Stimulation of gonad maturation in mullet fish Mugil dussumieri using MT, E2, hCG, and Ovaprim hormone by Tatak Dwi Cahyono, Muhammad Zairin Junior, Odang Carman

“…In the second experiment, egg diameter on day 30 for control showed that egg size ranged from 9-144 µm, hCG treatment showed egg size ranged from 9−441 µm, while Ovaprim egg size ranged from 9-111 µm. Blood glucose, blood cholesterol, testosterone and estradiol hormone level in the first and second experiment showed no significant difference. …”
Get full text

Regulatory Effect of Pyroptosis Related Genes Expression in Adipose Tissue of Aging Rats by Long-Time Weight-Bearing Running by GONG Lijing, TANG Shuning, YANG Luyao, SU Hao, NI Zhen, FU Pengyu

“…The IOD values of NLRP3, Caspase1 and IL-1β in sWAT of rats in the control group were higher than those in the baseline group (<italic>P</italic>&lt;0.05), and the IOD values of ASC, NLRP3, Caspase1, GSDMD and IL-1β in the resistance training group were lower than those in the control group (<italic>P</italic>&lt;0.05).ConclusionThe body fat percentage and blood lipid levels in aging rats are reduced by weight-bearing running training, via inhibiting the expression of NLRP3-mediated pyroptosis-related genes and protein of adipose tissue.…”
Get full text

Predictive Immunological, Virological, and Routine Laboratory Markers for Critical COVID-19 on Admission by Mercedes García-Gasalla, Juana M. Ferrer, Pablo A. Fraile-Ribot, Adrián Ferre-Beltrán, Adrián Rodríguez, Natalia Martínez-Pomar, Luisa Ramon-Clar, Amanda Iglesias, Inés Losada-López, Francisco Fanjul, Joan Albert Pou, Isabel Llompart-Alabern, Nuria Toledo, Jaime Pons, Antonio Oliver, Melchor Riera, Javier Murillas

“…SARS-CoV-2 was not detected in blood except in 3 patients who had indeterminate results. …”
Get full text

Basic Molecular Biology, Metabolic and Immunological Mechanisms of Fecal Microbiota Transplantation by O. V. Goloshchapov, A. V. Beynarovich, A. B. Chukhlovin, R. V. Klementeva, A. A. Shcherbakov, E. A. Bakin, I. K. Golubovskaya, N. D. Ventslovayte, O. S. Yudintseva, M. V. Gorchakova, V. E. Karev, M. A. Kucher, M. A. Suvorova, E. V. Svetkina, G. G. Rodionov, V. V. Gostev, S. V. Sidorenko, I. S. Moiseev, A. D. Kulagin

“…To monitor the basic effects of FMT, we performed targeted DNA sequencing of 16S rRNA gene (V3–V4) using MiSeq platform as well as multiplex real-time PCR, MS/gas chromatography technique, immunophenotyping of blood lymphocytes, histological and immunohistochemical techniques.Clinical case. …”
Get full text

Immune monitoring of trabectedin therapy in refractory soft tissue sarcoma patients - the IMMUNYON study by Paulo Rodrigues-Santos, Paulo Rodrigues-Santos, Paulo Rodrigues-Santos, Paulo Rodrigues-Santos, Paulo Rodrigues-Santos, Paulo Rodrigues-Santos, Jani Sofia Almeida, Jani Sofia Almeida, Jani Sofia Almeida, Jani Sofia Almeida, Jani Sofia Almeida, Jani Sofia Almeida, Luana Madalena Sousa, Luana Madalena Sousa, Luana Madalena Sousa, Patrícia Couceiro, Patrícia Couceiro, Patrícia Couceiro, Patrícia Couceiro, António Martinho, Joana Rodrigues, Ruben Fonseca, Manuel Santos-Rosa, Manuel Santos-Rosa, Manuel Santos-Rosa, Manuel Santos-Rosa, Manuel Santos-Rosa, Paulo Freitas-Tavares, José Manuel Casanova, José Manuel Casanova, José Manuel Casanova, José Manuel Casanova, José Manuel Casanova

