A Case of Primary Amyloidosis Involving Liver, Stomach, Intestines, and Heart without Evident Kidney Involvement by L. S. Kholopov, N. B. Gubegrits, O. A. Dyadyk, Yu. E. Chirkov, Yu. V. Tsohoyeva

“…Decreased hemoglobin levels, elevated levels of alkaline phosphatase, gamma-glutamyltransferase, and N-terminal prohormone of brain natriuretic peptide, signs of heart failure with preserved ejection fraction, and hepatomegaly became the basis for a clinical suspicion of AL amyloidosis and puncture liver biopsy. …”
Get full text

Multidisciplinary Assessment and Diagnosis of Conversion Disorder in a Patient with Foreign Accent Syndrome by Harrison N. Jones, Tyler J. Story, Timothy A. Collins, Daniel DeJoy, Christopher L. Edwards

“…The primary etiologies of FAS are cerebrovascular accidents or traumatic brain injuries which affect cortical and subcortical regions critical to expressive speech and language production. …”
Get full text

Development of Microneedle Patch Loaded with Bacopa monnieri Solid Lipid Nanoparticles for the Effective Management of Parkinson’s Disease by Delna Joy, Jobin Jose, Shabana Bibi, Akshay Bandiwadekar, Gopika Gopan, Clara Mariana Gonçalves Lima, Talha Bin Emran, Fahad A. Alhumaydhi, Harsha Ashtekar, Sandeep D. S, Carlos Adam Conte-Junior

“…The bloodless and painless microneedle arrays through the transdermal route deliver the drug across the blood-brain barrier at the desired concentration. The quality by design (QbD) approach was employed for optimizing the SLNs formulations. …”
Get full text

Wernicke’s Encephalopathy: An Unusual Consequence of the Acquired Immune Deficiency Syndrome—Case Report and Literature Review by Timothy R. Larsen, Dritan Dragu, Michael Williams

“…Lumbar puncture was unremarkable. Brain MRI revealed increased T2 signal in the medial thalamus bilaterally. …”
Get full text

Application of deconvolutional networks for feature interpretability in epilepsy detection by Sihao Shao, Yu Zhou, Ruiheng Wu, Aiping Yang, Qiang Li

“…In addition, The contributions of each channel to the seizure detection task have also been quantified, which led us to find that the FZ, CZ, PZ, FT9, FT10, and T8 brain regions have a more pronounced impact on epileptic seizures.DiscussionThis article presents a novel algorithm for epilepsy detection that accurately identifies seizures in different patients and enhances the model’s interpretability.…”
Get full text

Pharmacokinetic, Pharmacogenetic, and Other Factors Influencing CNS Penetration of Antiretrovirals by Jacinta Nwamaka Nwogu, Qing Ma, Chinedum Peace Babalola, Waheed Adeola Adedeji, Gene D. Morse, Babafemi Taiwo

“…CNS penetration is a function of several factors including sieving role of blood-brain and blood-CSF barriers and activity of innate drug transporters. …”
Get full text

Stephania japonica Ameliorates Scopolamine-Induced Memory Impairment in Mice through Inhibition of Acetylcholinesterase and Oxidative Stress by Md. Yusuf Al-Amin, Amitav Lahiry, Rafia Ferdous, Md. Kamrul Hasan, Md. Abdul Kader, AHM Khurshid Alam, Zahangir Alam Saud, Md. Golam Sadik

“…Similarly, the chloroform fraction exhibited potent antioxidant activity and effectively inhibited the peroxidation of brain lipid in vitro. The phytochemical profile revealed the high content of polyphenolics and alkaloids in the chloroform fraction. …”
Get full text

Potential Therapies by Stem Cell-Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche by Alejandro Luarte, Luis Federico Bátiz, Ursula Wyneken, Carlos Lafourcade

“…Considering the fact that many degenerative brain diseases have an impact on adult neurogenesis, we discuss how the modulation of the adult neurogenic niches may be a therapeutic target of stem cell-derived exosomes. …”
Get full text

The emerging roles of aberrant alternative splicing in glioma by Reda Ben Mrid, Sara El Guendouzi, Marco Mineo, Rachid El Fatimy

“…Abstract Gliomas represent a heterogeneous group of uniformly fatal brain tumors. Low and high-grade gliomas have diverse molecular signatures. …”
Get full text

Pendidikan Kesehatan dengan Media Booklet Terhadap Perilaku Ibu dalam Melakukan Deteksi Dini Tumbuh Kembang (DDTK) pada Anak by Ayuro Cumayunaro, Helda, Yonaniko Dephinto, Yelly Herien

“… Age of children in 1-36 months is a window of opportunity for children to learn all of the developmental aspects such as fine and gross motor skill, vision, cognitive, language skill, social development and emotional intelligence because 80% part of brain develop in this golden period. Unfortunately, some problems of child growth and development occur in this age. …”
Get full text

