Does semaglutide reduce alcohol intake in Danish patients with alcohol use disorder and comorbid obesity? Trial protocol of a randomised, double-blinded, placebo-controlled clinica... by Jens Juul Holst, Tina Vilsbøll, Claus Thorn Ekstrøm, Helene Benveniste, Nora D Volkow, Anders Fink-Jensen, Gitte M Knudsen, Mette Kruse Klausen, Tugba Kuzey, Julie Niemann Pedersen, Signe Keller Justesen, Line Rasmussen, Ulla B Knorr, Graeme Mason, George Koob

“…Glucagon-like peptide-1 (GLP-1) receptor agonists have shown promising effects in reducing alcohol consumption in preclinical experiments, and clinical trials are in high demand to investigate these potentially beneficial effects in patients diagnosed with AUD.Methods and analysis The effects of the once-weekly GLP-1 receptor agonist semaglutide will be investigated in a 26-week, randomised, placebo-controlled, double-blinded clinical trial. 108 patients diagnosed with AUD and comorbid obesity (body mass index (BMI)≥30 kg/m2)) will be randomised to treatment with either semaglutide or placebo in combination with cognitive behavioural therapy. …”
Get full text

Effects of exercise and exercise timing on energy intake and appetite control in Danish individuals with overweight or obesity with and without type 2 diabetes: a protocol for a ra... by Louise Groth Grunnet, Martin Bæk Blond, Jonas Salling Quist, Kristine Beaulieu, Graham Finlayson, Kristine Færch, Lea Jalking, Natja Poder Launbo, Marie Møller Jensen, Hanne Enghoff Pedersen, Marina Kjærgaard Gerstenberg

“…Fifty-eight women and men (aged 18–75 years) with overweight or obesity (body mass index ≥25 kg/m2) with or without T2D will be recruited. …”
Get full text

Extracellular vesicles-derived miR-21 as a biomarker for early diagnosis and tumor activity in breast cancer subtypes by Claudia Omarini, Virginia Catani, Ilenia Mastrolia, Angela Toss, Federico Banchelli, Chrystel Isca, Daniele Medici, Ornella Ponzoni, Marco Brucale, Francesco Valle, Maria Cristina Baschieri, Roberto D’Amico, Valentina Masciale, Chiara Chiavelli, Federica Caggia, Carlo Augusto Bortolotti, Federico Piacentini, Massimo Dominici

“…We assessed EV-derived miR-21 levels in one hundred women: 30 with early BC (EBC), 30 with metastatic BC on treatment progression (MBC), 30 cancer survivors on follow-up (FU) and 10 healthy donors (HD) as age- and body mass index (BMI)-matched controls. EVs isolated from serum samples were characterized using nanoparticle tracking analysis, scanning electron microscopy and atomic force microscopy to detect their concentration, size, morphology and mechanical properties. …”
Get full text

Smart phone-based transcutaneous electrical acupoint stimulation as adjunctive therapy for hypertension (STAT-H trial): protocol for a cluster randomised controlled trial by Yu Wang, Xiao Wang, Ying Lin, Chao-Qun Yan, Guang-Xia Shi, Cun-Zhi Liu, Jing-Wen Yang, Jian-Feng Tu, Shi-Yan Yan, Xin-Tong Su, Li-Qiong Wang, Si-Bo Kang, Bao-Hong Mi, He-Wen Li, Xue-Zhou Wang

“…Tertiary outcomes will include change in body mass index, change in waist circumference, physical activity and medication adherence. …”
Get full text

Effects of Local Heating and Whole-Body Hyperthermia on Neuromuscular and Cognitive Function in Young and Old Healthy Adults by Junli Wang

“…Methods: In the first study, weight (kg), body fat (%), height (cm), body mass index (BMI), skinfold thickness (mm), and the mean subcutaneous fat thickness were calculated (McArdle et al., 1984). …”
Get full text

