Knockdown MTDH Inhibits Glioma Proliferation and Migration and Promotes Apoptosis by Downregulating MYBL2 by Junqi Fu, Jun Peng, Guolong Tu

“…After knocking down of MTDH, the expressions of forkhead box M1 (FoxM1), MTDH, and MYBL2 were detected by WB cells. …”
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Immune Dysfunction in Rett Syndrome Patients Revealed by High Levels of Serum Anti-N(Glc) IgM Antibody Fraction by Anna Maria Papini, Francesca Nuti, Feliciana Real-Fernandez, Giada Rossi, Caterina Tiberi, Giuseppina Sabatino, Shashank Pandey, Silvia Leoncini, Cinzia Signorini, Alessandra Pecorelli, Roberto Guerranti, Solange Lavielle, Lucia Ciccoli, Paolo Rovero, Claudio De Felice, Joussef Hayek

“…Rett syndrome (RTT), a neurodevelopmental disorder affecting exclusively (99%) female infants, is associated with loss-of-function mutations in the gene encoding methyl-CpG binding protein 2 (MECP2) and, more rarely, cyclin-dependent kinase-like 5 (CDKL5) and forkhead box protein G1 (FOXG1). In this study, we aimed to evaluate the function of the immune system by measuring serum immunoglobulins (IgG and IgM) in RTT patients (n=53) and, by comparison, in age-matched children affected by non-RTT pervasive developmental disorders (non-RTT PDD) (n=82) and healthy age-matched controls (n=29). …”
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An annotated high-content fluorescence microscopy dataset with EGFP-Galectin-3-stained cells and manually labelled outlineszenodo by Salma Kazemi Rashed, Malou Arvidsson, Rafsan Ahmed, Sonja Aits

“…Labels can also easily be converted to boxes for object detection tasks. The dataset is already pre-divided into training, development, and test sets. …”
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Issues of strategic management of Russian innovative organizations’ intellectual property by Irina Rudaya

“…The main criteria of a successful integration of the Russian innovative economy into the global economy should be involvement of the Russian organizations as technologies owners in the global outsourcing processes as well as the Russian share in the global system of growth and application of the new knowledge – “a saving box” of new inventions and other objects of the industrial property, created as a result of intellectual work. …”
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Effect of Environmental Enrichment Within Cages on Production and Welfare in Laying Hens by U Özentürk, A Uysal

“…ABSTRACT This study aims to compare the effects of conventional cage systems (CC) and environmentally enriched cage systems (EEC) (which include nest boxes, perches, and pecking stones) on the productivity and welfare of laying hens, also considering the responses of two genotypes - Hyline Brown (HB) and Isa Tinted (IT). …”
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The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor by Joseph Franz, Jacob Jerome, Travis Lear, Qiaoke Gong, Nathaniel M. Weathington

“…To identify cellular factors that regulate human IL-22R, we screened receptor abundance while overexpressing constituents of the ubiquitin system and identify that IL-22R can be shuttled for degradation by multiple previously uncharacterized F-box protein E3 ligase subunits. We observe that in human cells IL-22R is destabilized by FBXW12. …”
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Thermal limits to stoloniferous leaves and root growth in Paspalum notatum, a south American native grass by Áurea Rodrigues Cordeiro, Alexandre Aparecido Duarte, Ana Paula de Faria, José Pires de Lemos Filho, Marcel Giovanni Costa França

“…Stolon fragments with roots and dry parts removed and the same number of nodes were placed in transparent plastic boxes on moistened filter papers and transferred to chambers at constant temperatures of 15, 20, 25, 30, 35 °C and alternating temperatures of 25/15 °C and 30/20 °C, all in a 12 h photoperiod. …”
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Development of a Cost-Effective Plasma Thawer: A Potential Game-Changer in Blood Transfusion Technology by Shamrez Shahid, Muhammad Danish Mujib Mujib, Ahmad Zahid Rao, Muhammad Abul Hasan, Saad Ahmed Qazi

“…The device consisted of two compartments: one dedicated to thawing plasma and equipped with a water-filled heater, a continuous temperature sensor, and an agitating frame for plasma bags, and the other housing the control box. Optimized thawing conditions were defined. …”
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Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4+ T cells by Jung-Eun Park, Tae-Sung Kim, Yan Zeng, Melissa Mikolaj, Jong Il Ahn, Muhammad S. Alam, Christina M. Monnie, Victoria Shi, Ming Zhou, Tae-Wook Chun, Frank Maldarelli, Kedar Narayan, Jinwoo Ahn, Jonathan D. Ashwell, Klaus Strebel, Kyung S. Lee

“…Loss of either Vpr’s C-terminal 17 residues or VprBP acidic region, the two elements required for binding to Plk4 cryptic polo-box, abrogates Vpr’s capacity to induce these events. …”
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Cerebral Arterial Stenosis Detection Based on a Retained Two-Stage Detection Algorithm by Hanqing Liu, Xiaojun Li, Jin Wei, Xiaodong Kang

