Acquired Elliptocytosis as a Manifestation of Myelodysplastic Syndrome Associated with Deletion of Chromosome 20q by Sukesh Manthri, Naresh K. Vasireddy, Sindhura Bandaru, Swati Pathak

“…Peripheral smear showed frequent elliptocytes, teardrop cells, schistocytes, and occasional spherocytes. Bone marrow biopsy did not show significant fibrosis to explain the elliptocytosis. …”
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Editorial for the Special Issue ‘Molecular Mechanisms of Leukemia’ by Jungeun An, Myunggon Ko

“…Leukemia encompasses a diverse and intricate group of hematological malignancies that arise from hematopoietic stem and progenitors (HSPCs) in the bone marrow [...]…”
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Mesenchymal Stem/Stromal Cells from Discarded Neonatal Sternal Tissue: In Vitro Characterization and Angiogenic Properties by Shuyun Wang, Lakshmi Mundada, Eric Colomb, Richard G. Ohye, Ming-Sing Si

“…Autologous and nonautologous bone marrow mesenchymal stem/stromal cells (MSCs) are being evaluated as proangiogenic agents for ischemic and vascular disease in adults but not in children. …”
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Successful Control of Acute Myelofibrosis with Lenalidomide by G. Vassilopoulos, M. Palassopoulou, K. Zisaki, M. Befani, E. Bouronikou, N. Giannakoulas, E. Stathopoulou, P. Matsouka

“…Acute panmyelosis with myelofibrosis (APMF) is a rare, fatal hematological neoplasm that is characterized by the acute onset of cytopenias and fibrosis in the bone marrow in the absence of splenomegaly or fibrosis-related morphological changes in the RBCs. …”
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Unusual Presentation with Orbital Mass in a Child with Precursor B-Cell Acute Lymphoblastic Leukemia by Lalita Sathitsamitphong, Rungrote Natesirinilkul, Worawut Choeyprasert, Pimlak Charoenkwan

“…After 4 weeks of induction chemotherapy for very high-risk ALL, although the bone marrow was in remission, the proptosis was partially resolved. …”
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Deferasirox improved iron homeostasis and hematopoiesis in ovariectomized rats with iron accumulation by Niloofar Honari, Mahtab Sayadi, Seyed Mehdi Sajjadi, Somayeh Solhjoo, Gholamreza Anani Sarab

“…Hematological parameters, iron profile, antioxidant markers, oxidative stress indicators, histopathological evaluation of uterine, bone, bone marrow, liver, and spleen tissues, flow cytometric analysis of hematopoietic CD markers, and relative expression of Hamp, Pu.1, Gata1, and Gdf11 genes were analyzed. …”
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A Case of De Novo CD5+ Disseminated Intravascular Large B-Cell Lymphoma Presenting as Multiorgan Failure by Daulath Singh, Devika Kapuria, Suparna Nanua, Rakesh Gaur

“…The patient later died due to multiorgan failure. A bone marrow biopsy showed 20–30% CD5+ B cells consistent with infiltrative large B-cell lymphoma. …”
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Erratum to “DNMT3A Mutations in Patients with Acute Myeloid Leukemia in South Brazil” by Annelise Pezzi, Lauro Moraes, Vanessa Valim, Bruna Amorin, Gabriela Melchiades, Fernanda Oliveira, Maria Aparecida da Silva, Ursula Matte, Maria S. Pombo-de-Oliveira, Rosane Bittencourt, Liane Daudt, Lucia Silla

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Ticam2 ablation facilitates monocyte exhaustion recovery after sepsis by Blake A. Caldwell, Susanti Ie, Amy Lucas, Liwu Li

“…After one week of recovery, we profiled bone marrow and splenic reservoir monocytes in Ticam2 -/- mice and found that, in contrast to the persistent exhaustion observed in wild-type monocytes, Ticam2 -/- monocytes largely resembled healthy controls. …”
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Functional and Biological Role of Endothelial Precursor Cells in Tumour Progression: A New Potential Therapeutic Target in Haematological Malignancies by Antonia Reale, Assunta Melaccio, Aurelia Lamanuzzi, Ilaria Saltarella, Franco Dammacco, Angelo Vacca, Roberto Ria

