Experimental paradigm to test the effects of providing social support: study protocol of the PROSPECT trial (Study 2) by Vivien Hajak, Simone Grimm, Ewa Gruszczyńska, Aleksandra Kroemeke, Natalia Józefacka, Lisa Marie Warner

“…Primary outcomes are immediate physiological (saliva cortisol, heart rate, heart rate variability, blood pressure), affective (positive and negative affect, anxiety), self-evaluative (e.g., self-esteem) and relationship outcomes. …”
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Cerebral hemodynamics and oxygen metabolism in patients with milder and severe forms of sickle cell disease and thalassemia by Liza Afzali‐Hashemi, Koen P. A. Baas, Anouk Schrantee, Erfan Nur, Chau Vu, Soyoung Choi, Silvie Suriany, John C. Wood, Aart J. Nederveen, Bart J. Biemond

“…In this work, we studied the cerebral hemodynamics and oxygen metabolism, and SCI lesion load in 75 severe and 26 mild adult SCD patients, 18 thalassemia patients (as anemic comparison group), and 30 healthy controls before and after a vasodilatory challenge with acetazolamide. Cerebral blood flow was significantly higher in patients with severe SCD and thalassemia compared to patients with mild SCD and controls (p < 0.05). …”
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Sequencing Analysis of Invasive Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Isolates Secondary to Gastrointestinal Colonization by Gaetano Maugeri, Maddalena Calvo, Dafne Bongiorno, Dalida Bivona, Giuseppe Migliorisi, Grete Francesca Privitera, Guido Scalia, Stefania Stefani

“…We described a six-month routine screening protocol from the Policlinico of Catania (Italy), while blood samples were collected from the same patients only in cases of a systemic infection suspicion. …”
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Liver Transplantation for Acute Liver Failure due to Mushroom Poisoning by Hayri Canbaz, Attila Bestemir, Sami Akbulut, Sezai Yilmaz, Yusuf Yavuz

“…No statistically significant differences were found between groups in terms of age, BMI, blood groups, hepatic encephalopathy grade, biochemical analysis obtained on the first days of hospital admission (AST, ALT, creatinine, ammonia, PTT, INR, albumin, platelets, HGB), ICU stay, cold ischemia time (CIT) and warm ischemia time (WIT), total bilirubin (P = .052), and time from poisoning to admission (P = .051). …”
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Disorders of circadian rhythms of heart rate variability in diabetic cardiac autonomic neuropathy: mechanisms and consequences by V.A. Serhiyenko, M.I. Dolynay, V.B. Sehin, Y.V. Lazur, A.A. Serhiyenko

“…Misalignment of circadian rhythms has been evidenced in patients with DM, and there is a close relationship between alterations in neuroendocrine sleep architecture, circadian clock oscillations, glucose metabolism, autonomic function, and diurnal profiles of blood pressure and heart rate. Metabolic syndrome, hypertension, myocardial infarction, and DM are characterized by increased SNS activity and decreased PSNS activity. …”
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Association between guidelines and medical practitioners’ perception of best management for patients attending with an apparently uncomplicated acute sore throat: a cross-sectional... by Alastair D Hay, Mark H Ebell, Ronny Gunnarsson, Pär-Daniel Sundvall, Katarina Hedin, Hannelore Wächtler, Naveen Manchal, Lynne Reid, Stefan Malmberg, Sean Hawkey

“…Objective To investigate the relationship between guidelines and the medical practitioners’ perception of optimal care for patients attending with an apparently uncomplicated acute sore throat in five countries (Australia, Germany, Sweden, UK and USA).Design International cross-sectional survey.Setting Primary healthcare (PHC).Participants Medical practitioners working in PHC.Main outcome measures ORs for: (A) perception of throat swabs as important, (B) perception of blood tests (C reactive protein, B-ESR and B-leucocytes) as important and (C) antibiotic prescriptions if no pathogenic bacteria isolated on throat swab.Results Guidelines differed significantly; those recommending throat swabs (Sweden and USA) were associated with practitioners perceiving them as important. …”
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Studying Alzheimer’s disease through an integrative serum metabolomic and lipoproteomic approach by Alessia Vignoli, Giovanni Bellomo, Federico Paolini Paoletti, Claudio Luchinat, Leonardo Tenori, Lucilla Parnetti

