Omega-3 long chain fatty acids and their metabolites in pregnancy outcomes for the modulation of maternal inflammatory- associated causes of preterm delivery, chorioamnionitis and... by Jose Miguel Rizo, Theresa Steeb, Johanna Eiblwieser, Pedro Antonio Regidor

“…The intake of PUFAs may result in an overall improvement of pregnancy outcomes by contributing to fetal brain growth and neurological development but more importantly though modulation of inflammation-associated pathologies. …”
Get full text

Hippocampal CA1 Pyramidal Neurons of Mecp2 Mutant Mice Show a Dendritic Spine Phenotype Only in the Presymptomatic Stage by Christopher A. Chapleau, Elena Maria Boggio, Gaston Calfa, Alan K. Percy, Maurizio Giustetto, Lucas Pozzo-Miller

“…Neurons in Mecp2-deficient mice show lower dendritic spine density in several brain regions. To better understand the role of MeCP2 on excitatory spine synapses, we analyzed dendritic spines of CA1 pyramidal neurons in the hippocampus of Mecp2tm1.1Jae male mutant mice by either confocal microscopy or electron microscopy (EM). …”
Get full text

Mapping dynamic regulation of gene expression using single-cell transcriptomics and application to complex disease genetics by Hanna Abe, Phillip Lin, Dan Zhou, Douglas M. Ruderfer, Eric R. Gamazon

“…Here, we develop genetic models of cell-type-specific and cell-state-adjusted gene expression in mid-brain neurons undergoing differentiation from induced pluripotent stem cells. …”
Get full text

Single-Cell Analyses Reveal Necroptosis’s Potential Role in Neuron Degeneration and Show Enhanced Neuron-Immune Cell Interaction in Parkinson’s Disease Progression by Xiaomei Zeng, Zhifen Han, Kehan Chen, Peng Zeng, Yidan Tang, Lijuan Li

“…However, few works have taken deeper insights into the causes of neuron death and cell-cell interaction between the cell types in the brain. Our bioinformatics analyses revealed necroptosis-related genes (NRGs) enrichment in neuron degeneration and selecting the cells by NRGs levels showed two subtypes within the main degenerative cell types in the midbrain. …”
Get full text

Photoplethysmography based psychological stress detection with pulse rate variability feature differences and elastic net by Fenghua Li, Peida Xu, Shichun Zheng, Wenfeng Chen, Yang Yan, Suo Lu, Zhengkui Liu

Get full text

Analysis of Several PLA2 mRNA in Human Meningiomas by Yves Denizot, Rafael De Armas, Karine Durand, Sandrine Robert, Jean-Jacques Moreau, François Caire, Nicolas Weinbreck, François Labrousse

“…However no difference was found for PLA2 transcript amounts in relation to the tumor grade, the subtype of meningiomas, the presence of inflammatory infiltrated cells, of an associated edema, mitosis, brain invasion, vascularisation or necrosis. In conclusion numerous genes encoding multiples forms of PLA2 are expressed in meningiomas where they might act on the phospholipid remodeling and on the local eicosanoid and/or cytokine networks.…”
Get full text

Current source density and functional connectivity extracted from resting-state electroencephalography as biomarkers for chronic low back pain by Keita Ueno, Keiko Yamada, Masaya Ueda, Yasuo Naito, Ryouhei Ishii

“…These results suggest potential targets for pain modulation through brain pathways and highlight the value of EEG biomarkers in understanding pain mechanisms and assessing treatment efficacy.…”
Get full text

Alteration in Oxidative Stress Enzymes and Proteins by Datura metel Stramonium Hydroethanolic Root Extract Promotes Hippocampus and Cerebral Cortex Neurons Damage in Adult Sprague... by oboma YI, Eberechukwu GC

“…Histology, biochemistry and immunohistochemical techniques were used to study cell injury in the brain tissue.Results: Biochemical alterations were observed in superoxide dismutase (SOD), Malondialdehyde (MDA), Glutathionine S-transferase (GST) and Catalase among the experimental groups. …”
Get full text

Functional capacity testing in patients with pulmonary hypertension (PH) using the one-minute sit-to-stand test (1-min STST). by Christina Kronberger, Roya Anahita Mousavi, Begüm Öztürk, Robin Willixhofer, Theresa-Marie Dachs, René Rettl, Luciana Camuz-Ligios, Nima Rassoulpour, Christoph Krall, Brigitte Litschauer, Roza Badr Eslam

“…<h4>Methods</h4>We evaluated 106 PH patients with the 1-min-STST and 6MWT and measured cardiorespiratory parameters (heart rate, blood pressure, oxygen saturation) before and after test conduction. N-terminal pro brain-type natriuretic peptide (NT-proBNP), WHO functional class (WHO-FC) and mean pulmonary artery pressure (mPAP) were defined as markers of PH severity.…”
Get full text

Primary cerebral cystic echinococcosis in a child from Roman countryside: Source attribution and scoping review of cases from the literature. by Adriano Casulli, Stefania Pane, Franco Randi, Paola Scaramozzino, Andrea Carvelli, Carlo Efisio Marras, Andrea Carai, Azzurra Santoro, Federica Santolamazza, Francesca Tamarozzi, Lorenza Putignani

“…The literature search identified 2,238 cases of CCE. In 80.51% of cases, brain was the only localization and single CCE cysts were present in 84.07% of cases. …”
Get full text

