Effects of Consuming Pulsed UV Light-Treated <i>Pleurotus citrinopileatus</i> on Vitamin D Nutritional Status in Healthy Adults by Chih-Ching Hsu, Chiao-Ming Chen, Yu-Ming Ju, Yu-Ching Wu, Huei-Mei Hsieh, Shu-Hui Yang, Chien-Tien Su, Te-Chao Fang, Widiastuti Setyaningsih, Sing-Chung Li

“…In a four-week randomized parallel trial, 36 healthy participants were assigned to three groups: a control group, a group consuming 10 g/day PUV-treated PC (PC-10 g), and a group consuming 100 g/day PUV-treated PC (PC-100 g). Blood samples collected pre- and post-intervention measured serum 25(OH)D₂, 25(OH)D₃, and biochemical parameters. …”
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Effect of glucagon-like peptide-1 receptor agonists on vascular risk factors among adults with type 2 diabetes and established atherosclerotic cardiovascular disease by Aaron King, Xi Tan, Neil Dhopeshwarkar, Rhonda Bohn, Katherine Dea, Charles E. Leonard, Adam de Havenon

“…Results: In the final cohorts ([1] OW GLP-1 RA including semaglutide: n = 20,084; [2] OW GLP-1 RA excluding semaglutide: n = 16,894; [3] semaglutide: n = 3,435), significant mean reductions (P < 0.001) were observed from baseline to post-index in hemoglobin A1c (%, [1] -1.1; [2] -1.1; [3] -1.2), low-density lipoprotein cholesterol (mg/dL, [1] -6.4; [2] -6.4; [3] -6.9), total cholesterol (mg/dL, [1] -11.0; [2] -11.1; [3] -10.7), triglycerides (mg/dL, [1] -31.8; [2] -31.4; [3] -33.1), systolic blood pressure (mmHg, [1] -1.5; [2] -1.2; [3] -3.1), body weight (kg, [1] -2.7; [2] -2.4; [3] -4.3) and body mass index (kg/m2; [1] -0.9; [2] -0.8; [3] -1.4). …”
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Assessing the Impact of Aldose Reductase (ALR2) Regulatory Gene Polymorphism in Diabetic Retinopathy Patients by Hadiza Rabe Musa, Amina Rabe Musa, Yahuza Gimba Muhammed, Usman Salisu Batagarawa, Aminu Ibrahim

“…The findings revealed a 6.7% prevalence of the SNP C(-106)T polymorphism. Fasting blood glucose and HbA1c levels were significantly (p<0.05) lower in the control group compared to the diabetic, cataract, and diabetic retinopathy groups. …”
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Protocol for a randomised ‘screen-and-treat’ Helicobacter pylori eradication trial in 14–18-years-old adolescents residing in three regions of Chile: effectiveness and microbiologi... by Ximena Aguilera, Camila Cabrera, Sergio George, Yalda Lucero, Beatriz Zabala Torres, Lilian Fernández, Nora Mamani, Anne Lagomarcino, Miguel O'Ryan

“…Follow-up will span up to 24 months post-treatment, involving UBT, gastroenterological assessments and blood and stool sample collections. Concurrently, a subset of 60 uninfected adolescents will undergo matched follow-up. …”
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Comprehensive safety and toxicity analysis of 2,2’-Bipyridine derivatives in combating MRSA biofilm formation and persistence by Priyanka, Priyanka, Mohini Sharma, Bhavna Vaid, Bhavna Vaid, Ram Bharti, Ram Bharti, Sachin Raut, Sachin Raut, R. S. Jolly, Neeraj Khatri, Neeraj Khatri

“…The murine thigh infection model was also used to investigate the in vivo efficacy.ResultsAll derivatives exhibited favorable physicochemical profiles and ADMET properties and are predicted to be safe based on their drug-like properties. in vitro studies demonstrated that derivatives are non-toxic to 3T3 L1, and in vivo studies confirmed their safety in mice at a dose of 300 mg/kg and their non-hemolytic nature against rabbit red blood cells. All compounds showed potent antibacterial activity against the tested bacteria, including the resistant MRSA strain 831. …”
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Genetic Markers Associated to Dyslipidemia in HIV-Infected Individuals on HAART by Rosmeri K. Lazzaretti, Aline S. Gasparotto, Marina G. de M. Sassi, Carísi A. Polanczyk, Regina Kuhmmer, Jussara M. Silveira, Rossana P. Basso, Cezar A. T. Pinheiro, Mariângela F. Silveira, Eduardo Sprinz, Vanessa S. Mattevi

