Efficacy of total transanal laparoscopic pull‑through and pure transanal endorectal pull‑through in the treatment of common‑type Hirschsprung disease by Guizhen Huang, Wenqian Huang, Chi Sun, Meng Li, Chaosheng He, Yi Su, Weili Xu, Suolin Li

“…The frequency and type of postoperative short- and long-term complications, pre- and postoperative anorectal manometry data, and daily bowel movement frequencies were recorded. The postoperative defecation function and quality of life scores were assessed and compared. …”
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29 m6A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 Transcriptomic Dataset... by Ming Liu, Keman Xu, Fatma Saaoud, Ying Shao, Ruijing Zhang, Yifan Lu, Yu Sun, Charles Drummer, Li Li, Sheng Wu, Satya P. Kunapuli, Gerard J. Criner, Jianxin Sun, Huimin Shan, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

“…We performed a database mining on 102 transcriptomic datasets for the expressions of 29 m6A-RNA methylation (epitranscriptomic) regulators (m6A-RMRs) in 41 diseases and cancers and made significant findings: (1) a few m6A-RMRs were upregulated; and most m6A-RMRs were downregulated in sepsis, acute respiratory distress syndrome, shock, and trauma; (2) half of 29 m6A-RMRs were downregulated in atherosclerosis; (3) inflammatory bowel disease and rheumatoid arthritis modulated m6A-RMRs more than lupus and psoriasis; (4) some organ failures shared eight upregulated m6A-RMRs; end-stage renal failure (ESRF) downregulated 85% of m6A-RMRs; (5) Middle-East respiratory syndrome coronavirus infections modulated m6A-RMRs the most among viral infections; (6) proinflammatory oxPAPC modulated m6A-RMRs more than DAMP stimulation including LPS and oxLDL; (7) upregulated m6A-RMRs were more than downregulated m6A-RMRs in cancer types; five types of cancers upregulated ≥10 m6A-RMRs; (8) proinflammatory M1 macrophages upregulated seven m6A-RMRs; (9) 86% of m6A-RMRs were differentially expressed in the six clusters of CD4+Foxp3+ immunosuppressive Treg, and 8 out of 12 Treg signatures regulated m6A-RMRs; (10) immune checkpoint receptors TIM3, TIGIT, PD-L2, and CTLA4 modulated m6A-RMRs, and inhibition of CD40 upregulated m6A-RMRs; (11) cytokines and interferons modulated m6A-RMRs; (12) NF-κB and JAK/STAT pathways upregulated more than downregulated m6A-RMRs whereas TP53, PTEN, and APC did the opposite; (13) methionine-homocysteine-methyl cycle enzyme Mthfd1 downregulated more than upregulated m6A-RMRs; (14) m6A writer RBM15 and one m6A eraser FTO, H3K4 methyltransferase MLL1, and DNA methyltransferase, DNMT1, regulated m6A-RMRs; and (15) 40 out of 165 ROS regulators were modulated by m6A eraser FTO and two m6A writers METTL3 and WTAP. …”
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Quo vadis autoimmune hepatitis? - Summary of the 5th international autoimmune hepatitis group research workshop 2024Keypoints by Bastian Engel, David N. Assis, Mamatha Bhat, Jan Clusmann, Joost PH. Drenth, Alessio Gerussi, María-Carlota Londoño, Ye Htun Oo, Ida Schregel, Marcial Sebode, Richard Taubert

“…Although standard treatment with corticosteroids and thiopurines improves the life expectancy of patients with AIH, remission rates and tolerability are generally overestimated and the development of alternative first-line and salvage therapies has been disappointingly slow compared to in rheumatological diseases or inflammatory bowel disease. Other gaps include the lack of disease-specific diagnostic markers for AIH. …”
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Intestinal Microbiome Changes in Fecal Microbiota Transplant (FMT) vs. FMT Enriched with Lactobacillus in the Treatment of Recurrent Clostridioides difficile Infection by Elvira Garza-González, Soraya Mendoza-Olazarán, Rayo Morfin-Otero, Andrea Ramírez-Fontes, Patricia Rodríguez-Zulueta, Samantha Flores-Treviño, Paola Bocanegra-Ibarias, Héctor Maldonado-Garza, Adrián Camacho-Ortiz

