Analysis of tumor-infiltrating exhausted T cells highlights IL-6 and PD1 blockade as a combined immunotherapy strategy for non-small cell lung cancer by Lulu Zhang, Lulu Zhang, Xiyuan Guo, Xiyuan Guo, Xiaoke Sun, Jue Liao, Qin Liu, Yingchun Ye, Zhihui Yang, Ratchada Cressey, Qing He, Qing Yuan, Qing Yuan

“…ObjectiveGiven the limitations of immunotherapy for treating non-small cell lung cancer (NSCLC), we investigated the phenotype and function of exhausted CD8+T cells and analyzed a novel combination immunotherapy to restore the effector killing function of tumor-infiltrating CD8+T lymphocyte (TIL).MethodsWe examined the expression and function of immunosuppressive molecules on CD8+T cells of peripheral blood mononuclear cells (PBMCs) and TILs by using prospectively collected peripheral blood, pleural effusions, and tumor tissues from patients with NSCLC and correlated the results with clinical data. …”
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Production of Arthrospira platensis algae to increase production efficiency and enhance immune system of grass carp, Ctenopharyngodon idella against Aeromonas hydrophila by Hossein Adineh

“…At the end of the test period, growth and nutritional performance, digestive enzyme activities, blood serum antibacterial activity against Aeromonas hydrophila bacteria, immune and antioxidant factors, and blood indices were measured. …”
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The effect of training intervention based on health belief model on self-care behaviors of women with gestational diabetes mellitus by Fatemeh Mohammadkhah, Amirhossein Kamyab, Babak Pezeshki, Samira Norouzrajabi, Ali Khani Jeihooni

“…Also, the comparison of averages of blood sugar levels after the intervention in the two groups indicated that fasting blood sugar level, A1C hemoglobin, and blood sugar levels measured 2 h after the meal significantly decreased in the intervention group (p < 0.001). …”
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Conversion of placental hemogenic endothelial cells to hematopoietic stem and progenitor cells by Guixian Liang, Shicheng Liu, Chunyu Zhou, Mengyao Liu, Yifan Zhang, Dongyuan Ma, Lu Wang, Jing-Dong J. Han, Feng Liu

“…Abstract Hematopoietic stem and progenitor cells (HSPCs) are critical for the treatment of blood diseases in clinic. However, the limited source of HSPCs severely hinders their clinical application. …”
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Combined Color-Doppler Flow and Angio Planewave UltraSensitive™ Imaging for Analysis of Hemodynamic Characteristics of Normal Upper Limb Arteries by Yanzhou Liu, Xiyue Zhang, Hang Yang, Xueyan Tan, Duo Huang, Hongmei Yuan, Lili Yu, Fang Yang, Yuan Zou, Xiuli He, Yuqun Luo, Fangzhao Cui, Ping Wang, Zukun Li, Qing Zhang, Ning Zhang, Binglei Jiang, Wensheng Yue

“…The measured ultrasonic parameters included the vessel diameter, blood-flow spectrum waveform, peak systolic velocity, end-diastolic velocity, resistance index, pulsatility index, ratio of PSV to EDV, blood-flow volume, along with systolic acceleration of each BA, radial artery, superficial palmar arch artery, palmar proper digital artery, and third-grade artery arch of the fingernail bed. …”
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Cultivatable Bacteriota of Chronic Wound of Patients with Diabetic Foot Syndrome with Critical Limb Ischemia Based on Wound Biopsy in Peri-Revascularization Period by Syedah Sarah Hussaini, Fran Dominic Grubesa, Mateusz Gajda, Martyna Schönborn, Katarzyna Bogucka, Mikołaj Maga, Paweł Maga, Jadwiga Wójkowska-Mach

“…The aim of this study was to evaluate the impact of improved blood supply on the change in the clinical status and culturable bacteriota of chronic wounds. …”
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Prevalence, awareness, treatment, control, and treatment-control rates of hypertension among adults in Hubei province: a cross-sectional survey by Tianjing HE, Lan ZHANG, Shuzhen ZHU, Miaoyan SHEN, Qian LI, Yumeng TANG, Mengge ZHOU, Jingju PAN

“…Of the 8 287 hypertensive participants, 3 807 (43.1% after complex weighting) were aware of their hypertension, 3 324 (37.2%) were receiving treatment, and 828 (9.2%) had their blood pressure under control. Of the 3 324 hypertensive participants receiving treatment for hypertension, 828 (24.6% after complex weighting) had their blood pressure under control. …”
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Danshen injection ameliorates unilateral ureteral obstruction-induced renal fibrosis by inhibiting ferroptosis via activating SIRT1/GPX4 pathway by Yiwen Cao, Huan Zhao, Shuyin Lin, Junqi Chen, Jingli Xiong, Zhijun Zeng, Ziyu Long, Yingru Su, Yingqi Zhong, Lingru Zhao, Mingshan Zhang, Junbiao Wu, Yuan Zhou, Jiuyao Zhou