“…We hypothesize that metabolic alterations present at the level of the brain could be reflected at a systemic level in blood serum of patients, and that these alterations could be used as prognostic biomarkers. …”
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Inflammatory and immunological markers and risk for mortality and cognitive impairment in a longitudinal study of older adults from the longevous project by M.R. Caldeira, C.M. Almada-Filho, M.C. Brunialti, R. Salomão, M.S. Cendoroglo

“…Senescence of the immunological system is characterized by alterations in immune system cells associated with aging, often linked to cognitive disorders and mortality.Objective:To determine the prevalence of immunological changes, including immunological risk profile (IRP), and its association with cognitive impairments or mortality in oldest-old individuals.Method:A longitudinal study of 201 older adults aged ≥80 years, able to walk unaided, with no cognitive or immunological impairment, and with no serious disease at baseline was conducted. Blood samples were collected at 2-year intervals between 2012 and 2014 during the morning period. …”
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Identification of Potential Biomarkers and Immune Features of Sepsis Using Bioinformatics Analysis by Fang-Chen Gong, Ran Ji, Yu-Ming Wang, Zhi-Tao Yang, Ying Chen, En-Qiang Mao, Er-Zhen Chen

“…The three datasets included 156 whole blood RNA samples from 89 sepsis patients and 67 healthy controls. …”
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Proximal tubule-on-chip as a model for predicting cation transport and drug transporter dynamics by Isy Petit, Quentin Faucher, Jean-Sébastien Bernard, Perrine Giunchi, Antoine Humeau, François-Ludovic Sauvage, Pierre Marquet, Nicolas Védrenne, Florent Di Meo

“…Using the RPTEC/TERT1 cell line, we set up a dual-flow system with antiparallel flows to mimic the dynamics of blood and urine. We assessed transporters mRNA expression, cellular polarization and protein expression via immunofluorescence, and monitored the transcellular transport of prototypic xenobiotics by determining their efflux ratios. …”
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Insulin Treatment Perception and Factors affecting the Acceptance in Type 2 Diabetes Mellitus Patients attending a Specialist Clinic in Ilorin, Nigeria by Olalekan A. Agede, John Kola Olarinoye, James Ayodele Ogunmodede, Nasiru Sanni, Matthew Olumuyiwa Bojuwoye, Christopher Muyiwa Opeyemi, Mary Olufunmilayo Ologe, Dapo S Oyedepo

“…Some insulin-experienced patients had positive perceptions of insulin, like their belief in insulin’s health benefits (p = 0.001) and ability to control blood glucose (p = 0.048). Insulin-naive individuals exhibited more negative attitudes toward insulin, emphasizing the need for targeted interventions and patients’ health education. …”
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Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic Rats by Anderson Kiyoshi Kaga, Pedro Octavio Barbanera, Nágilla Orleanne Lima do Carmo, Lucas Rodolfo de Oliveira Rosa, Ana Angélica Henrique Fernandes

“…After the experimental period, blood and cardiac tissue samples were collected to analyze energetic metabolism, lipid profile, and AI. …”
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Comparative evaluation of funduscopy, PCR and serology in the diagnosis of ocular toxoplasmosis at ECWA Eye Hospital, Kano by Biodun Bintu Adebakin, Mayor Orezime Atima, Ugbede Idakwo, Jamilu Abubakar Bala, Alhasan Sharif Abdullahi, Auwal Bello Muhammad, Jah Douglas Pam, Emeka John Dingwoke, Florence Olufunke Darda

“…Additionally, PCR was used to confirm the presence of T. gondii DNA in blood samples. The results from these methods were compared with assess their sensitivity, specificity and diagnostic value.Results Funduscopy detected T. gondii in 25.4% (67/264) of the patients, while ELISA showed a higher detection rate of 36.7% (97/264). …”
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Dietary and plasma atherogenic and thrombogenic indices and cardiometabolic risk factors among overweight and individuals with obesity by Reyhaneh Mokhtari, Mahdieh Abbasalizad Farhangi

