Maintenance Therapy with Trastuzumab in Her2 Positive Metastatic Parotid Ductal Adenocarcinoma by Muhammad Shahid Iqbal, Ghazia Shaikh, Sanjoy Chatterjee, Helen Cocks, Josef Kovarik

“…One distinct feature is their resemblance to ductal carcinomas of breast. A significant percentage of SDCs overexpress Her2 and the use of targeted therapy with trastuzumab can be considered in these patients. …”
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Vitamin D3 requirements and relative bioavailability for starter male White Pekin ducks fed either cholecalciferol or 25-hydroxycholecalciferol by Jing Tang, Lei Zhuang, Yating Li, Dawei Luo, Zhanbao Guo, Shuaiqin Wang, Jindang Cao, Mingkai Wang, Zhengkui Zhou, Ming Xie, Shuisheng Hou

“…For growth performance, breast muscle percentage, plasma Ca, and tibial indices of starter male Pekin ducks, the VD3 requirements were 281 to 633 IU/kg, whereas 25-OH-D3 requirements were 119 to 395 IU/kg. …”
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Extracellular HMGB1 blockade inhibits tumor growth through profoundly remodeling immune microenvironment and enhances checkpoint inhibitor-based immunotherapy by Coraline Radermecker, Pascale Hubert, Patrick Roncarati, Stephanie Demoulin, Charlotte Pilard, Marie Ancion, Celia Reynders, Thomas Lerho, Diane Bruyere, Alizee Lebeau, Margot Meunier, Marie-Julie Nokin, Elodie Hendrick, Olivier Peulen, Philippe Delvenne, Michael Herfs

“…Using several orthotopic, syngeneic mouse models of basal-like breast (4T1, 67NR and EpRas) or non-small cell lung (TC-1) cancer, the efficacy of several HMGB1 inhibitors alone and in combination with immune checkpoint blockade antibodies (anti-PD-1/PD-L1) was then investigated. …”
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Lutetium-177 labeled iPD-L1 as a novel immunomodulator for cancer-targeted radiotherapy by Myrna Luna-Gutiérrez, Erika Azorín-Vega, Rigoberto Oros-Pantoja, Blanca Ocampo-García, Pedro Cruz-Nova, Nallely Jiménez-Mancilla, Gerardo Bravo-Villegas, Clara Santos-Cuevas, Laura Meléndez-Alafort, Guillermina Ferro-Flores

“…On the other hand, anti-PD-L1 immunotherapy in combination with external beam radiotherapy has shown improved outcomes in the treatment of breast and lung cancer. The aim of this research was to prepare 177Lu-labeled iPD-L1 and to preclinically evaluate its radiotherapeutic potential and role as a tumor immunomodulator by measuring macrophage activation, IL-10, TGFβ, and PD-L1 expression in 4T1 triple-negative breast cancer cells and murine 4T1 tumors after treatment with 177Lu-iPD-L1. …”
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Metabolomics, network pharmacology, and microbiome analyses uncover the mechanisms of the Chinese herbal formula for the improvement of meat quality in spent hens by Zhihua Li, Md. Abul Kalam Azad, Chengwen Meng, Xiangfeng Kong, Jue Gui, Wenchao Lin, Yadong Cui, Wei Lan, Qinghua He

“…Results The results indicated that CHF supplementation improved the meat quality by reducing drip loss (P < 0.05), b* value (P = 0.058), and shear force (P = 0.099) and increasing cooked meat percentage (P = 0.054) and dry matter (P < 0.05) of breast muscle. The addition of CHF improved the nutritional value of breast muscle by increasing (P < 0.05) the content of C18:2n-6, n-6/n-3 polyunsaturated fatty acids (PUFA), total PUFA, PUFA-to-saturated fatty acids (SFA) ratio, and hypocholesterolemic-to-hypercholesterolemic ratio, and tending to increase serine content (P = 0.069). …”
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An Ecological Comparison of Floristic Composition in Seasonal Semideciduous Forest in Southeast Brazil: Implications for Conservation by Sérgio de Faria Lopes, Ivan Schiavini, Ana Paula Oliveira, Vagner Santiago Vale

“…We examined floristic patterns of ten seasonal semideciduous forest sites in southeastern Brazil and conducted a central sampling of one hectare for each site, where we took samples and identified all individual living trees with DBH (diameter at breast height, 1.30 m) ≥4.8 cm. Arboreal flora totaled 242 species, 163 genera, and 58 families. …”
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Obesity as a Major Risk Factor for Cancer by Giovanni De Pergola, Franco Silvestris

“…Reports from the International Agency for Research into Cancer and the World Cancer Research Fund (WCRF) have shown that the strongest evidence exists for an association of obesity with the following cancer types: endometrial, esophageal adenocarcinoma, colorectal, postmenopausal breast, prostate, and renal, whereas the less common malignancies are leukemia, non-Hodgkin’s lymphoma, multiple myeloma, malignant melanoma, and thyroid tumours. …”
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Malignant Transformation of a Mature Cystic Ovarian Teratoma into Thyroid Carcinoma, Mucinous Adenocarcinoma, and Strumal Carcinoid: A Case Report and Literature Review by Hilary D. Hinshaw, Ashlee L. Smith, Mohamed Mokhtar Desouki, Alexander B. Olawaiye

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A Reappraisal of Women’s Health Initiative Estrogen-Alone Trial: Long-Term Outcomes in Women 50–59 Years of Age by Eric Roehm

