Single-cell analysis identifies the CNP/GC-B/cGMP axis as marker and regulator of modulated VSMCs in atherosclerosis by Moritz Lehners, Hannes Schmidt, Maria T. K. Zaldivia, Daniel Stehle, Michael Krämer, Andreas Peter, Julia Adler, Robert Lukowski, Susanne Feil, Robert Feil

“…Overall, this study highlights the plasticity of cGMP signaling in VSMCs and suggests analogies between CNP-dependent remodeling of bone and blood vessels.…”
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Pure Testicular Seminoma Relapsing Late with Somatic Type Malignancy by Klaus-Peter Dieckmann, Petra Anheuser, Ralf Gehrckens, Waldemar Wilczak, Guido Sauter, Doris Höflmayer

“…Histologically, the specimen consisted of neurofibroma with areas of malignant peripheral nerve sheath tumour and spots with mature bone formation. FISH analysis disclosed isochromosome 12p in the majority of evaluated cells suggesting somatic type malignancy (STM) of GCT. …”
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Metagenomic next-generation sequencing assists in the diagnosis of visceral leishmaniasis in non-endemic areas of China by Rui Zhao, Guilun He, Lin Xiang, Melinda Ji, Rongheng He, Xudong Wei

“…In this study, we report two cases of leishmaniasis from Henan Province, China, in which Leishmania parasites were identified using mNGS technology, massively expediting diagnosis and treatment.ResultsOur report demonstrates that the mNGS method is applicable to peripheral blood samples (PB), which are far more readily available in clinical settings, in addition to bone marrow aspirate samples (BM), which are traditionally used for diagnosis of visceral leishmaniasis.ConclusionOur report validates the efficacy of mNGS technology as a rapid and accurate method of diagnosis for leishmaniasis.…”
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Periostin as a Biomarker of the Amniotic Membrane by Mariya P. Dobreva, Larissa Lhoest, Paulo N. G. Pereira, Lieve Umans, Susana M. Chuva de Sousa Lopes, An Zwijsen

“…So far such amniotic markers have not been reported. We postulated that bone morphogenetic protein (BMP) target genes are putative amniotic membrane markers mainly because deficiency in one of several components of the BMP signaling cascade in mice has been documented to result in defective development of the early amnion. …”
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Tumor Reduction with Pazopanib in a Patient with Recurrent Lumbar Chordoma by Maurício Fernando Silva Almeida Ribeiro, Micelange Carvalho de Sousa, Samir Abdallah Hanna, Marcos Vinicius Calfat Maldaun, Ceci Obara Kurimori, Luiz Guilherme Cernaglia Aureliano de Lima, Romulo Loss Mattedi, Rodrigo Ramella Munhoz

“…Chordomas are rare malignancies of bone origin that occur in the axial skeleton, typically the skull base and lumbar/sacral regions. …”
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Protocol for predicting the single-cell network-based gene activity landscape during human B cell development by Xin Huang, Xuetong Hou, Yizhen Li, Jun J. Yang, Jiyang Yu

“…We describe steps for acquiring bone marrow data; conducting single-cell downstream analysis; and leveraging the St. …”
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Abnormal Congenital Location of Stapes’ Superstructure: Clinical and Embryological Implications by Vânia Henriques, Rafaela Teles, Ana Sousa, Roberto Estevão, Jorge Rodrigues, Alexandra Gomes, Francisco Silva, Ângelo Fernandes, Fausto Fernandes

“…A stapes prosthesis was inserted and resulted in closure of the air-bone gap by 25 dB. A review of the literature was also performed using MEDLINE. …”
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The Influence of Electrolytic Concentration on the Electrochemical Deposition of Calcium Phosphate Coating on a Direct Laser Metal Forming Surface by Qianyue Sun, Yuhui Yang, Wenjing Luo, Jinghui Zhao, Yanmin Zhou

“…A calcium phosphate (CaP) coating on titanium surface enhances its biocompatibility, thus facilitating osteoconduction and osteoinduction with the inorganic phase of the human bone. Electrochemical deposition has been suggested as an effective means of fabricating CaP coatings on porous surface. …”
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Analysis of Primary Stability of Dental Implants Inserted in Different Substrates Using the Pullout Test and Insertion Torque by Nathalia Ferraz Oliscovicz, Antônio Carlos Shimano, Élcio Marcantonio Junior, César Penazzo Lepri, Andréa Candido dos Reis

“…The aim of the study was to evaluate mechanical behavior of implants inserted in three substrates, by measuring the pullout strength and the relative stiffness. 32 implants (Master Porous-Conexao, cylindrical, external hexagon, and surface treatment) were divided into 4 groups (n=8): pig rib bone, polyurethane Synbone, polyurethane Nacional 40 PCF, and pinus wood. …”
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Blockade of PLD2 Ameliorates Intestinal Mucosal Inflammation of Inflammatory Bowel Disease by Guangxi Zhou, Lin Yu, Wenjing Yang, Wei Wu, Leilei Fang, Zhanju Liu

