An exploration of the increasing prevalence of chronic pain among Canadian veterans: Life After Service Studies 2016 and 2019 by Jhalok Ronjan Talukdar, Dena Zeraatkar, Andrew Thomas, Jason W. Busse

“…Respondents who completed the 2019 LASS were more likely to endorse an anxiety or related disorder, mood disorder, probable posttraumatic stress disorder, and traumatic brain injury. In our adjusted regression model, year of survey administration was not associated with chronic pain (OR = 1.08, P = 0.8); however, we found large associations with obesity class 1 (body mass index [BMI] = 30.0–34.9; OR = 3.66; 95% confidence interval [CI] 1.46–9.17; ARI 27%), obesity class 2 (BMI = 35.0–39.9; OR = 8.10; 95% CI 1.67–39.3; ARI 47%), mood disorder (OR = 3.20; 95% CI 1.49–6.88; ARI 24%), and an anxiety or related disorder (OR = 4.53; 95% CI 1.28–16.0; ARI 33%).Conclusions The increase in chronic pain among Canadian veterans from 2016 to 2019 appears confounded by increased comorbidities associated with chronic pain among responders in 2019.…”
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Feasibility and acceptability for LION, a fully remote, randomized clinical trial within the VA for light therapy to improve sleep in Veterans with and without TBI: An MTBI2 sponso... by Jonathan E Elliott, Jessica S Brewer, Allison T Keil, Brittany R Ligman, Mohini D Bryant-Ekstrand, Alisha A McBride, Katherine Powers, Savanah J Sicard, Elizabeth W Twamley, Maya E O'Neil, Andrea D Hildebrand, Thuan Nguyen, Benjamin J Morasco, Jessica M Gill, Bradley A Dengler, Miranda M Lim

“…Sleep-wake disturbances frequently present in Veterans with mild traumatic brain injury (mTBI). These TBI-related sleep impairments confer significant burden and commonly exacerbate other functional impairments. …”
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A concise practical clinical guide to identifying spasticity in neurological shoulder dysfunction by Damon Hoad, Stephen Ashford, Stephen Ashford, Ganesh Bavikatte, Rachel Farrell, Rachel Farrell, Adrian Robertson, Jörg Wissel, Jörg Wissel

“…BackgroundSpasticity is a known complication to the hemiplegic shoulder following acquired brain injury. However, there is a current discrepancy between the diagnosis of arm spasticity and the subsequent assessment and treatment of spasticity in people with shoulder involvement.ObjectiveAn expert panel aimed to establish a consensus and provide a simple structured approach to identifying and assessing people with spasticity of the hemiplegic shoulder.MethodsA consensus group of six spasticity experts were interviewed individually via 1-h video calls to ascertain how they assess people with arm spasticity for shoulder involvement. …”
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Deep learning-based prediction of mortality using brain midline shift and clinical information by An-Rong Wu, Sun-Yuan Hsieh, Hsin-Hung Chou, Cheng-Shih Lai, Jo-Ying Hung, Bow Wang, Yi-Shan Tsai

“…Brain midline shift (MLS) indicates the severity of mass effect from intracranial lesions such as traumatic brain injury, stroke, brain tumor, or hematoma. Brain MLS can be used to determine whether patients require emergency surgery and to predict patients' prognosis. …”
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Deep Brain Stimulation in the treatment of disorders of consciousness by Joanna Olszak, Karolina Zalewa, Lidia Bartoszek, Dominika Orłowska, Wojciech Kapłan, Mikołaj Poleszczuk, Karol Poleszczuk, Alicja Milewska, Anna Czuba, Marta Kaus

“…Key factors influencing outcomes include the timing of DBS application, the extent of brain injury, and the specific brain regions targeted.  …”
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Remote photobiomodulation ameliorates behavioral and neuropathological outcomes in a rat model of repeated closed head injury by Chongyun Wu, Meng Li, Zhe Chen, Shu Feng, Qianting Deng, Rui Duan, Timon Cheng-Yi Liu, Luodan Yang