“…For every 37 women randomized to CEE at 50–59 years, one less woman experienced a global index endpoint (including coronary heart disease, invasive breast cancer, stroke, pulmonary embolism, colorectal cancer, hip fracture, and death) during the 13-year follow-up. …”
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LLM-driven multimodal target volume contouring in radiation oncology by Yujin Oh, Sangjoon Park, Hwa Kyung Byun, Yeona Cho, Ik Jae Lee, Jin Sung Kim, Jong Chul Ye

“…We validate our proposed LLMSeg within the context of breast cancer radiotherapy using external validation and data-insufficient environments, which attributes highly conducive to real-world applications. …”
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Impact of social support and breastfeeding success on the self-efficacy levels of adolescent mothers during the postpartum period by Veysel Can, Mehmet Bulduk, Emine Kurt Can, Nesrullah Ayşin

“…Methods Following ethical approval, The Socio-Demographic Data Form, the Breast Milk and Breastfeeding Information Form, the Multidimensional Scale of Perceived Social Support (MSPSS), the Breastfeeding Self-Efficacy Short Form Scale (BFSES) and the LATCH Breastfeeding Diagnostic and Assessment Scale were used to collect data and the study was completed with 163 participants. …”
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VEGF Spliced Variants: Possible Role of Anti-Angiogenesis Therapy by Caroline Hilmi, Mélanie Guyot, Gilles Pagès

“…Angiogenesis has been targeted in retinopathies, psoriasis, and a variety of cancers (colon, breast, lung, and kidney). Among these tumour types, clear cell renal cell carcinomas (RCCs) are the most vascularized tumours due to mutations of the von Hippel Lindau gene resulting in HIF-1 alpha stabilisation and overexpression of Vascular Endothelial Growth Factor (VEGF). …”
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Complexation by γ-cyclodextrin as a way of improving anticancer potential of sumanene by Artur Kasprzak, Agnieszka Żuchowska, Hidehiro Sakurai

“…Based on our preliminary biological studies, we discovered that the formation of such complexes resulted in the improvement of anticancer properties of sumanene, expressed by high cell viabilities in vitro of healthy human mammary fibroblasts (HMF) together with low viabilities of human breast adenocarcinoma cells (MDA-MB-231). Improved pharmacokinetic (ADME-Tox) properties for sumanene@γCD and sumanene@HP-γCD complexes in comparison to native sumanene were also supported by in sillico modeling studies. …”
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A Pleural Solitary Fibrous Tumor, Multiple Gastrointestinal Stromal Tumors, Moyamoya Disease, and Hyperparathyroidism in a Patient Associated with NF1 by Yoko Yamamoto, Ken Kodama, Shigekazu Yokoyama, Masashi Takeda, Shintaro Michishita

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Chemical Profiling Ethyl Acetate Extract of <i>Basilicum polystachyon</i> Leaves and Exploration of Anticancer SIRT1 Inhibitors Using <i>In Silico</i> Approach by Tukiran Tukiran, Muhammad Raihan

“…Cancer significantly increases prevalence and mortality rate making it a serious health concern currently, including breast cancer. The development of new drugs is a major effort to solve the cancer problems. …”
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Reversion of Hormone Treatment Resistance with the Addition of an mTOR Inhibitor in Endometrial Stromal Sarcoma by J. Martin-Liberal, C. Benson, C. Messiou, C. Fisher, I. Judson

“…The mammalian target of rapamycin (mTOR) pathway has been suggested to play a key role in the mechanisms of hormone resistance. Recent studies in breast and prostate cancer demonstrate that this resistance can be reversed with the addition of an mTOR inhibitor. …”
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BRAF V600E-mutated lung adenocarcinoma with thyroid metastasis as the initial manifestation: a case report by Yufei Liu, Yufei Liu, Hanhan Lei, Hanhan Lei, Lingling Cai, Lingling Cai, Yuyan Tan, Xinyu Song

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Clinical Characteristics of Choroidal Metastases by Bożena Romanowska-Dixon, Karolina Gerba-Górecka, Agnieszka Nowak, Joanna Kowal, Magdalena Dębicka-Kumela, Dagmara Nowak

“…The most common intraocular tumors in adults are metastases from primary tumors: breast cancer, lung cancer, and other organ neoplasms. …”
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A Severe Case of Drug-Induced Liver Injury after Gemcitabine Administration: A Highly Probable Causality Grading as Assessed by the Updated RUCAM Diagnostic Scoring System by Ilenia Mascherona, Caterina Maggioli, Maira Biggiogero, Oreste Mora, Lucia Marelli

“…Gemcitabine is an antineoplastic drug used in several forms of advanced pancreatic, lung, breast, ovarian, and bladder cancer. Common side effects include bone marrow suppression, fatigue, diarrhea, nausea, gastrointestinal upset, rash, alopecia, and stomatitis. …”
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Analisis Survival Pasien Kanker Payudara Usia Muda di RSUP DR. M. Djamil Padang Tahun 2008-2017 by M. Al Farisyi, Daan Khambri

“…Hasil penelitian menunjukkan insiden KPD terbanyak pada range usia 35-40 tahun, dengan ukuran tumor T3, diferensiasi derajat sedang, histopatologi tipe duktal karsinoma dengan Triple Negative Breast Cancer (TNBC) sebagai subtipe yang terbanyak. …”
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