Current Controversies in Newer Therapies to Treat Birth Asphyxia by Pia Wintermark

“…Unfortunately, this neuroprotective strategy seems efficient in preventing brain injury in some asphyxiated newborns, but not in all of them. …”
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Understanding the Mechanisms of Recovery and/or Compensation following Injury by Michael J. Hylin, Abigail L. Kerr, Ryan Holden

“…Injury due to stroke and traumatic brain injury result in significant long-term effects upon behavioral functioning. …”
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Risen Alive: The Lazarus Phenomenon by Waqar Haider Gaba, Shahad Abobakar El Hag, Shaima Mustafa Bashir

“…The patient survived; however, she developed significant neurological deficits secondary to prolonged anoxic brain injury. She was discharged after a ten-week stay in the hospital but did not achieve full neurologic, cognitive, and motor recovery. …”
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Unsupported walking with only half of the brain due to severe porencephaly by Josef Finsterer

“…The patient is a 65 year-old male with a history of Asian flu at 6 months of age, Mumps meningoencephalitis at 6 years of age, structural epilepsy since 15 years of age, traumatic brain injury with skull-base fracture at 51 years of age, arterial hypertension, diabetes, hyperlipidemia, previous alcoholism, and polyneuropathy. …”
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Management of Patients Presenting with Acute Subdural Hematoma due to Ruptured Intracranial Aneurysm by Serge Marbacher, Ottavio Tomasi, Javier Fandino

“…Many patients present comatose and differential diagnosis is complicated due to aneurysm rupture results in or mimics traumatic brain injury. Fast decision-making is required to treat this life-threatening condition. …”
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IGF-1 impacts neocortical interneuron connectivity in epileptic spasm generation and resolution by Carlos J. Ballester-Rosado, John T. Le, Trang T. Lam, Anne E. Anderson, James D. Frost, Jr., John W. Swann

“…Little is known about the mechanisms that generate epileptic spasms following perinatal brain injury. Recent studies have implicated reduced levels of Insulin-like Growth Factor 1 (IGF-1) in these patients’ brains. …”
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Neuroprotective Effects of Eugenol Acetate Against Ischemic Stroke by Chen L, Zhang R, Xiao J, Liang Y, Lan Z, Fan Y, Yu X, Xia S, Yang H, Bao X, Meng H, Xu Y, Yu L, Zhu X

“…In addition, EA alleviated ischemic brain injury and improved neuromotor function of MCAO mice. …”
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The Rise of Inflow Cisternostomy in Resource-Limited Settings: Rationale, Limitations, and Future Challenges by Ulrick Sidney Kanmounye

“…Low- and middle-income countries (LMICs) bear most of the global burden of traumatic brain injury (TBI), but they lack the resources to address this public health crisis. …”
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Terson’s syndrome: An interesting case report by Rajwinder Kaur, Mehak Mangla, Balbir Khan, Harleen Kaur

“…Terson’s syndrome is described as an intra-ocular hemorrhage (sub hyaloid, intraretinal, subretinal bleed, or vitreous) occurring secondary to raised intracranial pressure (ICP) secondary to any intra cranial hemorrhage or traumatic brain injury. This report presents a case of a 34-year-old male who was diagnosed with a ruptured aneurysm of the left middle cerebral artery, which led to intracranial hemorrhage followed by raised ICP. …”
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P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction by Segundo J. Guzman, Zoltan Gerevich

“…The findings discussed here may explain how P2Y1 receptor activation during brain injury, hypoxia, inflammation, schizophrenia, or Alzheimer’s disease leads to an impairment of cognitive processes. …”
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Purinergic Receptors of the Central Nervous System: Biology, PET Ligands, and Their Applications by Hamideh Zarrinmayeh PhD, Paul R. Territo PhD

“…Based on their endogenous ligands, purinergic receptors are classified into P1 or adenosine, P2X and P2Y receptors. During brain injury or under pathological conditions, rapid diffusion of extracellular adenosine triphosphate (ATP) or uridine triphosphate (UTP) from the damaged cells, promote microglial activation that result in the changes in expression of several of these receptors in the brain. …”
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An open window: the crucial role of the gut-brain axis in neurodevelopmental outcomes post-neurocritical illness by Victoria Ronan

“…The most common diagnoses for a neurocritical illness admission include traumatic brain injury, status epilepticus, post-cardiac arrest, hypoxic ischemic encephalopathy, meningo/encephalitis, and stroke. …”
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Beyond the Hit: The Hidden Costs of Repetitive Head Trauma by Sikandar Khan, Lora Talley

“…While impact-reducing techniques have shown some efficacy in decreasing brain injury incidence, proper tackling techniques, such as “heads-up play,” also play a vital role in minimizing risk. …”
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Peripheral Cytokines as a Chemical Mediator for Postconcussion Like Sickness Behaviour in Trauma and Perioperative Patients: Literature Review by Yasir Rehman, Nadia Rehman, Riaz Rehman

“…Besides brain injury and systemic infection, cognitive and concussion like sickness behaviour is associated with muscular trauma and perioperative patients, which represents a major obstacle to daily activities and rehabilitation. …”
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Surgical management of supratentorial and infratentorial epidural hematoma in Korea: three case reports by Su Young Yoon, Junepill Seok, Yook Kim, Jin Suk Lee, Jin Young Lee, Mou Seop Lee, Hong Rye Kim

“…Supratentorial and infratentorial epidural hematoma (SIEDH) is a rare but life-threatening complication following traumatic brain injury. However, the literature on SIEDH is sparse, consisting only of a few small series. …”
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Sedation and Analgesia in Children with Developmental Disabilities and Neurologic Disorders by Todd J. Kilbaugh, Stuart H. Friess, Ramesh Raghupathi, Jimmy W. Huh

“…Sedation and analgesia performed by the pediatrician and pediatric subspecialists are becoming increasingly common for diagnostic and therapeutic purposes in children with developmental disabilities and neurologic disorders (autism, epilepsy, stroke, obstructive hydrocephalus, traumatic brain injury, intracranial hemorrhage, and hypoxic-ischemic encephalopathy). …”
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Prospective multi-centre analysis of rural trauma team development training for medical trainees and traffic law enforcement professionals in Uganda: an interrupted time series stu... by Herman Lule, Micheal Mugerwa, Robinson Ssebuufu, Patrick Kyamanywa, Jussi P. Posti, Michael Lowery Wilson

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Based on bioinformatics, SESN2 negatively regulates ferroptosis induced by ischemia reperfusion via the System Xc−/GPX4 pathway by Jiejie Hu, Lijun Qin, Guoqiang Zhu, Jingjing Ren, Hongxia Wang, Jing Jin, Haixue Zheng, Dan Li, Zhaoming Ge

“…IntroductionCerebral ischemia–reperfusion (IR) causes severe secondary brain injury. Previous studies have demonstrated that ferroptosis is involved in IR-induced brain injury. …”
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Repeated social defeat in male mice induced unique RNA profiles in projection neurons from the amygdala to the hippocampus by Rebecca G. Biltz, Wenyuan Yin, Ethan J. Goodman, Lynde M. Wangler, Amara C. Davis, Braedan T. Oliver, Jonathan P. Godbout, John F. Sheridan

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Political economics in health and implications for neurosurgery diseases by Yi Han, Yutao Huang

“…This review will discuss the effects of political-economic factors on the prevalence and treatment of neurosurgical diseases, including stroke, traumatic brain injury (TBI), intracerebral hemorrhage (ICH), and brain malignant tumors. …”
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