“…This study evaluated the impact of 9 single nucleotide polymorphisms (SNPs) in 6 candidate genes (APOB, APOA5, APOE, APOC3, SCAP, and LDLR) over dyslipidemia in HIV-infected patients on stable antiretroviral therapy (ART) with undetectable viral loads. Blood samples were collected from 614 patients at reference services in the cities of Porto Alegre, Pelotas, and Rio Grande in Brazil. …”
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Related Pentacyclic Triterpenes Have Immunomodulatory Activity in Chronic Experimental Visceral Leishmaniasis by Jéssica Adriana de Jesus, Márcia Dalastra Laurenti, Leila Antonangelo, Caroline Silvério Faria, João Henrique Ghilardi Lago, Luiz Felipe Domingues Passero

“…Studies of toxicity in golden hamster showed that Lu did not alter blood biochemical parameters associated with liver and kidney functions; however, a slight increase of aspartate aminotransferase level in animals treated with 2.5 mg/kg of UA was detected. …”
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Effects of Ciprofol and Propofol General Anesthesia on Postoperative Recovery Quality in Patients Undergoing Ureteroscopy: A Randomized, Controlled, Double-Blind Clinical Trial by Shi S, Wu J, Wu Y, Han X, Dai H, Chen X, Sun Z, Wang F

“…There were no significant differences in time to spontaneous breathing recovery, extubation, recovery room stay, time to first ambulation, hospital stay, patient satisfaction, or other adverse events.Conclusion: Ciprofol provides comparable early postoperative recovery to Propofol during ureteroscopy and may be a preferable alternative for urological procedures, especially in patients with blood pressure concerns.Trial Registration: Chinese Clinical Trial Registry (ChiCTR2400082736).Keywords: ciprofol, propofol, postoperative recovery quality, ureteroscopic surgery…”
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Dopamine‐conjugated extracellular vesicles induce autophagy in Parkinson's disease by Jae Hoon Sul, Sol Shin, Hark Kyun Kim, Jihoon Han, Junsik Kim, Soyoung Son, Jungmi Lee, Seung Hyun Baek, Yoonsuk Cho, Jeongmi Lee, Jinsu Park, Donghoon Ahn, Sunyoung Park, Leon F. Palomera, Jeein Lim, Jongho Kim, Chanhee Kim, Seungsu Han, Ka Young Chung, Sangho Lee, Tae‐in Kam, Yunjong Lee, Jeongyun Kim, Jae Hyung Park, Dong‐Gyu Jo

“…Abstract The application of extracellular vesicles (EVs) as vehicles for anti‐Parkinson's agents represents a significant advance, yet their clinical translation is hampered by challenges in efficient brain delivery and complex blood‐brain barrier (BBB) targeting strategies. In this study, we engineered dopamine onto the surface of adipose‐derived stem cell EVs (Dopa‐EVs) utilizing a facile, two‐step cross‐linking approach. …”
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Unraveling the association and regulatory role of miR-146b-5p in coronary artery disease by Xiaozhu Ma, Shuai Mei, Yi He, Qidamugai Wuyun, Li Zhou, Ziyang Cai, Qiushi Luo, Yi Wen, Jiangtao Yan

“…In the study, we focus on the expression of miR-146b-5p in peripheral blood mononuclear cells (PBMCs) of patients with CAD and preliminarily investigate its function and underlying mechanism. …”
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D,L‐3‐hydroxybutyrate in the treatment of glucose transporter 1 deficiency syndrome (Glut1DS) by Aya Amer, Kathryn Murrell, Liza Edmonds, Isaac Bernhardt, Rhonda Akroyd, Bryony Ryder, Callum Wilson, Emma Glamuzina

“…Oral D,L‐3‐hydroxybutyrate (D,L‐3‐HB) crosses the blood–brain barrier, making it a potential treatment for Glut1DS. …”
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Mechanisms of the Effect of Starvation Duration on the Regulation of Feeding Rhythm and Metabolic Physiology of Cultured Large Yellow Croaker (<i>Larimichthys crocea</i>) by Xiaomeng Wang, Huang Liu, Chenglin Zhang, Chen Zhu, Huiyi Liu

“…It indicated that the rate of feeding of large yellow croaker was accelerated within 8 days of starvation, while the rate of feeding was slowed down at 16 days of starvation. Furthermore, the blood glucose concentration of large yellow croaker decreased significantly after 8 days of starvation, while it rebounded significantly in the S16 group. …”
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Set of 15 SNP-SNP Markers for Detection of Unbalanced Degraded DNA Mixtures and Noninvasive Prenatal Paternity Testing by Ranran Zhang, Yu Tan, Li Wang, Hui Jian, Jing Zhu, Yuanyuan Xiao, Mengyu Tan, Jiaming Xue, Fan Yang, Fan Yang, Weibo Liang