“…Overall, both groups had a reduction in bowel movements per day, from 8.6 to 3.2 in the first 48 h (62.7% reduction, p=0.001). …”
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Alcohol abuse in gastroenterological patients by M. V. Mayevskaya, I. G. Bakulin, A. A. Chirkov, Ye. O. Lyusina, V. D. Lun’Kov

“…Thirty-two percent of patients had liver cirrhosis of toxic and viral etiology, 18% had chronic toxic and viral hepatitis, 11% - non-alcoholic fatty liver disease and various biliary diseases respectively, chronic pancreatitis and chronic gastritis subgroups represented 6% of all patients each, irritable bowel syndrome and gastroesophageal reflux disease - 4% each, primary biliary cirrhosis, hepatocellular carcinoma, stomach and duodenal peptic ulcer disease - 2%. …”
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Systematic identification of secondary bile acid production genes in global microbiome by Yuwei Yang, Wenxing Gao, Ruixin Zhu, Liwen Tao, Wanning Chen, Xinyue Zhu, Mengping Shen, Tingjun Xu, Tingting Zhao, Xiaobai Zhang, Lixin Zhu, Na Jiao

“…Furthermore, we highlighted the associations between secondary bile acids (SBAs) and gastrointestinal and hepatic disorders, including inflammatory bowel disease (IBD), colorectal cancer (CRC), and nonalcoholic fatty liver disease (NAFLD), further elucidating disease-specific alterations in secondary bile acid production genes. …”
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Hymecromone Administration in Real Clinical Practice: Results of the Prospective Multicentre Observational Study in the Republic of Kazakhstan by A. V. Nersesov, D. A. Kaybullaeva, V. S. Rakhmetova, I. A. Lozinskaya, A. K. Kurmangalieva, V. S. Ayupova, A. B. Orazbaeva, A. K. Kanabaeva, Yu. O. Shulpekova

“…A visual analogue scale and RAPID questionnaire were used to characterise biliary pain; severity of associated symptoms, bowel habit and a quality of life according the SF-12 were also assessed. …”
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The Efficacy and Safety of Elobixibat for the Elderly with Chronic Constipation: A Multicenter Retrospective Cohort Study by Akira Tomie, Naohisa Yoshida, Munehiro Kugai, Ryohei Hirose, Osamu Dohi, Ken Inoue, Kotaro Okuda, Takayuki Motoyoshi, Kohei Fukumoto, Yoshikazu Inagaki, Hiroyuki Yoriki, Yutaka Inada, Takashi Okuda, Daisuke Hasegawa, Kiyoshi Ogiso, Takaaki Murakami, Koichi Soga, Rafiz Abdul Rani, Norimasa Yoshida, Yoshito Itoh

“…We then analyzed the discontinuation due to ineffectiveness, change of spontaneous bowel movements (SBM), stool consistency, the time until the first SBM, adverse events, and effect-related factors. …”
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The SERPINB4 gene mutation identified in twin patients with Crohn’s disease impaires the intestinal epithelial cell functions by Xiao-Mei Ouyang, Jun-Hui Lin, Ying Lin, Xian-Ling Zhao, Ya‐Ni Huo, Lai-Ying Liang, Yong-Dong Huang, Gui-Jing Xie, Peng Mi, Zhen-Yu Ye, Bayasi Guleng

