A Rare Cause of Acute Kidney Injury: Primary Renal Lymphoma in a Patient with Human Immunodeficiency Virus by Ruslinda Mustafar, Lydia Kamaruzaman, Beh Hui Chien, Azyani Yahaya, Noor’Ain Mohd Nasir, Rozita Mohd, Rizna Cader, Kong Wei Yen

“…Diagnosis of diffuse large B cell lymphoma with germinal center type, CD20 positive, and proliferative index 95% was confirmed via renal biopsy, and there was no bone marrow infiltrates. Unfortunately, the patient succumbs prior to initiation of chemotherapy.…”
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CRISPR/Cas Enzyme Catalysis in Liquid–Liquid Phase‐Separated Systems by Yaqin Zhang, Jianai Chen, Zhina Wu, Chenfei Zhao, Rui Wang, Zhiping Li, Jiasi Wang, Di Wang

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Current Status of Canine Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Veterinary Medicine by Tania Sultana, Soojung Lee, Hun-Young Yoon, Jeong Ik Lee

“…Although the application of various types of stem cells, such as bone marrow-derived mesenchymal stem cells (BM-MSCs), adipose tissue-derived mesenchymal stem cells (AT-MSCs), and umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs), has promising potential to improve the health of different species, it is crucial that the benefits and drawbacks are completely evaluated before use. …”
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Composite Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and T-Prolymphocytic Leukemia Presenting with Lymphocytosis, Skin Lesions, and Generalized Lymphadenopathy by Ali Sakhdari, Guilin Tang, Lawrence E. Ginsberg, Cheryl F. Hirsch-Ginsberg, Carlos E. Bueso-Ramos, L. Jeffrey Medeiros, Roberto N. Miranda

“…Retrospective testing demonstrated that composite CLL and T-PLL were both present in skin and lymph nodes as well as in blood and bone marrow since initial presentation. This case is also unique because it highlights that a subset of T-PLL patients can present with clinically indolent disease. …”
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Association Between MRI Findings of Facet Arthropathy and Synovitis With Health-Related Outcome and Pain Scores Following Therapeutic Lumbar Facet Injections by Michael S. Green, Michele Van Hal, Matthew Onimus, Christopher R. Hoffman, Dhruv K. C. Goyal, Valeria Potigailo, Khuram S. Kazmi

“…Facet synovitis is an entity characterized by edema and inflammatory changes affecting the facet joints, adjacent bone marrow, and surrounding soft tissues. Although its underlying etiology remains poorly understood, recent reports suggest a high incidence in patients with arthropathy and arthritis. …”
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Vitamin E and N-Acetylcysteine as Antioxidant Adjuvant Therapy in Children with Acute Lymphoblastic Leukemia by Youssef Al-Tonbary, Mohammad Al-Haggar, Rasha EL-Ashry, Sahar EL-Dakroory, Hanan Azzam, Ashraf Fouda

“…They were evaluated clinically for the occurrence of complications and by the laboratory parameters (blood levels of glutathione peroxidase (Glu.PX) antioxidant enzyme, malondialdehyde (MDA), tumor necrosis factor-𝛼 (TNF-𝛼), liver enzymes, and bone marrow picture). Results revealed reduced chemotherapy and radiotherapy toxicity as evidenced by decreasing level of MDA, increasing level of Glu.Px and decreased occurrence of toxic hepatitis, haematological complications, and need for blood and platelet transfusions in group I compared to group II. …”
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RNA N4‐acetylcytidine modification and its role in health and diseases by Qiang Wang, Yixiao Yuan, Qiang Zhou, YingDong Jia, Jing Liu, GuangJun Xiao, Chunhong Li, Xiulin Jiang

“…Additionally, it systematically summarizes the essential functions and mechanisms of ac4C modification in normal biological processes, including stem cell fate determination, spermatogenesis and oogenesis, embryonic development, cellular senescence, and bone remodeling. Furthermore, this review delves into the central roles and molecular mechanisms of ac4C modification in regulating malignant proliferation, cell cycle arrest, EMT, drug resistance, cell death, cancer metabolism, and tumor immunotherapy. …”
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Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Grow... by Alena Chumanevich, Piper Wedman, Carole A. Oskeritzian

“…Using a preclinical MC-dependent model of acute allergic responses and in vitro stimulated primary mouse bone marrow-derived MC (BMMC) or human primary skin MC, we report that S1P signaling resulted in substantial amount of VEGF-A release. …”
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A Comprehensive Review on the Beneficial Roles of Vitamin D in Skin Health as a Bio-Functional Ingredient in Nutricosmetic, Cosmeceutical, and Cosmetic Applications by Sofia Neonilli A. Papadopoulou, Elena A. Anastasiou, Theodora Adamantidi, Anna Ofrydopoulou, Sophia Letsiou, Alexandros Tsoupras

“…Primarily, vitamin D was known for its important role in bone health. Nevertheless, recent research has shown its importance for the brain, heart, muscles, immune system, and skin health, due to its distinct bio-functionality in almost every tissue in the human body. …”
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CD4+CD25highCD127low/-FoxP3+ Regulatory T-Cell Population in Acute Leukemias: A Review of the Literature by M. Niedźwiecki, O. Budziło, E. Adamkiewicz-Drożyńska, D. Pawlik-Gwozdecka, M. Zieliński, L. Maciejka-Kembłowska, T. Szczepański, P. Trzonkowski

“…The percentage of regulatory T-lymphocytes in peripheral blood and bone marrow was elevated compared to those in healthy individuals and correlated with progressive disease. …”
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Molecular cloning of EZH2 oncogene in chronic myeloid leukemia and therapeutic prospects by Juliana Costa Gaspar, Lucas Santos de Santana, Camila Menezes Freire de Souza, Marcos Montani Caseiro, Rosane Rezende de Souza Giuliani, Cleide Barbieri de Souza

