Feasibility and Safety of Sodium Glucose Cotransporter-2 Inhibitors in Adults with Heart Failure after the Fontan Procedure by Jun Muneuchi, Yuichiro Sugitani, Masaru Kobayashi, Hiroki Ezaki, Hiromu Yamada, Mamie Watanabe

“…In addition, administration of a SGLT-2 inhibitor resulted in weight loss (4/5), an increase in systemic oxygen saturation (4/5), an increase in serum albumin level (4/5), an increase in estimated glomerular filtration ratio (4/5), and a decrease in plasma brain natriuretic peptide level (4/5). Our case series supported the feasibility and safety of SGLT-2 inhibitors in patients with Fontan circulatory failure, although the exact changes in urinary output were unknown in all patients. …”
Get full text

Anticancer Activity of Kefir on Glioblastoma Cancer Cell as a New Treatment by Arghavan Fatahi, Neda Soleimani, Parviz Afrough

“…In the present study, we assessed the cytotoxic effect of kefir on the rate of growth and increase of glioblastoma cancer cell as the most severe form of brain tumors. In this experimental study, we used a U87 cancer cell line (glioblastoma). …”
Get full text

Case report: Discovery of novel CTNNB1 mutations and comparison of clinical characteristics in two patients with NEDSDV by Eojin Lee, Ja Young Choi, Shin-Seung Yang

“…NGS is crucial for the diagnosis of global developmental delay, particularly when brain magnetic resonance imaging (MRI) results appear normal. …”
Get full text

STRUCTURAL AND DYNAMIC PROPERTIES OF MUTANTS OF THE SOD1 PROTEIN ASSOCIATED WITH AMYOTROPHIC LATERAL SCLEROSIS by N. A. Alemasov, N. V. Ivanisenko, V. A. Ivanisenko

“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, which affects motor neurons in the brain and spinal cord and leads to patients’ death. …”
Get full text

Current Status of Plant-Based Bioactive Compounds as Therapeutics in Alzheimer’s Diseases by Dan Chen, Yun Sun

“…Numerous studies have shown that medicinal plants and their active ingredients can potentially mitigate AD by regulating various molecular mechanisms, including the production and aggregation of pathological proteins, oxidative stress, neuroinflammation, apoptosis, mitochondrial dysfunction, neurogenesis, neurotransmission, and the brain-gut microbiota axis. In this review, we analyzed the pathogenesis of AD and comprehensively summarized recent advancements in research on medicinal plants for the treatment of AD, along with their underlying mechanisms and clinical evidence. …”
Get full text

Successful Treatment of Posttransplant EBV-Associated Lymphoma and Plasmacytoma Solely Localized to the CNS by Per Boye Hansen, Signe Ledou Nielsen

“…The histological diagnoses of the isolated brain tumors were diffuse large B-cell lymphoma and plasmacytoma. …”
Get full text

Circuitry and Synaptic Dysfunction in Alzheimer’s Disease: A New Tau Hypothesis by Siddhartha Mondragón-Rodríguez, Humberto Salgado-Burgos, Fernando Peña-Ortega

“…Additionally, we will briefly address the role of brain circuit alterations as a potential biomarker for detecting the prodromal AD stage.…”
Get full text

Cytokines and Chemokines at the Crossroads of Neuroinflammation, Neurodegeneration, and Neuropathic Pain by Geeta Ramesh, Andrew G. MacLean, Mario T. Philipp

“…This review will focus on how cytokines and chemokines affect neuroinflammation and disease pathogenesis in bacterial meningitis and brain abscesses, Lyme neuroborreliosis, human immunodeficiency virus encephalitis, and neuropathic pain.…”
Get full text

The Smoothing Artifact of Spatially Constrained Canonical Correlation Analysis in Functional MRI by Dietmar Cordes, Mingwu Jin, Tim Curran, Rajesh Nandy

“…A wide range of studies show the capacity of multivariate statistical methods for fMRI to improve mapping of brain activations in a noisy environment. An advanced method uses local canonical correlation analysis (CCA) to encompass a group of neighboring voxels instead of looking at the single voxel time course. …”
Get full text

Neuroplasticity in Alzheimer's disease: a therapeutic alternative at the molecular level by Noel Jesús Niebla Gómez, Rodolfo Javier Rivero Morey, Víctor René Navarro Machado, Mariangel González León, Amanda Martínez Pérez

