Pooled screening for CAR function identifies novel IL-13Rα2-targeted CARs for treatment of glioblastoma by Douglas A Lauffenburger, Khloe S Gordon, Caleb R Perez, Andrea Garmilla, Maxine S Y Lam, Joey J Y Aw, Anisha Datta, Andrea Pavesi, Michael E Birnbaum

“…Nonetheless, they are of particular interest for the treatment of glioblastoma, which is an aggressive form of brain cancer with few effective therapeutic options, due to their ability to cross the highly selective blood-brain barrier.Methods Here, we use our pooled screening platform, CARPOOL, to expedite the discovery of CARs with antitumor functions necessary for solid tumor efficacy. …”
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Cervical Spinal Osteomyelitis with Epidural Abscess following an Escherichia coli Urinary Tract Infection in an Immunocompetent Host by Abdelmoniem Moustafa, Rowida Kheireldine, Zubair Khan, Hussam Alim, Mohammad Saud Khan, Mohd Amer Alsamman, Eslam Youssef

“…A 69-year-old male with a past medical history significant for prostatitis was admitted with fever, altered mental status, neck pain, progressive lower extremities weakness, and frequent falls for 7 days. Both blood and urine cultures grew E. coli. Lumbar puncture showed 94 RBCs, 24 WBCs (16% neutrophils and 46% lymphocytes), and elevated protein level at 1140 mg/dl with no bacteria. …”
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Prognostic value of atherogenic index of plasma in pulmonary hypertension by Meng-Qi Chen, An Wang, Chuan-Xue Wan, Bin-Qian Ruan, Jun Tong, Jie-Yan Shen

“…AIP was determined as the logarithm of the blood triglycerides ratio to high-density lipoprotein cholesterol.ResultsThe 1-year, 3-year, and 5-year incidence rates of clinical worsening outcomes in PH patients in this study were 20.0, 44.8, and 54.4%, respectively. …”
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Small Bowel Endoscopy Diagnostic Yield and Reasons of Obscure GI Bleeding in Chinese Patients by Ya-Fei He, Ning-Bo Hao, Wu-Chen Yang, Li Yang, Zhong-Li Liao, Chao-Qiang Fan, Jin Yu, Jian-Ying Bai, Shi-Ming Yang, Hong Guo

“…A lesion that was believed to be the source of the bleeding (ulceration, mass lesion, vascular lesion, visible blood, inflammation, or others) was considered to be a positive finding. …”
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Increased DNA Dicarbonyl Glycation and Oxidation Markers in Patients with Type 2 Diabetes and Link to Diabetic Nephropathy by Sahar Waris, Brigitte M. Winklhofer-Roob, Johannes M. Roob, Sebastian Fuchs, Harald Sourij, Naila Rabbani, Paul J. Thornalley

“…In a multiple logistic regression model for diabetic nephropathy, diabetic nephropathy was linked to systolic blood pressure and urinary CEdG. Conclusion. DNA oxidative and glycation damage-derived nucleoside adducts are increased in plasma and urine of patients with type 2 diabetes and further increased in patients with diabetic nephropathy.…”
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The Quebec Association of Gastroenterology Position Paper on Colorectal Cancer Screening - 2003 by AN Barkun, G Jobin, G Cousineau, S Dubé, R Lahaie, P Paré, B Stein, R Wassef

“…The objectives of the Association des gastro-entérologues du Québec Task Force were to determine the need for a policy on screening for colorectal cancer in Quebec, to evaluate the testing methods available and to propose one or more of these alternatives as part of a formal screening program, if indicated. Fecal occult blood testing (FOBT), endoscopy (including sigmoidoscopy and colonoscopy), barium enema and virtual colonoscopy were considered. …”
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Antioxidant and anti–inflammatory effects of Helichrysum plicatum DC. subsp. plicatum extract in an experimental model of acute urolithiasis by Selvinaz Yakan, Kıvılcım Eren Erdoğan, Yusuf Kenan Dağlıoğlu, Tuba Aydın, Ahmet Çakır

