Predictive Values of Preoperative Tests for Difficult Laryngoscopy and Intubation in Adult Patients at Tikur Anbessa Specialized Hospital by Tadese Tamire, Habtamu Demelash, Wosenyeleh Admasu

“…Difficulties in intubation have been associated with serious complications, such as brain damage or death, particularly when failed intubation has occurred. …”
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Effects of Muse Cell on a Mouse Model With Acute Encephalopathy by Tatsuya Kawaguchi, Tetsuji Mori, Kaori Adachi, Jun Fujii, Yoshihiro Maegaki, Fumiko Obata

“…Recently, it has been shown that the administration of multilineage‐differentiating stress‐enduring (Muse) cells, a population of mesenchymal stem cells, improves symptoms in various types of brain injuries when administered in the subacute phase (1–7 days after brain damage). We aimed to examine the effects of Muse cells in a cytokine storm–induced AE animal model using immunocompromised nonobese diabetic/severe combined immunodeficiency (NOD/SCID) neonatal mice. …”
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Exosomes of Antler Mesenchymal Stem Cells Improve Postoperative Cognitive Dysfunction in Cardiopulmonary Bypass Rats through Inhibiting the TLR2/TLR4 Signaling Pathway by Chun Yang, Shengnan Sun, Qi Zhang, Jia Guo, Tengfei Wu, Ying Liu, Min Yang, Yan Zhang, Yinghua Peng

“…AMSC-derived exosomes reduced neurological damage and brain damage and prevent apoptosis in CPB rats. Furthermore, AMSC-derived exosomes were found to reduce hippocampal neuronal apoptosis and the expression of TLR2, TLR4, MyD88, and NF-κB in CPB rats. …”
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Biomarker Profiling for Pyridoxine Dependent Epilepsy in Dried Blood Spots by HILIC-ESI-MS by Elizabeth Mary Mathew, Sudheer Moorkoth, Leslie Lewis, Pragna Rao

“…If identified earlier and treated prophylactically with pyridoxine, severe brain damage due to seizures can be prevented. Alpha-amino adipic semialdehyde (AASA), piperidine-6-carboxylic acid (P6C), and pipecolic acid (PA) are known biomarkers of pyridoxine dependent epilepsy. …”
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Protective effects of wogonin in the treatment of central nervous system and degenerative diseases by Qingan Fu, Qingyun Yu, Hongdan Luo, Zhekang Liu, Xiaowei Ma, Huijian Wang, Zhijuan Cheng

“…For patients with hemorrhagic stroke and traumatic brain injury, it accelerates hematoma regression, mitigates secondary brain damage, and promotes neurogenesis, making it an entirely new treatment option for patients with limited access to this type of therapy. …”
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Environmental maternal exposures and the risk of premature birth and intrauterine growth restriction: The Generation Gemelli study protocol of newborn exposome. by Leonardo Villani, Angelo Maria Pezzullo, Roberta Pastorino, Alessandra Maio, Francesca Stollagli, Chiara Tirone, Marta Barba, Angela Maria Cozzolino, Denise Pires Marafon, Martina Porcelli, Annamaria Sbordone, Maria Letizia Patti, Anthea Bottoni, Angela Paladini, Simona Fattore, Domenico Marco Romeo, Ornella Parolini, Wanda Lattanzi, Guido Rindi, Luca Tamagnone, Marco Marazza, Maurizio Genuardi, Elisabetta Tabolacci, Eugenio Maria Mercuri, Antonio Chiaretti, Tina Pasciuto, Maurizio Sanguinetti, Vincenzo Valentini, Giovanni Scambia, Walter Ricciardi, Giovanni Vento, Antonio Lanzone, Stefania Boccia

“…We will perform laboratory examinations including dosage of heavy metals and essential elements, investigation of placental distress and fetal brain damage of biomarkers, analysis of microbiota and of DNA methylation profile. …”
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In vivo MRS study of long-term effects of traumatic intracranial injection of a culture medium in mice by O. B. Shevelev, O. P. Cherkasova, I. A. Razumov, E. L. Zavjalov

