The First Case Report in Italy of Di George Syndrome Detected by Noninvasive Prenatal Testing by Giuseppina Rapacchia, Cristina Lapucci, Maria Carla Pittalis, Aly Youssef, Antonio Farina

“…We report here the first case of Di George syndrome detected by NIPT in Italy; blood was drawn at 12 weeks’ gestation. The patient had an amniocentesis to confirm the diagnosis by MLPA (multiplex ligation-dependent probe amplification) and an ultrasound aimed to detect the features associated with the syndrome. …”
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Advancing Insights into Large-Artery Stiffening in Humans Through the Application of Multi-omics by Marie-Joe Dib

“…Abstract A healthy aorta limits excess arterial pulsatility and protects the microvasculature from the effects of fluctuating blood flow and pressure. Aging and various pathologic states impair this cushioning function, a phenomenon known as large-artery stiffening (LAS). …”
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DEVELOPMENT AND IMPROVEMENT OF ASF SEROLOGICAL DIAGNOSTIC TECHNIQUES by D. V. Sharypova, O. V. Kapustina, I. Yu. Zhukov, N. N. Vlasova, A. S. Igolkin

“…The research is devoted to development of rapid test methods for rapid detection of antibodies to ASFV in blood sera of infected animals as well as to analysis of their use effectiveness. …”
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Multimodal Imaging of Neural Progenitor Cell Fate in Rodents by Yannic Waerzeggers, Markus Klein, Hrvoje Miletic, Uwe Himmelreich, Hongfeng Li, Parisa Monfared, Ulrich Herrlinger, Mathias Hoehn, Heinrich Hubert Coenen, Michael Weller, Alexandra Winkeler, Andreas Hans Jacobs

“…We show that both imaging modalities are sensitive in detecting reporter gene expressing NPCs; however, PET, by the use of 9-[4-[ 18 F]fluoro-3-hydroxymethyl)butyl]guanine ([ 18 F]FHBG), detects NPCs only at sites of disrupted blood-brain barrier. Furthermore, both imaging modalities can be used to detect stem cell fate and migration and indicate excessive proliferation and aberrant migration. …”
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COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells by Carla Longo de Freitas, Priscilla Yuri Okochi Alves da silva, Maria do Carmo Pinho Franco, Danilo Candido de Almeida

“…However, the permissiveness of blood vessels during SARS-CoV-2 infection remains unclear, but regardless endothelial infection, the vascular disfunction may occurred in response to molecular inflammatory signaling triggered by immune cells that attempt to limit infection. …”
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Clinical efficacy of antibiotic-loaded bone cement and negative pressure wound therapy in multidrug-resistant organisms diabetic foot ulcers: a retrospective analysis by Huihui Guo, Zhenqiang Xue, Siwei Mei, Tengfei Li, Haiyang Yu, Tao Ning, Yongbin Fu

“…The control group received conventional treatment, routine debridement, and NPWT treatment, while the experimental group received ALBC treatment in addition to the treatment plan of the control group. Measurements of blood inflammatory indicators, foot hemodynamic indicators, wound bacterial clearance time, wound healing time, and hospital stay were taken before and after treatment for both groups.ResultsInflammatory indexes, Vascular endothelial growth factor(VEGF), and internal diameter of dorsalis pedis arteriosus of both groups after treatment were significantly better than those before treatment, and the improvement of the experimental group was more obvious than that of the control group; the experimental group had a significantly shorter time of trauma bacterial turnover, healing time of trauma, and hospitalization time compared with that of the control group (P<0.05).…”
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Implication of diabetes mellitus in telomere length and alteration in some age related cell senescence markers of aged men in Kurdistan region-Iraq by Kaniaw Rafat Khafar, Dr. Esmail S Kakey

“…The study design was the setting of a medium private laboratory with participants being common people, which was classified into three groups according to age and health complication, control young, healthy aged, and diabetic aged groups. Blood sera was obtained for oxidative status including catalase (CAT), superoxide dismutase (SOD), Total antioxidant capacity (T-AOC), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and malondialdehyde (MDA)) and molecular markers (including telomere length (T/S) and mitochondrial DNA copy number (mtDNA)). …”
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Oleuropein Improves Cognitive Dysfunction and Neuroinflammation in Diabetic Rats through the PI3K/Akt/mTOR Pathway by Jianru Shang, Shan Che, Mingjie Zhu

“…A diabetic rat model was constructed using streptozotocin, and the diabetic rats were divided into 3 groups with different treatment for 4 weeks, named STZ group (gavaged with normal saline), STZ+LOE group (40 mg/kg oleuropein, and STZ+SITA group (30 mg/kg sitagliptin). The fasting blood glucose (FBG), fasting serum insulin levels, and HOMA-IR index were measured in rats. …”
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The Proviral Reservoirs of Human Immunodeficiency Virus (HIV) Infection by Andrey I. Murzin, Kirill A. Elfimov, Natalia M. Gashnikova

