Preclinical Evidences for an Antimanic Effect of Carvedilol by Greicy Coelho de Souza, Julia Ariana de S. Gomes, Ana Isabelle de Góis Queiroz, Maíra Morais de Araújo, Lígia Menezes Cavalcante, Michel de Jesus Souza Machado, Aline Santos Monte, David Freitas de Lucena, João Quevedo, André Ferrer Carvalho, Danielle Macêdo

“…Oxidative imbalance, alterations in brain-derived neurotrophic factor (BDNF), and mitochondrial dysfunction are implicated in bipolar disorder (BD) pathophysiology and comorbidities, for example, cardiovascular conditions. …”
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P Wave Duration/P Wave Voltage Ratio Plays a Promising Role in the Prediction of Atrial Fibrillation: A New Player in the Game by E. Karacop, A. Enhos, N. Bakhshaliyev, R. Ozdemir

“…In a univariate regression analysis, age, smoking, C-reactive protein, brain natriuretic peptide, left atrial diameter, left atrial volume index, P wave duration, P wave voltage, and P wave duration/P wave voltage were significantly associated with the development of new-onset AF. …”
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Significance of Glioma Stem-Like Cells in the Tumor Periphery That Express High Levels of CD44 in Tumor Invasion, Early Progression, and Poor Prognosis in Glioblastoma by Masahiro Nishikawa, Akihiro Inoue, Takanori Ohnishi, Shohei Kohno, Shiro Ohue, Shirabe Matsumoto, Satoshi Suehiro, Daisuke Yamashita, Saya Ozaki, Hideaki Watanabe, Hajime Yano, Hisaaki Takahashi, Riko Kitazawa, Junya Tanaka, Takeharu Kunieda

“…Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor and a subpopulation of glioma stem-like cells (GSCs) is likely responsible for the invariable recurrence following maximum resection and chemoradiotherapy. …”
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Multi-task aquatic toxicity prediction model based on multi-level features fusion by Xin Yang, Jianqiang Sun, Bingyu Jin, Yuer Lu, Jinyan Cheng, Jiaju Jiang, Qi Zhao, Jianwei Shuai

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Health-related adverse work outcomes associated with post COVID-19 condition: a cross-sectional study by Peter M Smith, Hind Sbihi, Wei Zhang, Adeera Levin, Naveed Z Janjua, Hiten Naik, Bingyue Zhu, Lee Er, Karen Tran

“…The risk of a health-related adverse work outcome was especially high in those with post-COVID-19 fatigue (aOR 4.6 (95% CI 2.7 to 7.9)), fever (aOR 4.0 (95% CI 1.7 to 9.6)), weakness (aOR 3.8 (95% CI 2.2 to 6.3)), palpitations (aOR 3.3 (95% CI 2.0 to 5.0)) and brain fog (aOR 3.2 (95% CI 2.0 to 5.0)).Conclusions PCC is associated with health-related adverse work outcomes. …”
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Identifying disulfidptosis-related biomarkers in epilepsy based on integrated bioinformatics and experimental analyses by Sijun Li, Lanfeng Sun, Hongmi Huang, Xing Wei, Yuling Lu, Kai Qian, Yuan Wu

“…One of the underlying mechanisms of epilepsy (EP), a brain disease characterized by recurrent seizures, is considered to be cell death. …”
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S1PR3-driven positive feedback loop sustains STAT3 activation and keratinocyte hyperproliferation in psoriasis by Panpan Lian, Li Li, Renwei Lu, Bin Zhang, Junaid Wazir, Chaode Gu, Bojie Ma, Wenyuan Pu, Wangsen Cao, Zhiqiang Huang, Zhonglan Su, Hongwei Wang

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Biochanin A Reduces Inflammatory Injury and Neuronal Apoptosis following Subarachnoid Hemorrhage via Suppression of the TLRs/TIRAP/MyD88/NF-κB Pathway by Ling-yun Wu, Zhen-nan Ye, Zong Zhuang, Yongyue Gao, Chao Tang, Chen-hui Zhou, Chun-xi Wang, Xiang-sheng Zhang, Guang-bin Xie, Jing-peng Liu, Meng-liang Zhou, Chun-hua Hang, Ji-xin Shi

