Breaking boundaries: role of the brain barriers in metastatic process by Nasim Izadi, Peter Solár, Klaudia Hašanová, Alemeh Zamani, Maryam Shahidian Akbar, Klára Mrázová, Martin Bartošík, Tomáš Kazda, Roman Hrstka, Marek Joukal

“…Abstract Brain metastases (BMs) are the most common intracranial tumors in adults and occur 3–10 times more frequently than primary brain tumors. Despite intensive multimodal therapies, including resection, radiotherapy, and chemotherapy, BMs are associated with poor prognosis and remain challenging to treat. …”
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In vivo MRS study of long-term effects of traumatic intracranial injection of a culture medium in mice by O. B. Shevelev, O. P. Cherkasova, I. A. Razumov, E. L. Zavjalov

“…Orthotopic transplantation of glioblastoma cells in the brain of laboratory mice is a common animal model for studying brain tumors. It was shown that 1H magnetic resonance spectroscopy (MRS) enables monitoring of the tumor’s occurrence and its development during therapy based on the ratio of several metabolites. …”
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Experimental study on monitoring microwave ablation efficacy by real-time shear wave elastography in ex vivo porcine brain by Rui Li, Yukang Zhang, Linggang Cheng, Shuai Zheng, Hongbing Li, Hongxia Zhang, Lijuan Du, Wen He, Wei Zhang

“…In recent years, microwave ablation (MWA) was expected to be applied in the minimally invasive treatment of brain tumors. This study aims to evaluate the feasibility and accuracy of microwave ablation in ex vivo brain tissue by Shear Wave Elastography (SWE) to explore the application value of real-time SWE in monitoring the process of MWA of brain tissue.Methods: Thirty ex vivo brain tissues were treated with different microwave power and ablation duration. …”
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Short-term outcome of endovascular stenting for symptomatic vertebrobasilar stenosis by Mohamed Abdel moneim Abdo Tolba, Mohammed Alaswad, Mohamed Mohamed Tawfik, Ahmed Zaki Akl, Mona Ali Eissa, Hala El-khawas, Hani Mahmoud Zaki Eldin, Mohamed Khaled Ahmed Elewa

“…Patients with previous stent at the target lesion, acute stroke, heavily calcified lesion, complete artery occlusion, massive infarction with marked neurological deficit, intracranial hemorrhage, intracranial brain tumors, contraindicated to antithrombotic and/or anticoagulant, pregnant women, and patients susceptible to follow-up loss were excluded. …”
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Single-cell sequencing elucidates the mechanism of NUSAP1 in glioma and its diagnostic and prognostic significance by Meng-Yu Zhao, Zhao-Lei Shen, Hongzhen Dai, Wan-Yan Xu, Li-Na Wang, Yu- Gu, Jie-Hui Zhao, Tian-Hang Yu, Cun-Zhi Wang, Jia-feng Xu, Guan-Jun Chen, Dong-Hui Chen, Wen-Ming Hong, Wen-Ming Hong, Fang Zhang

“…Gliomas, known for their poor prognosis, rank among the most lethal brain tumors. Despite advancements, there remains a critical need for precise, individualized treatment strategies.MethodsWe conducted a comprehensive analysis of RNA-seq and microarray data from the TCGA and GEO databases, supplemented by single-cell RNA sequencing (scRNA-seq) data from glioma patients. …”
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A covalent peptide-based lysosome-targeting protein degradation platform for cancer immunotherapy by Youmei Xiao, Zhuoying He, Wanqiong Li, Danhong Chen, Xiaoshuang Niu, Xin Yang, Wenxuan Zeng, Mengfan Wang, Yuzhen Qian, Ye Su, Feiyu Luo, Guanyu Chen, Juan Liu, Xinghua Sui, Xiuman Zhou, Yanfeng Gao

“…It is noteworthy that Pep-TACs can cross the BBB and prolong the survival of mice with in situ brain tumor. As a proof-of-concept, this study introduces a modular TFRC-based covalent peptide degradation platform for the degradation of membrane protein, and especially for the immunotherapy of brain tumors.…”
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Development and experimental validation of dephosphorylation-related biomarkers to assess prognosis and immunotherapeutic response in gliomas by Hui Tang, Xuping Yang, Xuping Yang, Guoqian Li, Ke Peng, Yang Sun, Longyang Jiang, Longyang Jiang, Yilan Huang, Yilan Huang

“…BackgroundGliomas are common aggressive brain tumors with poor prognosis. Dephosphorylation-related biomarkers are in a void in gliomas. …”
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Unveiling hotspots of emerging research in the miRNA-related mechanism underlying cancer through comprehensive bibliometric analysis with implications for precision medicine and no... by Zhirui Zhang, Wenhuan Song, Wenyu Chen, Wenze Cui, Wenyi Chen, Qinheng Zhang, Wenwen Ji, Yinglin Wang, Jiayi Wang, Wenhao Yu, Mingkun Yu, Mingkun Yu, Tao Hao, Hong Jiang

“…Prostate cancer showed a shift toward clinical applications, while leukemia and brain tumor research, though less extensive, highlighted miRNA’s potential in early diagnosis and treatment. …”
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Comparison of lifetime attributable risk of post-irradiation secondary cancer of boron neutron capture therapy, proton beam therapy, and X-ray therapy for pediatric and adolescent... by Shunsuke Suzuki, Shintaro Shiba, Hiroki Tanaka, Masashi Yamanaka, Kazuki Matsumoto, Koichi Tokuuye, Motoko Omura

