Increased Haematopoietic Supportive Function of USSC from Umbilical Cord Blood Compared to CB MSC and Possible Role of DLK-1 by Simone Maria Kluth, Teja Falk Radke, Gesine Kögler

“…In contrast to stromal cells from the adult bone marrow (BM) or adipose tissue, cord blood (CB) multipotent stromal cells (MSC) are biologically younger. …”
Get full text

Exercise as an Adjuvant Therapy for Hematopoietic Stem Cell Mobilization by Russell Emmons, Grace M. Niemiro, Michael De Lisio

“…Exercise, a safe and feasible intervention in patients undergoing HSCT, has been previously shown to robustly stimulate HSPC mobilization from the bone marrow. Exercise-induced HSPC mobilization is transient limiting its current clinical potential. …”
Get full text

Cell-Type-Specific Differentiation and Molecular Profiles in Skin Transplantation: Implication of Medical Approach for Genetic Skin Diseases by Noritaka Oyama, Fumio Kaneko

“…Moreover, particular cell lineages from bone marrow (BM) cells have been shown to harbour the diferentiation capacity into multiple skin cell phenotypes, including epidermal keratinocytes and dermal endothelial cells and pericytes, undercontrolled by chemokines or cytokines. …”
Get full text

Dynamics of Graft Function Measured by DNA-Technology in a Patient with Severe Aplastic Anemia and Repeated Stem Cell Transplantation by Anna Karastaneva, Christian Urban, Herwig Lackner, Wolfgang Schwinger

“…Although bone marrow transplantation (BMT) from an HLA identical sibling is considered as treatment of choice in pediatric patients with severe aplastic anemia (SAA), a significant number of them experience graft failure (GF) after BMT. …”
Get full text

Ganglioneuroma of the External Auditory Canal and Middle Ear by Hesham Saleh Almofada, Michael Steven Timms, M. Anas Dababo

“…At the age of 12 months, the patient was diagnosed with neuroblastoma stage IV with metastasis to the squamous temporal bone, bone marrow, and skull base. He received a high-risk protocol regimen resulting in complete remission. …”
Get full text

The Role Of Time Delays, Slow Processes And Chaos In Modulating The Cell-Cycle Clock by E.V. Presnov, Z. Agur

“…The complicated geometry of this strange attractor can be viewed as an unlimited reservoir of periods in the phase space.We hypothesize that the existence of such a reservoir is advantageous in morphogenetic tissues, such as the bone marrow, as it enables time- and site-specific selection of the optimal cell-cycle period for any specific micro- environment. …”
Get full text

Natural Catalytic Antibodies in Norm, Autoimmune, Viral, and Bacterial Diseases by Georgy A. Nevinsky, Valentina N. Buneva

“…A significant increase in the relative Abz activities associated with a specific reorganization of the immune system, including changes in the differentiation and proliferation of bone marrow hematopoietic stem cells and lymphocyte proliferation in different organs. …”
Get full text

Transforming Growth Factor-Beta and Matrix Metalloproteinases: Functional Interactions in Tumor Stroma-Infiltrating Myeloid Cells by Jelena Krstic, Juan F. Santibanez

“…Tumor stroma consists of several types of resident cells and infiltrating cells derived from bone marrow, which together play crucial roles in the promotion of tumor growth and metastasis. …”
Get full text

Acquired Myelodysplasia or Myelodysplastic Syndrome: Clearing the Fog by Ethan A. Natelson, David Pyatt

“…They are typically considered neoplasms because of frequent genetic aberrations and patient-limited survival with progression to acute myeloid leukemia (AML) or death related to the consequences of bone marrow failure including infection, hemorrhage, and iron overload. …”
Get full text

Role of Nasal Endoscopy in Chronic Osteomyelitis of Maxilla and Zygoma: A Case Report by J. S. Arunkumar, Ashok S. Naik, K. C. Prasad, S. G. Santhosh

