Editorial: Viral infection pathogenesis and pathology in nervous system by A. Alwin Prem Anand

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Exploring the microbiota-gut-brain axis: impact on brain structure and function by Lidya K. Yassin, Mohammed M. Nakhal, Alreem Alderei, Afra Almehairbi, Ayishal B. Mydeen, Amal Akour, Mohammad I. K. Hamad

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Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein by Marie-Lynn Cuypers, Tom Jaspers, Jarne Clerckx, Simon Leekens, Christopher Cawthorne, Guy Bormans, Frederik Cleeren, Nick Geukens, Bart De Strooper, Maarten Dewilde

Subjects: “…Blood–brain barrier…”
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Endothelial and neuronal engagement by AAV-BR1 gene therapy alleviates neurological symptoms and lipid deposition in a mouse model of Niemann-Pick type C2 by Charlotte Laurfelt Munch Rasmussen, Signe Frost Frederiksen, Christian Würtz Heegaard, Maj Schneider Thomsen, Eva Hede, Bartosz Laczek, Jakob Körbelin, Daniel Wüstner, Louiza Bohn Thomsen, Markus Schwaninger, Ole N. Jensen, Torben Moos, Annette Burkhart

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Systematic review of amyloid-beta clearance proteins from the brain to the periphery: implications for Alzheimer’s disease diagnosis and therapeutic targets by Letian Huang, Mingyue Liu, Ze Li, Bing Li, Jiahe Wang, Ke Zhang

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Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody by Eva Schlein, Ken G. Andersson, Tiffany Dallas, Stina Syvänen, Dag Sehlin

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Tiny but mighty, an exploration of microbes and plants as sources of small novel bioactive compounds against invasive mycoses. by Hannah Mai Peacock, James Anthony O'Connor

Subjects: “…blood-brain barrier…”
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miRNAs Participate in MS Pathological Processes and Its Therapeutic Response by Ting Wu, Guangjie Chen

“…It is believed that the increased migration of autoreactive lymphocytes across the blood-brain barrier (BBB) may be responsible for axonal demyelination of neurons. …”
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Efficacy of human umbilical cord mesenchymal stem cell in the treatment of neuromyelitis optica spectrum disorders: an animal study by Chunran Xue, Haojun Yu, Xuzhong Pei, Xiaoying Yao, Jie Ding, Xiying Wang, Yi Chen, Yangtai Guan

“…Conclusion Our results revealed that hUC-MSCs displayed therapeutic efficacy in NMOSD and showed potential in attenuating blood–brain barrier disruption, as well as AQP4 IgG and complement-induced astrocyte apoptosis.…”
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Parkinson’s disease and exosomes: from pathogenesis to diagnosis and treatment by A. Mišeikaitė, P. Vaitkienė

“…There is growing evidence of the importance of exosomes for cell-to-cell communication, mediating the exchange of biological information and substances, and the ability to cross the blood-brain barrier. Due to their ability to cross the blood-brain barrier, exosomes may be promising for drug or molecular transportation and help in the development of more effective treatments for PD and other diseases of the nervous system. …”
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Matrix Metalloproteinases in patients with Multiple Sclerosis. by Rebeca A. Fernández Carriera, Lourdes Fernández Queija, Rosa F. Lara Rodríguez, José Cabrera Gómez, Idalmis Suárez Luis, Mabel María León Ortiz, Sergio González García, Alina González-Quevedo Monteagudo

“…<strong>Fundament:</strong> The proteolitic rupture of the extracellular matrix due to metalloproteinase 2 and 9 is one of the aspects that can influence in the alteration of the permeability of the blood-brain barrier (BBB) in multiple sclerosis. <strong>Objective:</strong> To determine metalloproteinase activity with gelatinous activity in patients suffering from multiple sclerosis. …”
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Posterior Reversible Encephalopathy Syndrome as Presenting Form of Very Early Systemic Sclerosis by María Isabel Pedraza, Julia Barbado, Marina Ruiz, Ángel Luis Guerrero

