Currently prescribed drugs in the UK that could upregulate or downregulate ACE2 in COVID-19 disease: a systematic review by Paul Little, Simon J Griffin, Hajira Dambha-Miller, Nazrul Islam, Ali Albasri, Christopher R Wilcox, Sam Hodgson, Shareen Khan

“…More studies reported upregulation than downregulation with ACE-I (n=22), ARBs (n=55), insulin (n=8), thiazolidinedione (n=7) aldosterone agonists (n=3), statins (n=5), oestrogens (n=5) calcium channel blockers (n=3) glucagon-like peptide 1 (GLP-1) agonists (n=2) and Non-steroidal anti-inflammatory drugs (NSAIDs) (n=2).Conclusions There is an abundance of the academic literature and media reports on the potential of drugs that could attenuate or exacerbate COVID-19 disease. …”
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THE EFFECT OF ADDING 25-HYDROXYCHOLECALCIFEROL TO THE DIET ON SOME BIOCHEMICAL CHARACTERISTICS OF JAPANESE QUAIL by M. S. Dawod, M. A. Al-Bayar

“…While no significant differences were observed for albumin, calcium in blood serum and egg yolk…”
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Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures by Cristina de Mello-Sampayo, Alaíde Alves Agripino, Duarte Stilwell, Bruno Vidal, Ana Luisa Fernando, Beatriz Silva-Lima, Maria Fátima Vaz, Helena Canhão, M. Cristina Marques

“…Body weight, vertebral microarchitecture (L4-histomorphometry), femur biomechanical properties (bending tests), tibia ultrastructure (scanning electron microscopy), and femur and urinary calcium (atomic absorption) were also evaluated. The increased PINP/CTX ratio of hyperglycemic animals and the similar ratio between STZ + OVX and healthy animals contrasting with the lower ratio of OVX (in line with its histomorphometric data) suggest a tendency for improved bone formation in hyperglycemic-ovariectomized animals. …”
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Sustainable methodical approaches to recycling sludge waste: value-added products, and their agricultural applications by Abas Siraj Hamda, Tesfaye Kassaw Bedru, Mani Jayakumar, Workisa Bacha Garuma

“…Conclusion: The study shows sewage sludge's potential as a valuable organic resources with higher nutrient compositions (Nitrogen 2.5 - 5.5%, Phosphorus 0.8 - 2.5%, Potassium 1.5 - 3.5%, Calcium 1.2 - 4.5%, and Magnesium 0.3 - 0.8% respectively) and its possible uses in agriculture. …”
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A Rare Case of Severe Congenital RYR1-Associated Myopathy by Nicola Laforgia, Manuela Capozza, Lucrezia De Cosmo, Antonio Di Mauro, Maria Elisabetta Baldassarre, Francesca Mercadante, Anna Laura Torella, Vincenzo Nigro, Nicoletta Resta

“…The diagnostic procedure was completed with the complete exome sequencing of the proband and of his parents and his sister, which showed new mutations in the ryanodine receptor gene (RYR1), which maps to chromosome 19q13.2 and encodes the skeletal muscle isoform of a calcium-release channel in the sarcoplasmic reticulum (RyR1). …”
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Wood Ash Liquid Fertilizer as Sustainable Soil Nutritional Supplement Modulates Changes on Growth and Fruits Nutritional Compositions of Capsicum frutescens L. by Racheal Tope-akinyetun, Zainab Mustapha, Musa Hussaini, Temitayo Kelani, Anthony Ojewumi

“…Furthermore, sodium (11.17mg/100g), potassium (363.92 mg/100g), calcium (108.14 mg/100g), and magnesium (58.11 mg/100g) as well as moisture (68.32 %), fat (2.77 %), ash (3.55 %), crude fiber (2.49 %), crude protein (4.43%) and carbohydrate (9.20%) higher in the fruits of C. frutescens treated with 50% WALF. …”
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Comparing predictive risk to actual presence of coronary atherosclerosis on coronary computed tomography angiography by Emma Playford, Simon Stewart, Gerard Hoyne, Geoff Strange, Girish Dwivedi, Christian Hamilton-Craig, Gemma Figtree, David Playford