“…This increase is strictly related to the bone marrow microvessel density and correlated with a poor prognosis. …”
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Pancytopenia in a 70-Year-Old African-American Male: An Unusual Presentation of a Rare Disease by Aibek E. Mirrakhimov, Alaa M. Ali, Aram Barbaryan, Nwabundo Anusim, Raya Saba, Shawn G. Kwatra, Nasir Hussain, Teresita Zdunek, Alan D. Gilman

“…Blood work-up revealed pancytopenia and bone marrow was diagnostic for hairy cell leukemia.The patient was started on cladribine, with gradual improvement of his symptoms and blood count abnormalities. …”
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Utility of MYD88 in the Differential Diagnosis and Choice of Second-Line Therapy in a Case of Nonsecretory Lymphoplasmacytic Lymphoma versus Free Light Chain Waldenstrom’s Macroglo... by D. Kazmierski, M. L. Palomba, C. Barsigian

“…One year later, however, repeat bone marrow biopsy detected the MYD88 mutation and therapy with ibrutinib yielded a favorable response. …”
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Saponin-based adjuvant uptake and induction of antigen cross-presentation by CD11b+ dendritic cells and macrophages by Lisa GM Huis in ’t Veld, Lenneke AM Cornelissen, Lune van den Bogaard, Marleen Ansems, Nataschja I Ho, Gosse J Adema

“…Moreover, the MHCIIloCD11bhi bone marrow-derived DC (BMDC) subset was identified to be the most responsive DC subset to SBA treatment. …”
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Hematopoietic Stem Cell Function in a Murine Model of Sickle Cell Disease by Elisabeth H. Javazon, Mohamed Radhi, Bagirath Gangadharan, Jennifer Perry, David R. Archer

“…In vivo analysis demonstrated that normal bone marrow cells engraft with increased frequency into sickle mice compared to control mice. …”
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Cellular Mechanisms of Multiple Myeloma Bone Disease by Angela Oranger, Claudia Carbone, Maddalena Izzo, Maria Grano

“…Multiple myeloma (MM) is a hematologic malignancy of differentiated plasma cells that accumulates and proliferates in the bone marrow. MM patients often develop bone disease that results in severe bone pain, osteolytic lesions, and pathologic fractures. …”
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Dual-targeting CAR T cells for B-cell acute lymphoblastic leukemia and B-cell non-Hodgkin lymphoma by Gustavo de Oliveira Canedo, Claire Roddie, Persis J. Amrolia

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Regulatory Effect of Mesenchymal Stem Cells on T Cell Phenotypes in Autoimmune Diseases by Zhiping Wei, Jintao Yuan, Gaoying Wang, Dickson Kofi Wiredu Ocansey, Zhiwei Xu, Fei Mao

“…Research on mesenchymal stem cells (MSCs) starts from the earliest assumption that cells derived from the bone marrow have the ability to repair tissues. Several scientists have since documented the crucial role of bone marrow-derived MSCs (BM-MSCs) in processes such as embryonic bone and cartilage formation, adult fracture and tissue repair, and immunomodulatory activities in therapeutic applications. …”
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Expression of Shelterin Component POT1 Is Associated with Decreased Telomere Length and Immunity Condition in Humans with Severe Aplastic Anemia by Ting Wang, Shu-chong Mei, Rong Fu, Hua-quan Wang, Zong-hong Shao

“…Furthermore, ATR, phosphorylated ATR, and phosphorylated ATM/ATR substrate were all found similarly increased in bone marrow cells exposed to SAA serum, TNF-α, or IFN-γ. …”
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Protective Effects of Chronic Intermittent Hypobaric Hypoxia Pretreatment against Aplastic Anemia through Improving the Adhesiveness and Stress of Mesenchymal Stem Cells in Rats by Jing Yang, Li Zhang, Handong Wang, Zan Guo, Yixian Liu, Yi Zhang, Chuan Wang, Quanhai Li

“…The adhesive molecules of bone marrow mesenchymal stem cells (BMMSCs) in AA model, VLA-4, VCAM-1, and ICAM-1 were upregulated, and those of CD162 and CD164 were downregulated by CIHH pretreatment. …”
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A Rare Co-Occurrence of Triple Mutations in JAK2, CALR, and MPL in the Same Patient with Myelofibrosis by Sherine J. Thomas, D. P. Dash

“…Molecular profiling of bone marrow confirmed the previously noted mutations and an MPLW515R mutation. …”
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