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Moments of von mises and fisher distributions and applications
Published 2017-05-01“…While the emphasis of this paper lies in calculating the moments of spherical distributions, their usefulness is motivated by their relationship to population statistics in animal/cell movement models and demonstrated in applications to the modelling of sea turtle navigation, wolf movement and brain tumour growth.…”
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Early growth response 1 transcription factor and its context-dependent functions in glioblastoma
Published 2024-08-01“…Glioblastoma is the most aggressive form of primary brain tumour in adults. This tumour employs numerous transcription factors to advance and sustain its progression. …”
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Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells
Published 2021-03-01“…Abstract Medulloblastoma (MB) is the most common aggressive paediatric brain tumour and, despite the recent progress in the treatments of MB patients, there is still an urgent need of complementary or alternative therapeutic options for MB infants. …”
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Comparative proteomic analysis of astrocytoma tissues from patients with and without seizures
Published 2025-01-01“…Abstract Astrocytoma is a common type of glioma and a frequent cause of brain tumour-related epilepsy. Although the link between glioma and epilepsy is well established, the precise mechanisms underlying epileptogenesis in astrocytoma remain poorly understood. …”
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The comparison of biodistribution of glutathione PEGylated nanoliposomal doxorubicin formulations prepared by pre‐insertion and post‐insertion methods for brain delivery in normal...
Published 2023-04-01“…Abstract Several obstacles limit the efficacy of brain tumour treatment, most notably the blood‐brain barrier (BBB), which prevents the brain uptake of the majority of accessible medicines due to tight junctions. …”
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Advancing cancer therapy with custom-built alternating electric field devices
Published 2025-01-01“…To better understand how the position and morphology of cells can affect cell therapy responsiveness to alternating electric fields or currents, GBM results were compared to those from the semi-adherent brain tumour cell line, D425. Results Contrary to previous findings, there was no significant difference between the GIN 31 and GCE 31 cells exposed to alternating electric fields or currents treated with or without NP compared to cells untreated and unstimulated. …”
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The Genetic Landscape of Human Glioblastoma and Matched Primary Cancer Stem Cells Reveals Intratumour Similarity and Intertumour Heterogeneity
Published 2019-01-01“…Glioblastoma (GBM) is the most malignant human brain tumour, characterized by rapid progression, invasion, intense angiogenesis, high genomic instability, and resistance to therapies. …”
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An exceptionally rare case of a diffuse midline glioma with concomitant H3.1 K27M and G34R mutations in the HIST1H3C (H3C3) gene
Published 2025-01-01“…DNA methylation profiling (Illumina EPIC BeadArrays, brain tumour classifier (MNP v12.5 R package)) classified the tumour as ‘DMG, H3 K27-altered’ (calibrated score = 0.99). …”
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Neuroophthalmic Manifestations of Intracranial Tumours in Children
Published 2021-01-01“…All children between 0 and 16 years presenting with brain tumours confirmed by Magnetic Resonance Imaging (MRI) and treated surgically in our institute were included in this study. …”
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1H MR Spectroscopy in Gliomatosis: Is there a Sensitivity Issue?
Published 2011-01-01“…Objective. 1H MR spectroscopy (MRS) is widely performed for assessment of brain tumours and is considered a highly sensitive technique capable of differentiating benign from malignant conditions and tumour grading. …”
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Utilisation of High Molecular Weight and Ultra-High Molecular Weight Hyaluronan in Management of Glioblastoma
Published 2025-01-01“…Considering the limited treatment options available in the treatment of glioblastoma, in this review, we discuss the novel utilisation of ultra-high molecular weight HA—originally identified as a mechanism for maintaining longevity in the naked mole-rat—as both a protective and extracellular matrix-optimizing colloidal scaffold, and a means to deliver therapy in resected brain tumours. The unique properties of this unique form of HA cross-linked gel indicate potential future use in the prevention and treatment of both proliferative-based and inflammation-driven disease.…”
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MicroRNAs in Neurotoxicity
Published 2012-01-01“…Such toxicity can be a result of individuals predisposed due to genetic inheritance or from other sources such as brain tumours. Neurotoxicity can also be brought about by external agents like drugs and alcohol as well as brain injury with miRNAs playing a pivotal role in diseases. …”
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Is a “floater” always a floater? Case report and short review of sphenoid meningiomas’ ocular manifestation
Published 2024-05-01“…Meningiomas are the most common primary brain tumours. The incidence of meningiomas increases progressively with age and might be related to general diseases, e.g. neurofibromatosis type 2 and exposure to radiation. …”
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Predicting survival in malignant glioma using artificial intelligence
Published 2025-01-01“…Abstract Malignant gliomas, including glioblastoma, are amongst the most aggressive primary brain tumours, characterised by rapid progression and a poor prognosis. …”
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Utility of 5-ALA for resection of CNS tumours other than high-grade gliomas: a protocol for a systematic review
Published 2022-07-01“…We sought to conduct a systematic review of the literature summarising surgical outcomes, evaluate the quality of diagnostic accuracy reported in the literature and qualitatively assess the evidence to inform future studies.Methods and analysis We will search electronic databases (Medline, Embase) with subsequent interrogation of references lists of articles reporting the use of 5-ALA for brain tumours other than high-grade glioma adult patients, which also report the extent of resection and/or survival. …”
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Molecular Alterations of KIT Oncogene in Gliomas
Published 2007-01-01“…Gliomas are the most common and devastating primary brain tumours. Despite therapeutic advances, the majority of gliomas do not respond either to chemo or radiotherapy. …”
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Neurocognitive function and health-related quality of life among glioblastoma patients: A prospective study
Published 2025-01-01“…Background: Glioblastomas are aggressive brain tumours that significantly impact patients’ functional and psychological well-being, making the evaluation of health-related quality of life (HRQoL) essential. …”
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Improving the diagnostic accuracy of referrals for papilloedema (DIPP) study: protocol for a mixed-methods study
Published 2025-01-01“…Introduction Papilloedema can be the first sign of life-threatening disease, for example, brain tumours. Due to the potential seriousness of this clinical sign, the detection of papilloedema would normally prompt urgent hospital referral for further investigation. …”
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