Therapeutic drug monitoring for triazoles: A needs assessment review and recommendations from a Canadian perspective by Michel Laverdiere, Eric J Bow, Coleman Rotstein, Julie Autmizguine, Raewyn Broady, Gary Garber, Shariq Haider, Trana Hussaini, Shahid Husain, Philippe Ovetchkine, Jack T Seki, Yves Théorêt

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Nanotherapeutic smart approaches for combating Alzheimer’s disease and overcoming existing obstacles: A novel eco-friendly green approach by Ahmed M. Almehdi, Doha H. Aboubaker, Rania Hamdy, Ali El-Keblawy

“…The physiological characteristics of the highly selective blood-brain barrier and the electrostatic charge of the nanoporous extracellular matrix have long placed restrictions on the treatment of brain disorders. …”
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Dissemination of Evidence-Based Recommendations for Sickle Cell Disease to Primary Care and Emergency Department Providers in North Carolina: A Cost Benefit Analysis by Paula Tanabe, Audrey L. Blewer, Emily Bonnabeau, Hayden B. Bosworth, Denise H. Clayton, Nancy Crego, Marian F. Earls, Kern Eason, Grayson Forlines, Gary Rains, Matthew Young, Nirmish Shah

“…**Methods:** The SCD toolbox was adapted from the National Heart, Lung, and Blood Institute recommendations. Toolbox training was provided to quality improvement specialists who then disseminated the toolbox to primary care providers (PCPs) affiliated with the only NC managed care coordination system and ED providers. …”
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Human social buffer in goats and dogs by Anna Scandurra, Biagio D’Aniello, Maria Elena Pero, Claudia Pinelli, Alfredo Di Lucrezia, Raffaella Tudisco, Piera Iommelli, Vincenzo Mastellone, Pietro Lombardi

“…Cortisol levels were measured by collecting blood samples before and after the test. Non-parametric tests together with a GzLM showed that the effect of human social buffering in goats was different in comparison to dogs: goats exhibited higher cortisol levels after the test, while dogs did not show a significant change. …”
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Schumann Resonances and the Human Body: Questions About Interactions, Problems and Prospects by Ganna Nevoit, Mantas Landauskas, Rollin McCarty, Inga Arune Bumblyte, Maksim Potyazhenko, Giedre Taletaviciene, Gediminas Jarusevicius, Alfonsas Vainoras

“…SRs affect functional indicators of the cardiovascular system: heart rate and blood pressure. Studying the influence of SRs on the course and pathogenesis of non-communicable diseases is a promising direction. …”
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Supplemental technologies of liver ultrasound investigation at the 1-st type tyrosinemia in pediatrics by G. M. Dvoryakovskaya, S. A. Ivleva, I. V. Dvoryakovsky, S. I. Polyakova

“…Traditional US-investigation of hemodynamic parameters of portal system blood flow reveals early US-signs of portal hypertension. …”
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Functional Assessment of Diaphragm Muscle in Stroke Patients and Research of Rehabilitation Intervention by Juanjuan FU, Hui FENG, Huaping PAN

“…Before and after two weeks of treatment, both groups were evaluated using the mean values of normal for thick and motion of the right hemidiaphragms during quiet breathing and deep breathing, pulmonary function tests, including forced vital capacity(FVC)and forced expiratory volume in one second(FEV₁), arterial blood gas analysis(arterial partial pressure of oxygen PaO₂, oxygenation index, partial pressure of carbon dioxide PaCO₂, pH value)and a fatigue severity scale(FSS).Results:The ratio of diaphragm thickness, diaphragm displacement, forced vital capacity, FEV₁, FEV₁/FVC, oxygen and index, and SaO₂in the experimental group were significantly lower than those of the control group, pH value and fatigue index in the experimental group were significantly higher than those of the control group. …”
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Molecular Xenomonitoring (MX) allows real-time surveillance of West Nile and Usutu virus in mosquito populations. by Clément Bigeard, Laura Pezzi, Raphaelle Klitting, Nazli Ayhan, Grégory L'Ambert, Nicolas Gomez, Géraldine Piorkowski, Rayane Amaral, Guillaume André Durand, Agathe M G Colmant, Cynthia Giraud, Katia Ramiara, Camille Migné, Gilda Grard, Thierry Touzet, Stéphan Zientara, Rémi Charrel, Gaëlle Gonzalez, Alexandre Duvignaud, Denis Malvy, Xavier de Lamballerie, Albin Fontaine

“…Notably, WNV can also be transmitted through blood donations and organ transplants. The high proportion of asymptomatic infections caused by these viruses and their cryptic enzootic circulation make their early detection in the environment challenging. …”
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Effect of cognitive behavioral intervention on physical symptoms, B-type natriuretic peptide, red cell distribution width, C-reactive protein in elderly heart failure patients by Xiaoyan Li, Meixia Zhang, Zepeng Ren, Junfen Deng

“…The changes in the somatosensory scale scores of patients with heart failure before and after routine treatment were recorded. The changes in blood BNP, RDW, and CRP levels were measured before and within 4 weeks, 8 weeks after intervention. …”
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Association between maternal haemoglobin status during pregnancy and children’s mental and psychomotor development at 18 months of age: Evidence from rural Bangladesh by Sayedur Rahman, Lina Wallberg, Anisur Rahman, Eva-Charlotte Ekström, Maria Kippler, Jena D Hamadani, Syed Moshfiqur Rahman