“…This study assessed the prophylactic efficacy of remote photobiomodulation (PBM) targeted at the lungs against rCHI-induced brain injury and associated behavioral deficits. Utilizing the “Marmarou” weight-drop model, rCHI was induced in rats on days 0, 5, and 10. …”
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Single‐Nucleus RNA Sequencing Reveals That Gabra6+ Neurons in Prefrontal Cortex Promote the Progression of PTSD After Shockwave‐Induced TBI by Xiaowei Fei, Zehan Zhang, Ya‐nan Dou, Weihao Lv, Hongqing Chen, Li Wang, Xin He, Wangshu Chao, Peng Luo, Zhou Fei

“…Abstract Shockwave‐induced traumatic brain injury (TBI) results in the onset of post‐traumatic stress disorder (PTSD), triggered either by the TBI itself or other stressors. …”
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Development of clinical decision support for patients older than 65 years with fall-related TBI using artificial intelligence modeling. by Biche Osong, Eric Sribnick, Jonathan Groner, Rachel Stanley, Lauren Schulz, Bo Lu, Lawrence Cook, Henry Xiang

“…<h4>Background</h4>Older persons comprise most traumatic brain injury (TBI)-related hospitalizations and deaths and are particularly susceptible to fall-induced TBIs. …”
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Blast‐Overpressure Induced Modulation of PARP‐SIRT‐NRF2 Axis in Stress Signaling of Astrocytes and Microglia by Vijaya Prakash Krishnan Muthaiah, Kathiravan Kaliyappan, Ramkumar Thiayagarajan, Supriya Mahajan, Krishnamoorthy Gunasekaran

“…ABSTRACT Background The pathomechanism of blast traumatic brain injury (TBI) and blunt TBI is different. In blast injury, evidence indicates that a single blast exposure can often manifest long‐term neurological impairments. …”
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The effect of thermoelectric craniocerebral cooling device on protecting brain functions in post-cardiac arrest syndrome by Aydın Nadir, Deniz Kara, Ayda Turkoz

“…By utilizing a specialized thermal hypothermia device, this approach sought to mitigate ischemic brain injury associated with post-cardiac arrest syndrome, enhance survival rates, and improve neurological outcomes as measured by standardized scales.MethodsA prospective, single-center cohort study was conducted involving patients aged ≥18 years who experienced in-hospital cardiac arrest and achieved return of spontaneous circulation (ROSC). …”
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Incomplete recovery in patients with minor head injury directly discharged home from the emergency department: a prospective cohort follow-up study by Bram Jacobs, Joukje van der Naalt, Jan Cornelis ter Maaten, Sophie Maria Coffeng, Laura Jane Kim

“…We also evaluated the differences between patient groups in this least severe category of brain and head injury.Design Prospective cohort follow-up study.Setting Patients admitted to the emergency department (ED) of a tertiary hospital in the Netherlands.Participants 242 patients with MHI (n=100 with head injury only and n=142 with mild traumatic brain injury (mTBI)) discharged home directly after evaluation at the ED.Outcome measures The primary outcome measure was incomplete recovery at 3 months measured by the Glasgow Outcome Scale-Extended score &lt;8. …”
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Return to play following craniotomy for non-traumatic brain lesions by Jovanna A. Tracz, Matthew L. Farmer, Mark Hughes, Debraj Mukherjee, Paul M. Brennan

“…Most published data relate to RTP following sports-related brain injury. This study investigated factors that influence neurosurgical RTP decision-making following craniotomy for non-traumatic brain lesions. …”
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Motor Learning Deficits in a Neonatal Mouse Model of Hypoxic-Ischemic Injury by Maria Marlicz, Weronika Matysik, Emily Zucker, Sarah Lee, Hannah Mulhern, Jennifer Burnsed

