Maxillary osteonecrosis linked to Pembrolizumab therapy: a case report by Gosselin-Rousselle Louise, Gaudimier Zoé, Pamelard Pierre-Olivier, Sader Paul, Moizan Hervé

“…Introduction: Osteonecrosis of the jaw is a serious condition often associated with the use of bone-modifying agents or antiangiogenics. Recent evidence suggests that immune checkpoint inhibitors, including Pembrolizumab, might also contribute to osteonecrosis of the jaw. …”
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Hamster and Murine Models of Severe Destructive Lyme Arthritis by Erik Munson, Dean T. Nardelli, Brian K. Du Chateau, Steven M. Callister, Ronald F. Schell

“…This arthritis involves focal bone erosion and destruction of articular cartilage. …”
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High-Output Cardiac Failure Revealing Primary Plasma Cell Leukemia by Driss Chaoui, Bruno Gallet, Philippe Genet, Babette Mbungani, Ahmad Al Jijakli, Nina Arakelyan, Louisa Mesbah, Laurent Sutton

“…High-output cardiac failure in multiple myeloma (MM) is related to arteriovenous shunting in bone infiltrate disease. We describe such a complication in a patient with primary plasma cell leukemia (pPCL) without bone disease. …”
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An 11-Year-Old Male with Refractory Osteomyelitis by Clifford T. Mauriello, Ole A. Raustol, Maria A. Aguiar, Kenji M. Cunnion

“…The recognition of multifocal osteomyelitis led to reexamination of bone tissue specimens using special stains which demonstrated rare broad-based budding yeast. …”
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Garre’s Osteomyelitis of the Mandible Caused by Infected Tooth by Hayati Murat Akgül, Fatma Çağlayan, Sevcihan Günen Yılmaz, Gözde Derindağ

“…In Garre’s osteomyelitis, new bone formation can occur in many pathological conditions. …”
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Machine learning-powered, high-affinity modification strategies for aptamers by Gubu Amu, Xin Yang, Hang Luo, Sifan Yu, Huarui Zhang, Yuan Tian, Yuanyuan Yu, Shijian Ding, Yufei Pan, Zefeng Chen, Yixin He, Yuan Ma, Baoting Zhang, Ge Zhang

“…Sclerostin, which antagonizes the Wnt signaling pathway, negatively regulates bone formation. Our screened sclerostin aptamer was previously shown to exert bone anabolic potential. …”
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Piezoelectric-Assisted Removal of a Mandibular Cementoossifying Fibroma: An Innovative Technique by Adel Bouguezzi, Hajer Hentati, Abdellatif Chokri, Sameh Sioud, Jamil Selmi

“…Treatment is surgical with enucleation-resection depending on the lesion size or wider resection with bone reconstruction in cases of large fibromas. The use of piezoelectric bone surgery is associated with low surgical trauma, exceptional precision, and fast healing response. …”
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The Interaction between Bmal1 and Per2 in Mouse BMSC Osteogenic Differentiation by Haiya Zhuo, Yuhong Wang, Qing Zhao

“…Both Bmal1−/− mice and Per2−/− mice display obvious bone volume changes. In this study, we inhibited the expression of Bmal1 in bone marrow-derived mesenchymal stem cells (BMSCs) using a lentiviral vector harboring RNAi sequences, which increased the osteogenic differentiation capability of BMSCs. …”
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Sclerostin Antibody Therapy for the Treatment of Osteoporosis: Clinical Prospects and Challenges by Claire MacNabb, D. Patton, J. S. Hayes

“…A promising therapeutic candidate is sclerostin, a Wnt pathway antagonist and, as such, a negative regulator of bone formation. Sclerostin antibody treatment has demonstrated efficacy and superiority compared to other anabolic treatments for increasing bone formation in both preclinical and clinical settings. …”
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Evaluation of Stature Development During Childhood and Adolescence in Individuals with Familial Hypophosphatemic Rickets by Mauro M.S. Borghi, Veronica Coates, Hatim A. Omar

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Acute Bilateral Posterior Meniscal Root Tears in the Setting of a Noncontact Anterior Cruciate Ligament Rupture by Adam V. Daniel, Shayne R. Kelly, Patrick A. Smith

