Protocol for a first-in-human feasibility study of T regulatory cells (TR004) for inflammatory bowel disease using (ex vivo) Treg expansion (TRIBUTE) by Jennifer Clough, Peter Irving, A Toby Prevost, Graham M Lord, Joana Vasconcelos, James B Canavan, Beverley Rodger, D Macallan

“…Introduction Crohn’s disease (CD) is a chronic, immune-mediated inflammatory bowel disease (IBD), presenting with symptoms of abdominal pain and bleeding from the gastrointestinal tract. There is no known cure. …”
Get full text

Hematohidrosis in Pediatric Practice  – a Case Report and Review of the Literature by Oksana Matsyura, Lesya Besh, Svitlana Jefimova, Khrystyna Slivinska-Kurchak, Sergiy Gerasymov

“…We took into consideration: age of the patient, sex, location of bloody excretion, cause or trigger, treatment and its effectiveness.Our clinical case present a 9-year-old girl complained of a periodic bleeding from the intact skin of the face, neck, thighs (without visible damage to the skin) manifested by red or pink liquid, nosebleeds, and bloody discharge from the mucous membrane of the eyes. …”
Get full text

Endoscopic Mucosal Resection Performed Underwater for Nonampullary Duodenal Epithelial Tumor: Evaluation of Feasibility and Safety by Goro Shibukawa, Atsushi Irisawa, Ai Sato, Yoko Abe, Akane Yamabe, Noriyuki Arakawa, Yusuke Takasaki, Takumi Maki, Yoshitsugu Yoshida, Ryo Igarashi, Shogo Yamamoto, Tsunehiko Ikeda, Hiroshi Hojo

“…There were no serious adverse events including bleeding or perforation. Conclusions. UW-EMR may be a safe and effective treatment method for SNADET, if its therapeutic indication is adequately considered.…”
Get full text

Safety and effectiveness of appropriately and inappropriately dosed rivaroxaban or apixaban versus warfarin in patients with atrial fibrillation: a cohort study with nested case–co... by Luis Alberto García Rodríguez, Pareen Vora, Luke Roberts, Gunnar Brobert, Samuel Fatoba, María Eugenia Sáez, Antonio González-Pérez

“…Objectives To investigate effects of appropriately and inappropriately dosed apixaban/rivaroxaban versus warfarin on effectiveness and safety outcomes in patients with non-valvular atrial fibrillation (NVAF).Design Cohort study with nested case–control analyses using primary care electronic health records (IQVIA Medical Research Data UK database).Setting UK primary care.Participants Patients aged ≥18 years with NVAF newly prescribed apixaban (N=14 701), rivaroxaban (N=14 288) or warfarin (N=16 175) between 1 January 2012 and 30 June 2018, and followed up to 31 December 2018.Primary and secondary outcome measures Incident cases of ischaemic stroke/systemic embolism (IS/SE) and intracranial bleeding (ICB). Cases were matched to controls on age, sex and OAC naïve status. …”
Get full text

The evaluation of safe zones for the corona mortis using a cadaver simulation of the Modified Stoppa approach by Jade Naicker, Zithulele Nkosinathi Tshabalala, Andries Masenge, Obakeng Modisane, Steven Matshidza, Nkhensani Mogale

“…These risks arise from the inadvertent severing of vessels along the pelvic brim, resulting in bleeding, prolonged recovery, or even death. The specific vessels of concern include the corona mortis (CM) anastomosis and aberrant vasculature, which course over the superior pubic ramus. …”
Get full text

Relationship between sonorheometry parameters and laboratory values in a critical care setting in Italy: a retrospective cohort study by Antonio Romanelli, Renato Gammaldi, Alessandro Calicchio, Salvatore Palmese, Antonio Siglioccolo

“…Conclusions Quantra can provide useful information regarding coagulation status, showing modest correlations with the parameters obtained from laboratory tests. During diffuse bleeding, CT and FCS values can guide the proper administration of clotting factors and fibrinogens. …”
Get full text

Efficacy and Safety of Murivenna Anal Infiltration Compared to Diltiazem Topical Application in Chronic Anal Fissure: Protocol for a Prospective, Randomized, Open-Label Clinical Tr... by Pratap Shankar KM, Indu Puthan Purayil, Palengara Binitha, Amit Kumar Rai, Sophia Jameela, Azeem Ahmad, Chandra Sekhara Rao Bhogavalli, Narayanam Srikanth, Rabinarayan Acharya

“…The secondary outcomes will be the proportion of participants demonstrating complete healing after 7 days and 14 days of treatment, change in pain at or after defecation, cessation of bleeding, and any recurrence during the study period. …”
Get full text