“…Background/Objectives: Motor deficits following neonatal brain injury, from cerebral palsy to subtle deficits in motor planning, are common yet underreported. …”
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Striatal Injury with 6-OHDA Transiently Increases Cerebrospinal GFAP and S100B by Cristiane Batassini, Núbia Broetto, Lucas Silva Tortorelli, Milene Borsoi, Caroline Zanotto, Fabiana Galland, Tadeu Mello Souza, Marina Concli Leite, Carlos-Alberto Gonçalves

“…Both glial fibrillary acidic protein (GFAP) and S100B have been used as markers of astroglial plasticity, particularly in brain injury; however, they do not necessarily change in the same time frame or direction. …”
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Adolescent mice exposed to TBI developed PD-like pathology in middle age by Rong Sha, Mingzhe Wu, Pengfei Wang, Ziyuan Chen, Wei Lei, Shimiao Wang, Shun Gong, Guobiao Liang, Rui Zhao, Yingqun Tao

“…Abstract Traumatic brain injury (TBI) is identified as a risk factor for Parkinson’s disease (PD), which is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (SN). …”
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Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications by Pharaoh Fellow Mwale, Cheng-Ta Hsieh, Ting-Lin Yen, Jing-Shiun Jan, Rajeev Taliyan, Chih-Hao Yang, Wen-Bin Yang

“…Elevated CHI3L1 levels have been observed in neurological conditions such as traumatic brain injury (TBI), Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotrophic lateral sclerosis (ALS), Creutzfeldt-Jakob disease (CJD), multiple sclerosis (MS), Neuromyelitis optica (NMO), HIV-associated dementia (HAD), Cerebral ischemic stroke (CIS), and brain tumors. …”
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Case report: Monitoring consciousness with fNIRS in a patient with prolonged reduced consciousness following hemorrhagic stroke undergoing adjunct taVNS therapy by Fei Gao, Likai Wang, Likai Wang, Zhan Wang, Yaru Tian, Jingyi Wu, Mengchun Wang, Litong Wang

“…Disorders of consciousness (DoC) resulting from severe brain injury present substantial challenges in rehabilitation due to disruptions in brain network connectivity, particularly within the frontal-parietal network critical for awareness. …”
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Resveratrol Induces Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Neuron-Like Cells by Li Guo, Liang Wang, Li Wang, Shi Yun-peng, Jing-jing Zhou, Zongmao Zhao, De-Pei Li

“…The natural polyphenol resveratrol benefits patients with many diseases including ischemic brain injury. We hypothesize that resveratrol induces differentiation of hUC-MSCs into neuron-like cells. …”
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Astrocyte-Derived Interleukin 11 Modulates Astrocyte–Microglia Crosstalk via Nuclear Factor-κB Signaling Pathway in Sepsis-Associated Encephalopathy by Dandan Zhu, Peng Wang, Xiyue Chen, Kaituo Wang, Yunsong Wu, Min Zhang, Jianhua Qin

“…Intriguingly, we found that IL11 addition markedly rescued LPS-induced neuronal injuries on the microfluidic system and brain injury in the SAE mouse model. This study defines an unknown crosstalk of astrocyte–microglia mediated by IL11, which contributed to the neuropathogenesis of SAE, and suggested a potential therapeutic value of IL11 in the devastating disease.…”
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Strategies to Improve the Quality and Freshness of Human Bone Marrow-Derived Mesenchymal Stem Cells for Neurological Diseases by Da Yeon Lee, Sung Eun Lee, Do Hyeon Kwon, Saraswathy Nithiyanandam, Mi Ha Lee, Ji Su Hwang, Shaherin Basith, Jung Hwan Ahn, Tae Hwan Shin, Gwang Lee

“…Human bone marrow-derived mesenchymal stem cells (hBM-MSCs) have been studied for their application to manage various neurological diseases, owing to their anti-inflammatory, immunomodulatory, paracrine, and antiapoptotic ability, as well as their homing capacity to specific regions of brain injury. Among mesenchymal stem cells, such as BM-MSCs, adipose-derived MSCs, and umbilical cord MSCs, BM-MSCs have many merits as cell therapeutic agents based on their widespread availability and relatively easy attainability and in vitro handling. …”
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