Absorption of Polyunsaturated Fatty Acid (PUFA) Is Related to IgG Blood Levels of Neonatal Pigs during the First 48 Hours Postpartum by Kateryna Pierzynowska, Jarosław Woliński, Björn Weström, Radosław Jazwiec, Halyna Shmigel, Stefan G. Pierzynowski

“…This may have an impact on the dietary guidelines for human neonates, especially those born prematurely with low plasma Ig levels, since PUFAs are important factors for brain development in early life.…”
Get full text

Advancing Neuroscience and Therapy: Insights into Genetic and Non-Genetic Neuromodulation Approaches by Weijia Zhi, Ying Li, Lifeng Wang, Xiangjun Hu

“…This review categorizes neuromodulation techniques into genetic neuromodulation methods (including optogenetics, chemogenetics, sonogenetics, and magnetogenetics) and non-genetic neuromodulation methods (including deep brain stimulation, transcranial magnetic stimulation, transcranial direct current stimulation, transcranial ultrasound stimulation, photobiomodulation therapy, infrared neuromodulation, electromagnetic stimulation, sensory stimulation therapy, and multi-physical-factor stimulation techniques). …”
Get full text

Design, Sensing and Control of a Robotic Prosthetic Eye for Natural Eye Movement by J. J. Gu, M. Meng, A. Cook, P. X. Liu

“…The second generation model removes the impractical usage of the eye glass frame and uses the human brain EOG (electro-ocular-graph) signal picked up by electrodes placed on the sides of a person's temple to carry out the same eye movement detection and control tasks as mentioned above. …”
Get full text

Eptinezumab-jjmr, a humanized monoclonal specific to Calcitonin Gene Related Peptide, for the preventive treatment of migraine in adults by Amnon A. Berger, Joseph Keefe, Cain W. Stark, Matthew Moore, Giovanni F. Ramírez, Julia R. Cucarola, Andrew H. Han, Alan D. Kaye, Latha Ganti

“…The pathophysiology of migraines is actively studied, though recent research points to an initiating event causing migraine generation, that is then propagated by other brain regions, a significant one being the trigeminocervical complex. …”
Get full text

HMGB1 and Extracellular Histones Significantly Contribute to Systemic Inflammation and Multiple Organ Failure in Acute Liver Failure by Runkuan Yang, Xiaoping Zou, Jyrki Tenhunen, Tor Inge Tønnessen

“…Neutralization of histones can attenuate acute liver, lung, and brain injuries. In conclusion, HMGB1 and histones play a significant role in inducing systemic inflammation and MOF in ALF.…”
Get full text

Alterations of amino acids in older adults with Alzheimer’s Disease and Vascular Dementia by Xin Ma, Xin-Meng Wang, Guo-Zhang Tang, Yi Wang, Xue‑Chun Liu, Shuai-Deng Wang, Peng Peng, Xiu-Hong Qi, Xin-Ya Qin, Yue‑Ju Wang, Chen-Wei Wang, Jiang-Ning Zhou

Get full text

Transfection of the BDNF Gene in the Surviving Dopamine Neurons in Conjunction with Continuous Administration of Pramipexole Restores Normal Motor Behavior in a Bilateral Rat Model... by Alina Benítez-Castañeda, Verónica Anaya-Martínez, Armando de Jesús Espadas-Alvarez, Ana Luisa Gutierrez-Váldez, Luis Fernando Razgado-Hernández, Patricia Emmanuelle Reyna-Velazquez, Liz Quintero-Macias, Daniel Martínez-Fong, Benjamín Florán-Garduño, Jorge Aceves

“…Nigral neurons express brain-derived neurotropic factor (BDNF) and dopamine D3 receptors, both protecting the dopamine neurons and the spines of MSNs. …”
Get full text

Study of the neuronal response to olfactory stimuli in control and LPS-stimulated mice by functional magnetic resonance imaging by A. E. Akulov, A. V. Romashchenko, O. B. Shevelev, D. V. Petrovski, A. A. Savelov, M. P. Moshkin

“…Olfactory stimulus type affected neuronal response rate in an olfactory bulb but did not affect response parameters in other brain regions studied. This increase in neuronal activity is likely to be of adaptive significance as a mechanism supporting olfactory sensitivity increase, which plays the key role in the identification of potential sources of infection.…”
Get full text

Enhancing precision in multiple sclerosis lesion segmentation: A U-net based machine learning approach with data augmentation by Oezdemir Cetin, Berkay Canel, Gamze Dogali, Unal Sakoglu

“…The predicted locations of MS lesions were compared with the corresponding layers of white matter, gray matter, and cerebrospinal fluid within the brain. This innovative approach aims to enhance the accuracy and efficiency of MS lesion segmentation, contributing to advancements in precision medicine and the overall understanding of MS.…”
Get full text

Community support for injured patients: A scoping review and narrative synthesis. by Rashi Jhunjhunwala, Anusha Jayaram, Carol Mita, Justine Davies, Kathryn Chu