“…Inflammatory injury and neuronal apoptosis participate in the period of early brain injury (EBI) after subarachnoid hemorrhage (SAH). …”
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Glioma Image-Level and Slide-Level Gene Predictor (GLISP) for Molecular Diagnosis and Predicting Genetic Events of Adult Diffuse Glioma by Minh-Khang Le, Masataka Kawai, Kenta Masui, Takashi Komori, Takakazu Kawamata, Yoshihiro Muragaki, Tomohiro Inoue, Ippei Tahara, Kazunari Kasai, Tetsuo Kondo

“…The latest World Health Organization (WHO) classification of central nervous system tumors (WHO2021/5th) has incorporated molecular information into the diagnosis of each brain tumor type including diffuse glioma. Therefore, an artificial intelligence (AI) framework for learning histological patterns and predicting important genetic events would be useful for future studies and applications. …”
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Assessing Heat Resistance and Selecting Heat-Resistant Individuals of Largemouth Bass (<i>Micropterus salmoides</i>) with Tiered Thermal Exposure by Haijie Chen, Hui Qiao, Zhicheng Xv, Guili Song, Shuning Liu, Cheng Luo, Yong Long, Shimei Lin

“…To correlate the changes in tissue structure and gene expression with the heat resistance, a new batch of LMB juveniles (average body weight 23.66 ± 6.98 g) were subjected to tiered heat exposure. Brain and liver tissues were collected from the control (without heat exposure), resistant and sensitive (still alive but demonstrated abnormal symptoms) individuals when the temperature was maintained at 35.5 °C for 24 h. …”
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Multiple patterns of EEG parameters and their role in the prediction of patients with prolonged disorders of consciousness by Hui Li, Hui Li, Hui Li, Linghui Dong, Linghui Dong, Linghui Dong, Wenlong Su, Wenlong Su, Ying Liu, Ying Liu, Zhiqing Tang, Zhiqing Tang, Xingxing Liao, Xingxing Liao, Junzi Long, Junzi Long, Xiaonian Zhang, Xinting Sun, Hao Zhang, Hao Zhang, Hao Zhang, Hao Zhang

“…Electroencephalography (EEG) is a neurophysiological method that provides objective information for evaluating overall brain function. In this study, we aim to investigate the multiple features of pDoC using EEG and evaluate the prognostic values of these indicators.MethodsWe analyzed the EEG features: (i) spectral power; (ii) microstates; and (iii) mismatch negativity (MMN) and P3a of healthy controls, patients in minimally conscious state (MCS), and unresponsive wakefulness syndrome (UWS). …”
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Effect of Lamotrigine on Refractory Epilepsy: Clinical Outcomes and EEG Changes by Li Z, Wu P, Chen Q, Tong X, Yang Q

“…The clinical treatment effects, EEG (δ, θ, α, β) power levels, neurological function indicators [brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), pro-apoptotic protein Bcl-2, Bax], inflammatory response indicators [interleukin-1β (IL-1β), interleukin-6 (IL-6), prostaglandin E2 (PGE2)], and the incidence of adverse reactions were compared between the two groups.Results: The clinical treatment effect in the observation group was significantly better than that in the control group, with a higher total effective rate (93.62% vs 76.09%, P< 0.05). …”
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Effect of intermittent infusion hemodiafiltration on cerebral and hepatic oxygenation by Susumu Ookawara, Kiyonori Ito, Kazuma Fukuda, Tomoko Iida, Kazumi Yahagi, Haruhisa Miyazawa, Keiji Hirai, Mamoru Yoshizawa, Yoshiyuki Morishita

“…However, clinical studies comparing systemic tissue oxygenation, particularly in the brain and liver, between HD and intermittent infusion hemodiafiltration (I-HDF) are limited. …”
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Associations between media parenting practices and early adolescent consumption of R-rated movies and mature-rated video games by Jason M. Nagata, Karen Li, Shirley S. Sui, Jonanne Talebloo, Christopher D. Otmar, Iris Yuefan Shao, Orsolya Kiss, Kyle T. Ganson, Alexander Testa, Jinbo He, Fiona C. Baker

“…Methods Data from the Adolescent Brain Cognitive Development (ABCD) Study (N = 10,054, 12–13 years, Year 3, 2019–2021) were analyzed. …”
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Structural tailoring of etoricoxib: A spectrochemical, medicinal and pharmacological study by Bakul Akter, Silvia Aishee, Abdullah Hridoy, Md. Mehedi Hasan Pulok, Mohammad Ariful Islam, Antu Biswas, Aurna Patwary, Majedul Hoque, MD. Sazidul Islam, Md. Nipatul Hasan Nirob, Faisal Islam Chowdhury, Monir Uzzaman

