Antigen Presenting Cells and Stromal Cells Trigger Human Natural Killer Lymphocytes to Autoreactivity: Evidence for the Involvement of Natural Cytotoxicity Receptors (NCR) and NKG2... by Alessandro Poggi, Maria Raffaella Zocchi

“…Indeed, NK cells can kill and produce pro-inflammatory and regulating cytokines as IFN-γ, TNF-α and IL10 during interaction with autologous dendritic cells or bone marrow stromal cells or skin fibroblasts. The killing of antigen presenting and stromal cells is dependent on LFA1/ICAM1 interaction. …”
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Concise Review: Mesenchymal Stem Cells Ameliorate Tissue Injury via Secretion of Tumor Necrosis Factor-α Stimulated Protein/Gene 6 by Zhigang He, Jie Hua, Zhenshun Song

“…Numerous reports have described therapeutic benefits in various disease models after administration of the adult stem/progenitor cells from bone marrow or other tissues referred to as mesenchymal stem cells/multipotent mesenchymal stromal cells (MSCs). …”
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Manufacturing of Human Umbilical Cord Mesenchymal Stromal Cells on Microcarriers in a Dynamic System for Clinical Use by Florian Petry, J. Robert Smith, Jasmin Leber, Denise Salzig, Peter Czermak, Mark L. Weiss

“…Because of the limitations of hMSCs derived from the bone marrow during isolation and expansion, hMSCs derived from the umbilical cord stroma are a great alternative to overcome these issues. …”
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Impact of Thrombopoietin Receptor Agonists on Pathophysiology of Pediatric Immune Thrombocytopenia by Paschalis Evangelidis, Konstantinos Tragiannidis, Eleni Gavriilaki, Athanasios Tragiannidis

“…Various pathophysiological mechanisms are implicated in ITP pathogenesis, including the production of autoantibodies against components of platelets (PLTs) by B-cells, the activation of the complement system, phagocytosis by macrophages mediated by Fcγ receptors, the dysregulation of T cells, and reduced bone marrow megakaryopoiesis. ITP is commonly manifested with skin and mucosal bleeding, and it is a diagnosis of exclusion. …”
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Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression by Rosaria Alba Merendino, Giuseppe Di Pasquale, Filippo De Luca, Laura Di Pasquale, Edoardo Ferlazzo, Gabriella Martino, Maura Carmela Palumbo, Fortunato Morabito, Sebastiano Gangemi

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Durable Red Blood Cell Transfusion Independence in a Patient with an MDS/MPN Overlap Syndrome Following Discontinuation of Iron Chelation Therapy by Harpreet Kochhar, Chantal S. Leger, Heather A. Leitch

“…This observation suggests that reduction of iron overload may have a lasting favorable effect on bone marrow failure in at least some patients with acquired anemias.…”
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Articular Cartilage Repair Using Marrow Stimulation Augmented with a Viable Chondral Allograft: 9-Month Postoperative Histological Evaluation by James K. Hoffman, Sandra Geraghty, Nicole M. Protzman

“…Therefore, host mesenchymal stem cells that infiltrate the graft from the underlying bone marrow following marrow stimulation are provided with the optimal microenvironment to undergo chondrogenesis. …”
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Chronic Lymphocytic Leukemia and Myelofibrosis by Fares Darawshy, Arieh Ben-Yehuda, Karine Atlan, Deborah Rund

“…We describe an 86-year-old female diagnosed as having CLL and followed by the development of splenomegaly and progressively rising LDH levels 27 months later. A bone marrow biopsy was consistent with the diagnosis of PMF, with positive JAK-2 V617F mutation. …”
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Deep and Machine Learning for Acute Lymphoblastic Leukemia Diagnosis: A Comprehensive Review by Mohammad Faiz, Bakkanarappa Gari Mounika, Mohd Akbar, Swapnita Srivastava

“…Conventional diagnostic techniques for ALL, such as bone marrow and blood tests, can be expensive and time-consuming. …”
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Mitochondrial Quality Control Orchestrates the Symphony of B Cells and Plays Critical Roles in B Cell-Related Diseases by Wuhao Li, Peiyang Cai, Ye Xu, Weihong Tian, Licong Jing, Qiaoyi Lv, Yangjing Zhao, Hui Wang, Qixiang Shao