Clinical Features and Changes in Insulin Requirements in People with Type 2 Diabetes Requiring Insulin When Hospitalised with SARS-CoV-2 Infection by Antonella Corcillo, Aaisha Saqib, Niruthika Sithamparanathan, Amina Khanam, Jamal Williams, Abhiti Gulati, Dulmini Kariyawasam, Janaka Karalliedde

“…People requiring insulin were younger, had a higher preadmission HbA1c, were more frequently on oral medication for diabetes before the admission, and were more likely to be obese (body mass index ≥30 kg/m2), with p ≤ 0.001 for all. In multivariable logistic regression analyses, we observed that younger age and higher HbA1c before admission were independently associated with needing insulin, with one-year increase in age associated with decreased odds of needing insulin initiation (OR 0.91, 95% CI 0.83–0.99), and increasing preadmission HbA1c by 1 mmol/mol associated with an increased odds of insulin initiation (OR 1.05, 95% CI 1.002–1.11) (p < 0.05 for both). …”
Get full text

A Vitamin Pattern Diet Is Associated with Decreased Risk of Gestational Diabetes Mellitus in Chinese Women: Results from a Case Control Study in Taiyuan, China by Qiong Chen, Yongliang Feng, Hailan Yang, Weiwei Wu, Ping Zhang, Keke Wang, Ying Wang, Jamie Ko, Jiaxin Shen, Lingling Guo, Feng Zhao, Wenqiong Du, Shouhang Ru, Suping Wang, Yawei Zhang

“…Dietary nutrient patterns were identified using factor analysis, and their associations with GDM risk were evaluated using unconditional logistic regression models adjusting for total energy intake, maternal age, high blood pressure, education, maternal body mass index (BMI), parity, and family history of diabetes. …”
Get full text

Clinical outcome of non-alcoholic fatty liver disease: an 11-year follow-up study by Steven Dooley, Juan Du, Xiaoping Tang, Lan Chen, Jinzhu Jia, Fujun Li, Yanyan Shi, Christoph Meyer, Zhongwei Zhu, Yanming Zhang, Roman Liebe, Keming Hu, Tingting Zhou, Huier Zhang, Hong-Lei Weng, Tong Huang

“…Logistic and Cox regression revealed 16 risk factors, including body mass index (BMI), albumin, white blood cell, triglycerides (TG), high-density lipoprotein, glutamyl transpeptidase, alanine transaminase, creatinine, urea acid, glucose, systolic blood pressure, diastolic blood pressure, blood sedimentation, haemoglobin, platelet and apolipoprotein B2 (p&lt;0.05 for all factors). …”
Get full text

Relationship between Surface Electromyography Parameters and Balance Function in Patients with Lower Limb Spasm after Stroke by ZHENG Bao, LIU Yiwen, WANG Zongbao, XU Wanyue, XIONG Shanshan

“…ObjectiveTo investigate the correlation between electromyography (EMG) parameters of bilateral lower limb muscles and standing balance parameters in patients with hemiplegic lower limb spasm after stroke, and to provide basis for rehabilitation and treatment of balance function in patients with lower limb spasm after stroke.MethodsA total of 30 patients with hemiplegic lower limb spasm after stroke were recruited as the patient group from Anhui Provincial Hospital of Integrated Traditional Chinese and Western Medicine, and 30 healthy people with no history of trauma, gender, age and body mass index (BMI) matched were selected as healthy control group (referred to as healthy group). …”
Get full text

International diet quality index and revised diet quality index relationship with type 2 diabetes disease: a case-control study by Amr Ali Mohamed Abdelgawwad El-Sehrawy, Bilal AbdulMajeed Mukhlif, Enwa Felix Oghenemaro, M. M. Rekha, Rohit Kumawat, Shilpa Sharma, M. Ravi Kumar, Nagat Salah Shalaby, Munthar Kadhim Abosaoda, Abed J. Kadhim