“…Its mechanism depends on failure of the blood-brain barrier due to high systemic blood pressure (BP) and loss of integrity of vascular endothelium related with different triggers. …”
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Esophageal Gastrointestinal Stromal Tumor with Rare Intracranial Metastasis by José Carvalho, Margarida Teixeira, Francisco Teixeira Silva, Alexandra Esteves, Carlos Ribeiro, Diana Guerra

“…New tyrosine kinase inhibitors that may cross the blood-brain barrier could be the answer to these cases.…”
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Effect of Acupuncture on MMP-2/9 and VEGF Expression in Intracerebral Hemorrhage Model Rats by Xinyi HUANG, Zhuolin YANG, Qiulei MA, Qingzhang ZHOU, Xiaozhuo SUN

“…The VEGF-positive cells in the blood-brain barrier of 3,9 h acupuncture groups were significantly lower than the model group at the same time point, but, VEGF-positive cells of 24,48 h acupuncture groups was significantly more than the model group at the same time point, with statistically significant differences (<italic>P</italic>&lt;0.05).Conclusion:Acupuncture Neiguan and Shuigou at different time points can inhibit the expression of MMP-2/9 positive cells of rats with intracerebral hemorrhage and increase the expression of VEGF positive cells, and the earlier the acupuncture time after cerebral hemorrhage, the more can it promote angiogenesis and nerve regeneration, to protect the brain's nervous system.…”
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A Diet Enriched in Docosahexanoic Acid Exacerbates Brain Parenchymal Extravasation of Apo B Lipoproteins Induced by Chronic Ingestion of Saturated Fats by Menuka M. Pallebage-Gamarallage, Virginie Lam, Ryusuke Takechi, Susan Galloway, John C. L. Mamo

“…Chronic ingestion of saturated fatty acids (SFAs) was previously shown to compromise blood-brain barrier integrity, leading to brain parenchymal extravasation of apolipoprotein B (apo B) lipoproteins enriched in amyloid beta. …”
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Application of the Box–Behnken Design in the Development of Amorphous PVP K30–Phosphatidylcholine Dispersions for the Co-Delivery of Curcumin and Hesperetin Prepared by Hot-Melt Ex... by Kamil Wdowiak, Lidia Tajber, Andrzej Miklaszewski, Judyta Cielecka-Piontek

“…In vitro permeability across the gastrointestinal tract and blood–brain barrier was evaluated using the parallel artificial membrane permeability assay. …”
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Systematic Study of Steroid Drugs’ Ability to Cross Biomembranes—The Possible Environmental Impact and Health Risks Associated with Exposure During Pregnancy by Anna W. Sobańska, Aleksandra Orlikowska, Karolina Famulska, Lovro Bošnjak, Domagoj Bosiljevac, Aleksandra Rasztawicka, Andrzej M. Sobański

“…Thirty-seven steroid drugs of different types were investigated in silico for their environmental and pharmacokinetic properties (partition between soil and water, bioaccumulation in aquatic organisms, ability to be absorbed from the gastrointestinal tract and to cross biological barriers—skin, blood–brain barrier and placenta) using on-line tools and novel QSAR models. …”
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Disseminated Histoplasmosis with Miliary Histoplasmosis, Neurohistoplasmosis, and Histoplasma capsulatum Bacteremia in Probable Neurosarcoidosis by Peter V. Bui

“…Patients with neurosarcoidosis are suspected to have blood-brain barrier dysfunction. Lumbar puncture should be considered as part of initial investigative studies for infection. …”
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Chemokines and Chemokine Receptors in Multiple Sclerosis by Wenjing Cheng, Guangjie Chen

“…The migration of autoimmune T cells and macrophages from blood to central nervous system as well as the destruction of blood brain barrier are thought to be the major processes in the development of this disease. …”
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The Role of C1-Esterase Inhibitors in the Management of Vasogenic Edema in Glioblastoma by Gillian R. Naro, Nicholas Noverati, Timothy Craig

“…As the tumor grows and disrupts the blood-brain barrier (BBB), vasogenic edema can result. The edema has the potential to significantly contribute to a patient’s morbidity and mortality. …”
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