Development and experimental validation of a machine learning model for the prediction of new antimalarials by Mukul Kore, Dimple Acharya, Lakshya Sharma, Shruthi Sridhar Vembar, Sandeep Sundriyal

“…Rather than depending on high throughput screening (HTS) data, molecules tested at multiple doses against blood stages of Plasmodium falciparum were used for model development. …”
Get full text

Parametric and non-parametric estimation of reference intervals for routine laboratory tests: an analysis of health check-up data for 260 889 young men in the South Korean military by Taeyun Kim, Hyunji Choi, Sun Min Lee

“…The present study aimed to establish the RIs for routine common blood count (CBC) and biochemistry laboratory tests in homogeneous, healthy, male Korean soldiers in their 20s using a large health check-up data set, comparing parametric and non-parametric estimation.Design A multicentre, cross-sectional study.Setting Seven armed forces hospitals in South Korea.Participants A total of 609 649 men underwent health examination when promoted to corporal between January 2015 and September 2021. 260 889 eligible individuals aged 20–25 were included in the analysis.Main outcomes and measures The RIs were established by parametric and non-parametric methods. …”
Get full text

Bioaccumulation and Evaluation of Magnesium Oxide Nanoparticles Toxicity and Combination Effects of Vitamin E and C with it on Exposed Male Rats by Soma Ismael Majeed, Sulaf Mustafa Mohammed, Ali Mustafa Mohammad

“…Administration of vitamin E with MgO NPs significantly increased serum ROS and adversely affected blood parameters and histological damage to the liver and kidney. …”
Get full text

Inkjet-printed electronics for rapid and low-cost prototyping of digital microfluidic devices using an off-the-shelf printer by Babak Kamali Doust Azad, Amirhossein Roozbahani, Seyed Mohammad Tabatabaei, Amirali Valinejad, Alireza Fazelian, Kimia Shahmoradi, Fatemeh Khatami, Seyed Mohammad Kazem Aghamir, Mohammadreza Kolahdouz

“…Functional DMF chips are fabricated using tape, parafilm, and SU8 as dielectric and silicone oil as the hydrophobic layers, enabling actuation voltages as low as 144 VDC and 92 VAC@100 kHz for a whole-blood droplet. We detail our actuation and control circuitry, designed entirely with standard electronic modules and components. …”
Get full text

Seroprevalence Estimates of Q Fever and the Predictors for the Infection in Cattle, Sheep, and Goats in Nandi County, Kenya by J. Kiptanui, P. B. Gathura, P. M. Kitala, B. Bett

“…A cross-sectional study was carried out to investigate the estimates of seroprevalence of Q fever and to determine the predictors of the infection in cattle, sheep, and goats in six wards of Nandi County. A total of 1,140 blood samples were collected from 366 households. …”
Get full text

Effect of chikungunya, Mayaro and Una virus coinfection on vector competence of Aedes aegypti mosquitoes by Tessa M. Visser, Haidong D. Wang, Sandra R. Abbo, Chantal B.F. Vogels, Constantianus J.M. Koenraadt, Gorben P. Pijlman

“…We investigated the vector competence of Ae. aegypti for single, dual, and triple exposures with UNAV, MAYV and CHIKV, provided simultaneously in an infectious blood meal. Mosquitoes were incubated for ten days at 28 °C and 70 % humidity. …”
Get full text

High-Fat Diet-Induced Alterations in the Feeding Suppression of Low-Dose Nisoxetine, a Selective Norepinephrine Reuptake Inhibitor by Nicholas T. Bello, Amy L. Walters, Jessica L. Verpeut, Priscila P. Cunha

“…In a similar fashion, nisoxetine resulted in reductions in blood pressure and a compensatory increase in heart rate. …”
Get full text

Percutaneous Vertebroplasty under Local Anesthesia for Osteoporotic Vertebral Compression Fractures: A Prospective Interventional Study by Dhruv Gupta, Varun Kumar Agarwal

“…The procedure proved to be advantageous as it had shorter operative time, less blood loss, early recovery period, less postoperative work disability, lesser rate of complications, and scarring, clearly pointing toward a better acceptance of the percutaneous techniques.…”
Get full text

By activating endothelium histone H4 mediates oleic acid-induced acute respiratory distress syndrome by Yanlin Zhang, Jingjin Tan, Yiran Zhao, Li Guan, Shuqiang Li

“…Methods: ARDS was induced by intravenous injection of OA in mice, and evaluated by blood gas, pathological analysis, lung edema, and survival rate. …”
Get full text

Abnormal Glucose Tolerance Is Associated with a Reduced Myocardial Metabolic Flexibility in Patients with Dilated Cardiomyopathy by Domenico Tricò, Simona Baldi, Silvia Frascerra, Elena Venturi, Paolo Marraccini, Danilo Neglia, Andrea Natali

“…In 10 patients with DCM, 5 with normal glucose tolerance (DCM-NGT) and 5 with AGT (DCM-AGT), and 5 non-DCM subjects with AGT (N-AGT), we measured coronary blood flow and arteriovenous differences of oxygen and metabolites during Rest, Pacing (at 130 b/min), and Recovery. …”
Get full text