“…Multivariable logistic regression analysis explored the relationship between DQI-I, DQI-R, and their components with T2DM development odds.ResultsThe mean (SD) age and body mass index (BMI) of participants, comprising 53.7% men, were 37.8 (7.8) years and 27.7 (3.3) kg/m2, respectively. …”
Get full text

Associations of co-exposure to polycyclic aromatic hydrocarbons and vitamin D with early lung dysfunction: Mediating roles of metabolic score-visceral adiposity index by Baihao Lin, Wanlu Liu, Hank-Han Wang, Haixia Qian, Xinyu Zhu, Mengya Xu, Yuyu Zheng, Nada Alhazmi, Yansen Bai

“…Decreased associations of ΣOH-PAHs with FEV1, FVC, and early lung dysfunction, as well as with metabolic score-visceral adiposity index (MSV) were visualized with increased Σ25(OH)D among subjects with body mass index (BMI) < 28 kg/m2. Furthermore, 2.18 %, 18.20 %, 5.70 %, and 4.70 % of the associations of co-exposure to ΣOH-PAHs and Σ25(OH)D with FEV1, FVC, FEV1/FVC, and early lung dysfunction disease were mediated by MSV. …”
Get full text

Investigating service delivery and perinatal outcomes during the low prevalence first year of COVID-19 in a multiethnic Australian population: a cohort study by Vincent W Lee, N Wah Cheung, Dharmintra Pasupathy, Sarah J Melov, James Elhindi, Therese M McGee, Seng Chai Chua, Justin McNab, Thushari I Alahakoon

“…Multivariate logistic regression analysis was conducted adjusting for confounders including age, area-level socioeconomic status, gestation, parity, ethnicity and body mass index.Setting Obstetric population attending three public hospitals including a major tertiary referral centre in Western Sydney, Australia.Participants Women who delivered with singleton pregnancies over 20 weeks gestation. …”
Get full text

Placental Vascular Malperfusion in Pregnancies With Congenital Heart Disease by Nour Rahnama, MD, Arthur Colson, MD, PhD, Pamela Baldin, MD, PhD, Agnès Pasquet, MD, PhD, Damien Gruson, MD, PhD, David Vancraeynest, MD, PhD, Christophe Beauloye, MD, PhD, Frédéric Debiève, MD, PhD, Sophie Pierard, MD, PhD

“…Methods: In this prospective single-center study, we enrolled pregnant women with CHD who were followed from March 2021 to June 2023, along with a control group matched for age, parity, and body mass index. Placentas were analyzed for MVM using a scoring system based on the Amsterdam Placental Workshop Group Consensus guidelines. …”
Get full text

Dietary Micronutrient Intake and the Prevalence of Metabolic Conditions among Children from the United States–Affiliated Pacific Region in the Children’s Healthy Living Program by Lucia A Seale, Ashley B Yamanaka, Kristi Hammond, Eunjung Lim, Lynne R Wilkens, Pauline McFall, Tanisha F Aflague, Patricia Coleman, Travis Fleming, Leslie Shallcross, Jonathan Deenik, Rachel Novotny

“…Objectives: The study examined the association between micronutrient intake with body mass index (BMI in kg/m2) and the presence of insulin resistance proxy, acanthosis nigricans (AN), in 3529 children aged 2–8 y from the USAP region in the Children’s Healthy Living study. …”
Get full text

Risk of neonatal SARS-CoV-2 infection: a retrospective cohort study based on infected mothers with gestational diabetes mellitus by Jing Ni, Yongfei Zheng, Jiaqi Tian, Jiaqi Tian, Jiaqi Tian, Lin Zhang, Lin Zhang, Lin Zhang, Shuyin Duan

