Production, Purification, and Characterization of Thermostable α-Amylase Produced by Bacillus licheniformis Isolate AI20 by Yasser R. Abdel-Fattah, Nadia A. Soliman, Nabil M. El-Toukhy, Hamada El-Gendi, Rania S. Ahmed

“…Thereafter, the response surface methodology (RSM) was adopted to acquire the best process conditions among the selected variables, where a three-level Box-Behnken design was employed to create a polynomial quadratic model correlating the relationship between the three variables and α-amylase activity. …”
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Fabrication and In Vivo Evaluation of In Situ pH-Sensitive Hydrogel of Sonidegib–Invasomes via Intratumoral Delivery for Basal Cell Skin Cancer Management by Maha M. Ghalwash, Amr Gamal Fouad, Nada H. Mohammed, Marwa M. Nagib, Sherif Faysal Abdelfattah Khalil, Amany Belal, Samar F. Miski, Nisreen Khalid Aref Albezrah, Amani Elsayed, Ahmed H. E. Hassan, Eun Joo Roh, Shaimaa El-Housiny

“…Methods: Numerous S-INV formulations were developed using Box–Behnken Design Expert and tested before settling on the optimum S-INV formulation. …”
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Enhancing Qualitative Research: The Use of Design Probes and Cooking Sessions Deepens the Understanding of 9- to 11-Year-Old Children’s Food Perceptions by Lotte Pater, Elizabeth H. Zandstra, Vincenzo Fogliano, Bea L. P. A. Steenbekkers

“…In the first stage, children received a design probe box with assignments to be performed individually at home, aiming at gathering data about their everyday life and experiences in a familiar, informal setting. …”
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The influence of meteorological factors on the technical performance of football teams during matches by Yonghan Zhong, Shaoliang Zhang, Qing Yi, Miguel Ángel Gómez Ruano

“…Two technical indicators, “dribbles won” and “shots from the 6-yard box,” were both significantly influenced by two meteorological factors. …”
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Gene Editing in Pluripotent Stem Cells and Their Derived Organoids by Hang Zhou, Yun Wang, Li-Ping Liu, Yu-Mei Li, Yun-Wen Zheng

“…Are the tools for rewriting the code of life a boon to humanity or a Pandora’s box? These technologies raise concerns regarding ethical issues, unexpected mutations, viral infection, etc. …”
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Sustainability by extraction of bioactive compounds from onion seeds by Mestour, Selma, Meniai, Abdeslam-Hassen, Melloul, Sarra, Louaer, Mehdi

“…To achieve this, the effects of four key operating parameters like pressure, temperature, particle size and CO2 mass flowrate were investigated in ranges of [150, 250 bars], [35, 65 °C], [0.25, 0.85 mm] and [50, 100 g/min], respectively, using a Box-Behnken experimental design, for a constant extraction time of 3 h. …”
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Seismic Performance of Offshore Piers under Wave Impact and Chloride Ion Corrosion Environment by Yin Gu, Anhua Yu, Xiaolong Zhang

“…Firstly, through the scale model test of tsunami wave flume, the wave force of box girder structures and piers under different tsunami wave conditions is measured. …”
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Hybrid Method of Modal Analysis and Laser Shock Scanning to Visualize the Pyroshock Propagation in a Tension Joint by Yong-Woon Kim, Jae-Kyeong Jang, Jung-Ryul Lee, Hak-Seong Gim

“…For the proof of concept of the proposed method, we performed experiments of explosive bolt-induced shock and pyrolock-induced shock in the open-box-type tension joint and compared the hybrid simulation results with actual pyroshock. …”
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PAX6 enhances Nanog expression by inhibiting NOTCH signaling to promote malignant properties in small cell lung cancer cells by Xiao-Fang Guo, Ling-Ling Wang, Fei-Meng Zheng, He-Ping Li

“…The aberrant regulation of Paired box 6 (PAX6) expression has been proposed to play an important oncogenic role in several cancer types. …”
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Comprehensive Analysis of the Role of SLC2A3 on Prognosis and Immune Infiltration in Head and Neck Squamous Cell Carcinoma by Manru Chu, Ke Zheng, Xiaojie Li, Zhiqiang Luo, Xin Yang, Changbo Wei

“…Immune checkpoints and ESTIMATE score were analyzed via the SangerBox database. Results. SLC2A3 expression was upregulated in HNSCC tissues compared to normal tissues. …”
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Feedback loop centered on MAF1 reduces blood–brain barrier damage in sepsis-associated encephalopathy by Xuebiao Wei, Wenqiang Jiang, Zhonghua Wang, Yichen Li, Yuanwen Jing, Yongli Han, Linqiang Huang, Shenglong Chen