“…IntroductionThe pathogenesis of renal fibrosis is related to blood stasis, and the method of promoting blood circulation and removing blood stasis is often used as the treatment principle. …”
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Pathophysiology of tumor progression and possibilities of using polarization biomedical optics methods in the diagnosis of papillary thyroid cancer by Yu.Ye. Rohovyi, O.V. Bilookyi, O.H. Ushenko, V.V. Bilookyi

“…Clinical diagnosis of papillary thyroid cancer usually occurs at the stage of tumor progression accompanied by intensive processes of growth, invasion, formation of blood vessels to provide blood supply to the tumor, the structure and quantitative changes of which can be more informatively accurately assessed by polarization biomedical optics. …”
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Controlled Resistant Hypertension Following A Successful Renal Artery Stenting: A Rare Case Report in A Developing Country by Fatihatul Firdaus Munita, Badai Bhatara Tiksnadi, Januar Wibawa Martha, Margareta Ginanti Ratna

“…The patient showed a remarkable development following her decreasing blood pressure on follow-up. After one week, her blood pressure is controllable on a single antihypertensive and antiplatelet therapy. …”
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Is It the pH That Matters? Challenging the Pathophysiology of Acidemia in a Case of Severe Hypercapnia Secondary to Intraoperative CO2 Insufflation by Evan Merle, Saad Zaatari, Rory Spiegel

“…Remarkably, this patient remained hemodynamically normal despite having a blood pH below 6.81. This prompts a wider discussion about the effects of blood pH on human physiology. …”
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Umbilical Cord-Derived Mesenchymal Stem Cells Relieve Hindlimb Ischemia through Enhancing Angiogenesis in Tree Shrews by Cunping Yin, Yuan Liang, Jian Zhang, Guangping Ruan, Zian Li, Rongqing Pang, Xinghua Pan

“…In short, the isolated UC-MSCs notably contributed to restoring blood supply and alleviating the symptoms of limb ischemia through enhancing angiogenesis.…”
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Robot-Assisted Laparoscopic Radical Prostatectomy in the Morbidly Obese Patient by Jennifer Yates, Ravi Munver, Ihor Sawczuk

“…Parameters including operative time, estimated blood loss, hospital stay, pathology, and complication rate were examined. …”
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Clinicopathological analysis of sclerosing angiomatoid nodular transformation in the spleen by Shufei Wei, Yongliang Han, Yingyong Hou, Liangliang Wang

“…Histologically, angiomatoid nodules are composed of fattened, round, or irregular blood vessels, with or without red blood cells in the lumen, with unequal red blood cell extravasation, and fibrocytes around the nodules. …”
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Is There Really Relationship between Androgenetic Alopecia and Metabolic Syndrome? by Seyran Ozbas Gok, Asli Akin Belli, Emine Dervis

“…Age, duration of AGA, AGA onset age, anthropometric measures, body mass index, lipid parameters, fasting blood glucose, blood pressure, and presence of MS were recorded. …”
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Tumor Protective Activity of CD4+ but Not of CD8+ T Cells in DNA-Vaccinated Mice Challenged with bcr-abl-Transformed Cells by Martina Petráčková, Vincent Lučanský, Vladimír Vonka

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Minimally Invasive Approaches for Combined Gynecologic Surgeries: Our Three Years Clinical Experiences by İlknur İnegöl Gümüş, Önder Sürgit, Aysel Uysal, Serap Simavlı, Ayla Eser, İkbal Kaygusuz

“…Outcomes included operative time, intraoperative blood loss, hemoglobin levels, mean hospital stay and complication rate. …”
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OVERVIEW OF SELF-CARE BEHAVIOR IN PATIENTS WITH TYPE II DIABETES MELLITUS : LITERATURE REVIEW by Khotibul Umam, Ah Yusuf, Iswatun Iswatun

“…Based on a review article, the self-care regimen for type 2 Diabetes Mellitus patients generally includes physical activity, diet, controlling blood glucose levels, monitoring blood glucose and medication. …”
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Analysis of Sleep Quality and TCM Constitution Characteristics in 258 Outpatients: A Cross-Sectional Study Based on Outpatient Cases by Chang Liu, Jing Qu, Luquan Chen, Ruijie Liu

“…Insomnia is correlated and the TCM constitution bias, Qi deficiency, Yang deficiency, blood stasis, and Qi stagnation exhibiting the highest correlation.…”
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Benzocaine-Induced Methemoglobinemia in a Postoperative Bariatric Patient following Esophagogastroduodenoscopy by Khuram Khan, Irwin White-Gittens, Saqib Saeed, Leaque Ahmed

“…Paradoxically, these patients demonstrate normal to supranormal oxygen levels in the blood on blood gas analysis. We report a case of 34-year-old female postoperative Roux-en-Y gastric bypass patient who developed hypoxia and cyanosis after a routine EGD procedure to relieve a food impaction. …”
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