“…Besides, all fetal alleles in maternal plasma were confirmed by genotyping fetal genomic DNA from amniocentesis and paternal genomic DNA from peripheral blood. The results indicated that the SNP-SNP strategy based on the CE platform was useful for UDM detection and NIPPT.…”
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Temporal changes in plasma and milk lipids in response to an esophageal bolus of rumen-protected fish oil in lactating Holstein dairy cows by J.E. Rico, V. Sáinz de la Maza-Escolà, N.D. Senevirathne, P. Deme, N.J. Haughey, R. Gervais, J.W. McFadden

“…Cows were fed a total mixed ration to meet or exceed nutrient requirements and were milked thrice daily. Blood was sampled at 0, 2, 4, 6, 8, 10, 12, 16, 18, 20, 24, and 36 h, relative to bolus administration. …”
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Walnut oil prevents hyperlipidemia induced by high-fat diet and regulates intestinal flora and liver metabolism by Rui Yang, Dan Chen, Yanling Chen, Yage Ma, Chaoyin Chen, Shenglan Zhao

“…These findings indicated that walnut oil could improve the blood lipid profile in hyperlipidemia-model rats. …”
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Evaluation on role of the chest pain nurse in emergency management of patients with ST-elevation myocardial infarction (专职胸痛护士在ST段抬高型急性心肌梗死患者急救中的应用研究)... by QIAN Hongmei (钱宏梅), WEI Yingying (韦莹莹), WANG Yan (王艳)

“…Results The duration between hospital admission and admission to the emergency room, between hospital admission and first ECG diagnosis, between clinical admission and blood draw for cardiac troponin T test, cardiac troponin T test, between hospital admission and emergency room discharge, between catheterization room activation and catheterization room admission, between catheterization room admission and onset of PCU, Door-to-Balloon Time (D2B) in the experimental group was shorter than that in the control group, respectively (P＜0. 05). …”
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Fatal poisonings in Nordic countries in 2022 among people who use drugs by Pirkko Kriikku, Hilde Marie E. Edvardsen, Gunilla Thelander, Svava Thordardottir, Charlotte Uggerhøj Andersen, Ilkka Ojanperä, Anna K. Jönsson, Joachim Frost, Simon Kjær Hermansen, Gerd J.M. Delaveris, Kirsten Wiese Simonsen

“…This is the eighth report in a series of studies on PWUD conducted about every fifth year since 1984 by a working group representing Denmark, Finland, Iceland, Norway and Sweden.Data on the number of deaths, gender, age, place of death, main intoxicant, and drugs detected in blood were recorded. National data were compared between the Nordic countries as well as with the earlier studies. …”
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Cardiovascular disease attenuates the protective effect of folate on global cognitive function in an elderly population: a cross-sectional study by Jianqiang Zhang, Di Yue, Huifeng Zhang

“…However, there is a lack of systematic research on the association of dietary intake of folate and serum, and red blood cell (RBC) folate levels with global cognitive impairment (CoI) in the elderly population. …”
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Defining Nocturnal Polyuria in Adolescents by Tasmia Promi, Anthony Brooks, Gulzhan Tologonova, Marie-Claire Roberts, Sarita Dhuper, Meseret Tena, Oluwatoyin Bamgbola, Monique Hanono, Jeffrey P. Weiss, Karel Everaert, Tine DeBacker, Thomas F. Monaghan, Louis Salciccioli, Stephen Wadowski, Elka Jacobson-Dickman, Jason M. Lazar

“…On multivariable logistic regression with variables of sex, obesity, and elevated blood pressure, adding NUP as a categorical variable maximally increased the predictive value of the model upon utilizing a cutoff of 50 ml/h, increasing the R2 from 0.491 to 0.683. …”
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Tracking Immunity: An Increased Number of COVID-19 Boosters Increases the Longevity of Anti-RBD and Anti-RBD-Neutralizing Antibodies by Ching-Wen Hou, Stacy Williams, Veronica Boyle, Alexa Roeder, Bradley Bobbett, Izamar Garcia, Giavanna Caruth, Mitch Magee, Yunro Chung, Douglas F. Lake, Joshua LaBaer, Vel Murugan

“…Participants completed questionnaires about demographics, respiratory infection history, symptoms, and COVID-19 vaccination status. Blood samples were analyzed for anti-receptor binding domain (RBD) IgG and anti-nucleocapsid (NC) antibodies, offering a comprehensive view of immunity from both natural infection and vaccination. …”
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