“…The activation of SERPINB4 might represent a novel therapeutic target for inflammatory bowel disease.…”
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The impact of different gastrointestinal reconstruction techniques on gut microbiota after gastric cancer surgery by Yu Yang, Yu Yang, Hang-Yu Zhou, Guo-Min Zhou, Guo-Min Zhou, Jin Chen, Rui Ming, Dong Zhang, Huai-Wu Jiang, Huai-Wu Jiang

“…Fecal samples were collected from patients before surgery (before bowel preparation) and around one week after surgery for 16S rRNA sequencing analysis, through which differential biomarkers and related functional genes were sought.ResultsThe study results indicated that there was no significant difference in the diversity of the gut microbiota between the two groups. …”
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miR-129-5p Regulates the Immunomodulatory Functions of Adipose-Derived Stem Cells via Targeting Stat1 Signaling by He-Yang Zhang, Yu-Han Wang, Yan Wang, Yan-Nv Qu, Xiao-Hui Huang, Hui-Xin Yang, Chang-Ming Zhao, Youdi He, Si-Wei Li, Jin Zhou, Changyong Wang, Xiao-Xia Jiang

“…ASCs with miR-129-5p knockdown alleviated inflammatory bowel diseases and promoted tumor growth in vivo. …”
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Quinazolinone Derivative MR2938 Protects DSS-Induced Barrier Dysfunction in Mice Through Regulating Gut Microbiota by Ling Lv, Mireguli Maimaitiming, Jichen Yang, Shuli Xia, Xin Li, Pingyuan Wang, Zhiqing Liu, Chang-Yun Wang

“…<b>Background/Objectives</b>: Ulcerative colitis (UC), a chronic inflammatory bowel disease (IBD), is characterized by colorectal immune infiltration and significant microbiota compositional changes. …”
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Mesh Migration into the Neobladder and Ileum with Complicated Fistula Formation following Incisional Hernia Repair by Masatsugu Kuroiwa, Masato Kitazawa, Yusuke Miyagawa, Futoshi Muranaka, Shigeo Tokumaru, Satoshi Nakamura, Makoto Koyama, Yuta Yamamoto, Nao Hondo, Takehito Ehara, Satoru Miyazaki, Hirokazu Tanaka, Yuji Soejima

“…He underwent mesh removal, partial neobladder resection, and partial small bowel resection. He developed superficial incisional surgical site infection, which improved with drainage and antibiotics, and he was discharged 40 days after the surgery. …”
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Phenotypic and Complete Reference Whole Genome Sequence Analyses of Two <i>Paenibacillus</i> spp. Isolates from a Gray Wolf (<i>Canis lupus</i>) Gastrointestinal Tract by Jessika L. Bryant, Jennifer McCabe, C. Cristoph Klews, MiCayla Johnson, Ariel N. Atchley, Thomas W. Cousins, Maya Barnard-Davidson, Kristina M. Smith, Mark R. Ackermann, Michael Netherland, Nur A. Hasan, Peter A. Jordan, Evan S. Forsythe, Patrick N. Ball, Bruce S. Seal

“…Inflammatory bowel disease (IBD) is increasing among mammals around the world, and domestic dogs are no exception. …”
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Efficacy and safety of gut microbiome-targeted treatment in patients with depression: a systematic review and meta-analysis by Bo Pan, Yiming Pan, Yu-Song Huang, Meng Yi, Yuwei Hu, Xiaoyu Lian, Hui-Zhong Shi, Mingwei Wang, Guifen Xiang, Wen-Yi Yang, Zhong Liu, Fangfang Xia

“…Besides, the efficacy was shown in depressed patients without comorbidities (SMD −0.31, 95% CI [−0.40, −0.22], I 2  = 0%), whereas effectiveness was poor in those with digestive disorders, such as irritable bowel syndrome (SMD −0.37, 95% CI [−0.89, 0.16], I 2  = 74%), chronic diarrhea (SMD −0.34, 95% CI [−0.73, 0.05]), and chronic constipation (SMD −0.23, 95% CI [−0.57, 0.11], I 2  = 0%). …”
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Ambulatory Surgery for Perianal Crohn’s Disease: Study of Feasibility by S. Sibio, A. Di Giorgio, M. Campanelli, S. Di Carlo, A. Divizia, C. Fiorani, R. Scaramuzzo, C. Arcudi, G. Del Vecchio Blanco, L. Biancone, G. Sica

