The Beliefs, Myths, and Reality Surrounding the Word Hema (Blood) from Homer to the Present by John Meletis, Kostas Konstantopoulos

“…In Greek myths and historical works, one finds the first references to the uninterrupted vascular circulation of blood, the differences between venous and arterial blood, and the bone marrow as the site of blood production. The Greeks also speculated about mechanisms of blood coagulation and the use of blood transfusion to save life.…”
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Sacral Myeloid Sarcoma Manifesting as Radiculopathy in a Pediatric Patient: An Unusual Form of Myeloid Leukemia Relapse by Joana Ruivo Rodrigues, Manuel João Brito, Rui Pedro Faria Pais, Sílvia Carvalho

“…Myeloid sarcoma (MS), granulocytic sarcoma or chloroma, is defined as a localized extramedullary mass of blasts of granulocytic lineage with or without maturation, occurring outside the bone marrow. MS can be diagnosed concurrently with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). …”
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New Insights on Properties and Spatial Distributions of Skeletal Stem Cells by Jun-qi Liu, Qi-wen Li, Zhen Tan

“…Skeletal stem cells (SSCs) are postnatal self-renewing, multipotent, and skeletal lineage-committed progenitors that are capable of giving rise to cartilage, bone, and bone marrow stroma including marrow adipocytes and stromal cells in vitro and in an exogenous environment after transplantation in vivo. …”
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An Unusual Case of Systemic Lupus Erythematosus and Hemophagocytic Syndrome by Saika Sharmeen, Nazia Hussain

“…He simultaneously met the Systemic Lupus International Collaborating Clinics (SLICC) criteria for the diagnosis of systemic lupus erythematosus (SLE) and the diagnostic criteria of HS as described in the hemophagocytic lymphohistiocytosis (HLH) 2004 trial. The bone marrow on autopsy showed the presence of abundant hemosiderophages with focal hemophagocytosis. …”
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A Rare Case of Blastic Plasmacytoid Dendritic Cell Neoplasm Occurred in Postchemotherapy of Breast Cancer by Jiankun Tong, Sergei Aksenov, Beth M. Siegel, Lihong Wei, William H. Rodgers

“…BPDCN typically presents with skin lesions and may involve peripheral blood, bone marrow, lymph nodes, or extranodal sites. It usually arises de novo, and some BPDCN cases are associated with or develop into myeloid neoplasms. …”
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Immunomodulation in the Treatment of Refractory Catastrophic Antiphospholipid Syndrome by Karthik Nath, Andrew McCann

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The Use of Natural Health Products Especially Papaya Leaf Extract and Dandelion Root Extract in Previously Untreated Chronic Myelomonocytic Leukemia by Leena T. Rahmat, Lloyd E. Damon

“…We present a case study of a 76-year-old male with previously untreated CMML, whose hematological parameters remained stable and whose bone marrow blast counts vastly improved while taking papaya leaf extract and dandelion root extract.…”
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Mesenchymal Stem Cells Improve Healing of Diabetic Foot Ulcer by Yue Cao, Xiaokun Gang, Chenglin Sun, Guixia Wang

“…In this review, we clarify the mechanism of preclinical studies, as well as safety and efficacy of clinical trials in the treatment of DFU. Bone marrow-derived mesenchymal stem cells (BM-MSCs), compared with MSCs derived from other tissues, may be a suitable cell type that can provide easy, effective, and cost-efficient transplantation to treat DFU and protect patients from amputation.…”
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Adult acute megakaryoblastic leukemia with persistent diarrhea and extreme thrombocytosis: A very unusual case by Nevin Alayvaz Aslan, Gülsün Gülten

“…The hematologic evaluation included peripheral blood smear, bone marrow aspiration and biopsy, flow cytometry, and cytogenetic analysis. …”
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Acute Myeloid Leukemia Presenting with Pulmonary Tuberculosis by Merlin Thomas, Mushtak AlGherbawe

“…Although pulmonary tuberculosis could explain this clinical presentation we suspected associated blood dyscrasias in view of significant monocytosis and mild splenomegaly. Bone marrow aspiration revealed acute myeloid leukemia. …”
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Pivotal Roles of GM-CSF in Autoimmunity and Inflammation by Aoi Shiomi, Takashi Usui

“…Granulocyte macrophage-colony stimulating factor (GM-CSF) is a hematopoietic growth factor, which stimulates the proliferation of granulocytes and macrophages from bone marrow precursor cells. In autoimmune and inflammatory diseases, Th17 cells have been considered as strong inducers of tissue inflammation. …”
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CXCR4 and Axillary Lymph Nodes: Review of a Potential Biomarker for Breast Cancer Metastasis by David Hiller, Quyen D. Chu

