Lethal necrotizing granulomatous vasculitis after bariatric surgery and bilateral mammaplasty by O. V. Blagova, D. Kh. Aynetdinova, A. V. Nedostup, N. A. Novikova, Ye. A. Kogan, Yu. V. Lerner, L. V. Kozlovskaya, V. V. Rameyev, N. A. Mukhin

“…Autopsy revealed the signs of vasculitis with involvement of the brain, skin, mediastinal lymphnodes, lungs, as well as the signs of chronic inflammation, atrophy of breast gland lobules, embolization of the focal lymphatics by the implant substance, ulceronecrotic enteritis of defunctioning bowel, severe liver steatosis with the chronic vitamin deficiency. …”
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Low-exhaustion peripheral circulating γδ T cells serve as a biomarker for predicting the clinical benefit rate of non-small cell lung cancer (NSCLC) patients to chemotherapy or tar... by Dongdong Zhang, Guichao Liu, Jinhui Ye, Ke Li, Guojun Zhang, Qiang Quan, Xinhai Zhu, Peng Li

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Ezrin Polarization as a Diagnostic Marker for Circulating Tumor Cells in Hepatocellular Carcinoma by Ibrahim Büdeyri, Olaf Guckelberger, Elsie Oppermann, Dhruvajyoti Roy, Svenja Sliwinski, Felix Becker, Benjamin Struecker, Thomas J. Vogl, Andreas Pascher, Wolf O. Bechstein, Anna Lorentzen, Mathias Heikenwalder, Mazen A. Juratli

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The Relationship of Tumor-infiltrating Lymphocyte Ratio with Histopathological Parameters and Effect on Survival in Colorectal Cancers by İsra Serda Oğuz, Sinan Koca, Seval Ay Ersoy, Özgecan Dülgar, Ayşenur Toksöz, Mahmut Gümüş

“…Introduction: Tumor lymphocyte infiltration demonstrates a positive effect on patient survival in breast cancer, melanoma, renal cell carcinoma, and lung cancer. …”
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Phytochemical, Cytotoxic, and Antimicrobial Evaluation of the Fruits of Miswak Plant, Salvadora persica L. by Mohammed Al Bratty, Hafiz A. Makeen, Hassan A. Alhazmi, Sohier M. Syame, Ashraf N. Abdalla, Husham E. Homeida, Shahnaz Sultana, Waquar Ahsan, Asaad Khalid

“…The cytotoxic properties of the ethanol extract were investigated by MTT assay against the breast MCF7, ovary A2780, and colon HT29 cells. The fruit extract of S. persica was selective against the ovarian and colon cancer cells compared to normal fibroblast cells (MRC5) as it showed IC50 values 17.50, 8.35, and 5.12, against MCF7, A2780, and HT29 cells, respectively. …”
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Toxicity assessment of DMSO extracts of environmental aged beached plastics using human cell lines by Florane Le Bihanic, Bettie Cormier, Emilie Dassié, Sophie Lecomte, Justine Receveur, Stéphane Le Floch, Jérôme Cachot, Bénédicte Morin

“…In addition, the estrogenic effects of DMSO-extracts were evaluated using an estrogen-dependent reporter gene assay in T47D-Kbluc human breast cancer cells. Chemical profiles of the DMSO extracts were polymer-dependent, with polyvinyl chloride (PVC) highly contaminated with metals while polypropylene (PP) contained the lowest concentration of metals. …”
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Assessment of the impact of HIV infection on the hypothalamic-pituitary-ovarian axis and pubertal development among adolescent girls at a tertiary centre in Zimbabwe: a cross-secti... by Bothwell Takaingofa Guzha, Bismark Mateveke, Hamish Mubata, Tapiwa Chapupu, Vongai Dondo, Maxwell Chirehwa, Rendani Tshikosi, Tsungai Chipato, Zvavahera Mike Chirenje

“…Pubertal milestones were assessed using the age of menarche and Tanner stage for breast and pubic hair development. Growth was assessed using World Health Organisation growth charts. …”
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Application of quality control circle activities in reducing the incidence of abdominal distention after laparoscopic cholecystectomy (降低腹腔镜胆囊切除术后患者腹胀发生率的品管圈实践)... by RAN Maomei (冉茂梅), SHEN Bingying (申冰莹), HE Siming (何思铭), YANG Yuanyuan (杨圆圆), SHAO Jianmin (邵建敏), XU Yuanle (许远乐), PANG Mi (庞咪)

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An ensemble machine learning-based performance evaluation identifies top In-Silico pathogenicity prediction methods that best classify driver mutations in cancer by Subrata Das, Vatsal Patel, Shouvik Chakravarty, Arnab Ghosh, Anirban Mukhopadhyay, Nidhan K. Biswas

“…The top PCSAs demonstrated strong performance on a validation cohort including independent HNSC and other cancer types: breast, lung, and colorectal - reflecting its consistency, robustness and generalizability. …”
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Autoimmune brainstem encephalitis: Clinical associations, outcomes, and proposed diagnostic criteria by Michael Gilligan, Smathorn Thakolwiboon, Emma Orozco, Samantha Banks, Eoin P. Flanagan, Sebastian Lopez‐Chiriboga, Jan‐Mendelt Tillema, John R. Mills, Sean J. Pittock, Cristina Valencia Sanchez, Anastasia Zekeridou, Divyanshu Dubey, Andrew McKeon

“…Cancer was identified in 55 patients: germ cell (23 patients; 3 extra‐testicular), ductal breast adenocarcinoma (8), small cell carcinoma (6, lung 4), adenocarcinomas (6), neuroendocrine carcinoma (3), hematologic (2), squamous cell (2), and other (7). …”
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Generation Victoria (GenV): protocol for a longitudinal birth cohort of Victorian children and their parents by Elizabeth K. Hughes, William Siero, Alisha Gülenç, Susan A. Clifford, Tony Frugier, Simon M. Hall, Jatender Mohal, Kathryn North, Natasha Zaritski, Sharon Goldfeld, Richard Saffery, Melissa Wake

