Tumor Microenvironment‐Responsive Nanoparticles Enhance IDO1 Blockade Immunotherapy by Remodeling Metabolic Immunosuppression by Mengna Wang, Yuhong Liu, Yanshi Li, Tao Lu, Min Wang, Zhaobo Cheng, Lin Chen, Tongling Wen, Min Pan, Guohua Hu

“…Mechanistically, HMP1G NPs downregulated tumor cell‐derived IDO1 via the aryl hydrocarbon receptor/signal transducer and activator of transcription 3/interleukin signaling axis to improve kynurenine/tryptophan metabolism and immunosuppression. In a murine breast cancer model, treatment with HMP1G NPs elicited effective antitumor immunity and enhanced survival outcomes. …”
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Interleukin-10 Polymorphisms in Association with Prognosis in Patients with B-Cell Lymphoma Treated by R-CHOP by Min Kyeong Kim, Kyong-Ah Yoon, Eun Young Park, Jungnam Joo, Eun Young Lee, Hyeon-Seok Eom, Sun-Young Kong

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Improving ferroptosis-mediated immunotherapy for colorectal cancer through lysosome-targeted photodynamic therapy by Zhian Chen, Yutong Wang, Zhenhao Li, Meijuan Chen, Yingshi Li, Chuyue Lu, Zhenyu Lin, Hua Zheng, Lujia Chen, Qianbing Zhang

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Time to neonatal mortality and its predictors among preterm neonates admitted to the neonatal intensive care unit in northern Ethiopia, 2023/2024: a retrospective cohort study by Brhanu Fisseha, Eskedar Berhanie Gidey, Berhe Gebrehiwot Tewele, Teklehaimanot Gereziher Haile

“…The overall median survival time was 21 (95% CI: 20, 28) days. Initiation of breast milk (AHR = 0.38 (95% CI: 0.24, 0.61)), respiratory distress syndrome (AHR = 1.9 (95% CI: 1.07,3.63)), perinatal asphyxia (AHR = 2.05 (95% CI: 1.05, 4.00)), receiving kangaroo mother care practice (AHR = 0.5 (95% CI: 0.34, 0.83)), and gestational age (AHR = 1.6 (95% CI 1.07, 2.59) were the predictors of time to death. …”
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Evaluation of maSSS/maSES-PEG2-RM26 for their potential therapeutic use after labeling with Re-188. Could their [99mTc]Tc-labeled counterparts be used to estimate dosimetry? by Panagiotis Kanellopoulos, Quanyi Yu, Abouzayed Abouzayed, Ekaterina Bezverkhniaia, Vladimir Tolmachev, Anna Orlova

“…Abstract Background Gastrin releasing peptide receptor (GRPR)-directed radiopharmaceuticals for targeted radionuclide therapy may be a very promising addition in prostate and breast cancer patient management. Aiming to provide a GRPR-targeting theranostic pair, we have utilized the Tc-99m/Re-188 radiometal pair, in combination with two bombesin based antagonists, maSSS-PEG2-RM26 and maSES-PEG2-RM26. …”
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Biosynthesis of reduced graphene oxide using Turbinaria ornata and its cytotoxic effect on MCF‐7 cells by K. M. Smita, L. Stanley Abraham, V. Ganesh Kumar, Raguraman Vasantharaja, R. Thirugnanasambandam, Ajit Antony, K. Govindaraju, T. Senthil Velan

“…Hence, this study results in an efficient green reductant for producing rGO nanosheets that possess cytotoxicity against breast cancer cells.…”
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A community-based approach to address lung cancer screening disparities in the black community using the Witness Project® framework: development and pilot trial by Lisa Carter-Bawa, Jamie S. Ostroff, Deborah O. Erwin, Elan N. Shoulders, Detric Johnson, Mikhalya Brown, Francis Valenzona, Lina Jandorf