“…CXCR4 is a 7-transmembrane G-protein chemokine receptor that allows for migration of hematopoietic cells from the bone marrow to the peripheral lymph nodes. Research has shown CXCR4 to be implicated in the invasion and metastasis of several cancers, including carcinoma of the breast. …”
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Fine-Tuning Reception in the Bone: PPARγ and Company by Z. Elizabeth Floyd, Sanjin Zvonic, Mark E. Nuttall, Jeffrey M. Gimble

“…In addition, the interplay of PPARγ with other nuclear hormone receptors has implications for the balance between adipogenesis and osteogenesis in mesenchymal stem cells of the bone marrow stroma. This review will explore a range of factors influencing PPARγ activity and how these interactions may affect osteogenesis.…”
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Synchronous multiple myeloma and lung adenocarcinoma: A clinical series by Fang Ye, Huan Wang, Ningning Li, Aijun Liu, Wenming Chen

“…Background: Multiple myeloma (MM) is characterised by an increased number of monoclonal immunoglobulin-producing plasma cells that malignantly grow in the bone marrow. Lung cancer is one of the most common malignancies and at the advanced stage may become metastatic to the bone. …”
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Leukocytes: The Double-Edged Sword in Fibrosis by Jakub Kryczka, Joanna Boncela

“…Fibrosis is an extremely complicated and multistage process in which bone marrow-derived leukocytes act as both pro- and antifibrotic agents, and therefore, few, if any, effective therapies are available for the most severe and lethal forms of fibrosis. …”
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Comparative Evaluation of the Reticulocyte Hemoglobin Content Assay When Screening for Iron Deficiency in Elderly Anemic Patients by Torbjörn Karlsson

“…The aim of this study was to evaluate sensitivity and specificity for reticulocyte hemoglobin content (CHr) compared to other hematimetric and biochemical iron parameters, in particular, mean corpuscular hemoglobin (MCH), when screening for iron deficiency in elderly anemic patients. Bone marrow staining negative for iron was used as the gold standard criterion for iron deficiency anemia (IDA). …”
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Incidental Discovery of Multiorgan Extramedullary Plasmacytomas in the Setting of Newly Diagnosed Multiple Myeloma and Delayed Hemolytic Transfusion Reaction by Joselle Cook, Steven Song, Anthony Ventimiglia, Carol Luhrs

“…Extramedullary plasmacytomas (EMPs) are defined by the presence of clonal plasma cell proliferation outside of the bone marrow, portending an overall poor prognosis. This case highlights extramedullary plasmacytomas as an unusual presenting manifestation of multiple myeloma. …”
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Identification of mesenchymal stem cell populations with high osteogenic potential using difference in cell division rate by Maya Watanabe, Yukiyo Asawa, Dan Riu, Tomoaki Sakamoto, Kazuto Hoshi, Atsuhiko Hikita

“…In this study, we aimed to identify a highly osteogenic MSC population by using a similar approach for mouse bone marrow MSCs. Methods: Mouse bone marrow MSCs were fluorescently labeled with carboxyfluorescein succinimidyl ester (CFSE) and sorted according to the fluorescence intensity using flow cytometry on day 3 after labeling. …”
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Diabetic Ephrin-B2-Stimulated Peripheral Blood Mononuclear Cells Enhance Poststroke Recovery in Mice by Rose Hilal, Marine Poittevin, Adrien Pasteur-Rousseau, Adrien Cogo, Gabrielle Mangin, Marie Chevauché, Yasmine Ziat, José Vilar, Jean-Marie Launay, Jean-François Gautier, Dong Broquères-You, Bernard I. Levy, Tatyana Merkulova-Rainon, Nathalie Kubis

“…To date, feasibility studies have used bone marrow-derived mononuclear cells, but harvesting bone marrow cells is invasive thus complicating bedside treatment. …”
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MSC-Derived Exosome Promotes M2 Polarization and Enhances Cutaneous Wound Healing by Xiaoning He, Zhiwei Dong, Yina Cao, Han Wang, Shiyu Liu, Li Liao, Yan Jin, Lin Yuan, Bei Li

“…Moreover, we demonstrated that systemically infused bone marrow MSCs (BMMSCs) and jaw bone marrow MSCs (JMMSCs) could translocate to the wound site, promote macrophages toward M2 polarization, and enhance wound healing. …”
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