Early Healing Events around Titanium Implant Devices with Different Surface Microtopography: A Pilot Study in an In Vivo Rabbit Model by Ester Orsini, Stefano Salgarello, Désirée Martini, Beatrice Bacchelli, Marilisa Quaranta, Luciano Pisoni, Emma Bellei, Monika Joechler, Vittoria Ottani

“…In fact, SLA devices showed a more osteoconductive behavior retaining a less dense blood clot, which might be earlier and more easily replaced, and leading to a surface-conditioning layer which promotes osteogenic cell differentiation and appositional new bone deposition at the titanium surface. …”
Get full text

The concept of natural genome reconstruction. Part 1. Basic provisions of the “natural genome reconstruction” concept. Changing the genome of hematopoietic stem cells using several... by L. A. Yakubov, O. S. Taranov, S. V. Sidorov, S. D. Nikonov, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev

“…Such events can form the basis for the rejuvenation of the blood-forming cell system. The results of the laboratory’s work indicate that other stem cells in the body capture extracellular DNA fragments too. …”
Get full text

Computer-Aided Construction and Evaluation of Poly-L-Lysine/Hyodeoxycholic Acid Nanoparticles for Hemorrhage and Infection Therapy by Qin Qin, Wenxing Wu, Ling Che, Xing Zhou, Diedie Wu, Xiaohui Li, Yumin Yang, Jie Lou

“…<b>Results:</b> PLL-HDCA NPs demonstrated effective induction of platelet aggregation and significantly reduced bleeding time and blood loss in mouse models, including tail vein, femoral vein, artery, and liver bleeding. …”
Get full text

Multicomponent Dietary Supplementation: Impact on Tear Secretion and Ocular Surface Inflammation in Dry Eye Syndrome Patients by Shih-Chien Huang, Yen-Ping Lei, Min-Chien Hsiao, Yu-Kai Hsieh, Quei-Ping Tang, Connie Chen, Min-Yen Hsu

“…The participants were evaluated using Schirmer’s test and the ocular surface disease index (OSDI) as ocular surface parameters. Moreover, blood or tear oxidative stress, antioxidant capacities, and tear inflammatory indicators were measured at weeks 0 and 12. …”
Get full text

Nocardiosis in Renal Allograft Recipients by Chilaka Rajesh, Athul Thomas, Jeethu Joseph Eapen, Sabina Yusuf, Elenjickal Elias John, Anna T. Valson, Suceena Alexander, Vinoi George David, Joy Sarojini Michael, Santosh Varughese

“…The diagnosis was made by isolating the organism in culture from one or more of the following samples: sputum, blood, pus, or lung biopsy (either computed tomography [CT]-guided or bronchoscopic aspirate culture). …”
Get full text

Systemic Inflammatory Effects of Traumatic Brain Injury, Femur Fracture, and Shock: An Experimental Murine Polytrauma Model by C. Probst, M. J. Mirzayan, P. Mommsen, C. Zeckey, T. Tegeder, L. Geerken, M. Maegele, A. Samii, M. van Griensven

“…Subjects were sacrificed at 96 h. Blood was analysed for cytokines and by flow cytometry for lymphocyte populations. …”
Get full text

Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants by Shujun Lin, Wenshan Lin, Chunling Liao, Tianbiao Zhou

“…Furthermore, a difference in blood urea nitrogen levels between the MSC treatment group and control group was observed for 2-3, 4-5, 6-8, and ≥28 days. …”
Get full text

Regulation of energy balance by leptin as an adiposity signal and modulator of the reward system by Roshanak Asgari, Maria Caceres-Valdiviezo, Sally Wu, Laurie Hamel, Bailey E. Humber, Sri Mahavir Agarwal, Paul J. Fletcher, Stephanie Fulton, Margaret K. Hahn, Sandra Pereira

“…Obesity is characterized by expanded adipose tissue mass and consequently, elevated concentrations of leptin in blood. Leptin's therapeutic potential for most forms of obesity is hampered by leptin resistance and a narrow dose–response window. …”
Get full text

To Investigate the Associations of Dyslipidemia and BMI, as Risk Factors Leading to Insulin Resistance and Development of Type2 Diabetes Mellitus in Baqubah City by Safa Nadhum Mohammed, Walaa Esmael Jassim, Najah Ali Mohammed

“… Insulin resistance is a condition in which persons with type 2 diabetes make insulin but is unable to use it properly to transfer glucose into cells, resulting in high blood glucose levels. Obesity, particularly visceral fat (fat surrounding the organs) is a major cause of insulin resistance. …”
Get full text

Deep learning–assisted diagnosis of acute mesenteric ischemia based on CT angiography images by Lei Song, Xuesong Zhang, Jian Zhang, Jie Wu, Jinkai Wang, Feng Wang

“…PurposeAcute Mesenteric Ischemia (AMI) is a critical condition marked by restricted blood flow to the intestine, which can lead to tissue necrosis and fatal outcomes. …”
Get full text

The potential of serum elabela levels as a marker of diabetic retinopathy: results from a pilot cross-sectional study by Muhammed Seyithanoğlu, Selma Meşen, Aysegul Comez, Ali Meşen, Abdullah Beyoğlu, Yaşarcan Baykişi, Filiz Alkan Baylan