“…Chronic myeloid leukemia (CML) is a myeloproliferative neoplasia, caused in 95 % of the cases by a cytogenetic abnormality characterized by the reciprocal translocation between chromosomes 9 and 22 t(9; 22) (q34; q11), resulting in Philadelphia chromosome (Ph).Considering that CML cure is only possible with a successful bone marrow transplantation and that there are resistance cases to the tyrosine kinase inhibitor Imatinib Mesylate, prescribed in first line drug treatment; it is important to know in detail the genes and proteins that are possibly altered in CML, favoring effective therapeutic strategies, optimized diagnosis and minimal residual disease detection. …”
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Fairway to fractures: Income inequality and violent crime as the driving factors for golf club-related assaults – a case series of 21 compound skull fractures by R Grobler, E-M Geldenhuys, A J Vlok

“…Fractures were most commonly seen in the frontal bone (n=9), followed by parietal (n=8), temporal (n=3) and occipital (n=1) bones. …”
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P1-N1-P2 Cortical Auditory Evoked Potentials in Chronic Unilateral Acquired Conductive Hearing Loss in Adults by Abeir Osman Dabbous, Noha Ali Hosni, Alzahraa Al-Sayed Owais Emara, Adel Said El-Antably

“…All were subjected to history-taking, otologic examination, basic audiological evaluation, and bone conduction N1-P2 CAEP. RESULTS: The affected ears of the cases showed highly statistically significant shorter CAEPs N1, P2, N1-P2 latencies but not P1, and showed highly statistically significant larger N1, P2, N1P2, amplitude than the control group. …”
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In Vitro Differentiation of First Trimester Human Umbilical Cord Perivascular Cells into Contracting Cardiomyocyte-Like Cells by Peter Szaraz, Matthew Librach, Leila Maghen, Farwah Iqbal, Tanya A. Barretto, Shlomit Kenigsberg, Andrée Gauthier-Fisher, Clifford L. Librach

“…Based on the expression of cardiomyocyte markers (cTnT, MYH6, SIRPA, and CX43) FTM and term HUCPVCs achieved significantly increased cardiomyogenic differentiation compared to bone marrow MSCs, while their immunogenicity remained significantly lower as indicated by HLA-A and HLA-G expression and susceptibility to T cell mediated cytotoxicity. …”
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Establishment and Characterization of a Human Small Cell Osteosarcoma Cancer Stem Cell Line: A New Possible In Vitro Model for Discovering Small Cell Osteosarcoma Biology by Gaia Palmini, Roberto Zonefrati, Cecilia Romagnoli, Alessandra Aldinucci, Carmelo Mavilia, Gigliola Leoncini, Alessandro Franchi, Rodolfo Capanna, Maria Luisa Brandi

“…Osteosarcoma (OSA) is the most common primary malignant bone tumor, usually arising in the long bones of children and young adults. …”
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Vestiges humains des niveaux de l’Aurignacien ancien du site de Brassempouy (Landes) by Dominique Henry-Gambier, Bruno Maureille, Randall White

“…Second, four of the adult teeth show intentionally perforated or circum-incised roots, and the cranial fragment shows fracture patterns consistant with breakage of fresh bone.The primary goal of this article is to outline the morphometric characters of the different remains and to evaluate their taxonomic status. …”
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Pathological Role of Tonsillar B Cells in IgA Nephropathy by Yusuke Suzuki, Hitoshi Suzuki, Junichiro Nakata, Daisuke Sato, Tadahiro Kajiyama, Tomonari Watanabe, Yasuhiko Tomino

“…Although impaired immune regulation along the mucosa-bone marrow axis has been postulated to play an important role, the pathogenesis of IgA nephropathy (IgAN) is unknown; thus, no disease-specific therapy for this disease exists. …”
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Haemophagocytic Lymphohistiocytosis with Leptospirosis: A Rare but Devastating Complication by B. M. Munasinghe, A. G. Arambepola, N. Pathirage, U. P. M. Fernando, N. Subramaniam, S. Nimalan, T. Gajanthan

“…Subsequently, he developed severe acute hypoxemia requiring mechanical ventilation and acute renal failure requiring renal replacement therapy. Bone marrow biopsy and markedly elevated serum ferritin and triglyceride levels done on day 10 (with unresolving fever, hepatosplenomegaly, and pancytopaenia) confirmed the diagnosis of HLH. …”
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Multimodal Surgical and Medical Treatment for Extensive Rhinocerebral Mucormycosis in an Elderly Diabetic Patient: A Case Report and Literature Review by Paola Di Carlo, Roberto Pirrello, Giuliana Guadagnino, Pierina Richiusa, Antonio Lo Casto, Caterina Sarno, Francesco Moschella, Daniela Cabibi

“…Acute necrosis of the maxilla is seldom seen and extensive facial bone involvement is rare in patients with rhino-orbital-cerebral mucormycosis. …”
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Spectroscopic Analysis of a Theropod Dinosaur (Reptilia, Archosauria) from the Ipubi Formation, Araripe Basin, Northeastern Brazil by João Hermínio da Silva, Francisco Eduardo de Sousa Filho, Antônio Álamo Feitosa Saraiva, Nádia Amanda Andrade, Bartolomeu Cruz Viana, Juliana Manso Sayão, Bruno Tavares de Oliveira Abagaro, Paulo de Tarso Cavalcante Freire, Gilberto Dantas Saraiva

“…The results agree regarding the different composition of the stone matrix and the fossilized bone, indicating a partial substitution of the material by elements present in the depositional environment. …”
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