“…Methods Utilizing a user-centered design and guided by the original Witness Project® framework – an evidence-based lay health advisor intervention program originally developed to increase knowledge and awareness about breast cancer risk and screening in the Black community and later trans-created to the cervical and colorectal cancer screening contexts - Witness Project® Lung was developed and refined through qualitative input from key stakeholders in the Black faith community. …”
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Identification of natural phytochemicals as AKT2 inhibitors using molecular docking and dynamics simulations as potential cancer therapeutics by Jibon Kumar Paul, Mahir Azmal, Md Naimul Haque Shohan, Mohua Mrinmoy, ANM Shah Newaz Been Haque, Omar Faruk Talukder, Ajit Ghosh

“…Dysregulation of this pathway, particularly in the AKT2 isoform, is commonly observed in cancers such as breast, ovarian, and pancreatic cancers, leading to enhanced tumor progression, metastasis, and therapeutic resistance. …”
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Effects of oxidation and precursors (lysine, glyoxal and Schiff base) on the formation of Nε-carboxymethyl-lysine in aged, stored and thermally treated chicken meat by Suhong Huang, Xiaoli Dong, Yulong Zhang, Ming Huang, Yuandong Zheng

“…As post-mortem ageing and storage time increased, the CML content in cooked chicken breast significantly increased from 1.81 mg/kg to 2.00 mg/kg during 0−6 h, and then decreased from 2.00 mg/kg to 1.80 mg/kg during 6 h−1 day, finally increased again during 1−7 days, while the CML contents of raw and cooked leg significantly and continuously increased from 1.78 mg/kg to 2.08 mg/kg. …”
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Comparative analysis of species composition and quantitative analysis of udder microflora in cows with subclinical and clinical mastitis by N. N. Avduevskaya, A. V. Kapustin, A. V. Gorbatov, E. V. Ivanov

“…Due to the great relevance of the problem of mastitis in cows, the diversity of udder microflora in the affected animals, as well as to develop therapeutic and preventive measures on farms, studies were conducted to identify similarities and differences in the species composition of microorganisms in animals with sub­clinical and clinical breast inflammation, their proportion, to establish the correlation between the secreted microflora and the type of mastitis, as well as to study and compare the enzymatic properties of Staphylococcus aureus isolated from animals with clinical and subclinical mastitis. …”
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Effect of auriculotherapy on anxiety-fatigue and sleep disturbances in cancer patients: A scoping review by Silmara de Oliveira Silva, Vinicius dos Santos Lemos Pereira, Mariane Elivânia Silva, Jucielly Ferreira da Fonseca, Maria Carolina Batista da Silva, Roberta Paolli de Paiva Oliveira Arruda Camara, Rodrigo Assis Neves Dantas, Daniele Vieira Dantas

“…Asian countries were highly represented (62,5 %), followed by Latin America (12,5 %). Breast cancer was the most common tumor type, accounting for 68,75 %. …”
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pDC Activation by TLR7/8 Ligand CL097 Compared to TLR7 Ligand IMQ or TLR9 Ligand CpG by Jing Wu, Shuang Li, Tete Li, Xinping Lv, Mingyou Zhang, Guoxia Zang, Chong Qi, Yong-Jun Liu, Liang Xu, Jingtao Chen

“…Our previous study demonstrated that pDCs activated by the TLR7 ligand imiquimod (IMQ) and the TLR9 ligand CpG A can kill breast cancer cells in vitro and inhibit tumor growth in vivo. …”
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Parameter space exploration within dynamic simulations of signaling networks by Cristina De Ambrosi, Annalisa Barla, Lorenzo Tortolina, Nicoletta Castagnino, Raffaele Pesenti, Alessandro Verri, Alberto Ballestrero, Franco Patrone, Silvio Parodi

“…The core of the article deals with a Molecular Interaction Map (MIM), a network of biochemical interactions involved in a small signaling-network sub-region relevant in breast cancer. We explored robustness/sensitivity to random perturbations. …”
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Primena daljinske detekcije u inventuri mešovitih šuma hrasta lužnjaka by Borota Dragan, Pantić Damjan, Ponjarac Radenko, Popović Aleksandar