“…Logistic regression analysis identified an interaction between maternal SARS-CoV-2 infection and GDM on neonatal infection, where maternal SARS-CoV-2 infection (odds ratio [OR] = 0.31, 95%CI: 0.22-0.44) and vaccination for anti-SARS-CoV-2 (OR = 0.70, 95%CI: 0.50-0.98) were associated with lower odds of neonatal infection, while higher pre-pregnancy body mass index (BMI) (OR = 1.06, 95% CI: 1.02-1.10) and GDM (OR = 1.97, 95%CI: 1.21-3.21) were associated with higher odds of neonatal infection.ConclusionsWe demonstrate that the coexistence of GDM and perinatal SARS-CoV-2 infection was associated with an increased probability of neonatal SARS-CoV-2 infection.…”
Get full text

Assessment of six insulin resistance surrogate indexes for predicting stroke incidence in Chinese middle-aged and elderly populations with abnormal glucose metabolism: a nationwide... by Luqing Jiang, Tengxiao Zhu, Wenjing Song, Ying Zhai, Yu Tang, Fengxia Ruan, Zichen Xu, Lei Li, Xia Fu, Daoqin Liu, Aidong Chen, Qiwen Wu

“…Abstract Background Estimate glucose disposal rate (eGDR), Chinese visceral adiposity index (CVAI), triglyceride-glucose (TyG), TyG-body mass index (TyG-BMI), metabolic score for insulin resistance (METS-IR), and atherogenic index of plasma (AIP) are considered surrogate indexes of insulin resistance (IR). …”
Get full text

Ventilatory variables and computed tomography features in COVID-19 ARDS and non–COVID-19-related ARDS: a prospective observational cohort study by Li-Chung Chiu, Hsin-Hsien Li, Yu-Hsiang Juan, How-Wen Ko, Scott Chih-Hsi Kuo, Chung-Shu Lee, Tien-Ming Chan, Yu-Jr Lin, Li-Pang Chuang, Han-Chung Hu, Kuo-Chin Kao, Ping-Chih Hsu

“…In the non–COVID-19 group, body mass index, immunocompromised status, SOFA score, MP/PBW and total CT severity scores were independently associated with mortality. …”
Get full text

The Burden of Type 2 Diabetes in Adolescents and Young Adults in China: A Secondary Analysis from the Global Burden of Disease Study 2021 by Junting Yang, Siwei Deng, Houyu Zhao, Feng Sun, Xiantong Zou, Linong Ji, Siyan Zhan

“…The proportion of early-onset T2D within the total T2D burden fluctuated but remained higher than global levels. In 2021, high body mass index (BMI) was the primary attributable risk factor for DALYs of early-onset T2D (59.85%, 95% UI: 33.54% to 76.65%), and its contribution increased substantially from 40.08% (95% UI: 20.71% to 55.79%) in 1990, followed by ambient particulate matter pollution (14.77%, 95% UI: 8.24% to 21.24%) and diet high in red meat (9.33%, 95% UI: −1.42% to 20.06%). …”
Get full text

Identification of multiple complications as independent risk factors associated with 1-, 3-, and 5-year mortality in hepatitis B-associated cirrhosis patients by Duo Shen, Ling Sha, Ling Yang, Xuefeng Gu

“…The key predictive factors included posthospitalisation fever (PHF), body mass index (BMI), retinol binding protein (RBP), total bilirubin (TB) levels, and eosinophils (EOS). …”
Get full text

Sex differences in the relationships between 24-h rest-activity patterns and plasma markers of Alzheimer’s disease pathology by Maxime Van Egroo, Elise Beckers, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Heidi I. L. Jacobs

“…Multiple linear regression models were adjusted for age, sex, education, body mass index, and actigraphic recording duration. Results Higher IV, indicating worse 24-h rest-activity rhythm fragmentation, was associated with elevated levels of plasma NfL (t(85) = 4.26, P < 0.0001), GFAP (t(85) = 2.49, P = 0.01), and at trend level with lower Aβ42/40 ratio values (t(85) = -1.95, P = 0.054). …”
Get full text