6-Gingerol Normalizes the Expression of Biomarkers Related to Hypertension via PPARδ in HUVECs, HEK293, and Differentiated 3T3-L1 Cells by Yong-Jik Lee, Yoo-Na Jang, Yoon-Mi Han, Hyun-Min Kim, Hong Seog Seo

“…In addition, various factors, such as genetic predisposition, lifestyle factors, and the abnormality of organs related to blood pressure, are involved in the development of hypertension. …”
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Experimental Study on the Effect of Allogeneic Endothelial Progenitor Cells on Wound Healing in Diabetic Mice by Min Leng, Ying Peng, Manchang Pan, Hong Wang

“…Endothelial progenitor cells (EPCs) are involved in the neovascularization in traumatic and ischemic sites, but EPCs are “detained” in bone marrow under diabetic conditions, which results in reduction of the number of EPCs and their biological activity in peripheral blood. Based on our previous study to mobilize autologous bone marrow EPCs by administering AMD3100+G-CSF to realize the optimal effect, our present study is aimed at exploring the effects of transplanting EPCs locally in a wound model of diabetic mice. …”
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Fever and infections in surgical intensive care: an American Association for the Surgery of Trauma Critical Care Committee clinical consensus document by Deborah M Stein, Hee Soo Jung, Lisa M Kodadek, Bryce Robinson, Aussama Khalaf Nassar, Joseph Cuschieri, Michael Steven Farrell, Abhijit Pathak, Samuel Mandell, Jasmeet Paul, Rachel D Appelbaum, Eden Nohra, Thomas Carver, Jordan Michael Kirsch

“…We discuss the evaluation of fever, the indications to obtain cultures including urine, blood, and respiratory specimens for diagnosis of infections, the use of procalcitonin, and the decision to initiate empiric antibiotics. …”
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Metabolomics approach reveals key plasma biomarkers in multiple myeloma for diagnosis, staging, and prognosis by Xiaoxue Wang, Longhao Cheng, Aijun Liu, Lihong Liu, Lili Gong, Guolin Shen

“…Abstract Background Multiple myeloma (MM) is the most aggressive and prevalent primary malignant tumor within the blood system, and can be classified into grades RISS-I, II, and III. …”
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Personal glucose meter-based portable method for creatine kinase assay by Jinhwan Lee, Yejin Oh, Hyoyong Kim, Sangmo Lee, Hyun Gyu Park

“…We also verified that the developed strategy can reliably detect CK activity in heterogeneous human blood, ensuring its robust utility in various clinical applications. …”
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Non-Drug and Non-Invasive Therapeutic Options in Alzheimer’s Disease by Alina Simona Șovrea, Adina Bianca Boșca, Eleonora Dronca, Anne-Marie Constantin, Andreea Crintea, Rada Suflețel, Roxana Adelina Ștefan, Paul Andrei Ștefan, Mădălin Mihai Onofrei, Christoph Tschall, Carmen-Bianca Crivii

“…Singly or as an applied technique to change the permeability of the blood–brain–barrier (BBB), FUS and TPS have demonstrated the benefits of use in treating AD in animal and human studies. …”
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Cholecystokinin (CCK) Is a Mediator Between Nutritional Intake and Gonadal Development in Teleosts by Hangyu Li, Hongwei Liang, Xiaowen Gao, Xiangtong Zeng, Shuo Zheng, Linlin Wang, Faming Yuan, Shaohua Xu, Zhan Yin, Guangfu Hu

“…Cholecystokinin (CCK) is a satiety neuropeptide derived from the hypothalamus, and the present study observed that hypothalamic CCK expression is significantly influenced by food intake, which is mediated through blood glucose levels. Interestingly, CCK and its receptors were observed to exhibit a high expression in the hypothalamus–pituitary–gonad (HPG) axis of grass carp (<i>Ctenopharyngodon idellus</i>), suggesting that CCK is potentially involved in regulating fish reproduction through the HPG axis. …”
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Effectiveness of Sambiloto (Andrographis paniculata) Supplementation on Antibody Titers of Newcastle Disease, Avian Influenza and Infectious Bursal Disease in Broilers by Madi Hartono, Muhammad Mirandy Pratama Sirat, Purnama Edy Santosa, Ratna Ermawati