“…Atherosclerosis was extracted using natural language processing of the CCTA report, including the coronary artery calcium score (CACS) and the extent and severity of CAD. …”
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Enhancing water quality and well-being of Penaeus vannamei (Boone, 1931) in Inland saline systems using mixed biochar amendments by Newmei Tachangliu, Vidya S. Bharti, Chalungal T. Amal, Tao Kara, Saurav Kumar, Pankaj Kumar, A. K. Verma, Arun Konduri, Swaraj Adakney, Shamika Sawant

“…Compared to control, in biochar contained treatments the ammonia levels were reduced, the pH, alkalinity, calcium-magnesium ratio, and potassium in water, were increased significantly. …”
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Determination of Lime Requirement with Compost on Acidic Ultisols for Wheat Crop in the Gurage Zone of Ethiopia by Dereje Dejene, Teshome Yitbarek, Abdeta Jembere

“…Liming alone or integrated application increases soil pH (4.69 to 6.53), cation exchangeable capacity (CEC) (27.18 to 31.58 cmolckg−1), exchangeable calcium (3.56 to 8.43 cmolckg−1), available phosphorus (Av.P) (1.63 to 5.27 ppm), total nitrogen (TN) (0.19 to 0.24 ppm), and exchangeable acidity reduced (0.73 cmolckg−1 to trace). …”
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Space and Time Resolved Detection of Platelet Activation and von Willebrand Factor Conformational Changes in Deep Suspensions by Jacopo Biasetti, Kaushik Sampath, Angel Cortez, Alaleh Azhir, Assaf A. Gilad, Thomas S. Kickler, Tobias Obser, Zaverio M. Ruggeri, Joseph Katz

“…Anti-P-Selectin FITC-conjugated antibodies and the calcium-sensitive probe Indo-1 are used to detect activated platelets. …”
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Human Umbilical Cord Mesenchymal Stem Cells Attenuate Ocular Hypertension-Induced Retinal Neuroinflammation via Toll-Like Receptor 4 Pathway by Shangli Ji, Jie Xiao, Jian Liu, Shibo Tang

“…The expression levels of glial fibrillary acidic protein (GFAP), ionized calcium binding adapter molecule 1 (iba-1), and toll-like receptor 4 (TLR4) were assessed via immunohistochemistry, real-time quantitative PCR, and Western blot. …”
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A comprehensive review of massive transfusion and major hemorrhage protocols: origins, core principles and practical implementation by David Silveira Marinho, Denise Menezes Brunetta, Luciana Maria de Barros Carlos, Luany Elvira Mesquita Carvalho, Jessica Silva Miranda

“…The latter involves the use of antifibrinolytics, correction of preconditions of hemostasis (calcium, pH and temperature) and the early and rapid restoration of intravascular volume with blood products. …”
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Genetic variability and heritability estimates among nutritional traits of groundnut breeding lines by Richard Adu Amoah, James Yaw Asibuo, Richard Akromah, Kwabena Asare Bediako, Maxwell Lamptey, Collins Yeboah Osei, Samuel Awuah, Richard Boampong

“…Whiles mineral concentration analysis revealed that the mean estimates for the genotypes were potassium (K) 1190.37(mg/100g), phosphorus (P) 280.77 (mg/100g), calcium (Ca) 222.92 (mg/100g), magnesium (Mg) 202.00 (mg/100g), iron (Fe) 1.97 (mg/100g), zinc (Zn) 2.11 (mg/100g), sodium (Na) 12.63 (mg/100g). …”
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A Case of Acquired Reactive Perforating Dermatosis with Complete Resolution of Eruptions on Upper and Lower Limbs During the Treatment of Diabetes Mellitus and Peripheral Artery Di... by Yoshihito Mima, Tsutomu Ohtsuka, Ippei Ebato, Ryosuke Nishie, Satoshi Uesugi, Makoto Sumi, Yoshimasa Nakazato, Yuta Norimatsu