“…These findings suggest the usefulness of BNCT in pediatric and AYA patients with brain tumors from the perspective of post-irradiation secondary cancer.…”
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Transformers for Neuroimage Segmentation: Scoping Review by Maya Iratni, Amira Abdullah, Mariam Aldhaheri, Omar Elharrouss, Alaa Abd-alrazaq, Zahiriddin Rustamov, Nazar Zaki, Rafat Damseh

“…Half of all included studies were published in 2022, and more than two-thirds used transformers for segmenting brain tumors. The most common imaging modality was magnetic resonance imaging (n=59, 88.06%), while the most frequently used dataset was brain tumor segmentation dataset (n=39, 58.21%). 3D transformer models (n=42, 62.69%) were more prevalent than their 2D counterparts. …”
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Longitudinal MRI evaluation of the efficacy of non-enhanced lung cancer brain metastases by Xian Zhang, Jun Yang, Hong Hu, Yong Wang, Zhenfeng Zhang, Jinhao lv, Junping Li

“…Exclusion criteria included participants with a history of primary brain tumors, other malignancies, or neurological symptoms. …”
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Tumor Mesenchymal Stem-Like Cell as a Prognostic Marker in Primary Glioblastoma by Seon-Jin Yoon, Jin-Kyoung Shim, Jong Hee Chang, Ju Hyung Moon, Tae-Hoon Roh, Kyoung Su Sung, Ji-Hyun Lee, Eui-Hyun Kim, Sun Ho Kim, Yong-Kil Hong, Su-Jae Lee, Yong-Min Huh, Seok-Gu Kang

“…The isolation from brain tumors of tumor mesenchymal stem-like cells (tMSLCs) suggests that these cells play a role in creating a microenvironment for tumor initiation and progression. …”
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Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres by Natália Hogetop Freire, Alice Laschuk Herlinger, Julia Vanini, Matheus Dalmolin, Marcelo A. C. Fernandes, Carolina Nör, Vijay Ramaswamy, Caroline Brunetto de Farias, André Tesainer Brunetto, Algemir Lunardi Brunetto, Lauro José Gregianin, Mariane da Cunha Jaeger, Michael D. Taylor, Rafael Roesler

“…Changes in epigenetic processes such as histone acetylation are proposed as key events influencing cancer cell function and the initiation and progression of pediatric brain tumors. Valproic acid (VPA) is an antiepileptic drug that acts partially by inhibiting histone deacetylases (HDACs) and could be repurposed as an epigenetic anticancer therapy. …”
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The bacterial microbiome modulates the initiation of brain metastasis by impacting the gut-to-brain axis by Matteo Massara, Michelle Ballabio, Bastien Dolfi, Golnaz Morad, Vladimir Wischnewski, Eleni Lamprou, Joao Lourenco, Stéphanie Claudinot, Hector Gallart-Ayala, Rui Santalla Méndez, Annamaria Kauzlaric, Nadine Fournier, Ashish V. Damania, Matthew C. Wong, Julijana Ivanisevic, Nadim J. Ajami, Jennifer A. Wargo, Johanna A. Joyce

“…Summary: Brain metastases (BrMs) are the most common brain tumors in patients and are associated with poor prognosis. …”
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A Systematic Comparison Identifies an ATP-Based Viability Assay as Most Suitable Read-Out for Drug Screening in Glioma Stem-Like Cells by A. Kleijn, J. J. Kloezeman, R. K. Balvers, M. van der Kaaij, C. M. F. Dirven, S. Leenstra, M. L. M. Lamfers

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Oxidative stress induced protein aggregation via GGCT produced pyroglutamic acid in drug resistant glioblastoma by Deanna Tiek, Xiao Song, Xiaozhou Yu, Runxin Wu, Rebeca Iglesia, Alicia Catezone, Katy McCortney, Jordain Walshon, Craig Horbinski, Pouya Jamshidi, Rudolph Castellani, Robert Vassar, Jason Miska, Bo Hu, Shi-Yuan Cheng

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Corrigendum to “Identification of Differentially Expressed Genes in Pituitary Adenomas by Integrating Analysis of Microarray Data” by Peng Zhao, Wei Hu, Hongyun Wang, Shengyuan Yu, Chuzhong Li, Jiwei Bai, Songbai Gui, Yazhuo Zhang

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EGFR Amplification and Glioblastoma Stem-Like Cells by Katrin Liffers, Katrin Lamszus, Alexander Schulte

“…Glioblastoma (GBM), the most common malignant brain tumor in adults, contains a subpopulation of cells with a stem-like phenotype (GS-cells). …”
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Identification of Differentially Expressed Genes in Pituitary Adenomas by Integrating Analysis of Microarray Data by Peng Zhao, Wei Hu, Hongyun Wang, Shengyuan Yu, Chuzhong Li, Jiwei Bai, Songbai Gui, Yazhuo Zhang

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Single-nucleus and spatial landscape of the sub-ventricular zone in human glioblastoma by Yamhilette Licón-Muñoz, Vanessa Avalos, Suganya Subramanian, Bryan Granger, Frank Martinez, Leopoldo A. García-Montaño, Samantha Varela, Drew Moore, Eddie Perkins, Michael Kogan, Stefano Berto, Muhammad O. Chohan, Christian A. Bowers, Sara G.M. Piccirillo

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