Bayesian reinforcement learning models reveal how great-tailed grackles improve their behavioral flexibility in serial reversal learning experiments by Lukas, Dieter, McCune, Kelsey, Blaisdell, Aaron, Johnson-Ulrich, Zoe, MacPherson, Maggie, Seitz, Benjamin, Sevchik, August, Logan, Corina

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Dimethyl fumarate promotes the degradation of HNF1B and suppresses the progression of clear cell renal cell carcinoma by Yue Dai, Hongchen Li, Shiyin Fan, Kai Wang, Ziyi Cui, Xinyu Zhao, Xue Sun, Mingen Lin, Jiaxi Li, Yi Gao, Ziyin Tian, Hui Yang, Bingbing Zha, Lei Lv, Yanping Xu

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Phase II randomised, double-blind, placebo-controlled trial to assess the efficacy and safety of MLC1501 in patients with stroke: the MLC1501 study Assessing Efficacy in post-STrOk... by Narayanaswamy Venketasubramanian, Deidre Anne De Silva, Christopher P L H Chen, Cyrus G Escabillas, John Harold Hiyadan, Johnny K Lokin, Romulo U Esagunde, Joel M Advincula, Christian Oliver C Co, Maria Epifania V Collantes, Annabelle Y Lao, Yeow-Hoay Koh, Carol Huilian Tham

“…MLC1501 has a good safety profile as well as potential to be a treatment for recovery after brain injury. The results of this study will provide objective level B evidence on the efficacy of MLC1501 on long-term recovery and safety of 24 weeks of treatment among patients with IS.Trial registration number NCT05289947.…”
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Shramahara Mahakasya, a traditional polyherbal formulation, induces anti-anxiety activity in hippocampal neurons by effectuating SOD2-mediated protection against oxidative stress by Saakshi Saini, Viney Kumar, Swati Haldar, Samrat Chauhan, Pratibha Demiwal, Souvik Ghosh, Sumeet Gupta, Debabrata Sircar, Bidhan Mahajon, Partha Roy

“…The anxiolytic activity of SM was demonstrated by improved behavior of the animals in the elevated plus maze test and increased SOD activity in the brain. SM exhibited the most effective improvements in anxiety disorder at a dose of 100 mg/kg body weight in rats. …”
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Exploring environmental factors contributing to Parkinson’s disease in AfrAbian populations by Wael Mohamed

“…This study presents a plausible rationale for the adverse effects of environmental influences on the brain, which are pivotal in the progression or onset of Parkinson’s disease from an AfrAbian standpoint.…”
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Linezolid and serotonin syndrome by Haytham A. Wali

“…Despite its efficacy, linezolid can cause serotonin syndrome, a potentially fatal condition associated with excessive serotonin activity in the brain. This narrative review examined the pharmacological mechanisms of this interaction, particularly linezolid’s mild monoamine oxidase-inhibitory activity, which can trigger serotonin syndrome in combination with serotonergic drugs. …”
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Love Addiction - Current Diagnostic and Therapeutic Paradigms in Clinical Psychology. by Marilena Giovanna Maglia, Ines Lanzafame, Maria C Quattropani, Pasquale Caponnetto

“… # Conclusions Group psychotherapy has proved to be a valid alternative, in fact the scientific landscape suggests that most group therapies are successful because these dynamics involve the reward and attachment systems in the brain in most subjects. Although there is currently no official classification for this type of addiction, the continuing interests of clinical psychology open up new scenarios for achieving greater psychophysical well-being.…”
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Sensorimotor environment but not task rule reconfigures population dynamics in rhesus monkey posterior parietal cortex by Hao Guo, Shenbing Kuang, Alexander Gail

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Diverse neuronal activity patterns contribute to the control of distraction in the prefrontal and parietal cortex. by Panagiotis Sapountzis, Alexandra Antoniadou, Georgia G Gregoriou

“…Although experimental evidence suggests that brain areas in the prefrontal and parietal lobe contribute to the selection of task-relevant and the suppression of task-irrelevant stimuli, how conspicuous distractors are encoded and effectively ignored remains poorly understood. …”
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Pain Neuroscience Education for Acute Pain by Adriaan Louw, Teresa Schuemann, Kory Zimney, Emilio J Puentedura

“…However, modern pain science has illuminated the complexity of the human pain experience, incorporating psychosocial elements, nervous system sensitization, immune responses, and structural changes in the brain as factors. This contemporary understanding of pain has proven highly beneficial for both clinicians treating individuals in pain and those experiencing pain. …”
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Advances in the study of apathy related to cerebral small vessel disease by Shuo-han Bu, Shuo-han Bu, Xin-zhu Hu, Zhe Su, Li-tao Li, Li-tao Li