“…It was concluded that, according to the strongest evidence found, the fundamental therapeutic alternatives are those focused on enhancing neuronal plasticity; standing out within this group of therapies, physical exercise, transcranial magnetic stimulation and increased concentrations of brain-derived neurotrophic factor. Especially notable the repetitive transcranial magnetic stimulation, due to its demonstrated ability to promote neuronal plasticity through different ways.…”
Get full text

Reconstitution de gestes funéraires by David Peressinotto, Bruno Maureille, Yves Lecointe, Francis Geus

“…At the opposite, the very dry climate of the Middle Nubia can explain by itself the exceptional conservation of soft parts of the human body (hair, nails, brain, muscular fibres, human coprolithes) as it is frequently found at the North necropolis (SN) of the Saï island (Northern Province, Sudan). …”
Get full text

Homonymous Superior Quadrantanopia due to Erdheim-Chester Disease with Asymptomatic Pituitary Involvement by Roaa Ridha Amer, Sara Mohammed Qubaiban, Eman Abdulkarim Bakhsh

“…Plain X-ray of both knees showed bilateral patchy sclerosis of the distal femur and upper parts of the tibiae. Initial brain magnetic resonance imaging (MRI) showed bilateral enhancing masses in the temporal lobes anterior to the temporal horns, thickening of the pituitary stalk, partially empty sella, and involvement of the left cavernous sinus one year later. …”
Get full text

Primary Angiitis of the Central Nervous System: A Report of Three Cases from a Single Colombian Center by Nicolás Coronel-Restrepo, Fabio Bonilla-Abadía, Omar A. Cortes, Jorge H. Izquierdo, Alberto M. Shinchi, Juan C. Bravo, Gabriel J. Tobón, Carlos A. Cañas

“…Its clinical manifestations are very heterogeneous and make clinical diagnosis difficult. In most cases, a brain biopsy is required. Only the clinical suspicion and the ability to recognize the possible clinical and imagenological patterns of presentation make an accurate diagnosis possible. …”
Get full text

Dissociative Experiences Scale: Psychometric Analysis in Puerto Rico and Contributions to the Discussion of the Factor Structure by Juan González-Rivera

Get full text

Mice with Catalytically Inactive Cathepsin A Display Neurobehavioral Alterations by O. Y. Calhan, V. Seyrantepe

“…These patients present with a broad range of clinical phenotypes, including growth retardation, and neurological deterioration along with the accumulation of the vasoactive peptide, endothelin-1, in the brain. Previous in vitro studies have shown that CathA has specific activity against vasoactive peptides and neuropeptides, including endothelin-1 and oxytocin. …”
Get full text

Hyperammonemia: What Urea-lly Need to Know: Case Report of Severe Noncirrhotic Hyperammonemic Encephalopathy and Review of the Literature by Ruby Upadhyay, Thomas P. Bleck, Katharina M. Busl

Get full text

The Rise of Pluripotent Stem Cell-Derived Glia Models of Neuroinflammation by Srishti Kala, Andrew G. Strutz, Moriah E. Katt

“…Neuroinflammation has been implicated in nearly every major CNS disease ranging from Alzheimer’s disease to brain cancer. Understanding and modeling neuroinflammation is critical for the identification of novel therapeutic targets in the treatment of CNS diseases. …”
Get full text

Imatinib-resistance without BCR/ABL Point Mutation in Chronic Myeloid Leukemia by Aytan Shirinova

“…In the future, new molecules for BCR-ABL inhibitors, combination therapy, and molecules entering the blood-brain barrier may improve the outcomes of therapy and prevent imatinib resistance in CML.…”
Get full text

The impact of glycolysis on ischemic stroke: from molecular mechanisms to clinical applications by Yingquan Liu, Peijia Hu, Hongliang Cheng, Fangyuan Xu, Yu Ye

“…During ischemic conditions, glycolysis replaces oxidative phosphorylation as the primary energy source for brain tissue. However, in the ischemia–reperfusion state, neuronal cells show a particular reliance on aerobic glycolysis. …”
Get full text

Biomechanical Investigation of the Efficacy of Conventional Bicycle Helmets at Preventing Facial Injury by Ghaidaa A. Khalid

“…Epidemiological studies typically report incidences of 'head injury,' though rarely categorize head, brain, and facial injuries separately. Studies that do focus on facial injury suggest that helmets do not provide adequate protection. …”
Get full text