High peripheral T cell diversity is associated with lower risk of toxicity and superior response to dual immune checkpoint inhibitor therapy in patients with metastatic NSCLC by Alexandre Reuben, Mehmet Altan, Latasha Little, Jianjun Zhang, Ajay Sheshadri, Hai T Tran, Mara B Antonoff, Stephen G Swisher, John V Heymach, Saumil Gandhi, Natalie Vokes, Ziyi Li, Ruoxing Li, Runzhe Chen, Joshua Baguley, Jefferson Sinson, Greg Lizee

“…Blood samples were systematically obtained at baseline (n=107), after 12 weeks of ipilimumab and nivolumab (n=91), and at the time of grade ≥2 irAEs (n=77). …”
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The Role of Intravenous Selexipag in Managing PAH and Bridging Gaps in Oral Treatment: A Narrative Review by Goren S, Kidwai N, Aronow WS, Lanier GM

“…Selexipag is a medication used to treat patients with PAH by widening the blood vessels in the lungs. However, some patients may not be able to take oral selexipag as prescribed, which can worsen their condition. …”
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Verification of Lactobacillus brevis tolerance to simulated gastric juice and the potential effects of postbiotic gamma-aminobutyric acid in streptozotocin-induced diabetic mice by Amro Abdelazez, Heba Abdelmotaal, Smith Etareri Evivie, Maha Bikheet, Rokayya Sami, Hassan Mohamed, Xiangchen Meng

“…The body weight and hyperglycemia in the blood were assessed weekly, post-euthanasia blood plasma parameters, insulin, and histological examination were evaluated. …”
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Efficacy of Fetal Wharton’s Jelly Mesenchymal Stem Cells-Derived Small Extracellular Vesicles in Metabolic Syndrome by Illayaraja Krishnan, Magdalene Tan Mei Ling, Min Hwei Ng, Jia Xian Law, Mohd Rafizul Mohd Yusof, Thavachelvi Thangarajah, Zalina Mahmood, Nurul Izzati Uda Zahli, Shathiya Rajamanickam, Baskar Subramani, Yogeswaran Lokanathan

“…Background/Objective: Metabolic syndrome (MetS) is characterized by abdominal obesity, increased blood pressure (BP), fasting blood glucose (FBG) and triglyceride levels, and reduced high-density lipoprotein (HDL) levels. …”
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Memory B cells and their transcriptomic profiles associated with belimumab resistance in systemic lupus erythematosus in the maintenance phase by Takeshi Iwasaki, Takeshi Iwasaki, Hajime Yoshifuji, Koji Kitagori, Shuji Sumitomo, Shuji Akizuki, Ran Nakashima, Hideaki Tsuji, Ryosuke Hiwa, Mirei Shirakashi, Kosaku Murakami, Akira Onishi, Hideo Onizawa, Masao Tanaka, Fumihiko Matsuda, Akio Morinobu, Koichiro Ohmura, Koichiro Ohmura

“…RNA-Seq of whole blood was performed, and gene expression was quantified. …”
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Prevalence of Diabetes, Prediabetes, and Associated Factors in an Adult Chinese Population: Baseline of a Prediabetes Cohort Study by Xinjie Yu, Fang Duan, Da Lin, Hai Li, Jian Zhang, Qiuyu Wang, Xianglong Wang, Qian Zhao, Jiayu Deng, Guangwei Song, Qingqing Ji, Haihua Zheng, Xiang Chen, Guoyi Zhou

“…Meanwhile, higher systolic blood pressure (RRR = 1.03; 95% CI, 1.004–1.06, P=0.025) was the only factor significantly associated with a higher risk of PDM. …”
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Effects of a Meal Replacement on Body Composition and Metabolic Parameters among Subjects with Overweight or Obesity by Xiaohui Guo, Yifan Xu, Hairong He, Hao Cai, Jianfen Zhang, Yibin Li, Xinyu Yan, Man Zhang, Na Zhang, Rolando L. Maddela, Jessie Nicodemus-Johnson, Guansheng Ma

“…Body composition improvements corresponded with significant metabolic improvements of blood glucose (−4.7 ± 9.8%). Further improvements in visceral fat area (−7.7 ± 10.1%), accompanying with improvements in systolic (−3.7 ± 6.9%) and diastolic (−5.3 ± 7.7%) blood pressure, were only found in male subjects. …”
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Circulating tumor DNA for surveillance in high-risk melanoma patients: a study protocol by Magnús P.B. Obinah, Sarah A. Al-Halafi, Karin Dreisig, Tim S. Poulsen, Christoffer Johansen, Thomas Litman, Stig E. Bojesen, Estrid Høgdall, Annette H. Chakera, Lisbet R. Hölmich