Complement Inhibition as a Proposed Neuroprotective Strategy following Cardiac Arrest by Brad E. Zacharia, Zachary L. Hickman, Bartosz T. Grobelny, Peter A. DeRosa, Andrew F. Ducruet, E. Sander Connolly

“…In addition, it is well established that complement inhibition improves outcome in both global and focal models of brain ischemia. Due to the profound impact of GCI/R injury following OHCA, and the relative lack of effective neuroprotective strategies for this pathologic process, complement inhibition provides an exciting opportunity to augment existing treatments to improve patient outcomes. …”
Get full text

Characterization of a Novel Tc-Carbonyl Complex as a Functional Probe of P-Glycoprotein Transport Activity by Mary Dyszlewski, Helen M. Blake, Julie L. Dahlheimer, Christina M. Pica, David Piwnica-Worms

“…Biodistribution analysis following tail vein injection of Tc-CO-MIBI showed delayed liver clearance as well as enhanced brain uptake and retention in mdr1a/1b (−/−) gene deleted mice versus wild-type mice, directly demonstrating that Tc-CO-MIBI is a functional probe of Pgp transport activity in vivo.…”
Get full text

EEG Channel Selection Using Particle Swarm Optimization for the Classification of Auditory Event-Related Potentials by Alejandro Gonzalez, Isao Nambu, Haruhide Hokari, Yasuhiro Wada

“…Brain-machine interfaces (BMI) rely on the accurate classification of event-related potentials (ERPs) and their performance greatly depends on the appropriate selection of classifier parameters and features from dense-array electroencephalography (EEG) signals. …”
Get full text

A Case of Xanthoma of Bilateral Tendoachilles Reconstructed with Fascia Lata Graft X by S Jaikish, Balaji Sambandam

“…Aims and background: Cerebrotendinous xanthoma is an autosomal recessive disorder characterized by a lack of production of primary bile acids and accumulation of cholestanol in various tissues like the brain, spinal cord, peripheral nerves, eyes, and tendon in the form of xanthomas. …”
Get full text

The Effectiveness of ROMATIF Therapy (Mirror Therapy and Positive Affirmation) on Strength of Muscle and Self-acceptance in Post Stroke Patients by Putu Sintya Arlinda Arsa, Lie Liana Fuadiati, Desy Rinawaty

“… Introduction: Stroke is a neurological condition in which some brain cells die due to a disruption of cerebral blood flow caused by a blockage or rupture of blood vessels. …”
Get full text

The neurohormone tyramine stimulates the secretion of an insulin-like peptide from the Caenorhabditis elegans intestine to modulate the systemic stress response. by Tania Veuthey, Jeremy T Florman, Sebastián Giunti, Stefano Romussi, María José De Rosa, Mark J Alkema, Diego Rayes

“…These studies offer mechanistic insights into a brain-gut communication pathway that weighs adaptive strategies to respond to acute and long-term stressors.…”
Get full text

Diffusion Tensor Imaging in Alzheimer’s Disease and Mild Cognitive Impairment by G. T. Stebbins, C. M. Murphy

“…Studies have identified regions of increased MD and decreased FA in patients with AD and MCI in all lobes of the brain, as well as medial temporal lobe structures including the hippocampus, entorhinal cortex and parahippocampal white matter. …”
Get full text

Repeated Three-Hour Maternal Separation Induces Depression-Like Behavior and Affects the Expression of Hippocampal Plasticity-Related Proteins in C57BL/6N Mice by Yaoyao Bian, Lili Yang, Zhongli Wang, Qing Wang, Li Zeng, Guihua Xu

“…To determine whether adverse early life experiences induce changes in plasticity in the brain hippocampus, we established an MS paradigm. …”
Get full text

Recent advances in the science of human milk oligosaccharides by Tadasu Urashima, Katsumi Ajisaka, Tetsuro Ujihara, Eri Nakazaki

“…Approximately 200 varieties of HMOs have been characterized.Although HMOs are not utilized as an energy source by infants, they have important protective functions, including pathogenic bacteria and viral infection inhibitors and immune modulators, among other functions, and HMOs stimulate brain-nerve development. The Os concentration is average 11 g/L in human milk but >100 mg/L in mature bovine milk, which is used to manufacture infant formula, suggesting that human-identical milk oligosaccharides (HiMOs) should be incorporated into milk substitutes. …”
Get full text

High-fat diet and neuroinflammation: The role of mitochondria by Mingxue Song, Yao Bai, Fuyong Song

“…In recent years, increasing evidence has supported that high-fat diet (HFD) can induce the chronic, low-grade neuroinflammation in the brain, which is closely associated with the impairment of cognitive function. …”
Get full text