“…Background Anaemia is commonly caused by iron deficiency and screened by haemoglobin (Hb) concentration in blood. There is a scarcity of longitudinal data on the relationship between maternal Hb levels during pregnancy and neurodevelopment in children. …”
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Status of the Multidrug Resistance-1 Gene of Plasmodium falciparum in Four Malaria Epidemiological Strata, Two Decades after the Abolition of Chloroquine as First-Line Treatment fo... by David Denis Sofeu-Feugaing, Fabrice Nkengeh Ajonglefac, Marcel Nyuylam Moyeh, Tobias Obejum Apinjoh, Marianne Elodie Essende, Gilchrist Destin Talla Kouam, Stephen Mbigha Ghogomu

“…Despite numerous efforts to control malaria, it persists, and the emergence and spread of resistance to ACTs make the development of new drugs or the possible reintroduction of discontinued drugs increasingly urgent. Malaria-positive blood samples were collected from 798 patients on Whatman filter paper to determine the status of resistance to CQ. …”
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Renal Angiomyolipoma Mimicking a Well-Differentiated Retroperitoneal Liposarcoma by Honoka Fuse, Masaya Ito, Kosuke Takemura, Shuzo Ikuta, Toru Motoi, Tomotake Okuma, Madoka Kataoka, Fumitaka Koga

“…The tumor had irregular septa, thin blood vessels, and spotty small soft-tissue nodules. …”
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Diagnostic Value of CD25, CD69, and CD134 on Tuberculosis-Specific Antigen-Stimulated CD4+ T Cells for Tuberculous Pleurisy by Hanlu Shi, Liping Yang, Fujie Zhang, Yu Zhou, Yonglie Zhou

“…Moreover, we compared the differences in the diagnostic efficacy among the indexes from peripheral blood (PB) and pleural fluid (PF) for TP. The expression of each activation marker was significantly increased in TB-infected populations (patients with ATB and latent TB infection vs. healthy individuals; patients with TP vs. non-TP) and was significantly higher in the PF than in the PB of patients with TP. …”
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SARS-CoV-2 S-protein expression drives syncytia formation in endothelial cells by Katie V. Tieu, Madaline Espey, Aarthi Narayanan, Rebecca L. Heise, Farhang Alem, Daniel E. Conway

“…Because endothelial cells are exposed to physiological forces due to blood flow, we examined the effects of cyclic biaxial stretch and fluid shear stress. …”
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Autologous Cytokine-Induced Killer Cell Immunotherapy Enhances Chemotherapy Efficacy against Multidrug-Resistant Tuberculosis by Peijun Tang, Xingnian Chen, Junchi Xu, Yunlong Hu, Zhijian Ye, Xiafang Wang, Yumei Xiao, Xinghua Shen, Jianping Zhang, Yanjun Feng, Cuilin Shi, Xin Yu, Lixian Yi, Xinchun Chen, Binfeng Lu, Ping Xu, Zhongwen Sun, Meiying Wu

“…Cytokine-induced killer (CIK) immunotherapy is based on autologous infusion of in vitro expanded bulk T cells, which include both pathogen-specific and nonspecific T cells from patient peripheral blood mononuclear cells (PBMC) into TB patients. …”
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The Sequence of Prostaglandin-Endoperoxide Synthase 2 Gene in Women with Cervicitis by Maha A. Ahlial, Nazar Sh. Mohammed, Maysara S. Khalaf

“…The current study aims to determine the CA125, CA 19.9, and, CA 15.3 markers level and their relationship with the COX-2 gene. Venous blood samples were obtained from 100 women with cervicitis whose ages ranged from 18 to 60 years, and 100 healthy women as a control group. …”
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Siglec-E augments adipose tissue inflammation by modulating TRAF3 signaling and monocytic myeloid-derived suppressor cells during obesity by Ahmed Rakib, Mousumi Mandal, Md Abdullah Al Mamun, Sonia Kiran, Nelufar Yasmen, Lexiao Li, Daniel M. Collier, Jianxiong Jiang, Frank Park, Udai P. Singh

“…We analyzed the changes in immune phenotypes, inflammatory response, adipogenesis, and levels of cytokines and chemokines after HFD and ND feeding.ResultsHFD consumption significantly increased the body weight and blood glucose levels in siglec-E KO mice relative to those of WT mice. …”
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Predicting branch retinal vein occlusion development using multimodal deep learning and pre-onset fundus hemisection images by Eun Young Choi, Dongyoung Kim, Jinyeong Kim, Eunjin Kim, Hyunseo Lee, Jinyoung Yeo, Tae Keun Yoo, Min Kim

“…A U-net model segmented retinal optic discs and blood vessels (BVs), dividing them into upper and lower halves labeled for BRVO occurrence. …”
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Clinical value of quantitative echocardiographic features in preterm infants with necrotizing enterocolitis by Wenmei li, Wenqiang Sun, Zexi Sun, Huawei Wang, Xueping Zhu

“…Umbilical vein cannulation, antibiotic duration, total red blood cell infusion, duration of total parenteral and total enteral nutrition, respiratory failure, hemodynamically significant patent ductus arteriosus, anemia, neutropenia, hyperbilirubinemia were significantly higher than those in the control group. …”
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Two-centers machine learning analysis for predicting acid-fast bacilli results in tuberculosis sputum tests by Jichong Zhu, Yong Zhao, Chengqian Huang, Chenxing Zhou, Shaofeng Wu, Tianyou Chen, Xinli Zhan

“…In the validation cohort, 24 were AFB-positive, and 104 were AFB-negative. Blood samples were collected and analyzed using machine learning (ML) methods to identify key factors for TB diagnosis. …”
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