“…Participants in the highest tertile of AIP had higher systolic blood pressure (SBP: 132 ± 8 mmHg vs. 118 ± 6 mmHg in lower tertile, p < 0.001), total cholesterol (TC: 210 ± 15 mg/dL vs. 185 ± 12 mg/dL, p < 0.001), triglycerides (TG: 180 ± 20 mg/dL vs. 120 ± 15 mg/dL, p < 0.001), and glucose concentrations (fasting glucose: 105 ± 10 mg/dL vs. 90 ± 8 mg/dL, p < 0.001). …”
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Burn wound healing using adipose-derived mesenchymal stem cells and manganese nanoparticles in polycaprolactone/gelatin electrospun nanofibers in rats by Azin Shahmohammadi, Hadi Samadian, Saeed Heidari Keshel, Khodabakhsh Rashidi, Amir Kiani, Masoud Soleimani, Farjam Goudarzi

“…Methods: After the synthesis of nanoparticles and electrospinning of nanofibers, the SEM analysis, contact angle, mechanical strength, blood compatibility, porosity, swelling, biodegradability, cell viability, and adhesion assays were performed. …”
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Anti-Tissue-Transglutaminase IgA Antibodies Presence Determination Using Electrochemical Square Wave Voltammetry and Modified Electrodes Based on Polypyrrole and Quantum Dots by Angela Gabriela Pãun, Simona Popescu, Alisa Ioana Ungureanu, Roxana Trusca, Alina Popp, Cristina Dumitriu, George-Octavian Buica

“…The novel electrode measures anti-tissue antibody levels in real time using human blood serum samples. The modified electrode has great repeatability and an 8.7 U/mL detection limit. …”
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Cohort profile: the East London Health and Care Partnership Data Repository: using novel integrated data to support commissioning and research by George Howard, Kamaldeep Bhui, Amy Ronaldson, Evangelos Chandakas, Qiongwen Kang, Katie Brennan, Aminat Akande, Irene Ebyarimpa, Eleanor Wyllie, Richard Fradgley, Mark Freestone

“…Data completeness for risk factors (eg, blood pressure, cholesterol) was high in patients with long-term conditions.Future plans The data are being further cleaned and evaluated using imputation, Bayesian and economic methods, principally focusing on specific cohorts, including type II diabetes, depression and personality disorder. …”
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A Comparative Study of the Metabolic and Skeletal Response of C57BL/6J and C57BL/6N Mice in a Diet-Induced Model of Type 2 Diabetes by Elizabeth Rendina-Ruedy, Kelsey D. Hembree, Angela Sasaki, McKale R. Davis, Stan A. Lightfoot, Stephen L. Clarke, Edralin A. Lucas, Brenda J. Smith

“…C57BL/6N mice on a HF diet demonstrated an increase in plasma insulin and blood glucose as early as 4 wk, whereas these responses were delayed in the C57BL/6J mice. …”
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The association of dietary approaches to stop hypertension measured by the food frequency questionnaire with metabolic syndrome and some inflammatory biomarkers in adolescents with... by Maryam Behrooz, Alireza Ostadrahimi, Samaneh Hajjarzadeh, Mirhadi Mousavi, Afshin Ghalegolab Behbahani, Siamak Shiva

“…Adolescents with metabolic syndrome had significantly higher concentrations of triglycerides, low HDL-C, and high blood pressure compared with those without metabolic syndrome (P < 0.05). …”
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Role of Paricalcitol in Modulating the Immune Response in Patients with Renal Disease by Silvia Lucisano, Adriana Arena, Giovanna Stassi, Daniela Iannello, Gaetano Montalto, Adolfo Romeo, Giuseppe Costantino, Rosaria Lupica, Valeria Cernaro, Domenico Santoro, Michele Buemi

“…Serum calcium, phosphorus, 25(OH)-vitamin D, parathyroid hormone (PTH), erythrocyte sedimentation rate, high-sensitivity C-reactive protein, interleukin- (IL-) 17, IL-6, IL-1β, interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), plasmatic and urinary NGAL, and 24 h albuminuria and proteinuria were measured before and 24 h after an intravenous bolus of paricalcitol (5 mcg). Human peripheral blood mononuclear cells were isolated and stimulated with phytohaemagglutinin. …”
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