Determinants of well-being and their interconnections in Australian general practitioners: a qualitative study by Nick Glozier, Ian B Hickie, Christiane Klinner, Alyssa Milton, Diana Naehrig, Louise Acland, Brendan Goodger

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Classic and Novel Sex Hormone Binding Globulin Effects on the Cardiovascular System in Men by Carla Basualto-Alarcón, Paola Llanos, Gerardo García-Rivas, Mayarling Francisca Troncoso, Daniel Lagos, Genaro Barrientos, Manuel Estrada

“…SHBG is produced mainly in the liver, but it can also be expressed in several tissues including the brain, fat tissue, and myocardium. Expression of SHBG is controlled by peroxisome proliferator-activated receptor γ (PPARγ) and AMP-activated protein kinase (AMPK). …”
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An experimental study of the effects of SNPs in the TATA boxes of the <i>GRIN1, ASCL3</i> and <i>NOS1</i> genes on interactions with the TATA-binding protein by E. B. Sharypova, I. A. Drachkova, I. V. Chadaeva, M. P. Ponomarenko, L. K. Savinkova

“…The effect of allele A of the –27G&gt;A SNP (rs1195040887) in the NOS1 promoter is suggestive of an increased risk of ischemic damage to the brain in carriers. A comparison of experimental TBP–TATA affinity values (KD) of wild-type and minor alleles with predicted ones showed that the data correlate well (linear correlation coefficient r = 0.94, p &lt; 0.01).…”
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Effect of lethal yellow (AY) mutation and photoperiod alterations on mouse behavior by E. Y. Bazhenova, D. V. Fursenko, N. V. Khotskin, I. E. Sorokin, A. V. Kulikov

“…The lethal yellow (AY) mutation causes ectopic expression of agouti protein in the brain. Mice heterozygous for AY mutation (AY/a) are obese compared to their wild-type littermates (a/a). …”
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Improving natural red pigment production by Streptomyces phaeolivaceus strain GH27 for functionalization of textiles with in silico ADME prediction by Gehad H. El Sayed, Mohamed Fadel, Rasha Fouad, Hend M. Ahmed, Ahmed A. Hamed

“…It exhibited intermediate synthetic accessibility, exceptional permeability and absorption, elevated gastrointestinal absorption, and blood–brain barrier penetration; nonetheless, it did not adhere to the medicinal chemistry rule of three. …”
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A data driven approach for soft tissue biomarker identification linked to Chiari-like malformation and syringomyelia by Jake Cumber, Jake Cumber, Emma Scales-Theobald, Emma Scales-Theobald, Clare Rusbridge, Clare Rusbridge, Clare Rusbridge, Kevin Wells, Kevin Wells

“…CM is characterized by overcrowding of the brain and cervical spinal cord and is predisposed by skull-base shortening and miniaturization with brachycephalic toy dogs overwhelmingly represented. …”
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Th17 Cell Response in SOD1G93A Mice following Motor Nerve Injury by Allen Ni, Tao Yang, Nichole A. Mesnard-Hoaglin, Rafael Gutierrez, Evan B. Stubbs, Susan O. McGuire, Virginia M. Sanders, Kathryn J. Jones, Eileen M. Foecking, Junping Xin

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Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis by Louisane Desbiens, Catherine Lapointe, Marjan Gharagozloo, Shaimaa Mahmoud, Gunnar Pejler, Denis Gris, Pedro D’Orléans-Juste

“…Finally, whereas EAE triggered significant increases in brain levels of mMCP-4 mRNA and immunoreactive ET-1 in WT mice, the latter peptide was reduced to basal levels in mMCP-4 KO congeners. …”
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Biopsychosocial evaluation of patients with multiple sclerosis using a short set of categories of the international classification of functioning, disability and health, and its re... by D. Valadkevičienė, I. Žukauskaitė, D. Jatužis

“…MS patients with working capacity level of 30–40% had more difficulties of seeing, urination, muscle power functions, walking and moving around by means other than walking than MS patients with working capacity level of 45–55%; they also faced more difficulties in moving around functions and had a different brain structure than those with working capacity level of 60–100%. …”
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Case report: A rare case of a long-term survivor of glioblastoma who underwent two courses of hypofractionated radiotherapy as part of her care by Midhad Mrvoljak, Midhad Mrvoljak, Shubhendu Mishra, Liam Chen, Liam Chen, Elizabeth Neil, Elizabeth Neil, Eric Ehler, Stephanie Terezakis, Stephanie Terezakis, Lindsey Sloan, Lindsey Sloan