Get full text

The Recognition and Management of Adverse Effects in Electroconvulsive Therapy: Findings From a Finnish Survey Study by Saara H. Huoponen, Katrin Sisa, Tom Saari, Markku Taittonen, Ulla Ahlmén‐Laiho

“…Headache, myalgia and postictal confusion (PIC) emerged as the most frequently reported AEs. Nausea and high blood pressure were reported less often. Only a few units reported AEs known to be rare, such as accidental awareness during general anesthesia and the aspiration of gastric contents. …”
Get full text

Chlamydophila pneumoniae Infection and Its Role in Neurological Disorders by Carlo Contini, Silva Seraceni, Rosario Cultrera, Massimiliano Castellazzi, Enrico Granieri, Enrico Fainardi

“…Monocytes may traffic C. pneumoniae across the blood-brain-barrier, shed the organism in the CNS and induce neuroinflammation. …”
Get full text

No Contribution of GAD-65 and IA-2 Autoantibodies around Time of Diagnosis to the Increasing Incidence of Juvenile Type 1 Diabetes: A 9-Year Nationwide Danish Study by Steffen U. Thorsen, Christian B. Pipper, Henrik B. Mortensen, Flemming Pociot, Jesper Johannesen, Jannet Svensson

“…From the Danish Childhood Diabetes Register, we randomly selected 500 patients and 500 siblings for GADA and IA-2A analysis (1997 through 2005). Blood samples were taken within three months after onset. …”
Get full text

Ultrasound-Targeted Microbubble Destruction Improves the Migration and Homing of Mesenchymal Stem Cells after Myocardial Infarction by Upregulating SDF-1/CXCR4: A Pilot Study by Lu Li, Shengzheng Wu, Zheng Liu, Zhongxiong Zhuo, Kaibin Tan, Hongmei Xia, Lisha Zhuo, Xiaojun Deng, Yunhua Gao, Yali Xu

Get full text

Surfactin alleviated hyperglycaemia in mice with type 2 diabetes induced by a high-fat diet and streptozotocin by Xiaoyu Chen, Hongyuan Zhao, Fanqiang Meng, Libang Zhou, Zhaoxin Lu, Yingjian Lu

“…In the present study, 80 mg/kg body weight surfactin supplementation lowered fasting blood glucose (FBG) levels by 21.05 % and insulin resistance (IR) by 18.18 % compared with those in the T2DM group, reduced inflammation, and increased antioxidant activity in mice with T2DM induced by a high-fat diet (HFD) and streptozotocin (STZ). …”
Get full text

Overview of trygleseride level on coffee consumption by Amellya Octifani, Tarisa Suci Novianti, Farida Anwari, Arif Rahman Nurdianto, Fery Setiawan, Rizal Fauzi Nurdianto

“…The purpose of this study was to describe blood triglyceride levels in coffee addict students at Anwar Medika University using the GPO-PAP method. …”
Get full text

Diagnosing and Treating ANCA-Associated Vasculitis within the COVID-19 Era: A Challenging Case Report by Erjola Likaj, Larisa Shehaj, Deniona Nunci, Lordian Nunci, Irda Rrugeja, Merita Rroji, Saimir Seferi, Nertila Gjonaj, Alma Idrizi, Arjana Strakosha

“…Introduction: Anti-neutrophil cytoplasmic antibody (ANCA)- associated vasculitis (AAV) is a rare group of systemic autoimmune diseases that primarily target small blood vessels. Renal manifestations often present as pauci-immune focal and segmental necrotizing crescentic glomerulonephritis (PI-NCGN), which can progress to acute or chronic kidney failure and multiorgan involvement. …”
Get full text

Influence of Omega-3 and Green Tea Extract on Alcohol-Induced Liver Injury in Rats by Ridha Hassan Hussein, Zana Hassan Ibrahim

“…At the end of the experiment, the rats were fasted overnight, blood samples through the cardiac puncture and liver organ were collected for biochemical and histopathological analysis respectively. …”
Get full text