“…Additionally, oxalate (Ox), urea, calcium, and creatinine clearance levels were measured in both blood and urine, and routine histological evaluations were conducted. …”
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Revealing the impact of tadalafil-loaded proniosomal gel against dexamethasone-delayed wound healing via modulating oxido-inflammatory response and TGF-β/Macrophage activation path... by Nermin A Helmy, Elsayed A Abdel Aziz, Mustafa Abd El Raouf, Reda M S Korany, Doaa A Mansour, Sara M Baraka, Arwa A Hassan, Eman Gomaa, Mennatullah M Faisal, Walaa A A Basha, Esraa M Fahmy, Rashed A Alhotan, Anam Ayyoub, Shaimaa Selim

“…Moreover, the histopathological, Masson's Trichrome-stain, and immune-histochemical studies indicated a successful tissue recovery with the formation of new blood vessels in groups treated with TAD-loaded proniosomal gel, as manifested by well-organized collagen fibers, upregulation of transforming growth factor β1, and vascular endothelial growth factor immune expression in skin tissues (p < 0.05). …”
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Neutrophil Migration and Adhesion Molecule Expression after Acute High-Intensity Street Dance Exercise by Leandro Borges, Alexandre Dermargos, Stuart Gray, Maysa B. Barros Silva, Vinicius Santos, Tania Cristina Pithon-Curi, Renata Gorjão, Elaine Hatanaka

“…Fifteen amateur dancers (mean ± SE: age 22.4 ± 1.08 years, BMI 24.8 ± 0.69 kg/m2, and body fat 12.3 ± 1.52%) participated in a single high-intensity street dance class. Blood samples were taken before and after the class. …”
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Underlying Anticancer Mechanisms and Synergistic Combinations of Phytochemicals with Cancer Chemotherapeutics: Potential Benefits and Risks by Muhammad Ayaz, Asif Nawaz, Sajjad Ahmad, Osama F. Mosa, Alashary Adam Eisa Hamdoon, Modawy Alnour Khalifa, Abdul Sadiq, Farhat Ullah, Abdul Wadood, Atul Kabra, H. C. Ananda Murthy

“…The concomitant use of the majority of herbal medicines with chemotherapy has been demonstrated to be beneficial in multiple malignant tumors like cancer of blood, lungs, kidneys, liver, skin, and gastrointestinal tract. …”
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Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA): A Targeted Antioxidant Strategy to Counter Oxidative Stress in Retinopathy by Marco Zeppieri, Caterina Gagliano, Fabiana D’Esposito, Mutali Musa, Irene Gattazzo, Maria Sole Zanella, Federico Bernardo Rossi, Alessandro Galan, Silvia Babighian

“…Omega-3s have been shown to inhibit abnormal blood vessel growth in the retina, which is a significant factor in proliferative diabetic retinopathy and neovascular AMD. …”
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Endothelial cells under disturbed flow release extracellular vesicles to promote inflammatory polarization of macrophages and accelerate atherosclerosis by Zhe Hou, Li Deng, Fei Fang, Ting Zhao, Yaojia Zhang, Gang Li, Michael Z. Miao, Yongcang Zhang, Hongchi Yu, Xiaoheng Liu

“…ECs experience varying degrees and types of blood flow depending on their specific arterial locations. …”
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Recent advances in nanotechnology for Parkinson’s disease: diagnosis, treatment, and future perspectives by Virendra Kumar Yadav, Seshathiri Dhanasekaran, Nisha Choudhary, Deepak Nathiya, Vishal Thakur, Rachna Gupta, Sheersha Pramanik, Pankaj Kumar, Nishant Gupta, Ashish Patel

“…Nanomedicine utilizes nanoparticles for targeted drug delivery, leveraging their small size and high surface area to volume ratio to cross the blood-brain barrier and deliver therapeutic agents directly to affected brain regions. …”
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Preliminary and Comparative Experiment Study Between F-Flurpiridaz and N-NHHO Myocardial Perfusion Imaging With PET/CT in Miniature Pigs by Jiao Wang MD, Shuai Li Mpharm, Tian-wen Liu BS, Jie-min Zhang MD, PhD, Yue Chen MD, Jian-ming Li MD, PhD, Wen-gui Xu MD, PhD