“…Detection of mutation-specific ctDNA is performed on blood using digital droplet polymerase chain reaction (ddPCR) or NGS. …”
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Intrahepatic CD161hiCD8+T Cell Recruitment Has a Pathogenetic Potential in Chronic HBV Infection by Jianfei Li, Qian Liu, Wanlu Duan, Zhi Duan, Futing Liu, Mengqi Ruan, Qiyin Zong, Hao Zhang, Qiang Zhou, Qin Wang

“…Peripheral blood levels of CD161+CD8+T cells and their correlation with serum ALT levels were analyzed in CHB patients. …”
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The effect of yoga practices on health parameters: A review by Emirhan Pehlivan, Gökhan Çetinoğlu

“…However, the review found statistically insignificant decreases in fasting blood glucose levels, postprandial blood glucose levels, and HbA1c. …”
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Risk Factors for Bacterial Contamination of Bovine Meat during Slaughter in Ten Indonesian Abattoirs by Diyantoro, Dhandy Koesoemo Wardhana

“…The factor that had the greatest effect on the MPN of Escherichia coli was blood removal on the floor position (mean: 40.34 × 106 CFU/g; p=0.039) while the factors that significantly affected Staphylococcus aureus contamination were blood removal on the floor position (mean: 52.88 × 106 CFU/g; p=0.025) and carcass cutting which were not carried out by the abattoir (mean: 66.42 × 106 CFU/g; p=0.015).…”
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Folic Acid: Sources, Chemistry, Absorption, Metabolism, Beneficial Effects on Poultry Performance and Health by Herinda Pertiwi, Mohamad Yusril Nur Mahendra, Juriah Kamaludeen

“…The ingested FA will be absorbed in the intestinal lumen and transported into the liver through the blood vessels. Therefore, FA has a positive effect on the performance and health status of poultry. …”
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Utilizing MV-FLOW™ and multidimensional ultrasound characteristics for prognosticating FET outcomes in RIF patients: Study Protocol for a cross-sectional study. by Ying Zhou, Li-Ying Liu, Hua-Ju Yang, Yuan-Yuan Lai, Di Gan, Jie Yang

“…Prior to transfer, uterine endometrial receptivity of FET patients can be assessed using multimodal transvaginal ultrasound indicators to predict the success rate of the current FET cycle. Endometrial blood flow is a crucial element in evaluating endometrial receptivity. …”
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A Role for the Cytoskeleton in Heart Looping by Kersti K. Linask, Michael VanAuker

“…The cytoskeleton is associated with important mechanosensing and signaling pathways in cell biology and development. The initiation of blood flow during the looping period and the inherent stresses associated with increasing volumes of blood flowing into the heart may help to potentiate the process. …”
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Experimental Study of Irinotecan Induced Side Effects on Digestive and Immune System of Mice by Liya LIU, Thomas Joseph SFERRA, Senthilkumar SANKARARAMAN, Youqin CHEN

“…Body weight, diarrhea index, spleen index, thymus index, complete blood count and pathological changes of the jejunum, ileum and colon were measured on the second day and the fourth day after CPT-11 intervention.Results:Compared with the control group, mice body weight was decreased significantly on the second day and the fourth day upon CPT-11 intervention while diarrhea index was increased (<italic>P</italic>&lt;0.05); CPT-11 intervention also decreased spleen index, thymus index (<italic>P</italic>&lt;0.05), white blood cell count and neutrophil count profoundly along with significant jejunum, ileum and colon injury of the mice.Conclusion:CPT-11 can induce side effects about the digestive and immune system, which consistents with the clinical side effects of CPT-11, and this will be helpful for the further development of novel supplementary therapies for CPT-11 induced toxicity.…”
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Penile Livedoid Vasculopathy: First Reported Case by Ahmad Hallak, William Bennett, Mohammed Adib Tanbir, Supriya R. Donthamsetty, Bethaney Vincent

“…The pathogenesis is speculated to involve increasing coagulation or impaired thrombolysis leading to the occlusion of dermal blood vessels with fibrin thrombi. Livedoid vasculopathy is known to primarily affect the lower extremities. …”
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Studying Some Factors That Increase the Risk of Thalassemia in The City of Baquba by Sara Fawzi Sahm

“…Also, the effect of the type of Thalassemia factor on the infection of the disease shows that those who carry thalassemia major are more affected than those who carry thalassemia intermedia. The effect of the blood type factor on the infection rate shows that the highest number of infected people was those with blood type O. …”
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The Renin-Angiotensin System Modulates Inflammatory Processes in Atherosclerosis: Evidence from Basic Research and Clinical Studies by Fabrizio Montecucco, Aldo Pende, François Mach

“…The regulation of arterial blood pressure was considered from its first description of the main mechanism involved. …”
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Eicosanoid and cytokine levels in plasma of patients during mesenteric infarction by N. Nathan, Y. Denizot, P. Feiss

“…This study reports eicosanoid and cytokine levels in the blood of three atherosclerotic patients who ultimately died from MOF induced by mesenteric infarction. …”
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