“…ARPD is strongly associated with systemic diseases such as diabetes mellitus (DM) and chronic renal failure, which may contribute to ARPD through factors including microcirculatory disturbances and the deposition of metabolic byproducts, including advanced glycation end-products and calcium. Here, we report a case of ARPD that improved following DM treatment and catheter-based interventions for peripheral artery disease (PAD). …”
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Role of Paricalcitol in Modulating the Immune Response in Patients with Renal Disease by Silvia Lucisano, Adriana Arena, Giovanna Stassi, Daniela Iannello, Gaetano Montalto, Adolfo Romeo, Giuseppe Costantino, Rosaria Lupica, Valeria Cernaro, Domenico Santoro, Michele Buemi

“…Methods. 40 patients with end-stage chronic kidney disease (CKD) and secondary hyperparathyroidism and 40 healthy subjects were enrolled. Serum calcium, phosphorus, 25(OH)-vitamin D, parathyroid hormone (PTH), erythrocyte sedimentation rate, high-sensitivity C-reactive protein, interleukin- (IL-) 17, IL-6, IL-1β, interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), plasmatic and urinary NGAL, and 24 h albuminuria and proteinuria were measured before and 24 h after an intravenous bolus of paricalcitol (5 mcg). …”
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Optically Transparent Anionic Nanofibrillar Cellulose Is Cytocompatible with Human Adipose Tissue-Derived Stem Cells and Allows Simple Imaging in 3D by Jonathan J. Sheard, Mesude Bicer, Yiming Meng, Alessia Frigo, Rocío Martínez Aguilar, Thomas M. Vallance, Donata Iandolo, Darius Widera

“…Finally, aNFC is compatible with scanning electron microscopy (SEM) and light microscopy including the application of conventional dyes, fluorescent probes, indirect immunocytochemistry, and calcium imaging. Overall, the results indicate that aNFC represents a promising 3D material for the expansion of MSCs whilst allowing detailed examination of cell morphology and cellular behaviour.…”
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Nucleotide sequence variants, gene expression and serum profile of immune and antioxidant markers associated with brucellosis resistance/susceptibility in Shami goat by Ahmed A. Elsayed, Ahmed M. Sallam

“…On the other hand, there were significant reductions in the glucose, total protein albumin, urea, calcium, inorganic phosphorus, sodium, copper, zinc, iron, TAC, GSH, SOD, GPx, IL-10 and fibrinogen in the infected compared to the non-infected does. …”
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Renal Effects of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Patients with Liver Cirrhosis: A Nationwide Cohort Study by Wei-Fan Hsu, Shi-Hang Yu, Jaw-Town Lin, Jaw-Ching Wu, Ming-Chih Hou, Yi-Hsiang Huang, Chun-Ying Wu, Cheng-Yuan Peng

“…To avoid indication and immortal time biases, patients receiving regular ACEi/ARB therapy, defined as the ACEi/ARB cohort, were matched to patients receiving regular calcium channel blockers (CCBs), defined as the CCB cohort, at a ratio of 1 : 1 by age, sex, and propensity scores for comorbidities and medications (2,188 patients in each cohort). …”
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Treatment and prescribing trends of antihypertensive drugs in 2.7 million UK primary care patients over 31 years: a population-based cohort study by Tibor Schuster, Laurent Azoulay, Julie Rouette, Emily G. McDonald, James M. Brophy

“…Between 1988 and 2018, we identified all adult patients with at least one prescription for a thiazide diuretic, angiotensin-converting enzyme (ACE) inhibitor, angiotensin receptor blocker, beta-blocker or calcium channel blocker (CCB).Primary and secondary outcome measures We estimated the period prevalence of patients with antihypertensive drug prescriptions for each calendar year over a 31-year period. …”
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Identification of a binding site for small molecule inhibitors targeting human TRPM4 by Babatunde Ekundayo, Prakash Arullampalam, Christian E. Gerber, Anne-Flore Hämmerli, Sabrina Guichard, Mey Boukenna, Daniela Ross-Kaschitza, Martin Lochner, Jean-Sebastien Rougier, Henning Stahlberg, Hugues Abriel, Dongchun Ni

“…Abstract Transient receptor potential (TRP) melastatin 4 (TRPM4) protein is a calcium-activated monovalent cation channel associated with various genetic and cardiovascular disorders. …”
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