“…Glioblastoma (GB) is a primary brain tumor that is lethal and challenging to treat. …”
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Genetic coupling of enhancer activity and connectivity in gene expression control by Helen Ray-Jones, Chak Kei Sung, Lai Ting Chan, Alexander Haglund, Pavel Artemov, Monica Della Rosa, Luminita Ruje, Frances Burden, Roman Kreuzhuber, Anna Litovskikh, Eline Weyenbergh, Zoï Brusselaers, Vanessa Xue Hui Tan, Mattia Frontini, Chris Wallace, Valeriya Malysheva, Leonardo Bottolo, Elena Vigorito, Mikhail Spivakov

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A Bioclinical Pattern for the Early Diagnosis of Cardioembolic Stroke by Bruno Zecca, Clara Mandelli, Alberto Maino, Chiara Casiraghi, Giovanbattista Bolla, Dario Consonni, Paola Santalucia, Giuseppe Torgano

“…Plasma N-terminal prohormone of brain natriuretic peptide (NT-proBNP), D-dimer, C-reactive protein, serum albumin, and globulin levels have been investigated in 114 consecutive patients presenting at the emergency room within 6 hours of the ischemic stroke onset. …”
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Disruption of the CRF1 receptor eliminates morphine-induced sociability deficits and firing of oxytocinergic neurons in male mice by Alessandro Piccin, Anne-Emilie Allain, Jérôme M Baufreton, Sandrine S Bertrand, Angelo Contarino

“…The present findings demonstrate a major, sex-linked, role for the CRF1 receptor in sociability deficits and related brain alterations induced by morphine, suggesting new therapeutic strategy for opiate use disorders.…”
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Comparative Efficacy and Safety of Targeted Therapies for Chronic Thromboembolic Pulmonary Hypertension: A Systematic Review and Network Meta-Analysis by Yusi Chen, Fang Li, Jun Luo, Jingyuan Chen, Peng Luo, Jiang Li

“…Bosentan was significantly better than others with regard to reducing brain natriuretic peptide/N-terminal pro-B-type natriuretic peptide with a probability of 84.3%. …”
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Resveratrol Induces Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Neuron-Like Cells by Li Guo, Liang Wang, Li Wang, Shi Yun-peng, Jing-jing Zhou, Zongmao Zhao, De-Pei Li

“…The natural polyphenol resveratrol benefits patients with many diseases including ischemic brain injury. We hypothesize that resveratrol induces differentiation of hUC-MSCs into neuron-like cells. …”
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The Effect of Physical Activity on Alzheimer’s Disease - Systematic Review by Julia Lachowska, Karolina Senior, Jerzy Smandek, Maja Mielczarek, Paulina Sroczyńska, Jan Sroczyński

“…Evidence suggests that regular physical activity enhances cognitive function, reduces neuroinflammation, improves brain structure, and supports neuroplasticity. Both RET and aerobic exercise have been shown to delay the onset of cognitive decline, with RET also reducing amyloid plaque formation and promoting neuroprotection. …”
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Anatomical Covariance Analysis: Detection of Disrupted Correlation Network Related to Clinical Trait Fatigue in Multiple Sclerosis: A Pilot Study by Rosalia Dacosta-Aguayo, Glenn Wylie, John DeLuca, Helen Genova

“…In addition, it is unknown how brain regions such as IC play a role in state or trait fatigue. …”
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Controllable tip exposure of ultramicroelectrodes coated by diamond-like carbon via direct microplasma jet for enhanced stability and fidelity in single-cell recording by Zhiyuan Du, Qingda Xu, Ye Xi, Mengfei Xu, Jiawei Cao, Longchun Wang, Xiuyan Li, Xiaolin Wang, Qingkun Liu, Zude Lin, Bin Yang, Jingquan Liu

“…Abstract Precise and long-term electroanalysis at the single-cell level is crucial for the accurate diagnosis and monitoring of brain diseases. The reliable protection in areas outside the signal acquisition points at sharp ultramicroelectrode (UME) tips has a significant impact on the sensitivity, fidelity, and stability of intracellular neural signal recording. …”
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Functional connectome gradient of prefrontal cortex as biomarkers of high risk for internet gaming disorder by Xinwen Wen, Lirong Yue, Zhe Du, Jiahao Zhao, Mengjiao Ge, Cunfeng Yuan, Hongmei Wang, Qinghua He, Kai Yuan

“…We used functional connectome gradient (FCG) to capture the macroscopic hierarchical organization of human brain. Canonical correlation analysis was employed to identify components mapping relationships between FCG and behavioral scores. …”
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Exploring manual therapy in the management of irritable bowel syndrome in adults: A scoping review by Natalia Płóciennik-Korycka, Sara Maria Pani, Bogumiła Bruc, Paolo Contu, Magdalena Wrzesińska

“…Introduction: IBS is a prevalent gut-brain interaction disorder characterized by abdominal pain and altered bowel habits, significantly affecting quality of life (QoL). …”
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