“…A control group (n = 20) consisted of individuals without DM. Blood samples were collected during outpatient clinic admission to measure serum ELA levels, which were determined using a commercial ELISA kit. …”
Get full text

Consequences of the Lack of CD73 and Prostatic Acid Phosphatase in the Lymphoid Organs by Gennady G. Yegutkin, Kaisa Auvinen, Marika Karikoski, Pia Rantakari, Heidi Gerke, Kati Elima, Mikael Maksimow, Ileana B. Quintero, Pirkko Vihko, Marko Salmi, Sirpa Jalkanen

“…Single knockouts had decreased number of CD4+/CD25+/FoxP3+ regulatory T cells in thymus and CD73/PAP double knockouts exhibited reduced percentages of CD4+ cells in spleen, regulatory T cells in lymph nodes and thymus, and CD4+ and CD8+ cells in blood. These findings suggest that PAP has a synergistic role together with CD73 in the immune system by contributing to the balance of leukocyte subpopulations and especially to the number of regulatory T cells in lymph nodes and thymus.…”
Get full text

The Role of Serum Vitamin D Levels and Vitamin D Receptor (<i>VDR</i>) Gene Variants on Dental Caries by Ece Şengün Berber, Feyza Umay Koç, Ayça Aykut, Burcu Barutçuoğlu, Fahinur Ertuğrul, Merve Tosyalı, Mert Pekerbaş, Arzu Aykut Yetkiner

“…Methods: This study included 128 3–6-year-old children who were divided into 64 caries-free and 64 carious children. Blood samples were taken, and serum 25-hydroxyvitamin D levels were measured. …”
Get full text

Precise and interpretable neural networks reveal epigenetic signatures of aging across youth in health and disease by David Martínez-Enguita, Thomas Hillerton, Julia Åkesson, Daniel Kling, Maria Lerm, Mika Gustafsson

“…Here, we propose that the reliability of DNAm age clocks should stem from their capacity to detect comprehensive and targeted aging signatures.MethodsWe compiled publicly available DNAm whole-blood samples (n = 17,726) comprising the entire human lifespan (0–112 years). …”
Get full text

Thromboelastography in Patients with Inflammatory Bowel Disease by Yonghua Shen, Liangliang Shi, Juanjuan Zhang, Hao Zhu, Yuling Yao, Zhenqing Liu, Xiaoping Zou, Xiaoqi Zhang

“…Thirty-four patients with CD, 29 patients with UC, and 53 healthy volunteers were enrolled into this study. Blood levels of R, K, α Angle, G, maximal amplitude (MA), and LY30 with TEG were determined. …”
Get full text

Helicobacter pylori Infection and Anemia in Taiwanese Adults by Hsiang-Yao Shih, Fu-Chen Kuo, Sophie S. W. Wang, Yi-Chang Liu, Meng-Chieh Wu, Yang-Pei Chang, Guei-Fen Chiu, Pi-Yu Chang, Deng-Chyang Wu, Ming-Chia Hsieh, Yao-Li Chen

“…The status of Helicobacter pylori (H.p) infection was confirmed and blood samples from the same participants were taken on the same day to check the level of hemoglobin, serum iron, ferritin, and total iron-binding capacity (TIBC). …”
Get full text

Is There a Mild Form of Pediatric Appendicitis? An Eight-Year Single-Center Retrospective Review by Eric Scheier, Khaled Khalilia, Pavel Peslin, Stav Amir, Luba Pasherstnik Bizer

“…Fourteen had spontaneous resolution and twenty-five were treated medically. White blood cell count (14.1 versus 10.2, <i>p</i> = 0.005) and appendiceal diameter (8.6 mm versus 7.6 mm, <i>p</i> = 0.078) were higher for children with conservative treatment. …”
Get full text

Assessment of effectiveness of oral supplementation of isolated fiber of carrot on metabolic parameters in mature rats by Maria Rosana Ramirez, Debora Manuale, Juan Carlos Yori

“…The groups were as follows: animals fed a standard diet, control group; high fiber supplementation (70 mg); low fiber supplementation (35 mg); for 12 weeks. Blood samples were collected at the time of sacrifice. …”
Get full text

The Role of PDGFs and PDGFRs in Colorectal Cancer by Roberta M. Manzat Saplacan, Loredana Balacescu, Claudia Gherman, Romeo I. Chira, Anca Craiu, Petru A. Mircea, Cosmin Lisencu, Ovidiu Balacescu

“…PDGFs are important growth factors for normal tissue growth and division, with an important role in blood vessel formation. PDGFs/PDGFRs signaling pathway has been demonstrated to be involved in angiogenesis mainly by targeting pericytes and vascular smooth muscle cells. …”
Get full text

Glycemic Variability Assessed by Continuous Glucose Monitoring and Short-Term Outcome in Diabetic Patients Undergoing Percutaneous Coronary Intervention: An Observational Pilot Stu... by Annunziata Nusca, Angelo Lauria Pantano, Rosetta Melfi, Claudio Proscia, Ernesto Maddaloni, Rocco Contuzzi, Fabio Mangiacapra, Andrea Palermo, Silvia Manfrini, Paolo Pozzilli, Germano Di Sciascio

“…However a complete assessment of glycemic status may not be fully described by glycated hemoglobin or fasting blood glucose levels, whereas daily glycemic fluctuations may influence cardiovascular risk and have even more deleterious effects than sustained hyperglycemia. …”
Get full text