“…These cells form a heterogeneous group, represented by peripheral blood mononuclear cells (PBMCs), tissue-resident lymphoid and monocytic cells, and glial cells of the central nervous system. …”
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Association of Renal Resistive Index, Renal Pulsatility Index, Systemic Hypertension, and Albuminuria with Survival in Dogs with Pituitary-Dependent Hyperadrenocorticism by Hung-Yin Chen, Yu-Hsin Lien, Hui-Pi Huang

“…This study evaluated associations between systemic blood pressure (SBP), renal RI, pulsatility index (PI), and albuminuria in dogs with pituitary-dependent hyperadrenocorticism (PDH). …”
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The Enteric Nervous System and Its Emerging Role as a Therapeutic Target by Mark A. Fleming, Lubaina Ehsan, Sean R. Moore, Daniel E. Levin

“…The functions of the ENS range from the propulsion of food to nutrient handling, blood flow regulation, and immunological defense. …”
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Data Mining Mycobacterium tuberculosis Pathogenic Gene Transcription Factors and Their Regulatory Network Nodes by Guangxin Yuan, Yu Bai, Yuhang Zhang, Guangyu Xu

“…In this study, using the National Center for Biotechnology Information (NCBI) GEO Datasets, whole blood gene expression profile data were obtained in patients with active pulmonary tuberculosis. …”
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A Case of Anterior Spinal Artery Syndrome Caused by Streptococcus mitis Endocarditis by Aria Mahtabfar, Hamoon Eshraghi, Melroy D’Souza, William Berrigan, Kathleen Casey

“…Diagnosis of septic emboli secondary to IE was made after the echocardiogram showed the presence of vegetations on the aortic valve, blood cultures were positive for Streptococcus mitis, and thoracic spine MRI was indicative of an infarction at T10. …”
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Diagnosis and Management of Atypical Chronic Myeloid Leukemia with a t(2;13)(q33;q12) Translocation by John S. Wang, Omar Elghawy, Brett R. Kurpiel, Michael G. Douvas

“…Subsequent peripheral blood and bone marrow studies lead to the diagnosis of aCML. …”
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Peroxisome Proliferator-Activated Receptor Targets for the Treatment of Metabolic Diseases by Francisco A. Monsalve, Radha D. Pyarasani, Fernando Delgado-Lopez, Rodrigo Moore-Carrasco

“…The most widely recognized metabolic risk factors are atherogenic dyslipidemia, elevated blood pressure, and elevated plasma glucose. Individuals with these characteristics commonly manifest a prothrombotic state and a proinflammatory state as well. …”
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Methodological considerations and implications for appetite and feeding behaviour research in PKU; Current knowledge, practical application and future perspectives by Ben Green

“…While adequate energy intake is an important factor for maintaining satisfactory blood phenylalanine concentrations, appetite and feeding behaviour should, therefore, represent an integral consideration for PKU but is currently understudied. …”
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Neonatal necrotizing enterocolitis complicated by glutaric acidemia type II: a case report by Yuli Zhang, Yuli Zhang, Longfei Chen, Miao Duan

“…Diagnosis of GAII was confirmed through tandem mass spectrometry analysis of a blood sample. Genetic metabolic diseases may complicate or mimic common infections, leading to potential misdiagnosis. …”
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Advances in Focal Segmental Glomerulosclerosis Treatment From the Perspective of the Newest Mechanisms of Podocyte Injury by Zhu Y, Xu G

“…Notably, some medications such as Rituximab and Sparsentan, may simultaneously target multiple downstream mechanisms, Furthermore, exploring molecular strategies for established medications and developing novel treatments guided by biomarkers such as Anti-CD40 antibody, blood microRNA, urinary microRNA, and tumor necrosis factor-alpha (TNF-α) may provide additional therapeutic avenues for patients with FSGS.Keywords: focal segmental glomerulosclerosis, podocyte injury, targeted therapies, biomarkers…”
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Phenotyping of Leukocytes and Leukocyte-Derived Extracellular Vesicles by Lotte Hatting Pugholm, Rikke Bæk, Evo Kristina Lindersson Søndergaard, Anne Louise Schacht Revenfeld, Malene Møller Jørgensen, Kim Varming

“…Furthermore, the cellular expression of CD9, CD63, and CD81 varied between leukocytes present in whole blood and cultured leukocytes. In summary, these data demonstrate that the cellular and vesicular presentation of selected lineage-specific and vesicle-related markers may differ, supporting the accumulating observations that sorting of molecular cargo into EVs is tightly controlled.…”
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Management of Acute Wilsonian Hepatitis with Severe Hemolysis: A Successful Combination of Chelation and MARS Dialysis by Jeremy Hassoun, Nathalie Hammer, Giulia Magini, Belen Ponte, Marie Ongaro, Anne-Laure Rougemont, Nicolas Goossens, Jean-Louis Frossard, Laurent Spahr

“…We report here the case of a young woman who presented with classic acute Wilsonian hepatitis complicated by liver and renal failure and a severe hemolysis related to massive nonceruloplasmin bound copper accumulation requiring repeated blood transfusions. The early initiation of a combined treatment including conventional chelation therapy and repeated MARS dialysis sessions allowed a rapid control of hemolysis, a progressive decrease of free copper overload, and clinical recompensation without liver transplantation.…”
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