermore, we have studied the effect of compounds on proliferation, cell cycle, and cell death in two human cancer cell lines (Caco-2 and HCT-116). Results. Compounds 1, 3, and 4 exhibited a good free radical scavenging effect, and compound 3 is the most effective with IC50 value of 2.525 μmol/mL. …”
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Species Differences in the Biotransformation of Aflatoxin B1: Primary Determinants of Relative Carcinogenic Potency in Different Animal Species by David L. Eaton, David E. Williams, Roger A. Coulombe

“…John Groopman has played a leading role in every step of the way—from initial laboratory studies on specific AFB1 metabolites to the application of molecular biomarkers in epidemiological studies associating dietary AFB1 exposure with liver cancer, and the design and conduct of chemoprevention clinical trials to reduce cancer risk from unavoidable aflatoxin exposures by alteration of specific AFB1 biotransformation pathways. …”
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Self-Assembly Iron Oxide Nanoclusters for Photothermal-Mediated Synergistic Chemo/Chemodynamic Therapy by Xiang Li, Zhen Wang, Mian Ma, Zhouqing Chen, Xiang-long Tang, Zhong Wang

“…Although chemodynamic therapy (CDT) is promising for cancer treatment, its clinical application is still limited because of unresolved issues. …”
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N-Cadherin based adhesion and Rac1 activity regulate tension polarization in the actin cortex by Seyedsajad Moazzeni, Kelly Kyker-Snowman, Rick I. Cohen, Huan Wang, Ran Li, David I. Shreiber, Jeffrey D. Zahn, Zheng Shi, Hao Lin

“…These results provide a pathway to reconcile opposing theories for tissue surface tension generation and perspectives in cancer treatment.…”
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Anti-angiogenic effects of cationic zinc (II) phthalocyanine derivatives through photodynamic therapy by Seyma Isik, Mukaddes Ozcesmeci, Ayfer Kalkan Burat, Esin Hamuryudan, Ozge Can, Muge Serhatli

“…The ability of ZnPc1 to simultaneously target tumor cells and disrupt angiogenesis establishes it as a potent candidate for integrated cancer therapies that combine both antitumor and antiangiogenic strategies, offering a more effective approach to combat cancer progression.…”
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Gastric Microbiota Associated with Gastric Precancerous Lesions in <i>Helicobacter pylori</i>-Negative Patients by Han-Na Kim, Min-Jeong Kim, Jonathan P. Jacobs, Hyo-Joon Yang

“…The gastric microbiota associated with <i>H. pylori</i>-negative gastric precancerous lesions showed an increased abundance of oral microbes linked to gastric cancer and a reduction in anti-inflammatory bacteria. …”
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Analysis of vaginal microbiota before and after treatment of high-grade squamous intraepithelial lesions of the uterine cervix by Patrícia Mendonça Ventura, Isabel Cristina Chulvis do Val Guimarães, Luis Guillermo Coca Velarde, Susana Cristina Aidé Viviani Fialho, Douglas Guedes Ferreira, Matheus Madureira Fernandes, Rafael Augusto Chaves Machado

“…The persistence of HPV is the main cause for the development of precursor lesions and cervical cancer. There are environmental and non-environmental factors that contribute to the persistence of the virus. …”
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Association between Endocrine Disrupting Phenols in Colostrums and Maternal and Infant Health by B. Yi, C. Kim, M. Park, Y. Han, J. Y. Park, M. Yang

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Potential Toxic Metal Concentration and Risk Assessment in Agricultural Soil and Lentil Crop (Lens culinaris Medik) in Dawunt Woreda, Northwest Wollo, Ethiopia by Baynesagn Biyazen Belay, Asamene Embiale Taye

“…Thus, the results revealed no significant adverse health risks (cancer and noncancer) for adults and children. Therefore, the inhabitants in the study area have no significant health impacts due to either the consumption of lentil crops or exposure to agricultural soil particles.…”
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Role of silent mutations in KRAS-mutant tumors by Jun Lu, Chao Zhou, Feng Pan, Hongyu Liu, Haohua Jiang, Hua Zhong, Baohui Han, Xiangxiang Pan

“…Kirsten-RAS (KRAS) mutations, predominantly oncogenic, are pivotal drivers in various cancers. While extensive research has elucidated the molecular mechanisms and biological consequences of active KRAS mutations, the functional significance of silent mutations remains relatively understudied. …”
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Role of Ultrasound-guided Tru-cut Needle Biopsy in the Diagnosis of Suspicious Breast Masses at South Valley University Hospitals by Ghada M. Abd ElRazik, Dalia Besharii Hamada, Mohammed M. Mubarak, Ahmed M. Khalaf-Awad

“…Background: The global increase in breast cancer emphasizes early detection through screening and improved molecular subtype understanding. …”
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Lipid-lowering drug targets and lung related diseases: a Mendelian randomization study by Haifeng Yu, Xiaofei Zhang, Bian Wen, Shuo Hu, Bin Ni

“…RESULTS Our study did not find any significant association between genetically proxied APOB, CETP, HMGCR, NPCIL, PCSK9, and LDLR inhibition (equivalent to a one standard deviation reduction in LDL-C) with the risk of Small Cell Lung Cancer, Non-Small Cell Lung Cancer, idiopathic pulmonary fibrosis, and Pneumonia (P > 0.05). …”
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Systemic Inflammatory Cytokines Predict the Infectious Complications but Not Prolonged Postoperative Ileus after Colorectal Surgery by G. S. A. Boersema, Z. Wu, A. G. Menon, G. J. Kleinrensink, J. Jeekel, J. F. Lange

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RNA modification writer-based immunological profile and genomic landscape of tumor microenvironment in lung adenocarcinoma by Qiang Xu, Lingyu Kong, Zhezhu Han, Xiuying Jin, Mingyan Ding, Zhengri Piao, Songnan Zhang

“…The risk-score model was positively correlated with the immune- and proliferation-related pathways. In response to anti-cancer treatment, high-risk score is related with high TMB, which has been discovered to correlate with immunotherapy effectiveness. …”
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Oral Glutamine Supplement Inhibits Ascites Formation in Peritoneal Carcinomatosis Mouse Model by Ming-Jen Chen, Tsang-En Wang, Shu-Jung Tsai, Ching-Chung Lin, Chia-Yuan Liu, Horng-Yuan Wang, Shou-Chuan Shih, Yu-Jen Chen

“…Twenty BALB/c nude mice generated by direct orthotopic injection of human pancreatic cancer PANC-1 cells were randomized to receive either a stock laboratory diet or a stock diet supplemented with glutamine. …”
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