Stochastic demethylation and redundant epigenetic suppressive mechanisms generate highly heterogeneous responses to pharmacological DNA methyltransferase inhibition by Mie K. Jakobsen, Sofie Traynor, Aaraby Y. Nielsen, Christina Dahl, Mette Staehr, Simon T. Jakobsen, Maria S. Madsen, Rasmus Siersbaek, Mikkel G. Terp, Josefine B. Jensen, Christina B. Pedersen, Anup Shrestha, Jonathan R. Brewer, Pascal H. G. Duijf, Odd L. Gammelgaard, Henrik J. Ditzel, Alexei F. Kirkin, Per Guldberg, Morten F. Gjerstorff

“…The analysis was performed on breast cancer patient-derived xenograft tumors and cell lines, employing a comprehensive set of techniques, including targeted single-cell mRNA sequencing. …”
Get full text

How to Analyze and Enhance Participation in Electronic Networks of Practice by Charkhsaz Fatemeh, Isaai Mohammad Taghi, Dayani Malihe

“…This study proposes an exploratory methodology for analyzing participation in Electronic Networks of Practice, focusing on a network of 500 specialists in breast cancer treatment as a case study. The research addresses a critical gap in understanding how conversational dynamics influence participation in professional forums. …”
Get full text

Trastuzumab Resistance: Role for Notch Signaling by Kinnari Mehta, Clodia Osipo

“…Epidermal growth factor receptor-2 (ErbB-2/HER2) is a potent breast oncogene that has been shown to be amplified in 20% of breast cancers. Overexpression of ErbB-2 predicts for aggressive tumor behavior, resistance to some cytotoxic and antihormonal therapies, and poor overall survival. …”
Get full text

Heterogeneous Chromosomal Aberrations in Intraductal Breast Lesions Adjacent to Invasive Carcinoma by Michaela Aubele, Margaret Cummings, Axel Walch, Horst Zitzelsberger, Jörg Nährig, Heinz Höfler, Martin Werner

“…There is evidence that breast cancer is a heterogeneous disease phenotypically as well as molecular biologically. …”
Get full text

Breast Angiosarcoma Metastatic to the Ovary by Frederico F. Souza, Amol Katkar, Annick D. Van den Abbeele, Pamela J. Dipiro

“…Primary angiosarcoma can arise anywhere in the body and when it arises in the breast, it usually affects women in their 3rd and 4th decades and accounts for one in 1700–2300 cases of primary breast cancer. Although unusual, breast angiosarcomas tend to metastasize hematogenously rather than lymphogenously, have high rates of local recurrence, that often develop metastases soon after treatment, and have a dismal prognosis. …”
Get full text

tRNA modifications: greasing the wheels of translation and beyond by Minjie Zhang, Zhipeng Lu

Get full text

Exercise as a Mean to Control Low-Grade Systemic Inflammation by Neha Mathur, Bente Klarlund Pedersen

“…Chronic noncommunicable diseases (CNCDs), which include cardiovascular disease, some cancers, for example, colon cancer, breast cancer, and type 2 diabetes, are reaching epidemic proportions worldwide. …”
Get full text

A Rare Case of a Synchronous Anaplastic Carcinoma Thyroid with Ductal Carcinoma Breast by Saptarshi Ghosh, P. B. Ananda Rao, Shreyasee Sarkar, Sivasankar Kotne, S. P. V. Turlapati, Anindita Mishra

“…The plausible association of breast cancers with thyroid carcinomas should thus be evaluated in larger cohort studies. …”
Get full text

A Near-Infrared Optical Tomography System Based on Photomultiplier Tube by Huacheng Feng, Jing Bai, Xiaolei Song, Gang Hu, Junjie Yao

“…It plays an important role in many fields, such as detecting breast cancer and monitoring the cerebra oxygenation. …”
Get full text

Supernumerary breast. A case Presentation by Juan Miguel Guerra Cabrera, María Elena Antelo Gordillo

“…To keep into account the presence of supernumerary breasts will be a need for the prevention of breast cancer. This case has been presented due to all these reasons and the unusual features of this case.…”
Get full text

Predicting cell morphological responses to perturbations using generative modeling by Alessandro Palma, Fabian J. Theis, Mohammad Lotfollahi

“…We show that IMPA accurately captures morphological and population-level changes of both seen and unseen perturbations on breast cancer and osteosarcoma cells. Additionally, IMPA accounts for batch effects and can model perturbations across various sources of technical variation, further enhancing its robustness in diverse experimental conditions. …”
Get full text