Spatial Cognitive EEG Feature Extraction and Classification Based on MSSECNN and PCMI by Xianglong Wan, Yue Sun, Yiduo Yao, Wan Zuha Wan Hasan, Dong Wen

“…This study systematically validates the model using cognitive training data from a brain-controlled car and manually operated UAV tasks, with cognitive state assessments performed through spatial cognition games combined with EEG signals. …”
Get full text

Effect of Chronic Morphine Consumption on Synaptic Plasticity of Rat’s Hippocampus: A Transmission Electron Microscopy Study by Mohammad Hassan Heidari, Abdollah Amini, Zohreh Bahrami, Ali Shahriari, Abolfazle Movafag, Reihane Heidari

“…It is well known that the synapses undergo some changes in the brain during the course of normal life and under certain pathological or experimental circumstances. …”
Get full text

Role of sirtuins in epigenetic regulation and aging control by E. M. Samoilova, S. E. Romanov, D.  A. Chudakova, P. P. Laktionov

Get full text

Hybrid probe combining MicroLED and neural electrode for precise neural modulation and multi-site recording by Gota Shinohara, Tasuku Kayama, Ayumu Okui, Wataru Oda, Atsushi Nishikawa, Alexander Loesing, Nahoko Kuga, Takuya Sasaki, Hiroto Sekiguchi

“…The thin MicroLED probes minimize invasiveness while maintaining optical performance. Validated in mouse brain models, the system achieves selective neural activation and recording with minimal thermal effects. …”
Get full text

Haemophilus parasuis Subunit Vaccines Based on Native Proteins with Affinity to Porcine Transferrin Prevent the Expression of Proinflammatory Chemokines and Cytokines in Pigs by R. Frandoloso, S. Martínez-Martínez, E. F. Rodríguez-Ferri, S. Yubero, D. Rodríguez-Lázaro, M. Hernández, C. B. Gutiérrez-Martín

“…However, overexpression of all proinflammatory molecules was observed in CHG group, mainly in the target infection tissues (brain, lungs, and spleen). High expression of CCL-2, CXCL-8, IL-1α, IL-1β, and IL-6 can be considered one of the characteristics of H. parasuis infection by serovar 5.…”
Get full text

Mtazamo Wa Walimu Wa Kiswahili Ka Tika Shule Za Upili Kuhusu UbadilishaJi Wa Mtaala Wa Elimu Wilay Ani Kabale Nchini Uganda. by Akakikunda, Brenda

“…Marys'College Rushoroza, Kigezi High School na BrainStorm High. Wahojiwa kumi ndio waliolengwa katika Utafiti huu kutoka katika Kila shule lililohusishwa yaani walimu watano na wanafunzi watano. …”
Get full text

Effect of High Alcohol Consumption Among the Youth in Kitumba Sub County-Kabale District. by Twijukye, Junior

“…The effects of alcohol consumption on the youths according to the study findings were; school dropout, increased thefts, loss of jobs, committing suicide, wastage of money, increased stress, poor coordination, slurred speech, destruction of the reproductive system, damage of; the brain, liver, kidney, and breast, contraction of HIV, and death. …”
Get full text

Association of inflammation cytokines with cognitive function in first-episode major depressive disorder by Yan Qing Xi, Yan Qing Xi, Yan Qing Xi, Zong Qi Wang, Zong Qi Wang, Zong Qi Wang, Guo Juan Li, Guo Juan Li, Guo Juan Li, Zhuo Qun Hao, Zhuo Qun Hao, Zhuo Qun Hao, Jia Hui Nie, Jin Xiang Li, Yu Ting Tan, Xiao Dong Hu, Xiao Dong Hu, Gen Wei Wang, Sha Liu, Sha Liu, Yan Fang Wang, Yan Fang Wang, Yan Fang Wang

“…Current studies suggest that the occurrence of MDD may be related to oxidative stress-induced inflammation, hypothalamic-pituitary-adrenal axis disorders, diminished monoamine function and microbe-brain-gut axis, among other pathways. In recent years, the relationship between the immune-inflammatory response and MDD has been a hot topic of research, but how the relationship between immunoinflammation and cognitive function is manifested in MDD is still unclear. …”
Get full text

Multi-omics analysis reveals the interplay between intratumoral bacteria and glioma by Ting Li, Zhanyi Zhao, Meichang Peng, Lu Zhang, Cheng Wang, Feiyang Luo, Meiqin Zeng, Kaijian Sun, Zhencheng Fang, Yunhao Luo, Yugu Xie, Cui Lv, Jiaxuan Wang, Jian-Dong Huang, Hongwei Zhou, Haitao Sun

“…Six genera were found to be significantly enriched in glioma tissues compared to adjacent normal brain tissues, including Fusobacterium, Longibaculum, Intestinimonas, Pasteurella, Limosilactobacillus, and Arthrobacter. …”
Get full text

Navigating Ethical Dilemmas Of Generative AI In Medical Writing by Qurrat Ulain Hamdan, Waleed Umar, Mahnoor Hasan

“…AI is a field of computer science which deals with the development of programs or computational models that are inspired by the human brain’s ability to learn and adapt.1 Perhaps the most prominent advancement AI contributes is generative AI, which has led to the development of robotic “human-like” tools that can generate text, audio, images, and even video with a simple prompt. …”
Get full text