Outcomes of Combined Left Atrial Appendage Occlusion and Transcatheter Mitral Edge-to-Edge Repair by Abdullah Al-Abcha, MD, Pietro Di Santo, MD, Charanjit S. Rihal, MD, MBA, Trevor Simard, MD, PhD, Benjamin Hibbert, MD, PhD, Mohamad Alkhouli, MD, MBA

“…The primary endpoint was a composite of all-cause mortality, stroke, life-threatening, or major bleeding at 45 days. Results: A total of 24 patients were included between October 2020 and March 2024. …”
Get full text

自发性脑出血术后早期使用阿司匹林的可能性：来自中国学者的首个脑出血围手术期管理高级别循证依据 Possibility of Early Use of Aspirin after Spontaneous Intracerebral Hemorrhage Surgery: The First High-Level Evidence-Based Evidenc... by 周航，陈高(ZHOU Hang, CHEN Gao)

“…The recently published early-start antiplatelet treatment after neurosurgery in patients with spontaneous intracerebral hemorrhage (E-start) study indicates that for intracerebral hemorrhage patients with a high risk of ischemic events, early initiation of postoperative antiplatelet therapy can bring significant benefits without increasing the risk of bleeding. As the first high-level evidence-based evidence on perioperative management of intracerebral hemorrhage in China, the E-start study is instrumental in improving the treatment and management standards for intracerebral hemorrhage and enhancing patient outcomes.…”
Get full text

Undetermined Ruptured Low‐Grade Appendiceal Mucinous Neoplasm Following High‐Energy Blunt Abdominal Trauma Requiring Emergency Laparotomy by Ippei Matsuo, Tetsuya Yumoto, Akari Tsuji, Ryo Tanabe, Toshihisa Matsumura, Mikoto Shimabara, Masaaki Akai, Shoji Takagi, Hiromichi Naito, Atsunori Nakao

“…ABSTRACT Blunt abdominal trauma causing intraperitoneal injury and/or bleeding can be life‐threatening, requiring immediate intervention. …”
Get full text

Is It Possible to Achieve Favorable Accelerated Dental Changes with No Periodontal Complications When Retracting Upper Anterior Teeth Assisted by Flapless Corticotomy Compared to T... by Hanin Nizar Khlef, Mohammad Younis Hajeer

“…The values of gingival, papillary bleeding and plaque indices in the TC group were significantly greater than those in the FC group after performing the corticotomy (P<0.001, P<0.003, P=0.002, respectively). …”
Get full text

Complete blood count parameters and inflammation-related biomarkers in patients with colorectal carcinoma by Koržinek Martha, Ćelap Ivana, Fabijanec Marija, Žanić Tena, Ljubičić Neven, Baršić Neven, Verbanac Donatella, Barišić Karmela, Rajković Marija Grdić

“…Lower hemo globin levels in CRC patients are possibly due to more frequent and excessive bleeding. Higher levels of basophils and eosinophils in CRC patients are indicators of inflammatory reaction, which is linked to CRC.…”
Get full text

Bronchotracheal Stenting Management by Rigid Bronchoscopy under Extracorporeal Membrane Oxygenation (ECMO) Support: 10 Years of Experience in a Tertiary Center by Sabrina Meyer, Anne-Sophie Dincq, Lionel Pirard, Sebahat Ocak, Jean-Paul D’Odémont, Philippe Eucher, Benoît Rondelet, André Gruslin, Laurie Putz

“…Only two local complications caused by the cannulation of ECMO were reported, and anticoagulation was adapted to avoid bleeding at the operating site and clot formation in the system. …”
Get full text

Predictors of missed hospital appointments in patients with posterior compartment pelvic floor disorders in a tertiary referral centre by Tanzeela Gala, Mehak Saini, Abigail Fernandes, Carlotta Sarzo, Noman Shahzad, Carlene Igbedioh, Alexis Schizas, Linda Ferrari, Alison Hainsworth

“…Missed appointments recorded were: TTAC — 45 (2.2%), BFC — 309 (15.8%), EAUS — 476(24%), PFUS — 484(37.2%) and DP — 432(26.2%).Predictors determined were: Male gender, age <50 years, complaints of rectal pain and bleeding for missing telephone and face-to-face appointments, low socioeconomic status for missing face-to-face appointments, and mixed and other ethnic groups with missing telephone appointments. …”
Get full text