Neostigmine Attenuates Proinflammatory Cytokine Expression in Preoptic Area but Not Choroid Plexus during Lipopolysaccharide-Induced Systemic Inflammation by Andrzej P. Herman, Dorota Tomaszewska-Zaremba, Marta Kowalewska, Aleksandra Szczepkowska, Małgorzata Oleszkiewicz, Agata Krawczyńska, Maciej Wójcik, Hanna Antushevich, Janina Skipor

“…The study was designed to examine whether the administration of neostigmine (0.5 mg/animal), a peripheral inhibitor of acetylcholinesterase (AChE), during an immune/inflammatory challenge provoked by intravenous injection of bacterial endotoxin—lipopolysaccharide (LPS; 400 ng/kg)—attenuates the synthesis of proinflammatory cytokines in the ovine preoptic area (POA), the hypothalamic structure playing an essential role in the control of the reproduction process, and in the choroid plexus (CP), a multifunctional organ sited at the interface between the blood and cerebrospinal fluid in the ewe. Neostigmine suppressed (p<0.05) LPS-stimulated synthesis of cytokines such as interleukin- (IL-) 1β, IL-6, and tumor necrosis factor (TNF) α in the POA, and this effect was similar to that induced by the treatment with systemic AChE inhibitor—donepezil (2.5 mg/animal). …”
Get full text

Single-Port Laparoscopic Surgery Is Feasible and Safe for Hepatic Left Lateral Sectionectomy for Benign Liver Lesions by Yuan Cheng, Ze-sheng Jiang, Xiao-ping Xu, Wen-fa Huang, Guo-lin He, Chen-jie Zhou, Jia-sheng Qin, Yi Gao, Ming-xin Pan

“…There was no significant difference in the operative time, estimated intraoperative blood loss, length of hospital stay, and incidences of postoperative complications (biliary leakage, hemorrhage, and contusion at incision) between groups (all P>0.05). …”
Get full text

Multimodal Imaging of Nonenhancing Glioblastoma Regions by Flóra John MD, Natasha L. Robinette MD, Alit J. Amit-Yousif MD, Edit Bosnyák MD, Geoffrey R. Barger MD, Keval D. Shah MD, Sandeep Mittal MD, Csaba Juhász MD, PhD

“…Methods: Structural MRI, relative cerebral blood volume (rCBV) maps from perfusion MRI, and α-[ 11 C]-methyl- l -tryptophan (AMT)-PET images were analyzed in 20 patients with glioblastoma. …”
Get full text

Gonadal health benefits of black cumin (Nigella sativa) seed oil on chronic lead-exposed male Wistar rats by Afrina Mustari, Mahabub Alam, Samia Rashid, A.G.M.Sofi Uddin Mahamud, Mohammad Alam Miah, Emdadul Hauqe Chowdhury

“…Rats were euthanized, blood was obtained, and serum was prepared to perform hormonal study. …”
Get full text

Potential Effect of Human Platelet Lysate on in vitro Expansion of Human Corneal Endothelial Cells Compared with Y-27632 ROCK Inhibitor by Mohammad Amir Mishan, Sahar Balagholi, Tahereh Chamani, Sepehr Feizi, Zahra-Soheila Soheili, Mozhgan Rezaei Kanavi

Get full text

Impact of clinical pharmacist integration on diabetes management: a prospective cohort by Nur Burcu Kutluay, Muhammed Yunus Bektay, Betul Sumbul-Sekerci, Abdusselam Sekerci, Fikret Vehbi Izzettin

“…A statistically significant improvement was observed in weight, waist circumference, blood glucose, cholesterol, HbA1c, and HOMA-IR levels when comparing pre- and post-pharmacist intervention over the 90-day interval (p < 0.05). …”
Get full text

Comparison of lateral tail vein and retro-orbital venous sinus as routes of inoculation to study Group B streptococcal systemic infection by Jéssica da Conceição Mendonça, Stephen Lumsdaine, Lindsey R. Burcham

“…Despite differences in initial dissemination and brain bacterial burden, we found that the route of infection did not significantly impact bacterial burden in the blood, kidney, spleen, heart, and lung tissues at experimental endpoints; and similarly did not impact animal health scores during infection; cytokine and proinflammatory protein abundance in the brain tissue; or overall animal survival. …”
Get full text