Deep Seated Lobular Capillary Hemangioma (Pyogenic Granuloma) of the Colon: A Rare Case Requiring Surgery beyond Endoscopic Management by Jaechun Park, Minjung Jung

“…A 41-year-old woman presented with an incidental colonic mass during a systemic workup after adjuvant chemotherapy for HER2-positive breast cancer. Abdominal computed tomography revealed a deep seated colonic mass in the splenic flexure. …”
Get full text

Bayesian Classifier with Simplified Learning Phase for Detecting Microcalcifications in Digital Mammograms by Imad Zyout, Ikhlas Abdel-Qader, Christina Jacobs

“…Detection of clustered microcalcifications (MCs) in mammograms represents a significant step towards successful detection of breast cancer since their existence is one of the early signs of cancer. …”
Get full text

AI Horizons in Indian Healthcare: A Vision for Transformation and Equity by Neelesh Kapoor, S N Sanjana, Shubha B. Davalagi, P S Balu, Soumitra Sethia

“…Notable implementations include AI-driven disease detection systems, telemedicine platforms, and public health surveillance tools, with successful applications in tuberculosis screening, breast cancer detection, and ophthalmological care. While these advancements show promise, significant challenges persist, related to data privacy concerns and interoperability issues, including the need for robust ethical frameworks. …”
Get full text

Neoadjuvant anti-PD-1-based immunotherapy: evolving a new standard of care by Drew M Pardoll, Suzanne L Topalian

“…Groundbreaking regulatory approvals in triple-negative breast cancer, non-small cell lung cancer and melanoma will certainly be followed by additional approvals in other disease indications, as clinical and basic research are burgeoning globally in hundreds of clinical trials across dozens of cancer types. …”
Get full text

New Antibody Conjugates in Cancer Therapy by Serengulam V. Govindan, David M. Goldenberg

“…The area of drug-conjugated antibodies is progressing with encouraging data published for the trastuzumab-DM1 conjugate in a phase I clinical trial in HER2-positive breast cancer. The Dock-and-Lock platform technology has contributed to the design and the evaluation of complex antibody-cytokine and antibody-toxin conjugates. …”
Get full text

Identification of Potential Biomarkers and Metabolic Changes in the Serum of Breast Lump Patients Among Kelantanese Based on 1H NMR Metabolomics by Ahmad Zulkefly, Wan Norlina Wan Azman, Julia Omar, Nurul Syakima Ab Mutalib, Desy Fitrya Syamsumir, M Maulidiani, Faridah Abas, Maya Mazuwin Yahya, Muhamad Syahmi Yamin, Wan Faiziah Wan Abdul Rahman, Tengku Ahmad Damitri Al-Astani Tengku Din

“…The study revealed significant metabolite variations across the groups and proposed D-glucose, glycerol, and glycine as potential biomarkers for breast cancer diagnosis. Metabolic pathways such as alanine, aspartate, glutamate metabolism, and glycine, serine, and threonine metabolism were implicated. …”
Get full text

Gaussian barebone mechanism and wormhole strategy enhanced moth flame optimization for global optimization and medical diagnostics. by Jingjing Ma, Zhifang Zhao, Lin Zhang

“…Subsequently, BWEMFO-KELM undergoes diagnostic and predictive experimentation on three distinct medical datasets: the breast cancer dataset, colorectal cancer datasets, and mammographic dataset. …”
Get full text

Ewing’s Sarcoma of the Lung as a Second Malignancy in Long-Term Survivor of Childhood Hodgkin’s Lymphoma: A Rare Case Report and Literature Review by Sumit Bharti, Deepak Bhasin, Gautam Goyal, Priya Sharma

“…Literature shows evidence of various malignancies in these survivors, including sarcomas; breast cancers; mesothelioma; and solid secondary malignancies like breast cancer, thyroid cancer, and bone or soft tissue sarcoma. …”
Get full text

Successful Deep Inferior Epigastric Perforator Flap Harvest despite Preoperative Therapeutic Subcutaneous Heparin Administration into the Abdominal Pannus by Joseph W. Duncumb, Kana Miyagi, Parto Forouhi, Charles M. Malata

“…We report three cases of successful deep inferior epigastric perforator (DIEP) flap harvest despite patients injecting therapeutic doses of low molecular weight heparin into their abdomens for thrombosed central venous lines (portacaths™) used for administering primary chemotherapy in breast cancer.…”
Get full text