“…Interference with forkhead box O1 (FOXO1) inhibited MAF1 expression and activated the RIG-I/IRF3 signaling pathway, while MAF1 overexpression promoted PTEN expression, decreased cell apoptosis, and normalized autophagy. …”
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Study on the Application of a Photocatalytic Titanium Dioxide Coating on Glass Beads for the Treatment of Perfluorooctane Sulfonic Acid by Dao Duy Nam, Cao Thi Hong Hanh, Nghiem Minh Huyen, Dieu-Anh Van, Ha Vinh Hung, Vu Minh Trang, Vu Quang Minh, Nguyen Bich Ngoc, Vu Thi Thu Ha, Huynh Trung Hai

“…The study employed the response surface method (RSM) using the Box–Behnken design (BBD) to optimize treatment conditions at a PFOS concentration of 0.1 mg/L. …”
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Automatic Adaptive Algorithm for Delineation of Cerebral-Spinal Fluid Regions for Non-contrast Magnetic Resonance Imaging Volumetry and Cisternography in Mice by Ryszard Gomolka

“…Key steps include computing a bounding box enclosing the brain parenchyma in three dimensions, applying an adaptive intensity threshold, and refining CSF regions independently in sagittal, axial, and coronal planes. …”
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SOX7 is involved in polyphyllin D-induced G0/G1 cell cycle arrest through down-regulation of cyclin D1 by Zheng Bin, Wang Gang, Gao Wenbo, Wu Qiquan, Zhu Weizhi, Weng Guobin

“…Our previous study showed that the sex-determining region Y-box 7 (SOX7) was low-expressed and served as a tumor suppressor in PCa cells. …”
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Effect of Saturated Near Surface on Nitrate and Ammonia Nitrogen Losses in Surface Runoff at the Loess Soil Hillslope by Yu-bin Zhang, Fen-li Zheng, Ning Cao

“…A laboratory study was designed to evaluate the effects of near-surface hydraulic gradients on NO3–N and NH4–N losses in surface runoff from soil boxes at 27% slope undersimulated rainfall of a loess soil hillslope. …”
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Designing and testing novel artificial shelter traps to mass-trap overwintering brown marmorated stink bugs: a proof-of-concept study in Northwestern China by Jin-Ping Zhang, Gonzalo Avila, Gang Ma, Qian-Qian Mi, Adriana Najar-Rodriguez, Ju-Hong Chen, Chun-Sen Ma, Feng Zhang

“…Results Although trapped BMSB numbers were generally low across all traps tested, the black corflute trap was found to attract the highest average number of BMSB males and females, followed by the wooden-made trap, the bee-hive box and finally the wooden-made locked trap, which attracted the lowest numbers of BMSB. …”
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The link between spreading depolarization and innate immunity in the central nervous system by Kadir Oguzhan Soylu, Muge Yemisci, Hulya Karatas

“…Research has established a clear link between SD and the activation of pro-inflammatory pathways, particularly through the release of cytokines like interleukin-1β and tumor necrosis factor-α, and the involvement of inflammatory mediators such as cyclooxygenase-2 and high mobility group box 1 (HMGB1). Mechanistically, the opening of pannexin-1 (Panx1) channels and the activation of the (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome play critical roles in this process, facilitating the release of inflammatory signals that can exacerbate conditions like migraine. …”
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Epidemic Situation of Brucellosis in Jinzhou City of China and Prediction Using the ARIMA Model by Lulu Wang, Chen Liang, Wei Wu, Shengwen Wu, Jinghua Yang, Xiaobo Lu, Yuan Cai, Cuihong Jin

“…Moreover, the ARIMA(1,1,1)(0,1,1)12 model was finally selected among quite a few plausible ARIMA models based upon the parameter test, correlation analysis, and Box–Ljung test. Notably, the incidence from 2005 to 2014 forecasted using this ARIMA model fitted well with the actual incidence data. …”
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Upaya Mengoptimalkan Bandar Lurus Sebagai Saluran Drainase Utama Kawasan Air Pacah Kota Padang by Februarman Februarman

“…Hasil simulasi HEC-RAS, untuk kedua nilai debit tersebut menunjukkan terjadinya luapan di sepanjang ruas tengah Bandar Lurus yang alirannya akan membebani saluran Bandar Maransi dan box culvert yang berada di dekat Rumah Sakit Islam Siti Rahmah. …”
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FECI-RTDETR a Lightweight Unmanned Aerial Vehicle Infrared Small Target Detector Algorithm Based on RT-DETR by Renzheng Xue, Shijie Hua, Haiqiang Xu

“…Finally, the original GIoU loss is replaced with Inner-GIoU loss, using a scaling factor to control the auxiliary enclosing box, which accelerates convergence speed and enhances detection accuracy for small targets. …”
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