“…In addition, there is a lack of data on the delayed effects of invasive brain damage. Therefore, this study investigates the long-term dyna mics of the neurometabolic profile, assessed using 1H MRS, after intracranial injection of a culture medium used in orthotopic modeling of glioma in mice. …”
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Inhibition of TLR4 Signalling-Induced Inflammation Attenuates Secondary Injury after Diffuse Axonal Injury in Rats by Yonglin Zhao, Yahui Zhao, Ming Zhang, Junjie Zhao, Xudong Ma, Tingqin Huang, Honggang Pang, Jiaxi Li, Jinning Song

“…Recent studies show that toll-like receptor 4 (TLR4) plays a critical role in promoting adaptive immune responses and have been shown to be associated with brain damage. The purpose of this study was to investigate the role of the TLR4 signalling pathway in secondary axonal injury in the cortices of DAI rats. …”
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Conversational Therapy through Semi-Immersive Virtual Reality Environments for Language Recovery and Psychological Well-Being in Post Stroke Aphasia by A. Giachero, M. Calati, L. Pia, L. La Vista, M. Molo, C. Rugiero, C. Fornaro, P. Marangolo

“…Aphasia is a highly disabling acquired language disorder generally caused by a left-lateralized brain damage. Even if traditional therapies have been shown to induce an adequate clinical improvement, a large percentage of patients are left with some degree of language impairments. …”
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Clinical characteristics and associated factors of pediatric acute necrotizing encephalopathy: a retrospective study by Huiling Zhang, Yilong Wang, Qianyun Ding, Xuekun Li, Sheng Ye

“…Background In the clinic, pediatric acute necrotizing encephalopathy (ANE) primarily affects children under 5 years of age and is characterized by severe brain damage and high mortality. However, some challenges remain regarding the diagnosis and treatment of ANE. …”
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Evaluation of the Psychiatric Disorders among Amphetamine Addicts in Rehabilitation Centers: A Cross-Sectional Analysis by Saud D. AlOtaibi, Hossam A. Elsisi, Mohammed J. AlShammary, Saud A. AlQader, Hejab A. AlHarbi, Bayan R. AlOlaiyan, Ahmad O. Alanazi, Firas S. AlMendeel, Yazeed N. AlHarbi, Ibrahim AlKhalaf, Ahmad H. Alhowail, Abdelhamid Mohamed Elwy, Ashraf M. Emara

“…These effects are attributed to brain damage, neurotoxicity, and neuronal inflammation, particularly when these substances are abused over extended periods and at higher doses.…”
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Combined effects of co-exposure to microcystin-LR and polystyrene microplastics on growth, brain pathology and thyroid hormone homeostasis in adult zebrafish by Wang Lin, Ling Liao, Ling Ling, Huimin Luo, Ying Jiang, Xinru Li, Yilong Yao, Pinhong Yang

“…The presence of PSMPs exacerbated the brain damage cause by MCLR, resulting in more pronounced ventriculomegaly and hyperemia. …”
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Momordica Charantia Polysaccharides Attenuates MPP+-Induced Injury in Parkinson’s Disease Mice and Cell Models by Regulating TLR4/MyD88/NF-κB Pathway by Dengjun Guo, Jie Zhou, Meng Zhang, Reyisha Taximaimaiti, Xiaoping Wang, Hai Wang

“…Compared with the Control group, MPTP treatment can induce brain damage in mice (all P<0.05), change the metabolic state of neurotransmitters (all P<0.05), induce inflammation (all P<0.05), and induce apoptosis and the occurrence of oxidation reaction (all P<0.05); however, MCPs treatment can significantly reverse the above changes (all P<0.05). …”
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Item-level measurement properties of the pediatric awareness and sensory motor assessment in children with medical complexity by Brooke Mulrenin, Bryant A. Seamon, Carrie Cormack, Kimberly Lane Kascak, Cynthia Dodds

“…IntroductionChildren with medical complexity (CMC) are medically fragile with severe brain damage and chronic conditions, necessitating daily care. …”
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Management of acute bacterial meningitis in a limited resource setting: an Egyptian consensus model by Samy Zaky, Mohamed Elbadry, Maysaa A. Saeed, Hanaa Fathelbab, Fatma Abdelsalam, Mohammed Gamal Abdel-Hamid, Alshaimaa Eid, Asmaa Bakr, Amira Maher, Mona Mohammed Abdelrahman, Mohamed A. Metwally, Mahmoud Saad Berengy, Enaam Ali AlMowafy, Hassan Goabar, Amin Abdel Baki, Ahmed Corie, Osama Hammad, Entesar Elsharkawy, Ahmed Saad, Fatma Ali-Eldin, Ahmed Mahdy, Ramadan Zaky, Reham Hammad, Gamal Essmat