“…The development of B cells from the bone marrow to the periphery is tightly regulated by a complex set of immune signals, and each subset of B cells has a unique metabolic profile. …”
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Multiple Myeloma with Foamy Mott Cells by Karen Nalbandyan, Daniel Benharroch, Benzion Samueli, Michael Kafka, Anna Gourevitch

“…Herein, we report the case of a patient who presented with skeletal pain and CT confirmed lytic lesions. A bone marrow biopsy revealed multiple myeloma with unusual foamy Mott cells. …”
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Mesenchymal Stem Cells in Restoration of Fertility at Experimental Pelvic Inflammatory Disease by Nataliia Volkova, Mariia Yukhta, Anatoliy Goltsev

“…Based on this, we investigated the effect of intravenous administration of cryopreserved mesenchymal stem cells (cMSCs) of bone marrow on experimental chronic inflammation of the ovaries. …”
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Intravascular Large B-Cell Lymphoma Mimicking Temporal Arteritis by Ifeyinwa Emmanuela Obiorah, Metin Ozdemirli

“…The lymphoma is usually widely disseminated in the vascular spaces of any organ at the time of diagnosis including the skin and bone marrow. Lymph nodes are typically spared. The clinical picture depends on the specific organ involvement making the correct diagnosis very difficult. …”
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A Novel del(20q) in Aggressive Nodal Marginal Zone Lymphoma by Jason B. Kern, Deiter J. Duff, Jamie L. Odem, Magda Esebua, Lisa R. Smith, Donald Doll, Michael Wang

“…Cytogenetic evaluation of both lymph node and bone marrow tissue revealed del(20q). This was an unexpected finding, as del(20q) is associated with myelodysplastic syndromes and myeloproliferative neoplasms and rarely seen in diffuse large B-cell lymphoma, follicular lymphoma, and T-cell lymphoma, but has not previously been described in MZL. …”
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ALK-Negative Anaplastic Large Cell Lymphoma Presenting as Disseminated Intravascular Coagulation and Hemophagocytic Lymphohistiocytosis: A Potentially Fatal Presentation by Uroosa Ibrahim, Amina Saqib, Maryam Rehan, Jean Paul Atallah

“…In addition, she had a ferritin of 32,522 ng/mL, low haptoglobin, and elevated LDH, and bone marrow biopsy showed hemophagocytic lymphohistiocytes. …”
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Current Status of Human Adipose–Derived Stem Cells: Differentiation into Hepatocyte-Like Cells by Feras Al Battah, Joery De Kock, Tamara Vanhaecke, Vera Rogiers

“…Recent in vitro studies have demonstrated that mesenchymal stem cells (MSCs) from various sources, including human bone marrow, adipose tissue, and umbilical cord, can be differentiated into hepatocyte-like cells when appropriate conditions are used. …”
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Typical Facial Lesions: A Window of Suspicion for Progressive Disseminated Histoplasmosis—A Case of Asian Prototype by Prasan K. Panda, Siddharth Jain, Rita Sood, Rajni Yadav, Naval K. Vikram

“…Antemortem skin biopsy and bone marrow aspiration along with postmortem liver, lung, and spleen biopsy showed disseminated histoplasmosis. …”
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Limited Renal Intravascular Lymphoma: A Case Report and Review of the Literature by Guillermo Enrique Quintero Vega, Daniel Osorio, José Antonio de la Hoz Valle, Daniela Rodríguez Feria

“…An infection panel, a bone marrow biopsy, and a PET-CT scan were performed and ruled out the possibility of infections and neoplasms. …”
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Recurrent Monostotic Fibrous Dysplasia in the Mandible by Nilton Alves, Reinaldo José de Oliveira, Denise Takehana, Naira Figueiredo Deana

“…Fibrous dysplasia (FD) is a condition in which normal bone marrow is replaced by an abnormal proliferation of new fibrous connective tissue. …”
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H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer Therapy by Monika Podhorecka, Andrzej Skladanowski, Przemyslaw Bozko

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