“…PLD2 selective inhibitor (CAY10594) was administrated daily by oral gavage in DSS-induced colitis mice. Bone marrow neutrophils from colitis mice were harvested to examine the migration using Transwell plate. …”
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Translocation (6;15)(q12;q15): A Novel Mutation in a Patient with Therapy-Related Myelodysplastic Syndrome by Saba F. Ali, Rebecca J. Sonu, Denis M. Dwyre, Brian A. Jonas, Hooman H. Rashidi

“…The patient was successfully treated with chemotherapy and an autologous bone marrow transplant but subsequently developed a new FLT3-ITD negative t-MDS with a unique translocation, t(6;15)(q12;q15), three years after transplant. …”
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An annotated heterogeneous ultrasound database by Yuezhe Yang, Yonglin Chen, Xingbo Dong, Junning Zhang, Chihui Long, Zhe Jin, Yong Dai

“…Due to challenges such as operator dependence, noise, limited field of view, difficulty in imaging through bone and air, and variability across different systems, diagnosing abnormalities in ultrasound images is particularly challenging for less experienced clinicians. …”
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The Influence of Mg2+ Ions on the In Vitro Efficacy of Chitosan-Titanium Dioxide Nanotubes (CTNTs) Scaffolds by Siew Shee Lim, Shui Wei Kho, Nehemiah Li Heng Ang, Cheng Heng Pang, Hwei-San Loh

“…Based on current results, CTNTs scaffolds with Mg2+ ions may be a potential biomaterial for bone regeneration.…”
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Phylogeography of the woolly mammoth (<i>Mammuthus primigenius</i>) in the Minusinsk Depression of southern Siberia in the Late Pleistocene by S. A. Modina, M. A. Kusliy, D. G. Malikov, A. S. Molodtseva

“…Within the framework of this effort, libraries for high-throughput sequencing of seven bone samples of woolly mammoths were obtained, two-round enrichment using biotinylated probes of modern mtDNA of Elephas maximus immobilised on magnetic microspheres and sequencing with subsequent bioinformatic analysis were carried out. …”
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Sudden Vision Loss Secondary to Optic Nerve Infiltration as a Presenting Symptom of Metastatic Lung Adenocarcinoma by M. M. Shamim, M. Whaley, H. Rana, S. K. Jeffus, S. Bhatti, A. B. Sallam

“…He was found to have a right lung mass, multiple metastatic pulmonary nodules, and liver and bone metastases. Biopsy from a mediastinal lymph node confirmed the diagnosis of metastatic lung adenocarcinoma. …”
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Analsisis pemasaran dan keuangan digital terhadap daya saing global hasil pertanian komoditas ekspor di provinsi Sulawesi-Selatan by Muhammad Irfan Arya, Farhan Djufri, Hartina Beddu

“…Research locations in Luwu, East Luwu, Enrekang, North Toraja and Bone Regencies. The sample size was 400 farmers. …”
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A Wearable Iron-Based Implant as an Intramedullary Nail in Tibial Shaft Fracture of Sheep by Sitaria F. Siallagan, Marzuki Silalahi, Arief Boediono, Sri Estuningsih, Deni Noviana

“…A stable repaired fracture is the key factor responsible for the recovery of a damaged bone. The iron-based implant is one of the biodegradable metals that have been proven safe as a fracture fixation device. …”
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Long Course Hyperbaric Oxygen Stimulates Neurogenesis and Attenuates Inflammation after Ischemic Stroke by Ying-Sheng Lee, Chung-Ching Chio, Ching-Ping Chang, Liang-Chao Wang, Po-Min Chiang, Kuo-Chi Niu, Kuen-Jer Tsai

“…Several studies have provided evidence with regard to the neuroprotection benefits of hyperbaric oxygen (HBO) therapy in cases of stroke, and HBO also promotes bone marrow stem cells (BMSCs) proliferation and mobilization. …”
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Design, Fabrication, and Characterization of 3D-Printed Multiphase Scaffolds Based on Triply Periodic Minimal Surfaces by Josette Vigil, Kailey Lewis, Nicholas Norris, Alp Karakoç, Timothy A. Becker

“…The present work investigates the influence of material phases and their volume fractions on the elastic behavior of triply periodic minimal surface (TPMS) scaffolds for the potential modeling of bone scaffolds. A graphical tool using TPMS functions, namely Schwarz-D (diamond), gyroid, and modified gyroid, was developed and used to design and additively manufacture 3D multiphase scaffold models. …”
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Beneficial effects of the fructus Sophorae extract on experimentally induced osteoporosis in New Zealand white rabbits by CHAKULESKA LIDIJA, SHKONDROV ALEKSANDAR, POPOV GEORGI, ZLATEVA-PANAYOTOVA NADYA, PETROVA RENETA, ATANASOVA MARIYANA, KRASTEVA ILINA, DOYTCHINOVA IRINI, SIMEONOVA RUMYANA

“…In the present study fructus Sophorae extract (FSE) was administered orally for three months at a dose of 200 mg kg–1 in ovariectomized (OVX) New Zealand rabbits. 3D computed tomography scans and histopathological images revealed microstructural disturbances in the bones of the castrated animals. FSE recovered most of the affected parameters in bones in a manner similar to zoledronic acid (ZA) used as a positive control. …”
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