Intraperitoneal fipronil effects on liver histopathological, biochemistry and morphology in Caspian kutum, Rutilus frisii kutum (Kamenskii, 1901) by R. Alijani Ardeshir, H. Zolgharnein, A.A. Movahedinia, N. Salamat, E. Zabihi, J. Regenstein

“…Sub-lethal test doses of 10, 20, and 30% of the LD50 at 96 h were used to assess the effect of fipronil on the fish’s liver.  The blood plasma of 90 fish were used (18 at each test dose and in controls) on days 7 and 14 for biochemistry. …”
Get full text

Review of osteokines in spinal cord injury: potential biomarkers during rehabilitation by Jing Liu, Jingyi Yang, Qi Wu, Zixuan Fang, Tong Wang, Zun Wang, Daoming Xu

“…Abstract After spinal cord injury (SCI), mechanical unloading, denervation, as well as negative changes in blood supply, inflammation state, and hormone levels produce significant negative effects on bone density, leading to a high prevalence of osteoporosis after SCI. …”
Get full text

Can Platelet Count and Mean Platelet Volume be Used as Markers of Postdural Puncture Headache in Obstetric Patients? by Osman Uzundere, Cem Kıvılcım Kaçar, Sedat Kaya

“…The postoperative hemoglobin, hematocrit, platelet count (PC), and mean platelet volume (MPV) values were recorded, along with age, blood type, Rh factor, gravida, parity, and gestational age. …”
Get full text

Effect of Time of Cord Clamping on the Serum Bilirubin Level among Full-Term Babies Born in an Ethiopian Hospital Setting: An Exploratory Three-Arm Randomized Controlled Trial by Biruk Hailu Tesfaye, Mulugeta Betre Gebremariam, Abiy Seifu Estifanos, Asrat D. Gebremedhin

“…While the time of cord clamping was not a significant predictor of total serum bilirubin levels at 24 hours postbirth, cord blood total serum bilirubin (coefficient: 0.24; p<0.05) and bilirubin nomogram high-risk zone (coefficient: 6.25; p<0.001) were found to be significant predictors. (4) Conclusion. …”
Get full text

The molecular prevalence of Theileria equi in the Arabian stallion in Egypt with special reference to biochemical parameters by Noora F. Thabet, Omaima M. Kandil, Omnia M. Kandil, Khalid M. Fararh

“…Theileria equi, a blood parasite spread by ticks, is thought to be a severe infectious disease that impacts the health of horses. …”
Get full text

Fluorescent Particles Based on Aggregation-Induced Emission for Optical Diagnostics of the Central Nervous System by Shan Liu, Jinkuan Liu, Xue Li, Xiaoxin Du, Cheng Yin, Yong Luo, Chenzhong Li

“…AIEgens offer promising opportunities for imaging the central nervous system (CNS), including nerve cells, neural tissues, and blood vessels. This review focuses on the application of AIEgens in CNS imaging, exploring their roles in the diagnosis of various neurological diseases. …”
Get full text

Involvement of Neuropeptide Y within Paraventricular Nucleus in Electroacupuncture Inhibiting Sympathetic Activities in Hypertensive Rats by Qi Zhang, Yingying Tan, Xin Wen, Fangfang Li

“…Although electroacupuncture (EA) has been used to decrease the blood pressure (BP) clinically, the underlying mechanisms are not clearly clarified. …”
Get full text

Primary Vaginal Myeloid Sarcoma: A Rare Case Report and Review of the Literature by Gaurang Modi, Irappa Madabhavi, Harsha Panchal, Apurva Patel, Asha Anand, Sonia Parikh, Pritam Jain, Swaroop Revannasiddaiah, Malay Sarkar

“…The patient’s routine blood investigations were normal including peripheral smear, lactose dehydrogenase, uric acid, 2D echocardiography, conventional cytogenetics, bone marrow aspiration, and biopsy. …”
Get full text

3D CT/MRI fusion image-assisted treatment of lumbar burst fractures with laminar fractures by Zhenhui Zhang, Qiangqiang Pan, Qingde Wang, Wei Mei, Xuyi Chen

“…The follow-up time was (17.8 ± 1.6) months, the average operative time was 115.6 min (85–162 min), and the mean blood loss was 185.3 mL (136–240 mL). At the last follow-up, ASIA scale of neurological function was as follows: 5 cases were grade C, eight were grade D, and twenty-five were grade E. …”
Get full text

The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients w... by Michael Yaroustovsky, Ekaterina Rogalskaya, Marina Plyushch, Ludmila Klimovich, Nataliya Samsonova, Marina Abramyan

“…To analyse the clinical informativity of the neutrophil oxidative response level (“Response”) during an Endotoxin Activity Assay (EAA) as a new biomarker defining the indications and effectiveness of intensive care in cardiac surgical patients with septic complications. Methods. Blood samples were taken from 198 adult patients who were admitted to the ICU after cardiac surgery (SIRS: 34, MODS: 36, and sepsis: 128). …”
Get full text