“…Five treatments with different doses, namely drinking water without liquid extract of Andrographis paniculata (P0); drinking water with liquid extract of A. paniculata 3 mg/kg BW (P1); 6 mg/kg BW (P2); 12 mg/kg BW (P3); (24 mg/kg BW (P4) 31-day-old broiler blood serum was obtained from the brachial vein using a 3 mL disposable syringe. …”
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Evaluation of the Effect of Cichorium intybus L. on the Liver Enzymes in Burn Patients: A Randomized Double-Blind Clinical Trial by Abdolkhalegh Keshavarzi, Rahimeh Akrami, Mohammad M. Zarshenas, Saeid Zareie, Tayyeb Ghadimi, Ali Najafi, Mahsa Rostami Chijan, Azizallah Dehghan, Elham Zarenezhad

“…Also, these two herbs possess blood-cleansing, detoxifying, laxative, and invigorating activities. …”
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Monosomy 21 Seen in Live Born Is Unlikely to Represent True Monosomy 21: A Case Report and Review of the Literature by Trent Burgess, Lilian Downie, Mark D. Pertile, David Francis, Melissa Glass, Sara Nouri, Rosalynn Pszczola

“…We report a case of a neonate who was shown with routine chromosome analysis on peripheral blood lymphocytes to have full monosomy 21. Further investigation on fibroblast cells using conventional chromosome and FISH analysis revealed two additional mosaic cell lines; one is containing a ring chromosome 21 and the other a double ring chromosome 21. …”
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Initial validation of the clinical significance of the NETest in Japanese gastroenteropancreatic neuroendocrine tumor patients by Hao Zhang, Takahiro Tsuchikawa, Satoshi Takeuchi, Kenji Hirata, Kimitaka Tanaka, Aya Matsui, Yoshitsugu Nakanishi, Toshimichi Asano, Takehiro Noji, Toru Nakamura, Shintaro Takeuchi, Masataka Wada, Satoshi Hirano

“…Between 2021 and 2023, blood and clinical data were collected from patients with GEPNET. …”
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A Retrospective Observational Cohort Analysis of Oncology Patients with Febrile Neutropenia in the Emergency Department of a Tertiary Care Hospital in Oman by Badar Al-Aamri, Aisha AL Breiki, Darpanarayan Hazra, Talib Al-Aamri, Manar Al-Shehi

“…High-risk patients exhibited significantly higher rates of positive blood cultures (31.6% vs. 1.6%) and positive urine cultures (20.8% vs. 7.7%). …”
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Hepatic and immune modulatory effectiveness of lactoferrin loaded Selenium nanoparticles on bleomycin induced hepatic injury by Khaled G. Abdel-Wahhab, Mahmoud Ashry, Laila K. Hassan, Marwa H. El-Azma, Ghada M. Elqattan, Mohamed H. A. Gadelmawla, Fathia A. Mannaa

“…Fifty adult male rats (160–200 g) were equally divided into five groups: (1) the saline control group, (2) BLM-injected (15 mg/kg twice a week, ip), and (3–5) groups treated orally with LF (200 mg/kg/day), SeNPs (0.0486 mg/kg/day) or LF/SeNPs combination (200.0486 mg/kg/day) for 6 weeks post BLM-intoxication. Blood and liver samples were subjected to biochemical, histopathological, and immunohistochemical analyses. …”
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Analysis of Sodium Chloride Intake and Treg/Th17 Lymphocytes in Healthy Individuals and Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus by Marlen Vitales-Noyola, Esther Layseca-Espinosa, Lourdes Baranda, Carlos Abud-Mendoza, Perla Niño-Moreno, Adriana Monsiváis-Urenda, Yvonne Rosenstein, Roberto González-Amaro

