Ponatinib alleviates non-alcoholic steatohepatitis through TFEB-mediated autophagy by Zhuomiao Lin, Meiqing Yang, Xihui Yu, Guozhu Tan, Jiahong Zhong

“…Here we aimed to determine the effect of ponatinib in non-alcoholic steatohepatitis.MethodsWe explored the function and mechanism of ponatinib using a mouse model of NASH induced by a methionine and choline deficient (MCD) diet and LO2 cells cultured in MCD mimic medium.ResultsHere, we found that ponatinib reduced liver lipid deposition, fibrosis, and inflammation induced by MCD diet without affecting body weight and blood glucose. Meanwhile, we found that ponatinib attenuated steatohepatitis and inflammation in LO2 cells induced by MCD mimic medium. …”
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Hereditary Hemorrhagic Telangiectasia in a Sudanese Patient by Omer Ali Mohamed Ahmed Elawad, Ahmed Abdalazim Dafallah Albashir, Mohammed Mahgoub Mirghani Ahmed, Ahmed Ali Mohamed Ahmed Elawad, Osman Eltieb Elbasheer Mohamed

“…She was treated with intravenous frusemide, iron supplement, tranexamic acid, blood transfusion, and nasal packing. Conclusions. …”
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Isolation and characterization of a highly pathogenic strain of Vibrio harveyi EFL-2201 from pearl gentian grouper by Biao Yuan, Zhixia Zhuang, Xiaoru Wang, Huabin Huang, Qingpi Yan

“…The spleen, which had the highest bacterial load among all tissues, was subjected to transcriptome sequencing at 24 hpi, revealing significant enrichment in pathways related to immunity, cell cycle, and red blood cell oxygen transport. In conclusion, this study unveiled the pathogenic mechanisms of V. harveyi and immune response mechanisms of pearl gentian grouper spleens to infection, laying a theoretical foundation for the prevention and control of V. harveyi-induced disease.…”
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Designing a multi-period multi-stage supply chain network under uncertainty by Maryam Hemmati, Masoud Rabbani, Mohammad Reza Mehregan

“…The supply chain of perishable goods, including food, dairy products, medicines, and blood products, has recently received attention due to their impact on human life. …”
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Novel gene manipulation approaches to unlock the existing bottlenecks of CAR-NK cell therapy by Fatemeh Dehghan, Yekta Metanat, Mandana Askarizadeh, Ehsan Ahmadi, Vahid Moradi

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Alpelisib-Induced Diabetic Ketoacidosis and Insulin-Resistant Hyperglycemia by Michael Loke, DO, Vishal Sehgal, MD, Niraj Gupta, MD

“…One month prior to this hospitalization, the patient was started on alpelisib. On presentation, blood glucose level was 612 mg/dL and hemoglobin A1c level was 11.9% (107 mmol/mol), a 4.6% (27 mmol/mol) increase from 2 months prior. …”
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Methotrexate-Associated Nonalcoholic Fatty Liver Disease with Transaminitis in Rheumatoid Arthritis by Rajalingham Sakthiswary, Grace Yin Lai Chan, Ee Tzun Koh, Khai Pang Leong, Bernard Yu Hor Thong

“…Compared to the controls, the cases had significantly higher mean cumulative dose of MTX (4.03 ± 2.25 g versus 10.04 ± 9.94 g, P≤0.05), weekly dose of MTX (11.3 ± 4.8 mg versus 13.1 ± 4.4 mg weekly, P=0.033), and fasting blood glucose (P=0.029). Following multivariate regression analysis, only cumulative dose of MTX remained significant (P=0.015). …”
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Latent tuberculosis prevalence in healthcare workers in Laos: a cross-sectional study by Sypaseuth Duangmixay, Siriphone Virachith, Judith M. Hübschen, Phitsada Siphanthong, Sakhone Suthepmany, Somphou Sayasone, Antony P. Black

“…Methods Healthcare workers from high-risk departments from 3 central hospitals in Laos were included (n = 196) and venous blood was tested by IGRA. A questionnaire was administered to determine their knowledge, attitude and practice towards TB and LTBI. …”
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Management of a Novel Autoimmune Disease, COPA Syndrome, in Pregnancy by Archana Ayyar, Rachel D. Seaman, Kalpalatha Guntupalli, Mary C. Tolcher

“…At time of entry to care, patients should have a baseline work-up including a radiographic imaging, complete blood count, complete metabolic panel, lactate dehydrogenase, and a 24-hour urine protein collection for baseline. …”
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Necrobiosis Lipoidica through the Microscope by Parul Mehrotra, Rajalakshmi Tirumalae

“…Histopathologic features common to all cases were altered collagen, tiered arrangement of necrobiosis, myointimal hyperplasia and luminal narrowing of blood vessels, and perivascular lymphohistiocytic infiltrate. …”
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Ischemic Stroke Lesion Segmentation on Multiparametric CT Perfusion Maps Using Deep Neural Network by Ankit Kandpal, Rakesh Kumar Gupta, Anup Singh

