Brown fat thermogenesis and branched-chain amino acids in metabolic disease by Zachary Brown, Takeshi Yoneshiro

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Maternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesis by Wenwen Zhu, Jiali Fang, Chenbo Ji, Hong Zhong, Tianying Zhong, Xianwei Cui

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Transcriptional Activity of PGC-1α and NT-PGC-1α Is Differentially Regulated by Twist-1 in Brown Fat Metabolism by Hee-Jin Jun, Thomas W. Gettys, Ji Suk Chang

“…Brown fat expresses two PGC-1α isoforms (PGC-1α and NT-PGC-1α) and both play a central role in the regulation of cellular energy metabolism and adaptive thermogenesis by interacting with a wide range of transcription factors including PPARγ, PPARα, ERRα, and NRF1. …”
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Effect of rhGH treatment on lipidome and brown fat activity in prepuberal small for gestational age children: a pilot study by Lorena González, Carolina Gonzalez-Riano, Pablo Fernández-García, Rubén Cereijo, Aina Valls, Andrea Soria-Gondek, Nativitat Real, Belén Requena, Joan Bel-Comos, Patricia Corrales, David Jiménez-Pavón, Coral Barbas, Francesc Villarroya, David Sánchez-Infantes, Marta Murillo

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Brown Adipose Tissue Growth and Development by Michael E. Symonds

“…Maximally stimulated brown fat can produce 300 watts/kg of heat compared to 1 watt/kg in all other tissues. …”
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Influence of leptin administration to pregnant mice on fetal gene expression and adaptation to sweet and fatty food in adult offspring of different sexes by E. I. Denisova, E. N. Makarova

“…Consuming SFD, females had increased Ucp1 expression in brown fat, while males had accumulated fat, decreased blood triglycerides and liver Fasn expression. …”
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The Values and Limitations of FDG-PET/CT for Diagnosis of Hibernoma by Jong Hoon Park, Koichi Ogura, Tomohiro Fujiwara, Akihito Nagano, Kunihiko Numoto, Takashi Terauchi, Akihiko Yoshida, Akira Kawai

“…Hibernoma is a rare benign lipogenic tumor of brown fat that develops in a wide variety of locations. …”
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The Effect of Irisin as a Metabolic Regulator and Its Therapeutic Potential for Obesity by Hui Li, Fang Wang, Mu Yang, Jiao Sun, Yi Zhao, Dongqi Tang

“…Various studies in mice have shown that irisin could respond to systematic exercise training and promote white-to-brown fat transdifferentiation, but the role and function of irisin in humans are controversial. …”
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The widely used Ucp1-Cre transgene elicits complex developmental and metabolic phenotypes by Manasi Suchit Halurkar, Oto Inoue, Archana Singh, Rajib Mukherjee, Meghana Ginugu, Christopher Ahn, Christian Louis Bonatto Paese, Molly Duszynski, Samantha A. Brugmann, Hee-Woong Lim, Joan Sanchez-Gurmaches

“…Due to its high relevance to metabolic studies, we perform comprehensive analysis of the Ucp1-Cre Evdr line which is widely used for brown fat research. Hemizygotes exhibit major brown and white fat transcriptomic dysregulation, indicating potential altered tissue function. …”
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Genomic and transcriptomic insights into vitamin A-induced thermogenesis and gene reuse as a cold adaptation strategy in wild boars by Mingpeng Zhang, Aleksei Traspov, Jiawen Yang, Min Zheng, Veronika R. Kharzinova, Huashui Ai, Natalia A. Zinovieva, Lusheng Huang

“…This may compensate for the pig’s lack of brown fat/UCP1 thermogenesis. These findings provide new insights into the molecular basis of cold adaptation and improve our understanding of Eurasian wild boar migration history.…”
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Adipose-Derived Stromal Cells Attenuate Adipose Inflammation in Obesity through Adipocyte Browning and Polarization of M2 Macrophages by Wen-Chao Zhang, Feng Qin, Xiao-Jun Wang, Zhi-Fei Liu, Lin Zhu, Ang Zeng, Ming-Zi Zhang, Nan-Ze Yu, Xiao Long

“…Furthermore, the multilocular lipid droplets located in the center was increased in differentiated brown adipocytes, and brown fat-associated proteins, UCP1, PPAR-γ, and LPL were highly expressed in brown adipocytes differentiated from ADSCs. …”
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Adipocyte-specific Steap4 deficiency reduced thermogenesis and energy expenditure in mice by Han Wang, Lizi Zhang, Xing Chen, Lingzi Hong, Junjie Zhao, Wen Qian, Lam Khue Pham, Belinda Willard, Xiaoxia Li, Katarzyna Bulek, Xiao Li

“…Consistently, brown adipocyte-specific Steap4 deficiency impaired mitochondrial function, increased brown fat whitening, reduced energy expenditure, and exacerbated insulin resistance in a high-fat model. …”
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