“…ADMET and PASS predictions confirmed the drug-like properties of most derivatives, particularly ETC19 and ETC9, which also showed improved absorption, better blood-brain barrier penetration, and reduced toxicity. …”
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Hesperidoside abolishes dichlorvos-mediated neurotoxicity in rats by suppressing oxidative stress, acetylcholinesterase inhibition, and NF-κB-p65/p53/caspase-3-mediated apoptosis by Adio J. Akamo, Adetutu O. Ojelabi, Oluwatobi T. Somade, Iyabode A. Kehinde, Adewale M. Taiwo, Boluwatife A. Olagunju, Mushafau A. Akinsanya, Adedayo A. Adebisi, Tobi S. Adekunbi, Abiola F. Adenowo, Florence Anifowose, Olufemi M. Ajagun-Ogunleye, Ofem E. Eteng, Jacob K. Akintunde, Regina N. Ugbaja

“…Background: In third-world countries, poisoning due to dichlorvos (DDVP), an organophosphate insecticide, is prevalent due to its widespread usage in household and agriculture, with the brain bearing the brunt of the consequences. Hence, this study assessed the likely beneficial impact of hesperidoside (HESP) on the DDVP-mediated cerebral dysfunction in rat model. …”
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Prior Anticoagulation and Risk of Hemorrhagic Transformation in Acute Stroke: A Post Hoc Analysis of the PRODAST Study by Gerrit M. Grosse, Anika Hüsing, Andreas Stang, Nils Kuklik, Marcus Brinkmann, Martin Grond, Jens D. Rollnik, Lars Marquardt, Andrea Kraft, Eckhard Schlemm, Carsten Eggers, Christoph C. Eschenfelder, Christian Weimar, Hans‐Christoph Diener

“…These findings were confirmed using sensitivity analyses accounting for thrombolysis and mechanical thrombectomy, as well as timing of brain imaging. Antiplatelet therapy had hardly any association with the end points compared with no antithrombotic pretreatment. …”
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Association of pituitary neuroendocrine tumors and neurofibromatosis type 1: assessing causation versus coincidence. Case report by Mercedes Aguilar-Soto, Julia M. Zuarth-Vázquez, Laura Leyva-Figueroa, Karla Zarco-Ávila, Armando Gamboa-Domínguez, Aldo Eguiluz-Melendez, Laura C. Hernández-Ramírez

“…Similar cases were searched in the literature.ResultsA 54-year-old-man was incidentally diagnosed with a clinically non-functioning PitNET via brain imaging. He had a personal and family history of NF1 and carried the germline pathogenic variant NF1 (NM_001042492.3): c.147C&gt;A, p.Y49*. …”
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Multicentre, multitime, multidimension, prospective follow-up cohort study on patients during the first wave of COVID-19 in China: a study protocol by Ming Zhang, Xuan Niu, Tonghui Liu, Chao Zheng, Huijie Yuan, Yanan Zhu, Huiping Liu, Shan Wu, Zhaoyao Luo, Jia Zhu, Danwei Hou, Tianhua Wei, Zhimin Zhu, Weipeng Huang, Weixian Bai, Xinyi Yu, Wenrui Bao

“…Confirmed patients with mild or moderate COVID-19 will complete the following programmes during the acute infection phase and at 3, 12 and 24 months after infection: (a) blood test at the local laboratory, (b) multimodal brain and spine MRI scan and (c) the neuropsychological scales and questionnaires. …”
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Inferior vena cava ultrasound in acute decompensated heart failure: design rationale of the CAVA‐ADHF‐DZHK10 trial by Alexander Jobs, Reinhard Vonthein, Inke R. König, Jane Schäfer, Matthias Nauck, Svenja Haag, Carlo Federico Fichera, Thomas Stiermaier, Jakob Ledwoch, Alisa Schneider, Miroslava Valentova, Stephan vonHaehling, Stefan Störk, Dirk Westermann, Tobias Lenz, Natalie Arnold, Frank Edelmann, Philipp Seppelt, Stephan Felix, Matthias Lutz, Felix Hedwig, Martin Borggrefe, Clemens Scherer, Steffen Desch, Holger Thiele

“…The primary endpoint is change in N‐terminal pro‐brain natriuretic peptide from baseline to hospital discharge. …”
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