“…Osteomyelitis is an acute or chronic inflammatory process that can involve cortical and trabecular aspects of bone or bone marrow. Cranial bones are infrequently involved, but spreading of inflammation with involvement of surrounding structures represents important risk, such as cerebral abscess, encephalitis, or meningitis. …”
Get full text

Forward programming of hPSCs to neutrophils using chemically defined media by Hayley E. Hall, Xiaoping Bao, Cheng Dong, Xiaojun Lance Lian

“…Due to their terminally differentiated state, PMNs possess a short lifespan and exhibit limited proliferative potential, which makes continuous replenishment from the bone marrow essential for maintaining immune homeostasis. …”
Get full text

The Hematopoietic Niche in Myeloproliferative Neoplasms by Annette H. Schmitt-Graeff, Roland Nitschke, Robert Zeiser

“…Specialized microanatomical areas of the bone marrow provide the signals that are mandatory for the maintenance and regulation of hematopoietic stem cells (HSCs) and progenitor cells. …”
Get full text

Evaluation of Quality of Life and Care Needs of Turkish Patients Undergoing Hematopoietic Stem Cell Transplantation by Neslisah Yasar, Semiha Akin

“…Their quality of life was assessed using Functional Assessment of Cancer Therapy-Bone Marrow Transplant Scale. The mean patient age was 44.99 ± 13.92 years. …”
Get full text

Proteomic profiling of iPSC and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing by Margeaux Hodgson-Garms, Matthew J. Moore, Mikaël M. Martino, Kilian Kelly, Jessica E. Frith

“…This study analysed the secretomes of bone-marrow (BM.MSCs), umbilical-cord (UC.MSCs), adipose-tissue (AT.MSCs) and clinical/commercial-grade induced pluripotent stem cell-derived MSCs (iMSCs), under resting and inflammatory licenced conditions. iMSCs recapitulated the inflammatory licensing process, validating their comparability to tissue-derived MSCs. …”
Get full text

Visceral Leishmaniasis or Systemic Lupus Erythematosus Flare? by Sunny Garg, Mousumi Kundu, Amit Nandan Dhar Dwivedi, Lalit Prashant Meena, Neeraj Varyani, Asif Iqbal, Kamlakar Tripathi

“…Despite negative results of rk-39 test and bone marrow biopsy, a very high suspicion for visceral leishmaniasis (VL) led us to go for direct agglutination test (DAT) and polymerase chain reaction (PCR) for leishmanial antigen that revealed positive results. …”
Get full text

Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients by Deepa Bhartiya, Kalpana Sriraman, Seema Parte

“…The spontaneous return of fertility after bone marrow transplantation or heterotopic grafting of cryopreserved ovarian cortical tissue has surprised many, and a possible link with stem cells has been proposed. …”
Get full text

A Curious Case of Hemolytic Anemia with Pseudoreticulopenia by Scott Mayer, Nikhilesh Srinivasan, Jenny Nguyen, Ryan Spilman, Dmitriy Scherbak

“…Reticulopenia may be associated with AIHAs secondary to bone marrow dysfunction, but this patient had a normal function marrow confirmed on biopsy. …”
Get full text

Therapeutic Potential of Mesenchymal Stem Cells in Regenerative Medicine by Devang M. Patel, Jainy Shah, Anand S. Srivastava

“…MSCs are of keen interest because they can be isolated from a small aspirate of bone marrow or adipose tissues and can be easily expanded in vitro. …”
Get full text

A Rare Case of HHV-8 Associated Hemophagocytic Lymphohistiocytosis in a Stable HIV Patient by Nonso Osakwe, Diane Johnson, Natalie Klein, Dalia Abdel Azim

“…The patient was found to have anemia which persisted despite repeated transfusion of packed red cells. A bone marrow biopsy to investigate anemia revealed hemophagocytosis. …”
Get full text

Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft Models by Pallavi Sontakke, Jenny Jaques, Edo Vellenga, Jan Jacob Schuringa

“…These models range from (conditional) transgenic models, knock-in models, and murine bone marrow retroviral transduction models followed by transplantation. …”
Get full text