“…There was a variety of methodologies represented and the groups included patients with spinal cord injury (N = 2), traumatic brain or head injury (N = 7), burns (N = 4), intimate partner violence (IPV) (N = 5), mixed injuries (N = 5), torture (N = 1), and brachial plexus injury (N = 1). …”
Get full text

False-Negative CSF Cryptococcal Antigen with Cryptococcus gattii Meningoencephalitis in Southeastern United States: A Case Report and Literature Review by Shawn Esperti, Austen Stoelting, Andrew Mangano, Dveet Patel, Jilian Sansbury, Robert Sherertz

“…The patient’s condition quickly worsened and the patient returned one day later with right arm weakness and dysarthria. Brain MRI revealed T2/flair signal abnormalities in the left frontal lobe with associated parenchymal enhancement. …”
Get full text

Structural Correlates of Neurological Signs in Huntington’s Disease: A Quantitative Approach by E. A. Loh, J. K. A. Roberts, E. Mohr

“…Computed tomographic (CT) brain scan measures of the basal ganglia of patients in the “early” and “late” stages of the disease were correlated with scores on a quantified neurological examination (QNE) and compared with scans of age-matched control groups. …”
Get full text

NET formation-mediated in situ protein delivery to the inflamed central nervous system by Yina Wu, Jinwon Park, Quoc-Viet Le, Junho Byun, Jaehyun Choi, Enzhen Xu, Jaiwoo Lee, Yu-Kyoung Oh

“…Abstract Delivering protein drugs to the central nervous system (CNS) is challenging due to the blood-brain and blood-spinal cord barrier. Here we show that neutrophils, which naturally migrate through these barriers to inflamed CNS sites and release neutrophil extracellular traps (NETs), can be leveraged for therapeutic delivery. …”
Get full text

Endoscopic Endonasal Resection of Meckel’s Cave Epidermoid Cysts: Case Discussion and Literature Review by Jehad Zakaria, Pravesh Saini, Mariya Yanovskaya, John T. Tsiang, Krishnan Ravindran, Stephen Johans, Chirag R. Patel, Anand V. Germanwala

“…In cases where surgical excision is indicated, resection is often carried out via a frontosphenotemporal craniotomy from an anterolateral approach or a temporal craniotomy with or without a petrosectomy for a lateral corridor; both of these routes are associated with brain retraction and potential neurovascular injury. …”
Get full text

Impact of Duodopa on Quality of Life in Advanced Parkinson's Disease: A UK Case Series by T. Foltynie, C. Magee, C. James, G. J. M. Webster, A. J. Lees, P. Limousin

“…Treatment options in advanced Parkinson’s disease (PD) include subcutaneous apomorphine, pallidal or subthalamic nucleus Deep Brain Stimulation (DBS), or levodopa/carbidopa intestinal gel (LCIG/Duodopa). …”
Get full text

System Consolidation of Spatial Memories in Mice: Effects of Enriched Environment by Joyce Bonaccorsi, Simona Cintoli, Rosa Mastrogiacomo, Sigrid Baldanzi, Chiara Braschi, Tommaso Pizzorusso, Maria Cristina Cenni, Nicoletta Berardi

“…Declarative memories are thought to undergo a first rapid and local consolidation process, followed by a prolonged process of system consolidation, which consist in a time-dependent gradual reorganization of brain regions supporting remote memory storage and crucial for the formation of enduring memories. …”
Get full text

Corpus callosotomy for treatment of pediatric epilepsy: two clinical cases and a literature review by R. Matonytė, S. Ročka, J. Grikinienė

“…The corpus callosum is the most important pathway for the spread of epileptic activity between the two hemispheres of the brain. Its cutting precludes epileptic discharges from traveling between hemispheres (i.e., generalization). …”
Get full text

Region-Dependent Alterations in Cognitive Function and ERK1/2 Signaling in the PFC in Rats after Social Defeat Stress by Qiong Wang, Feng Shao, Weiwen Wang

“…Using a classical model of depression, this study investigated the effects of social defeat stress on emotional behaviors, on cognitive flexibility in the attentional set-shifting task (AST), and on the expression of extracellular signal-regulated kinase 1 and 2 (ERK1 and ERK2) and their downstream signaling molecules cAMP-response element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in two subregions of the PFC, the medial prefrontal cortex (mPFC), and the orbitofrontal cortex (OFC). …”
Get full text

Generalized Extension of Referred Trigeminal Pain due to Greater Occipital Nerve Entrapment by Jung-woo Hyung, Byung-chul Son

“…Another speculation is that spontaneous pain may occur throughout the body due to dysfunction of the descending brain stem pain-modulating pathway by sensitization and hyperexcitation of the MDH and trigeminal brainstem sensory nuclear complex (TBSNC).…”
Get full text

The Effect of Phase I Cardiac Rehabilitation on the Rate of Delirium After Coronary Artery Bypass Graft Surgery by Kolsoum Parnan Emamverdi, Zahra Sadat Manzari, Seyed Reza Mazloum

“…Phase one cardiac rehabilitation program can improve pulmonary aerobic capacity and subsequently increase brain tissue perfusion. As a result, due to its hypoxia-reducing effects, it may be able to reduce delirium levels. …”
Get full text