“…Those who do recover, especially if there was delayed appropriate intervention, can have permanent disabilities, such as brain damage, hearing loss, and learning disabilities. …”
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Salidroside promotes pro-angiogenesis and repair of blood brain barrier via Notch/ITGB1 signal path in CSVD Model by Tu Zhilan, Zhang Zengyu, Jin Pengpeng, Yang Hualan, Li Chao, Xi Yan, Guo Zimin, Hou Shuangxing, Li Weiwei

“…Previous studies have demonstrated that SAL could reduce arteriosclerosis, and thus combat ischemic brain damage. However, the in-depth function of the salidroside in Cerebral Small Vascular Disease (CSVD) has not been discovered, and related molecular mechanism is still unclear. …”
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Interleukin 10 Plays an Important Role in Neonatal Rats with Hypoxic-Ischemia Associated with B-Cell Lymphoma 2 and Endoplasmic Reticulum Protein 29 by Xue Bai, Liu-Lin Xiong, Chang-Le Fang, Hao-Li Zhou, Lu-Lu Xue, Yue Hu, Qing-Jie Xia, Jia Liu, Jun-Yan Zhang, Ting-Hua Wang, Si-Jin Yang

“…This study was designed to investigate the expression variation of IL-10 in the multiple sites including cortex, hippocampus, and lung tissues of neonatal hypoxic-ischemic (HI) rats and explore the crucial role of IL-10 in alleviating HI brain damage. In this study, neonatal Sprague-Dawley rats were subjected to the right common carotid artery ligation, followed by 2 h of hypoxia. …”
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Interleukin-1 Receptor-Associated Kinase-3 Aggravates Neuroinflammatory Injury After Intracerebral Hemorrhage via Activation NF-&kappa;B/IL-17A Pathway in Mice by Wang J, Li Y, Tan C, Shao J, Tang W, Kong Q, Sheng W, Ding Z, Li F, Piao J, Lv D, Hu L, Wang Q, Jiang X

“…Jun Wang,1,&ast; Yulong Li,1,&ast; Chunyu Tan,1,&ast; Jinlian Shao,1 Weitai Tang,2 Quan Kong,3 Wenqianjun Sheng,1 Zhiquan Ding,1 Feng Li,1 Jifeng Piao,1 Dingyi Lv,1 Libin Hu,1 Qinghua Wang,1 Xiaodan Jiang1 1Neuromedicine Center, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, People’s Republic of China; 2Department of Neurosurgery, The People’s Hospital of Luoding & Affiliated Luoding Hospital of Guangdong Medical University, Luoding, 527200, People’s Republic of China; 3Neurosurgery Department of Zengcheng Campus, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Qinghua Wang; Xiaodan Jiang, Email wqh1123@126.com; jiangxiao_dan@163.comBackground: Neuroinflammatory reactions are crucial factors in secondary brain damage following intracerebral hemorrhage (ICH). …”
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Roles of Rufy3 in experimental subarachnoid hemorrhage-induced early brain injury via accelerating neuronal axon repair and synaptic plasticity by Yang Wang, Jianguo Xu, Wanchun You, Haitao Shen, Xiang Li, Zhengquan Yu, Haiying Li, Gang Chen

“…Moreover, LV-Rufy3 also alleviated brain damage indicators, including cortical neuronal cell apoptosis and degeneration, brain edema, and cognitive impairment after SAH. …”
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Diffusion Tensor Imaging as Neurologic Predictor in Patients Affected by Traumatic Brain Injury: Scoping Review by Federica Paolini, Salvatore Marrone, Gianluca Scalia, Rosa Maria Gerardi, Lapo Bonosi, Umberto Emanuele Benigno, Sofia Musso, Alba Scerrati, Domenico Gerardo Iacopino, Francesco Signorelli, Rosario Maugeri, Massimiliano Visocchi

“…<b>Background</b>: Diffusion tensor imaging (DTI), a variant of Diffusion Weighted Imaging (DWI), enables a neuroanatomical microscopic-like examination of the brain, which can detect brain damage using physical parameters. DTI’s application to traumatic brain injury (TBI) has the potential to reveal radiological features that can assist in predicting the clinical outcomes of these patients. …”
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