Topical Application of Orabase Bromelain Gel Reduces Inflammatory Process, Bone Loss and Steatosis in Experimental Periodontitis by Even Herlany Pereira Alves, Hélio Mateus Silva Nascimento, Luiz Felipe de Carvalho França, Any Carolina Cardoso Guimarães Vasconcelos, Larissa dos Santos Pessoa, Felipe Rodolfo Pereira da Silva, John Arlley Sousa Pinho de Lira, Paulo Roberto Carneiro Gomes, André dos Santos Carvalho, André Luiz dos Reis Barbosa, Daniel Fernando Pereira Vasconcelos

“…The clinical parameters of tooth mobility (TM), gingival bleeding index (GBI) and probing pocket depth (PPD) were evaluated and, after euthanasia, gingival and liver tissue were collected by biopsy for biochemical evaluation of myeloperoxidase (MPO), malonaldehyde (MDA), glutathione (GSH) and from the jaws for morphometric analysis of alveolar bone height. …”
Get full text

Effectiveness of sacral neuromodulation with 3D-printing and ultrasound localization for treating neurogenic bladder in patients with pelvic structural anomalies by Runze Liu, Yuxuan Zhou, Qiang Hao, Yaoguang Zhang, Peng Zhang, Guoqing Chen, Yong Zhang

“…Metrics compared included the number of punctures, average puncture duration, intraoperative SNS tuning time, effective initial voltage, postoperative testing duration, phase two conversion rates, and the incidence of bleeding and infection. Results: The study group experienced significantly fewer punctures compared to the control group (2.21 ± 0.92 vs 9.29 ± 4.37) (P < 0.01), had a shorter average puncture duration (5.71 ± 2.69 min vs. 28.60 ± 9.69 min) (P < 0.01), and required a lower effective initial voltage (0.87 ± 0.23v vs. 1.38 ± 0.52v) (P < 0.01). …”
Get full text

Balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension: short- and long-term results from a cohort in Brazil by Fabio Solano de Freitas Souza, Marcelo Gottschald Ferreira, Iury Andrade Melo, Marta Ferreira Leite de Sá, Camila Melo Coelho Loureiro, Rosalvo Abreu, Paulo Henrique Alves de Carvalho, Mateus dos Santos Viana, Valdemar Oliveira Jr, Luiz Eduardo Fonteles Ritt

“…Two deaths were recorded (due to CTEPH progression and gastrointestinal bleeding, respectively). Conclusions: Among this first group of patients treated with BPA in Brazil, there was significant short- and long-term clinical improvement, together with a low frequency of complications.…”
Get full text

Hemodynamic Evaluation of Nonselective β-Blockers in Patients with Cirrhosis and Refractory Ascites by Alberto Ferrarese, Valerie Tikhonoff, Edoardo Casiglia, Paolo Angeli, Silvano Fasolato, Diego Faggian, Alberto Zanetto, Giacomo Germani, Francesco Paolo Russo, Patrizia Burra, Marco Senzolo

“…Patients with cirrhosis and refractory ascites, with an indication to start NSBB in primary prophylaxis for variceal bleeding, were enrolled. During two consecutive LVP, while being, respectively, off and on NSBB, cardiac output (CO), systemic vascular resistances (SVR), peripheral vascular resistances (PVR), and plasma renin activity (PRA) were noninvasively assessed. …”
Get full text

ULSOSEAL Technique: A Unique Technique to Achieve Hemostasis Using ExoSeal in High-Risk Patients after Common Femoral Artery Puncture by Yohsuke Honda, Shinsuke Mori, Tomoya Fukagawa, Toshihiko Kishida, Takahide Nakano, Shigemitsu Shirai, Masafumi Mizusawa, Kenji Makino, Masakazu Tsutsumi, Norihiro Kobayashi, Masahiro Yamawaki, Yoshiaki Ito

“…There was no incidence of vessel occlusion, pseudoaneurysm, arteriovenous fistula, infection, and secondary bleeding. One patient developed a hematoma (>5 cm in size); however, it occurred before the use of ExoSeal due to side leakage from the inserted sheath. …”
Get full text

Economic and Humanistic Burden of Moderate and Severe Hemophilia A and B in Spain: Real-World Evidence Insights from the CHESS II Study by Carmen Peral, Alfonso De Lossada Juste, Nadia Lwoff, Nataly Espinoza-Cámac, Miguel Ángel Casado, Tom Burke, Jose Alvir, Sheena Thakkar, Enrico Ferri Grazzi

“…**Background:** Hemophilia is a congenital disorder characterized by deficiency or absence of clotting factor VIII in hemophilia A (HA) or clotting factor IX in hemophilia B (HB), resulting in frequent, repeated, and prolonged spontaneous or traumatic bleeding into joints or soft tissue. Severity is classified by the patient's baseline level of clotting factor activity as mild (>5%-40%), moderate (1%-5%), or severe (<1%). …”
Get full text