“…A cascade detector refined object classification and bounding box regression before prediction. The experimental results show that the retained algorithm increases mAP by 7.3% and 7.5%, respectively, compared with Faster R-CNN and Libra R-CNN. …”
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Structural Characterizations and Biological Evaluation of a Natural Polysaccharide from Branches of <i>Camellia oleifera</i> Abel by Shengjia Lu, Yali Zhang, Yanghui Ou, Jianghui Xin, Hongliang Yao, Litao Guan

“…Objectives: In this work, we obtain a natural polysaccharide from the branches of <i>C. oleifera</i> and optimize its extraction using Box–Behnken design (BBD), which is a statistical method commonly used in response surface methodology. …”
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Synthesis and Optimization of 2,5-Dihydroxyterephthalic Acid in a Slurry Reactor by Reza Pirdadeh Beiranvand, Saeed Ovaysi

“…An additional 14 more experiments devised by the Box–Behnken design scheme are performed to determine a quadratic model for the DHTA yield against the three parameters mentioned above. …”
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Evolution of Magnetohydrodynamic Turbulence in the Expanding Solar Wind: Residual Energy and Intermittency by Chen Shi, Nikos Sioulas, Zesen Huang, Marco Velli, Anna Tenerani, Victor Réville

“…To account for the spherical expansion of the solar wind, we implement the expanding box model. The initial turbulence comprises uncorrelated counterpropagating Alfvén waves and exhibits an isotropic power spectrum. …”
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Plucking Point and Posture Determination of Tea Buds Based on Deep Learning by Chengju Dong, Weibin Wu, Chongyang Han, Zhiheng Zeng, Ting Tang, Wenwei Liu

“…The plucking points and the central points of the tea bud’s bounding box were calculated and matched as pairs using the nearest point method (NPM) and the point in range method (PIRM) proposed in this study. …”
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Improving the thermal performance of PVC windows with pultruded thermoplastic reinforcement by Kirill Minchenkov, Sergey Gusev, Ivan Sergeichev, Alexander Safonov

“…The results of the hot box test show that the U-value of the window sash and frame with the composite reinforcement is 12% lower than that of a window with a steel reinforcement. …”
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Estimation of neutral beam injector power transferred to KSTAR plasmas by Jong-Gu Kwak, J.H. Jeong, S.C. Hong

“…Lastly. when the ion source tun on or turn off in condition other ion sources are operated, the beam transmission power is also affected because of sharing the beam box for ion sources so that the careful power estimation is necessary for such kind of beam power modulation experiments in KSTAR.…”
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Modeling and Optimization of the BSCF-Based Single-Chamber Solid Oxide Fuel Cell by Artificial Neural Network and Genetic Algorithm by Minh-Vien Le, Tuan-Anh Nguyen, T.-Anh-Nga Nguyen

“…The empirical regression models, such as artificial neural networks (ANNs), can be used as a black-box tool to simulate systems without solving the complicated physical equations merely by utilizing available experimental data. …”
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Decreased Circulating T Regulatory Cells in Egyptian Patients with Nonsegmental Vitiligo: Correlation with Disease Activity by Doaa Salah Hegab, Mohamed Attia Saad Attia

“…Regulatory T cells (Tregs), specifically CD4+CD25+ and Forkhead box P3+ (FoxP3+) Tregs, acquired notable attention because of their role in a variety of autoimmune pathologies. …”
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Investigation of thermal conductivity of Prosopis juliflora / Acacia leucophloea / Acacia nilotica fibers / ceramic fillers / epoxy composites by Cholapancheri Krishnaswamy Hemalatha, Gopalan Venkatachalam, Mohan Bhuvaneshwari

“…The prepared samples are tested for thermal conductivity and the optimisation of parameters is scrutinized using the Box–Behnken Design (BBD). ANOVA via Minitab is used to develop regression correlation and for optimization respectively. …”
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Fracture Resistance of Endodontically Treated Maxillary Premolars Restored by Various Direct Filling Materials: An In Vitro Study by Jozef Mincik, Daniel Urban, Silvia Timkova, Renata Urban

“…The specimens were randomly divided into 8 groups, 8 specimens each: group A intact teeth, group B unfilled cavity, group C composite made by oblique layering technique, group D composite with 2 mm cusp coverage, group E bulk-filled posterior composite, group F glass-ionomer, group G amalgam, and group H composite with proximal boxes. The specimens were subjected to an axial compression load with the mean values of fracture resistance in group A: 1289 N, group B: 181.75 N, group C: 445.38 N, group D: 645.88 N, group E: 355.13 N, group F: 352.00 N, group G: 191.38 N, and group H: 572.00 N. …”
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