“…Cerebral small vessel disease (CSVD) is a complex clinical-imaging pathological syndrome caused by small vessel lesions in the brain, which is characterized by aging-related, insidious onset and slow progression. …”
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The underappreciated contribution of Oskar Fischer to the knowledge of Frontotemporal Lobar Degeneration by Eliasz Engelhardt, Lea Tenenholz Grinberg

“…The historical development of FTD concept is rooted in the pioneering work of Arnold Pick, who first described clinical cases of focal brain atrophy. Oskar Fischer significantly advanced this field by detailing the histopathological features of these conditions, such as the ‘spongiform cortical wasting’, and identifying characteristic neuronal changes such as the ‘ballooned cells’. …”
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Editorial: To Know or Not to Know: causes and evolution of lack of awareness of cognitive decline in neurodegenerative diseases, volume II by Federica Cacciamani, Federica Cacciamani, Kristy A. Nielson, Kristy A. Nielson, Bernard J. Hanseeuw, Bernard J. Hanseeuw, Geoffroy P. Gagliardi, Geoffroy P. Gagliardi, Patrizia Vannini, Patrizia Vannini

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The biological foundations of fixation: a general theory by Robert A. Dielenberg

“…This leads to the idea that the brain functions as a fixation-projection machine. …”
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Robots as social companions for space exploration by Matthieu J. Guitton

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Adherent junctions: Physiology, role in hydrocephalus and potential therapeutic targets by Zhiye Chen, Jian He, Yating Guo, Yue Hao, Wentao Lv, Zexin Chen, Junqiang Wang, Yijian Yang, Kaiyue Wang, Zhikun Liu, Qian Ouyang, Zhangjie Su, Pingsheng Hu, Gelei Xiao

“…In addition, the damage of the brain barrier can lead to brain edema and aggravate the symptoms. …”
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The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis by Femke Van Gaever, Femke Van Gaever, Fleur Mingneau, Fleur Mingneau, Sam Vanherle, Sam Vanherle, Yasmine Driege, Yasmine Driege, Mira Haegman, Mira Haegman, Elien Van Wonterghem, Elien Van Wonterghem, Junhua Xie, Junhua Xie, Roosmarijn E. Vandenbroucke, Roosmarijn E. Vandenbroucke, Jerome J. A. Hendriks, Jerome J. A. Hendriks, Rudi Beyaert, Rudi Beyaert, Jens Staal, Jens Staal, Jens Staal

“…ABA, which is abundant in fruits such as figs, apricots and bilberries, is known to cross the blood-brain barrier and has demonstrated neuroprotective effects in conditions like depression and Alzheimer's disease.MethodsIn this study, we investigated whether ABA supplementation enhances remyelination in both ex vivo and in vivo mouse models.ResultsOur results indicated that ABA enhanced remyelination and that this enhanced remyelination is associated with increased lipid droplet load, reduced levels of degraded myelin, and a higher abundance of F4/80+ cells in the demyelinated brain of mice treated with ABA. …”
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Dose-response associations of device-measured sleep regularity and duration with incident dementia in 82391 UK adults by Wenxin Bian, Raaj K. Biswas, Matthew N. Ahmadi, Yu Sun Bin, Svetlana Postnova, Andrew J. K. Phillips, Nicholas A. Koemel, Jean-Philippe Chaput, Shantha M. W. Rajaratnam, Peter A. Cistulli, Emmanuel Stamatakis

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Lumateperone tosylate, A Selective and Concurrent Modulator of Serotonin, Dopamine, and Glutamate, in the Treatment of Schizophrenia by Kunal Maini, Janice W. Hollier, Haley Gould, Victoria Bollich, John LaForge, Elyse M. Cornett, Amber N. Edinoff, Adam M. Kaye, Alan D. Kaye

“… # Summary Schizophrenia is a complex, severe mental illness that affects how the brain processes information. There are many medications used to treat schizophrenia. …”
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Case study: An unusual and fatal injury: stab wound of a bovine aortic arch anomaly by Sergio AM Vieira, Ryan J Keet, Jacobus D Winter, Sharon R Čačala, George V Oosthuizen

“…We present a patient who sustained a stab wound to a bovine arch, which proved non-salvageable because proximal and distal vascular control could not be provided without rendering the brain anoxic. We provide an overview of the bovine arch abnormality and a brief review of the management of aortic arch injuries.…”
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