“…In high, mixed, middle-aged and maturing Penduculate oak stands, the possibility of using aerial photogrammetry in the inventory was tested, both to obtain informa­tion related to site and stand information and to determine numerical elements (number of trees, basal area and volume per hectare) obtained on the basis of data read from the images (crown diameter, height and estimated breast height diameter of the tree based on the selected mathematical model). …”
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HPV E6/E7, hTERT, and Ki67 mRNA RT-qPCR Assay for Detecting High-Grade Cervical Lesion with Microscope Slides by Geehyuk Kim, Jemberu Taye, Kwangmin Yu, Sunyoung Park, Jungho Kim, Sunghyun Kim, Dongsup Lee, Hye-young Wang, Kwang Hwa Park, Hyeyoung Lee

“…After breast and colon cancer, cervical cancer is the third most common cancer of women worldwide. …”
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Clinical application of third-generation dual-source CT-based dynamic imaging reconstruction for pulmonary embolism imaging by Kai Liao, Biao Ye, Xi Li, Wei Liu, Tongtong Jia, Zongbao Han, Ziyi Liang, Yongli Duan, Xiaoli Sun, Jianmei Zhang, Rengui Wang, Jiao Gong

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Wharton’s Jelly-Derived Mesenchymal Stromal Cells and Fibroblast-Derived Extracellular Matrix Synergistically Activate Apoptosis in a p21-Dependent Mechanism in WHCO1 and MDA MB 23... by Kevin Dzobo, Matjaz Vogelsang, Nicholas E. Thomford, Collet Dandara, Karlien Kallmeyer, Michael S. Pepper, M. Iqbal Parker

“…In this study we investigated the effect of Wharton’s Jelly-derived MSCs (WJ-MSCs) and a fibroblast-derived ECM (fd-ECM) on esophageal (WHCO1) and breast (MDA MB 231) cancer cells in vitro. Both WJ-MSCs and the fd-ECM, alone or in combination, downregulate PCNA, cyclin D1, Bcl-2, Bcl-xL, and MMPs and upregulate p53 and p21. p21 induction resulted in G2 phase cell cycle arrest and induced apoptosis in vitro. …”
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An experimental study of the effects of SNPs in the TATA boxes of the <i>GRIN1, ASCL3</i> and <i>NOS1</i> genes on interactions with the TATA-binding protein by E. B. Sharypova, I. A. Drachkova, I. V. Chadaeva, M. P. Ponomarenko, L. K. Savinkova

“…For example, ASCL3 is overexpressed in breast cancer, and NOS1, in ovarian cancer cell lines. …”
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Discrete vulnerability to pharmacological CDK2 inhibition is governed by heterogeneity of the cancer cell cycle by Vishnu Kumarasamy, Jianxin Wang, Michelle Roti, Yin Wan, Adam P. Dommer, Hanna Rosenheck, Sivasankar Putta, Alec Trub, John Bisi, Jay Strum, Patrick Roberts, Seth M. Rubin, Costakis Frangou, Karen McLean, Agnieszka K. Witkiewicz, Erik S. Knudsen

“…The co-expression of these genes occurs in breast cancer patients highlighting their clinical significance as predictive biomarkers for CDK2-targeted therapies. …”
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Small Magnets, Big Future: Low-Field MRI Technology and Clinical Utility by Mohamamdreza Elhaie, Abolfazl Koozari, Iraj Abedi, Mahmoud Mohammadi-Sadr, Abbas Monsef

“…The literature has demonstrated the utility of low-field MRI in applications such as musculoskeletal, breast, and abdominal imaging. Conclusion: In conclusion, these studies demonstrated the potential of low-field MRI as a cost-efficient alternative to high-field MRI for several clinical applications. …”
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