“…All CD patients under regular follow-up at our inflammatory bowel disease referral center, presenting with symptomatic perianal fistulas, were offered surgical consultation. …”
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Prevalence and Related Risk Factors of Intestinal Parasitosis among Private School-Going Pupils of Dharan Submetropolitan City, Nepal by Bijay Kumar Shrestha, Manita Tumbahangphe, Jenish Shakya, Anu Rai, Kabita Dhakal, Bidhya Dhungana, Romika Shrestha, Jyoti Limbu, Kabiraj Khadka, Santoshi Ghimire, Sujata Chauhan, Lata Chalise, Ashu Ghimire

“…The strong associated risk factors of intestinal parasitic infections were nail-biting habit, source of drinking water, biannual deworming, thumb-sucking, hand sanitation before having food and after toilet, knowledge of parents on parasitosis, health and sanitation, keeping cat/dog as pet, and wearing protective shoes during play (P=0.001). Bowel syndromes like abdominal cramp and constipation also had a strong statistical association (P=0.001) with the prevalence of parasitic infection. …”
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Transanal endoscopic cooperative surgery as a less invasive resection technique for anorectal tumors extending beyond the dentate line: Case series by Kohei Shigeta, Kazunori Takada, Kinichi Hotta, Kenichiro Imai, Sayo Ito, Junya Sato, Yoichi Yamamoto, Masao Yoshida, Yuki Maeda, Noboru Kawata, Hirotoshi Ishiwatari, Hiroyuki Matsubayashi, Akio Shiomi, Hiroyasu Kagawa, Manabe Shoichi, Yusuke Yamaoka, Shunsuke Kasai, Yusuke Tanaka, Yasuyuki Hirashima, Ayako Mochizuki, Shusuke Yoshikawa, Arata Tsutsumida, Wataru Omata, Takuma Oishi, Hiroyuki Ono

“…TaECS was performed in an operating room after ensuring adequate bowel preparation. The oral side of the tumor was dissected endoscopically with resection margins precisely evaluated using magnifying endoscopy. …”
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Gegen Qinlian Decoction Attenuates Colitis-Associated Colorectal Cancer via Suppressing TLR4 Signaling Pathway Based on Network Pharmacology and In Vivo/In Vitro Experimental Valid... by Yaoyao Xu, Qiaoyan Cai, Chunyu Zhao, Weixiang Zhang, Xinting Xu, Haowei Lin, Yuxing Lin, Daxin Chen, Shan Lin, Peizhi Jia, Meiling Wang, Ling Zhang, Wei Lin

“…<b>Background</b>: Gegen Qinlian Decoction (GQD), is used for intestinal disorders like ulcerative colitis, irritable bowel syndrome, and colorectal cancer. But the precise mechanisms underlying its anti-inflammatory and anti-tumor effects are not fully elucidated. …”
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Lysosomes finely control macrophage inflammatory function via regulating the release of lysosomal Fe2+ through TRPML1 channel by Yanhong Xing, Meng-meng Wang, Feifei Zhang, Tianli Xin, Xinyan Wang, Rong Chen, Zhongheng Sui, Yawei Dong, Dongxue Xu, Xingyu Qian, Qixia Lu, Qingqing Li, Weijie Cai, Meiqin Hu, Yuqing Wang, Jun-li Cao, Derong Cui, Jiansong Qi, Wuyang Wang

“…More importantly, in vivo stimulation of TRPML1 ameliorates multiple clinical signs of Dextran sulfate sodium-induced colitis in mice, suggesting TRPML1 has potential in treating inflammatory bowel disease.…”
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