“…The radioactive ratio of the left ventricular myocardium to cardiac blood pool and adjacent liver were high. Compared with 13 N-NH 3 ·H 2 O, there were no significant differences in functional parameters, including SRS, Extend, TPD and LVEF. …”
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Comparison of Initial Clinical Presentations between Primary Hyperparathyroidism Patients from New Brunswick and Changsha by Lingqiong Meng, Shuying Liu, Aseel Al-Dayyeni, Zhifeng Sheng, Zhiguang Zhou, Xiangbing Wang

“…The following characteristics were compared between the groups: age, gender, BMI, serum calcium, alkaline phosphatase (AKP), albumin, intact PTH (iPTH), 25-hydroxyvitamin D (25 (OH) D), fasting blood glucose levels, and bone mineral density (BMD). …”
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Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential by Masayo Aoki, Hiroaki Aoki, Rajesh Ramanathan, Nitai C. Hait, Kazuaki Takabe

“…The S1P concentration gradient between various tissues promotes S1PR1-dependent migration of T cells from secondary lymphoid organs into the lymphatic and blood circulation. S1P suppresses T cell egress from and promotes retention in inflamed peripheral tissues. …”
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Childhood occasional hypertension and its association with size at birth and early growth: a population-based retrospective cohort study from China by Shuang Zhang, Leishen Wang, Tao Zhang, Yijuan Qiao, Wei Li, Weiqin Li

“…Information on birth weight, body mass index (BMI) at 2 and 5 ~ 6 years old, and blood pressure at 5 ~ 6 years old was retrospectively collected. …”
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Elevation of Platelet and Monocyte Activity Markers of Atherosclerosis in Haemodialysis Patients Compared to Peritoneal Dialysis Patients by Ksenija Stach, Susanne Karb, Ibrahim Akin, Martin Borggrefe, Bernhard Krämer, Thorsten Kälsch, Anna-Isabelle Kälsch

“…For this prospective comparative study, HD patients (n=41) and PD patients (n=10) were included. In whole blood samples, surface expression of CD62P and CD40L on platelets, tissue factor binding on monocytes, and platelet-monocyte aggregates were measured by flow cytometry. …”
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Mast Cell Activation, Neuroinflammation, and Tight Junction Protein Derangement in Acute Traumatic Brain Injury by Duraisamy Kempuraj, Mohammad Ejaz Ahmed, Govindhasamy Pushpavathi Selvakumar, Ramasamy Thangavel, Sudhanshu P. Raikwar, Smita A. Zaheer, Shankar S. Iyer, Casey Burton, Donald James, Asgar Zaheer

“…We analyzed mast cell activation by toluidine blue staining, serum chemokine C-C motif ligand 2 (CCL2) level by enzyme-linked immunosorbent assay (ELISA), and proteinase-activated receptor-2 (PAR-2), a mast cell and inflammation-associated protein, vascular endothelial growth factor receptor 2 (VEGFR2), and blood-brain barrier tight junction-associated claudin 5 and Zonula occludens-1 (ZO-1) protein expression in the brains of TBI mice. …”
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Is Lipid Profile Associated with Bone Mineral Density and Bone Formation in Subjects with Spinal Cord Injury? by Hadis Sabour, Abbas Norouzi Javidan, Sahar Latifi, Mohammad Reza Hadian, Seyed-Hassan Emami Razavi, Farzad Shidfar, Mohammad Reza Vafa, Hamidreza Aghaei Meybodi

“…Dual-energy X-ray absorptiometry (DXA) was used to assess BMD in femoral neck, trochanter, intertrochanteric zone, and lumbar vertebras. Blood samples were taken to measure serums lipids and bone biomarkers including osteocalcin, cross-linked type I collagen (CTX), and bone alkaline phosphatase (BALP). …”
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