“…Levels and suppressive function of CD4+CD25+Foxp3+ and CD4+CD69+Foxp3− Treg cells were determined by flow cytometry in blood samples. Levels and in vitro differentiation of Th17 cells were also assessed. …”
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Chronic Ethanol Feeding Modulates Inflammatory Mediators, Activation of Nuclear Factor-κB, and Responsiveness to Endotoxin in Murine Kupffer Cells and Circulating Leukocytes by Miriam Maraslioglu, Elsie Oppermann, Carolin Blattner, Roxane Weber, Dirk Henrich, Christian Jobin, Elke Schleucher, Ingo Marzi, Mark Lehnert

“…Similarly, LPS-stimulated IL-1β release from whole blood was significantly enhanced in ethanol-fed mice. …”
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DNA methylation of leptin before and after weight loss intervention program among sample of Egyptian obese females: Epigenetic approach in obesity by Nayera E. Hassan, Sahar A. El-Masry, Waheba A. Zarouk, Nayra S. Mehanna, Rehab M. Mosaad, Maha M Kobesiy, Mohamed S. Kishta, Mohamed Selim, Mahmoud A.S. Afify, Khadija Alian, Aya Khalil, Heba T. Aboud

“…Conclusion These results support the assumption that in obesity, there is a link between LEPR methylation and LEP blood levels. The epigenetic profile of LEP gene could be affected by serum LEP via feedback regulation.…”
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Cardiac manifestation of phenylketonuria in adulthood by Péter Homródi, Emese Tóth-Zsámboki, Róbert Gábor Kiss, Orsolya Lovász, Gábor Zoltán Duray

“…Introduction: Since the introduction of mandatory infant screening for 26 hereditary metabolic diseases from a drop of blood, many rare diseases – including phenylketonuria (PKU) – have been recognized in time. …”
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Probiotics alleviate painful diabetic neuropathy by modulating the microbiota–gut–nerve axis in rats by Ye Jiang, Jing Yang, Min Wei, Jiayin Shou, Shixiong Shen, Zhuoying Yu, Zixian Zhang, Jie Cai, Yanhan Lyu, Dongsheng Yang, Yongzheng Han, Jinpiao Zhu, Zhigang Liu, Daqing Ma, Guo-gang Xing, Min Li

“…Probiotics administration effectively attenuated intestinal barrier impairment, reduced serum lipopolysaccharide and proinflammatory cytokines, and mitigated disruptions in the blood-nerve barrier. Furthermore, probiotics treatment inhibited the activation of the TLR4/MyD88/NF-κB signaling pathway and reduced proinflammatory cytokines in the sciatic nerve of the PDN rats. …”
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Risks to human and animal health from the presence of bromide in food and feed by EFSA Scientific Committee, Susanne Hougaard Bennekou, Ana Allende, Angela Bearth, Josep Casacuberta, Laurence Castle, Tamara Coja, Amélie Crépet, Thorhallur Halldorsson, Laurentius (Ron) Hoogenboom, Helle Knutsen, Konstantinos Koutsoumanis, Claude Lambré, Søren Nielsen, Dominique Turck, Antonio Vicent Civera, Roberto Villa, Holger Zorn, Vasileios Bampidis, Jacqueline Castenmiller, Marie‐Christine Chagnon, Bruce Cottrill, Keyvin Darney, Jürgen Gropp, Secundino Lopez Puente, Martin Rose, Marco Vinceti, Maria Bastaki, Petra Gergelová, Luna Greco, Matteo Lorenzo Innocenti, Judit Janossy, Anna Lanzoni, Andrea Terron, Diane Benford

“…Dose–response modelling of decreased blood thyroxine concentrations in rats resulted in a reference point of 40 mg/kg body weight (bw) per day. …”
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The Evaluation of the Efficacy of a Novel Subunit Vaccine in the Prevention of <i>Cryptosporidium parvum</i>-Caused Diarrhoea in Neonatal Calves by Martine Reijnders, Mark van Roosmalen, Hans Holtslag, Susan Arts, Suzanne Pel, Divine Dufé, Marianne Kaashoek, Geert Vertenten, Tine van Werven, Steven Sietsma, Christophe Roy, Nicolas Herman

“…Additionally, the levels of Gp40 antibodies in the blood of the calves was notably higher in the vaccination groups, demonstrating the principle of passive immunization. …”
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