“…ACL reconstruction (ACLR) was performed and intraoperatively, both medial and lateral root tears were found. A standard bone patellar-tendon bone (BTB) autograft ACLR was performed with combined medial and lateral root repair utilizing a transtibial pull-out method for both. …”
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Solitary Plasmacytoma of the Mesentery: A Systematic Clinician’s Diagnosis by Georgia Mitropoulou, Adamantia Zizi-Sermpetzoglou, Hippokrates Moschouris, Athanasios Kountourogiannis, Despoina Myoteri, Dionysios Dellaportas

“…Plasmacytoma is an uncommon plasma cell neoplasm and its localized form is solitary plasmacytoma of the bone and solitary extramedullary plasmacytoma. Solitary plasmacytoma of the mesentery is extremely rare, reported only in a handful of cases. …”
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How can the buffalo carcass be used rationally? by Ricardo Alexandre Silva Pessoa

“…There is a high volume of waste bones, which could be used in food, such as bone broth, for example. …”
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Beyond BRAFV600E: Investigating the Clinical and Genetic Spectrum of Langerhans Cell Histiocytosis in Children by Xue Tang, Ju Gao, Xia Guo, Zhi Wan, Jing‐jing Sun

“…Among the 303 LCH patients with MAP2K1 or other BRAF alterations, patients with the MAP2K1 mutation had a higher prevalence of single‐system bone involvement (SS‐bone) than patients carrying the BRAF mutation (p = 0.0072). …”
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lncRNA HHIP-AS1 Promotes the Osteogenic Differentiation Potential and Inhibits the Migration Ability of Periodontal Ligament Stem Cells by Qianyi Qin, Haoqing Yang, Chen Zhang, Xiao Han, Jing Guo, Zhipeng Fan, Jie Guo

“…Alveolar bone remodeling under orthodontic force is achieved by periodontal ligament stem cells (PDLSCs), which are sensitive to mechanical loading. …”
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Biomechanical Responses and Injury Characteristics of Knee Joints under Longitudinal Impacts of Different Velocities by Yan Xiong, Xueliang Zhao, Hongyi Xiang, Yunjiao Wang, Zhikang Liao, Xiyan Zhu, Hui Zhao

“…The finite element simulation of knee joints found that medial cortical bone stress appeared earlier than the lateral peak and that the medial bone stress concentration was more obvious when the knee was longitudinally impacted. …”
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Can growth in captivity alter the calcaneal microanatomy of a wild ungulate? by Cottereau, Romain, Ortiz, Katia, Locatelli, Yann, Houssaye, Alexandra, Cucchi, Thomas

“…Reduced mobility associated with captivity induces changes in biomechanical stress on the skeleton of domesticated animals. Due to bone plasticity, bone’s morphology and internal structure can respond to these new biomechanical stresses over individuals’ lifetime. …”
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Comparison of Atypical and Osteoporotic Femoral Shaft Fractures in the Elderly: A Multicenter Study by Takanori Miura, Hiroaki Kijima, Noriyuki Ishikawa, Toshihito Ebina, Takayuki Tani, Shuichi Chida, Tetsuya Suzuki, Satoshi Yumto, Hiroshi Tazawa, Naohisa Miyakoshi, Yoichi Shimada

“…This study compared the bone healing time and rates of complications in atypical femoral shaft fractures and osteoporotic femoral shaft fractures. …”
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Fetal Cartilage Progenitor Cells in the Repair of Osteochondral Defects by Bruno C. Menarim, DVM, PhD, Chan Hee Mok, PhD, Kirsten E. Scoggin, PhD, Alexis Gornik, DVM, Emma N. Adam, DVM, PhD, Shavahn C. Loux, PhD, James N. MacLeod, VMD, PhD

“…Untreated lesions unexpectedly failed to represent critical-sized defects and at 2 weeks exhibited new subchondral bone covered by a fibrocartilage layer that thinned over time. …”
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Comparison of growth hormone therapy response according to the presence of growth hormone deficiency in children born small for gestational age with short stature in Korea: a retro... by Ha Young Jo, Hyun Ji Jang, Chong Kun Cheon, Ju Young Yoon, Sukdong Yoo, Jung Hyun Lee, Jeong Eun Lee, Ye Jin Kim, Sejin Kim, Hyun-Ji Kim, Im Jeong Choi, Min Jung Kwak

“…Regardless of the presence of GHD, the difference between chronological age and bone age decreased annually. Notably, there was significantly rapid bone age progression among patients without GHD. …”
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