“…<b>Results:</b> The final optimized network takes three image sequences, namely CT, cerebral blood volume (CBV), and time to max (Tmax), as input to perform segmentation. …”
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The Efforts to Implement a Malaria Elimination Strategy in The Highly Endemic Malaria Region of Papua Province, Indonesia by Erni Juwita Nelwan

“…Nainggolan et al. investigated the role of host factors, particularly ABO blood groups, in the likelihood of developing severe malaria. …”
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A Case of a Patient Who Is Diagnosed with Mild Acquired Hemophilia A after Tooth Extraction Died of Acute Subdural Hematoma due to Head Injury by Tomohisa Kitamura, Tsuyoshi Sato, Eiji Ikami, Yosuke Fukushima, Tetsuya Yoda

“…Acquired hemophilia A (AHA) is a rare disorder which results from the presence of autoantibodies against blood coagulation factor VIII. The initial diagnosis is based on the detection of an isolated prolongation of the activated partial thromboplastin time (aPTT) with negative personal and family history of bleeding disorder. …”
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Increased Chromosomal and Oxidative DNA Damage in Patients with Multinodular Goiter and Their Association with Cancer by Hamiyet Donmez-Altuntas, Fahri Bayram, Nazmiye Bitgen, Sibel Ata, Zuhal Hamurcu, Gulden Baskol

“…CBMN-cyt assay parameters in peripheral blood lymphocytes of patients with multinodular goiter and controls were evaluated, and plasma 8-OHdG levels were measured. …”
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Toward reliable diabetes prediction: Innovations in data engineering and machine learning applications by Md. Alamin Talukder, Md. Manowarul Islam, Md Ashraf Uddin, Mohsin Kazi, Majdi Khalid, Arnisha Akhter, Mohammad Ali Moni

“…Objective Diabetes is a metabolic disorder that causes the risk of stroke, heart disease, kidney failure, and other long-term complications because diabetes generates excess sugar in the blood. Machine learning (ML) models can aid in diagnosing diabetes at the primary stage. …”
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Posterior Transpedicular Dynamic Stabilization versus Total Disc Replacement in the Treatment of Lumbar Painful Degenerative Disc Disease: A Comparison of Clinical Results by Tunc Oktenoglu, Ali Fahir Ozer, Mehdi Sasani, Yaprak Ataker, Cengiz Gomleksiz, Irfan Celebi

“…We compared the average duration of surgery, blood loss during the surgery and the length of hospital stay of both groups. …”
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Colonic Mucosal Ulceration and Gastrointestinal Bleeding Associated with Sevelamer Crystal Deposition in a Patient with End Stage Renal Disease by Sudheer Nambiar, Unnikrishnan Kunjan Pillai, Joe Devasahayam, Tony Oliver, Asha Karippot

“…Lower gastrointestinal bleeding refers to blood loss from a site in the gastrointestinal tract distal to the ligament of Treitz. …”
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A Comparative In Vitro Study of the Effects of Separate and Combined Products of Citrus e fructibus and Cydonia e fructibus on Immunological Parameters of Seasonal Allergic Rhiniti... by E. W. Baars, M. C. Jong, I. Boers, A. F. M. Nierop, H. F. J. Savelkoul

“…This paper examined the effects of the combined product, Citrus e fructibus/Cydonia e fructibus (Citrus/Cydonia; Citrus and Cydonia: each 0.01 g/mL), and separate products of Citrus (0.01 g/mL) and Cydonia (0.01 g/mL) on the immunological pathways involved in seasonal allergic rhinitis (SAR). Peripheral blood mononuclear cells (PBMCs) from five healthy and five grass pollen-allergic donors were isolated and analyzed in vitro after polyclonal and allergen-specific stimulation of T cells in the presence of the three extracts. …”
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Insights Into Genetic Variations of the OCT1 Gene in Metformin Poor Responders Among Bangladeshi Type 2 Diabetic Patients by Rokeya Begum, Arindita Das, Md. Jahangir Alam, Gazi Nurun Nahar Sultana

“…Clinical features of 56 Bangladeshi T2DM patients (who showed altered response to metformin) were analyzed, and genomic DNA was extracted from their blood samples. Subsequently, the entire exons (1–11), along with flanking introns of the OCT1 gene were amplified and sequenced. …”
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The Role of Monocyte/Macrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation by Asmaa Ibrahim Gomaa, Nermine Ahmed Ehsan, Ahmed A. Elrefaei, Mervat Mohamed Sultan, Maha Mohamed Elsabaawy

“…Hepatic macrophages, which can either arise from circulating blood-derived monocytes (BDM) or from resident tissue Kupffer cells, are central in the pathogenesis of chronic liver injury. …”
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