“…Many participants supplement universal data with additional biosamples (e.g., infant stool, breast milk) and brief digital remote ‘GenV and Me’ assessments over the first 5 years. …”
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Reinnervation of Free Nipple Grafts Associated With Improved Erection Function by Katya Remy, MD, Seth E. Fruge, MD, Ian L. McCulloch, MD, Kristyn Vicente, BA, Makayla Kochheiser, BA, Katherine H. Carruthers, MD, William G. Austen, Jr, MD, Lisa Gfrerer, MD, PhD, Ian L. Valerio, MD

“…Most patients undergoing breast surgery with free nipple grafts lose nipple erection (NE) function. …”
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Synthesis, X-Ray Crystal Structures, Biological Evaluation, and Molecular Docking Studies of a Series of Barbiturate Derivatives by Assem Barakat, Hazem A. Ghabbour, Abdullah Mohammed Al-Majid, Qurat-ul-ain, Rehan Imad, Kulsoom Javaid, Nimra Naveed Shaikh, Sammer Yousuf, M. Iqbal Choudhary, Abdul Wadood

“…All barbiturates derivatives (4a–4x, 4z, and 5a–5m) were found to be noncytotoxic against human prostate (PC-3), Henrietta Lacks cervical (HeLa) and Michigan Cancer Foundation-7 breast (MCF-7) cancer cell lines, and 3T3 normal fibroblast cell line, except 4y which was cytotoxic against all the cell lines.…”
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Quality and Flavor Analysis of 14 Kinds of Commercially Available Hemp Pepper Chicken by Cong LIU, Xin LIU, Peng WANG, Xinglian XU, Yin WANG, Jianchao LI

“…The results showed that the hardness of 14 kinds of hemp pepper chicken breast ranged from 1742.81 to 4587.54 g, and the shear force ranged from 14.41 to 35.07 N. …”
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Assessments of prostate cancer cell functions highlight differences between a pan‐PI3K/mTOR inhibitor, gedatolisib, and single‐node inhibitors of the PI3K/AKT/mTOR pathway by Adrish Sen, Salmaan Khan, Stefano Rossetti, Aaron Broege, Ian MacNeil, Ann DeLaForest, Jhomary Molden, Laura Davis, Charles Iversrud, Megan Seibel, Ross Kopher, Stephen Schulz, Lance Laing

“…Gedatolisib is currently being evaluated in a Phase 1/2 clinical trial in combination with darolutamide in patients with mCRPC previously treated with an AR inhibitor, and in a Phase 3 clinical trial in combination with palbociclib and fulvestrant in patients with HR+/HER2− advanced breast cancer.…”
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Maximizing the performance of heat stressed broilers by optimizing starch-to-lipid ratios, digestible amino acid, and metabolizable energy during the finisher phase by Dilshaan Duhra, Denise Beaulieu, Tory Shynkaruk, Juliano C. de Paula Dorigam, Rose Whelan, Karen Schwean-Lardner

“…Although a practical recommendation was not possible for optimal breast meat yield (% live weight) and F:G ratios, the results, indicated that increasing DigLys would improve these parameters under heat stress.…”
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Dietary fiber consumption and outcomes of different cancers: an umbrella review by Xingyu He, Jiayi Hou, Lei Liu, Xin Chen, Lijie Zhang, Caojia Pang, Yu Tong, Hongling Li, Feng Chen, Rong Peng, Zheng Shi

“…Results: High fiber intake significantly lowers the risk of cancers affecting the digestive, reproductive, and urinary systems, including esophageal adenoma, squamous cell carcinoma, gastric, pancreatic, colon, rectal, colorectal adenoma, breast, ovarian, endometrial, prostate, renal cell, and bladder cancers. …”
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Nuclear talin-1 provides a bridge between cell adhesion and gene expression by Alejandro J. Da Silva, Hendrik S.E. Hästbacka, Mikael C. Puustinen, Jenny C. Pessa, Jens C. Luoto, Erika Sundström, Benjamin T. Goult, Guillaume Jacquemet, Eva Henriksson, Lea Sistonen

“…Importantly, small interfering RNA (siRNA)-mediated depletion of endogenous TLN1 triggers extensive changes in the gene expression profile of human breast epithelial cells. To determine the functional impact of nuclear TLN1, we expressed a TLN1 fusion protein containing a nuclear localization signal. …”
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Web-based interventions for fear of cancer recurrence: A scoping review with a focus on suggestions for the development and evaluation of future interventions. by Solveiga Zibaite, Sheela Tripathee, Helen Moffat, Beatrix Elsberger, Sara Maclennan

“…Interventions were most commonly trialled with women breast cancer patients. Top three countries where studies were conducted were USA, Australia and the Netherlands. …”
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Tousled-like kinase loss confers PARP inhibitor resistance in BRCA1-mutated cancers by impeding non-homologous end joining repair by Min-ah Kim, Banseok Kim, Jihyeon Jeon, Jonghyun Lee, Hyeji Jang, Minjae Baek, Sang-Uk Seo, Dongkwan Shin, Anindya Dutta, Kyung Yong Lee

“…Consequently, TLK deficiency induces PARPi resistance in triple-negative breast cancer (TNBC) and ovarian cancer (OVCA) cell lines with BRCA1 deficiency, as TLK deficiency in BRCA1-depleted cells, impairs 53BP1 recruitment to DSBs and reduces NHEJ efficiency, while restoring HR. …”
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